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Volumn 9, Issue 6, 2014, Pages 2051-2060

Use of regulators and inhibitors of Pim-1, a serine/threonine kinase, for tumour therapy (Review)

Author keywords

Cytokine; Hormone; Inhibitor; MicroRNA; Phosphoinositide 3 kinase like protein kinase; Pim kinase

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE COMPETITIVE INHIBITOR; ADENOSINE TRIPHOSPHATE MIMETIC INHIBITOR; ANTINEOPLASTIC AGENT; ESTROGEN; INECALCITOL; MICRORNA; PROTEIN KINASE PIM 1; PROTEIN KINASE PIM 1 INHIBITOR; UNCLASSIFIED DRUG; CYTOKINE; HORMONE; PROTEIN KINASE INHIBITOR;

EID: 84899697597     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2139     Document Type: Review
Times cited : (19)

References (97)
  • 1
    • 0021233675 scopus 로고
    • Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region
    • Cuypers HT, Selten G, Quint W, et al : Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cell 37: 141-150, 1984. (Pubitemid 14079845)
    • (1984) Cell , vol.37 , Issue.1 , pp. 141-150
    • Cuypers, H.T.1    Selten, G.2    Quint, W.3
  • 3
    • 2942700011 scopus 로고    scopus 로고
    • Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors
    • DOI 10.1128/MCB.24.13.6104-6115.2004
    • Mikkers H, Nawijn M, Allen J, et al: Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors. Mol Cell Biol 24: 6104-6115, 2004. (Pubitemid 38787993)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.13 , pp. 6104-6115
    • Mikkers, H.1    Nawijn, M.2    Allen, J.3    Brouwers, C.4    Verhoeven, E.5    Jonkers, J.6    Berns, A.7
  • 4
    • 0022522805 scopus 로고
    • The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases
    • Selten G, Cuypers HT, Boelens W, et al: The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases. Cell 46: 603-611, 1986. (Pubitemid 16022415)
    • (1986) Cell , vol.46 , Issue.4 , pp. 603-611
    • Selten, G.1    Cuypers, H.T.2    Boelens, W.3
  • 5
    • 32944458740 scopus 로고    scopus 로고
    • Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL
    • Macdonald A, Campbell DG, Toth R, McLauchlan H, Hastie CJ and Arthur JS: Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL. BMC Cell Biol 7: 1, 2006.
    • (2006) BMC Cell Biol , vol.7 , pp. 1
    • Macdonald, A.1    Campbell, D.G.2    Toth, R.3    McLauchlan, H.4    Hastie, C.J.5    Arthur, J.S.6
  • 6
    • 0026019439 scopus 로고
    • The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG
    • Saris CJ, Domen J and Berns A: The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG. EMBO J 10: 655-664, 1991. (Pubitemid 21905520)
    • (1991) EMBO Journal , vol.10 , Issue.3 , pp. 655-664
    • Saris, C.J.M.1    Domen, J.2    Berns, A.3
  • 7
    • 48549096958 scopus 로고    scopus 로고
    • Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels
    • Morishita D, Katayama R, Sekimizu K, Tsuruo T and Fujita N: Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Res 68: 5076-5085, 2008.
    • (2008) Cancer Res , vol.68 , pp. 5076-5085
    • Morishita, D.1    Katayama, R.2    Sekimizu, K.3    Tsuruo, T.4    Fujita, N.5
  • 8
    • 0025006441 scopus 로고
    • Primary structure of the putative human oncogene, pim-1
    • DOI 10.1016/0378-1119(90)90195-W
    • Reeves R, Spies GA, Kiefer M, Barr PJ and Power M: Primary structure of the putative human oncogene, pim-1. Gene 90: 303-307, 1990. (Pubitemid 20261714)
    • (1990) Gene , vol.90 , Issue.2 , pp. 303-307
    • Reeves, R.1    Spies, G.A.2    Kiefer, M.3    Barr, P.J.4    Power, M.5
  • 10
    • 78650606450 scopus 로고    scopus 로고
    • For better or for worse: The role of Pim oncogenes in tumorigenesis
    • Nawijn MC, Alendar A and Berns A: For better or for worse: the role of Pim oncogenes in tumorigenesis. Nat Rev Cancer 11: 23-34, 2011.
    • (2011) Nat Rev Cancer , vol.11 , pp. 23-34
    • Nawijn, M.C.1    Alendar, A.2    Berns, A.3
  • 12
    • 79960411328 scopus 로고    scopus 로고
    • Roles of Pim-3, a novel survival kinase, in tumorigenesis
    • Mukaida N, Wang YY and Li YY: Roles of Pim-3, a novel survival kinase, in tumorigenesis. Cancer Sci 102: 1437-1442, 2011.
    • (2011) Cancer Sci , vol.102 , pp. 1437-1442
    • Mukaida, N.1    Wang, Y.Y.2    Li, Y.Y.3
  • 13
    • 0033603454 scopus 로고    scopus 로고
    • Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway
    • Mochizuki T, Kitanaka C, Noguchi K, Muramatsu T, Asai A and Kuchino Y: Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway. J Biol Chem 274: 18659-18666, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 18659-18666
    • Mochizuki, T.1    Kitanaka, C.2    Noguchi, K.3    Muramatsu, T.4    Asai, A.5    Kuchino, Y.6
  • 15
    • 9144225473 scopus 로고    scopus 로고
    • 2TM cell cycle checkpoint
    • DOI 10.1074/jbc.M404440200
    • Bachmann M, Hennemann H, Xing PX, Hoffmann I and Möröy T: The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint. J Biol Chem 279: 48319-48328, 2004. (Pubitemid 39540988)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.46 , pp. 48319-48328
    • Bachmann, M.1    Hennemann, H.2    Pei, X.X.3    Hoffmann, I.4    Moroy, T.5
  • 16
    • 29244464759 scopus 로고    scopus 로고
    • The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C
    • DOI 10.1016/j.biocel.2005.10.010, PII S1357272505003092
    • Bachmann M, Kosan C, Xing PX, Montenarh M, Hoffmann I and Möröy T: The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C. Int J Biochem Cell Biol 38: 430-443, 2006. (Pubitemid 41821890)
    • (2006) International Journal of Biochemistry and Cell Biology , vol.38 , Issue.3 , pp. 430-443
    • Bachmann, M.1    Kosan, C.2    Xing, P.X.3    Montenarh, M.4    Hoffmann, I.5    Moroy, T.6
  • 17
    • 0036320651 scopus 로고    scopus 로고
    • Pim-1 expression is sufficient to induce cytokine independence in murine hematopoietic cells, but is dispensable for BCR-ABL-mediated transformation
    • DOI 10.1016/S0301-472X(02)00808-1, PII S0301472X02008081
    • Nosaka T and Kitamura T: Pim-1 expression is sufficient to induce cytokine independence in murine hematopoietic cells, but is dispensable for BCR-ABL-mediated transformation. Exp Hematol 30: 697-702, 2002. (Pubitemid 34831689)
    • (2002) Experimental Hematology , vol.30 , Issue.7 , pp. 697-702
    • Nosaka, T.1    Kitamura, T.2
  • 18
    • 77953180976 scopus 로고    scopus 로고
    • PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers
    • Brault L, Gasser C, Bracher F, Huber K, Knapp S and Schwaller J: PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. Haematologica 95: 1004-1015, 2010.
    • (2010) Haematologica , vol.95 , pp. 1004-1015
    • Brault, L.1    Gasser, C.2    Bracher, F.3    Huber, K.4    Knapp, S.5    Schwaller, J.6
  • 19
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - microRNAs with a role in cancer
    • Esquela-Kerscher A and Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269, 2006.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 20
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • DOI 10.1038/nrc1997, PII NRC1997
    • Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer 6: 857-866, 2006. (Pubitemid 44629897)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.11 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 21
    • 33747876113 scopus 로고    scopus 로고
    • MicroRNA-cancer connection: The beginning of a new tale
    • DOI 10.1158/0008-5472.CAN-06-0800
    • Calin GA and Croce CM: MicroRNA-cancer connection: the beginning of a new tale. Cancer Res 66: 7390-7394, 2006. (Pubitemid 44289189)
    • (2006) Cancer Research , vol.66 , Issue.15 , pp. 7390-7394
    • Calin, G.A.1    Croce, C.M.2
  • 22
    • 84857122981 scopus 로고    scopus 로고
    • The proto-oncogene Pim-1 is a target of miR-33a
    • Thomas M, Lange-Grünweller K, Weirauch U, et al : The proto-oncogene Pim-1 is a target of miR-33a. Oncogene 31: 918-928, 2012.
    • (2012) Oncogene , vol.31 , pp. 918-928
    • Thomas, M.1    Lange-Grünweller, K.2    Weirauch, U.3
  • 23
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • DOI 10.1016/j.cell.2004.12.035, PII S0092867404012607
    • Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120: 15-20, 2005. (Pubitemid 40094598)
    • (2005) Cell , vol.120 , Issue.1 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 24
    • 34250805982 scopus 로고    scopus 로고
    • MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing
    • DOI 10.1016/j.molcel.2007.06.017, PII S1097276507004078
    • Grimson A, Farh KK, Johnston WK, Garrett-Engele P, Lim LP and Bartel DP: MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell 27: 91-105, 2007. (Pubitemid 46991392)
    • (2007) Molecular Cell , vol.27 , Issue.1 , pp. 91-105
    • Grimson, A.1    Farh, K.K.-H.2    Johnston, W.K.3    Garrett-Engele, P.4    Lim, L.P.5    Bartel, D.P.6
  • 27
    • 55549114664 scopus 로고    scopus 로고
    • The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities
    • Bonci D, Coppola V, Musumeci M, et al: The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. Nat Med 14: 1271-1277, 2008.
    • (2008) Nat Med , vol.14 , pp. 1271-1277
    • Bonci, D.1    Coppola, V.2    Musumeci, M.3
  • 28
    • 0026457216 scopus 로고
    • Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages
    • Birg F, Courcoul M, Rosnet O, et al : Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages. Blood 80: 2584-2593, 1992.
    • (1992) Blood , vol.80 , pp. 2584-2593
    • Birg, F.1    Courcoul, M.2    Rosnet, O.3
  • 30
    • 16944365287 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines
    • Yokota S, Kiyoi H, Nakao M, et al: Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines. Leukemia 11: 1605-1609, 1997. (Pubitemid 27458595)
    • (1997) Leukemia , vol.11 , Issue.10 , pp. 1605-1609
    • Yokota, S.1    Kiyoi, H.2    Nakao, M.3    Iwai, T.4    Misawa, T.5    Okuda, T.6    Sonoda, Y.7    Abe, T.8    Kahsima, K.9    Matsuo, Y.10    Naoe, T.11
  • 32
    • 13544268345 scopus 로고    scopus 로고
    • Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival
    • DOI 10.1182/blood-2004-05-2006
    • Kim KT, Baird K, Ahn JY, et al: Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival. Blood 105: 1759-1767, 2005. (Pubitemid 40223700)
    • (2005) Blood , vol.105 , Issue.4 , pp. 1759-1767
    • Kim, K.-T.1    Baird, K.2    Ahn, J.-Y.3    Meltzer, P.4    Lilly, M.5    Levis, M.6    Small, D.7
  • 34
    • 84866125820 scopus 로고    scopus 로고
    • MicroRNA-16 is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1
    • Kim KT, Carroll AP, Mashkani B, Cairns MJ, Small D and Scott RJ: MicroRNA-16 is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1. PLoS One 7: e44546, 2012.
    • (2012) PLoS One , vol.7
    • Kim, K.T.1    Carroll, A.P.2    Mashkani, B.3    Cairns, M.J.4    Small, D.5    Scott, R.J.6
  • 35
    • 0034554796 scopus 로고    scopus 로고
    • Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
    • Mizuki M, Fenski R, Halfter H, et al: Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood 96: 3907-3914, 2000.
    • (2000) Blood , vol.96 , pp. 3907-3914
    • Mizuki, M.1    Fenski, R.2    Halfter, H.3
  • 36
    • 0033820091 scopus 로고    scopus 로고
    • Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation
    • Tse KF, Mukherjee G and Small D: Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation. Leukemia 14: 1766-1776, 2000.
    • (2000) Leukemia , vol.14 , pp. 1766-1776
    • Tse, K.F.1    Mukherjee, G.2    Small, D.3
  • 37
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F, Towatari M, Kiyoi H, et al: Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene 19: 624-631, 2000. (Pubitemid 30102913)
    • (2000) Oncogene , vol.19 , Issue.5 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3    Tanimoto, M.4    Kitamura, T.5    Saito, H.6    Naoe, T.7
  • 38
    • 0033199236 scopus 로고    scopus 로고
    • STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells
    • DOI 10.1093/emboj/18.17.4754
    • Nosaka T, Kawashima T, Misawa K, Ikuta K, Mui AL and Kitamura T: STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J 18: 4754-4765, 1999. (Pubitemid 29415529)
    • (1999) EMBO Journal , vol.18 , Issue.17 , pp. 4754-4765
    • Nosaka, T.1    Kawashima, T.2    Misawa, K.3    Ikuta, K.4    Mui, A.L.-F.5    Kitamura, T.6
  • 39
    • 77953787211 scopus 로고    scopus 로고
    • MiR-33 contributes to the regulation of cholesterol homeostasis
    • Rayner KJ, Suárez Y, Dávalos A, et al: MiR-33 contributes to the regulation of cholesterol homeostasis. Science 328: 1570-1573, 2010.
    • (2010) Science , vol.328 , pp. 1570-1573
    • Rayner, K.J.1    Suárez, Y.2    Dávalos, A.3
  • 40
    • 84868606462 scopus 로고    scopus 로고
    • Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells
    • Tian Z, Zhao JJ, Tai YT, et al : Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells. Blood 120: 3958-3967, 2012.
    • (2012) Blood , vol.120 , pp. 3958-3967
    • Tian, Z.1    Zhao, J.J.2    Tai, Y.T.3
  • 41
    • 79960963683 scopus 로고    scopus 로고
    • MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma
    • Ibrahim AF, Weirauch U, Thomas M, Grünweller A, Hartmann RK and Aigner A: MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma. Cancer Res 71: 5214-5224, 2011.
    • (2011) Cancer Res , vol.71 , pp. 5214-5224
    • Ibrahim, A.F.1    Weirauch, U.2    Thomas, M.3    Grünweller, A.4    Hartmann, R.K.5    Aigner, A.6
  • 45
    • 79551501872 scopus 로고    scopus 로고
    • Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation
    • Chen J, Yin H, Jiang Y, et al: Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation. Arterioscler Thromb Vasc Biol 31: 368-375, 2011.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 368-375
    • Chen, J.1    Yin, H.2    Jiang, Y.3
  • 46
    • 77951885494 scopus 로고    scopus 로고
    • Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway
    • Katare RG, Caporali A, Oikawa A, Meloni M, Emanueli C and Madeddu P: Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway. Circ Heart Fail 3: 294-305, 2010.
    • (2010) Circ Heart Fail , vol.3 , pp. 294-305
    • Katare, R.G.1    Caporali, A.2    Oikawa, A.3    Meloni, M.4    Emanueli, C.5    Madeddu, P.6
  • 47
    • 79957497037 scopus 로고    scopus 로고
    • Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling
    • Katare R, Caporali A, Zentilin L, et al: Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circ Res 108: 1238-1251, 2011.
    • (2011) Circ Res , vol.108 , pp. 1238-1251
    • Katare, R.1    Caporali, A.2    Zentilin, L.3
  • 48
    • 33846019681 scopus 로고    scopus 로고
    • RT-PCR-based analysis of microRNA (miR-1 and -124) expression in mouse CNS
    • DOI 10.1016/j.brainres.2006.11.035, PII S0006899306032641
    • Mishima T, Mizuguchi Y, Kawahigashi Y, Takizawa T and Takizawa T: RT-PCR-based analysis of microRNA (miR-1 and -124) expression in mouse CNS. Brain Res 1131: 37-43, 2007. (Pubitemid 46053907)
    • (2007) Brain Research , vol.1131 , Issue.1 , pp. 37-43
    • Mishima, T.1    Mizuguchi, Y.2    Kawahigashi, Y.3    Takizawa, T.4    Takizawa, T.5
  • 50
    • 57749089758 scopus 로고    scopus 로고
    • Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1
    • Nasser MW, Datta J, Nuovo G, et al: Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1. J Biol Chem 283: 33394-33405, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 33394-33405
    • Nasser, M.W.1    Datta, J.2    Nuovo, G.3
  • 51
    • 84868283942 scopus 로고    scopus 로고
    • Overexpression of osteopontin, αvβ3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer
    • Jin Y, Tong DY, Chen JN, et al: Overexpression of osteopontin, αvβ3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer. PloS One 7: e48575, 2012.
    • (2012) PloS One , vol.7
    • Jin, Y.1    Tong, D.Y.2    Chen, J.N.3
  • 52
    • 0037097701 scopus 로고    scopus 로고
    • Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis
    • DOI 10.1182/blood.V99.12.4531
    • Nieborowska-Skorska M, Hoser G, Kossev P, Wasik MA and Skorski T: Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis. Blood 99: 4531-4539, 2002. (Pubitemid 34627224)
    • (2002) Blood , vol.99 , Issue.12 , pp. 4531-4539
    • Nieborowska-Skorska, M.1    Hoser, G.2    Kossev, P.3    Wasik, M.A.4    Skorski, T.5
  • 53
    • 77649133970 scopus 로고    scopus 로고
    • miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts
    • Eiring AM, Harb JG, Neviani P, et al: miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell 140: 652-665, 2010.
    • (2010) Cell , vol.140 , pp. 652-665
    • Eiring, A.M.1    Harb, J.G.2    Neviani, P.3
  • 56
    • 70349168446 scopus 로고    scopus 로고
    • Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation
    • Huang X, Ding L, Bennewith KL, et al: Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell 35: 856-867, 2009.
    • (2009) Mol Cell , vol.35 , pp. 856-867
    • Huang, X.1    Ding, L.2    Bennewith, K.L.3
  • 57
    • 0027218972 scopus 로고
    • Breast cancer epidemiology: Summary and future directions
    • Kelsey JL: Breast cancer epidemiology: summary and future directions. Epidemiol Rev 15: 256-263, 1993.
    • (1993) Epidemiol Rev , vol.15 , pp. 256-263
    • Kelsey, J.L.1
  • 58
    • 80052836892 scopus 로고    scopus 로고
    • ERβ1 represses FOXM1 expression through targeting ERα to control cell proliferation in breast cancer
    • Horimoto Y, Hartman J, Millour J, et al: ERβ1 represses FOXM1 expression through targeting ERα to control cell proliferation in breast cancer. Am J Pathol 179: 1148-1156, 2011.
    • (2011) Am J Pathol , vol.179 , pp. 1148-1156
    • Horimoto, Y.1    Hartman, J.2    Millour, J.3
  • 59
    • 84871388902 scopus 로고    scopus 로고
    • Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors
    • Malinen M, Jääskeläinen T, Pelkonen M, et al: Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors. Mol Cell Endocrinol 365: 270-276, 2013.
    • (2013) Mol Cell Endocrinol , vol.365 , pp. 270-276
    • Malinen, M.1    Jääskeläinen, T.2    Pelkonen, M.3
  • 60
    • 77951092239 scopus 로고    scopus 로고
    • Dehydroepiandrosterone: A new treatment for vascular remodeling diseases including pulmonary arterial hypertension
    • Dumas de la Roque E, Savineau JP and Bonnet S: Dehydroepiandrosterone: A new treatment for vascular remodeling diseases including pulmonary arterial hypertension. Pharmacol Ther 126: 186-199, 2010.
    • (2010) Pharmacol Ther , vol.126 , pp. 186-199
    • Dumas De La Roque, E.1    Savineau, J.P.2    Bonnet, S.3
  • 63
    • 0036634939 scopus 로고    scopus 로고
    • Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer
    • Guzey M, Kitada S and Reed JC: Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer. Mol Cancer Ther 1: 667-677, 2002.
    • (2002) Mol Cancer Ther , vol.1 , pp. 667-677
    • Guzey, M.1    Kitada, S.2    Reed, J.C.3
  • 64
    • 84859104276 scopus 로고    scopus 로고
    • Inecalcitol, an analog of 1α,25(OH)(2) D(3), induces growth arrest of androgen-dependent prostate cancer cells
    • Okamoto R, Delansorne R, Wakimoto N, et al: Inecalcitol, an analog of 1α,25(OH)(2) D(3), induces growth arrest of androgen-dependent prostate cancer cells. Int J Cancer 130: 2464-2473, 2012.
    • (2012) Int J Cancer , vol.130 , pp. 2464-2473
    • Okamoto, R.1    Delansorne, R.2    Wakimoto, N.3
  • 65
    • 84883199057 scopus 로고    scopus 로고
    • Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer
    • Ha S, Iqbal NJ, Mita P, et al: Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer. Oncogene 32: 3992-4000, 2013.
    • (2013) Oncogene , vol.32 , pp. 3992-4000
    • Ha, S.1    Iqbal, N.J.2    Mita, P.3
  • 66
    • 84862489015 scopus 로고    scopus 로고
    • PIM-1 kinase interacts with the DNA binding domain of the vitamin D receptor: A further kinase implicated in 1,25-(OH)2D3 signaling
    • Maier CJ, Maier RH, Rid R, et al: PIM-1 kinase interacts with the DNA binding domain of the vitamin D receptor: a further kinase implicated in 1,25-(OH)2D3 signaling. BMC Mol Biol 13: 18, 2012.
    • (2012) BMC Mol Biol , vol.13 , pp. 18
    • Maier, C.J.1    Maier, R.H.2    Rid, R.3
  • 67
    • 33646940750 scopus 로고    scopus 로고
    • Molecular biology of prostate-cancer pathogenesis
    • DOI 10.1097/01.mou.0000193384.39351.64, PII 0004230720060500000003
    • Shand RL and Gelmann EP: Molecular biology of prostate-cancer pathogenesis. Curr Opin Urol 16: 123-131, 2006. (Pubitemid 43791779)
    • (2006) Current Opinion in Urology , vol.16 , Issue.3 , pp. 123-131
    • Shand, R.L.1    Gelmann, E.P.2
  • 68
    • 84901372456 scopus 로고    scopus 로고
    • Current trends for the use of androgen deprivation therapy in conjunction with radiotherapy for patients with unfavorable intermediate-risk, high-risk, localized, and locally advanced prostate cancer
    • Mar 3, Epub ahead of print
    • Roach M III: Current trends for the use of androgen deprivation therapy in conjunction with radiotherapy for patients with unfavorable intermediate-risk, high-risk, localized, and locally advanced prostate cancer. Cancer: Mar 3, 2014 (Epub ahead of print).
    • (2014) Cancer
    • Roach III, M.1
  • 69
    • 0033119571 scopus 로고    scopus 로고
    • Antiapoptotic signaling in LNCaP prostate cancer cells: A survival signaling pathway independent of phosphatidylinositol 3'-kinase and Akt/protein kinase B
    • Carson JP, Kulik G and Weber MJ: Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3'-kinase and Akt/protein kinase B. Cancer Res 59: 1449-1453, 1999. (Pubitemid 29160109)
    • (1999) Cancer Research , vol.59 , Issue.7 , pp. 1449-1453
    • Carson, J.P.1    Kulik, G.2    Weber, M.J.3
  • 71
    • 79952104214 scopus 로고    scopus 로고
    • Activation of a non-genomic Pim-1/Bad-Pser75 module is required for an efficient pro-survival effect of Bcl-xL induced by androgen in LNCaP cells
    • Kumar JK, Ping RY, Teong HF, Goh S and Clément MV: Activation of a non-genomic Pim-1/Bad-Pser75 module is required for an efficient pro-survival effect of Bcl-xL induced by androgen in LNCaP cells. Int J Biochem Cell Biol 43: 594-603, 2011.
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 594-603
    • Kumar, J.K.1    Ping, R.Y.2    Teong, H.F.3    Goh, S.4    Clément, M.V.5
  • 72
    • 84861117814 scopus 로고    scopus 로고
    • PI3K-like kinases restrain Pim gene expression in endothelial cells
    • Min X, Tang J, Wang Y, et al: PI3K-like kinases restrain Pim gene expression in endothelial cells. J Huazhong Univ Sci Technolog Med Sci 32: 17-23, 2012.
    • (2012) J Huazhong Univ Sci Technolog Med Sci , vol.32 , pp. 17-23
    • Min, X.1    Tang, J.2    Wang, Y.3
  • 74
    • 2942525073 scopus 로고    scopus 로고
    • Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro
    • DOI 10.1182/blood-2003-11-3827
    • Zippo A, De Robertis A, Bardelli M, Galvagni F and Oliviero S: Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro. Blood 103: 4536-4544, 2004. (Pubitemid 38745981)
    • (2004) Blood , vol.103 , Issue.12 , pp. 4536-4544
    • Zippo, A.1    De Robertis, A.2    Bardelli, M.3    Galvagni, F.4    Oliviero, S.5
  • 75
    • 8444247043 scopus 로고    scopus 로고
    • IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils
    • Stout BA, Bates ME, Liu LY, Farrington NN and Bertics PJ: IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils. J Immunol 173: 6409-6417, 2004. (Pubitemid 39487801)
    • (2004) Journal of Immunology , vol.173 , Issue.10 , pp. 6409-6417
    • Stout, B.A.1    Bates, M.E.2    Liu, L.Y.3    Farrington, N.N.4    Bertics, P.J.5
  • 77
    • 84863686744 scopus 로고    scopus 로고
    • IL-6 stimulates STAT3 and Pim-1 kinase in pancreatic cancer cell lines
    • Block KM, Hanke NT, Maine EA and Baker AF: IL-6 stimulates STAT3 and Pim-1 kinase in pancreatic cancer cell lines. Pancreas 41: 773-781, 2012.
    • (2012) Pancreas , vol.41 , pp. 773-781
    • Block, K.M.1    Hanke, N.T.2    Maine, E.A.3    Baker, A.F.4
  • 80
    • 84873413695 scopus 로고    scopus 로고
    • Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities
    • Blanco-Aparicio C and Carnero A: Pim kinases in cancer: diagnostic, prognostic and treatment opportunities. Biochem Pharmacol 85: 629-643, 2013.
    • (2013) Biochem Pharmacol , vol.85 , pp. 629-643
    • Blanco-Aparicio, C.1    Carnero, A.2
  • 81
    • 70350218944 scopus 로고    scopus 로고
    • Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes
    • Mumenthaler SM, Ng PY, Hodge A, et al : Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes. Mol Cancer Ther 8: 2882-2893, 2009.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2882-2893
    • Mumenthaler, S.M.1    Ng, P.Y.2    Hodge, A.3
  • 82
    • 79960685617 scopus 로고    scopus 로고
    • Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia
    • Chen LS, Redkar S, Taverna P, Cortes JE and Gandhi V: Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia. Blood 118: 693-702, 2011.
    • (2011) Blood , vol.118 , pp. 693-702
    • Chen, L.S.1    Redkar, S.2    Taverna, P.3    Cortes, J.E.4    Gandhi, V.5
  • 83
    • 84868551769 scopus 로고    scopus 로고
    • Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma
    • Yang Q, Chen LS, Neelapu SS, Miranda RN, Medeiros LJ and Gandhi V: Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma. Blood 120: 3491-3500, 2012.
    • (2012) Blood , vol.120 , pp. 3491-3500
    • Yang, Q.1    Chen, L.S.2    Neelapu, S.S.3    Miranda, R.N.4    Medeiros, L.J.5    Gandhi, V.6
  • 84
    • 84864928386 scopus 로고    scopus 로고
    • Initial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the pediatric preclinical testing program
    • Batra V, Maris JM, Kang MH, et al: Initial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the pediatric preclinical testing program. Pediatr Blood Cancer 59: 749-752, 2012.
    • (2012) Pediatr Blood Cancer , vol.59 , pp. 749-752
    • Batra, V.1    Maris, J.M.2    Kang, M.H.3
  • 85
    • 77950538522 scopus 로고    scopus 로고
    • Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells
    • Chen LS, Redkar S, Bearss D, Wierda WG and Gandhi V: Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells. Blood 114: 4150-4157, 2009.
    • (2009) Blood , vol.114 , pp. 4150-4157
    • Chen, L.S.1    Redkar, S.2    Bearss, D.3    Wierda, W.G.4    Gandhi, V.5
  • 86
    • 77956585637 scopus 로고    scopus 로고
    • PIM kinase inhibitors down-regulate STAT3(Tyr705) phosphorylation
    • Chang M, Kanwar N, Feng E, et al: PIM kinase inhibitors down-regulate STAT3(Tyr705) phosphorylation. Mol Cancer Ther 9: 2478-2487, 2010.
    • (2010) Mol Cancer Ther , vol.9 , pp. 2478-2487
    • Chang, M.1    Kanwar, N.2    Feng, E.3
  • 87
    • 84862986683 scopus 로고    scopus 로고
    • PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells
    • Siu A, Virtanen C and Jongstra J: PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells. Oncotarget 2: 1134-1144, 2011.
    • (2011) Oncotarget , vol.2 , pp. 1134-1144
    • Siu, A.1    Virtanen, C.2    Jongstra, J.3
  • 88
    • 77954888748 scopus 로고    scopus 로고
    • Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression
    • Xie Y, Burcu M, Linn DE, Qiu Y and Baer MR: Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression. Mol Pharmacol 78: 310-318, 2010.
    • (2010) Mol Pharmacol , vol.78 , pp. 310-318
    • Xie, Y.1    Burcu, M.2    Linn, D.E.3    Qiu, Y.4    Baer, M.R.5
  • 89
    • 84872675468 scopus 로고    scopus 로고
    • The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms
    • Natarajan K, Bhullar J, Shukla S, et al: The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms. Biochem Pharmacol 85: 514-524, 2013.
    • (2013) Biochem Pharmacol , vol.85 , pp. 514-524
    • Natarajan, K.1    Bhullar, J.2    Shukla, S.3
  • 90
    • 83555166222 scopus 로고    scopus 로고
    • Targeting PIM kinase activity significantly augments the efficacy of cytarabine
    • Kelly KR, Espitia CM, Taverna P, et al: Targeting PIM kinase activity significantly augments the efficacy of cytarabine. Br J Haematol 156: 129-132, 2012.
    • (2012) Br J Haematol , vol.156 , pp. 129-132
    • Kelly, K.R.1    Espitia, C.M.2    Taverna, P.3
  • 93
    • 84864306058 scopus 로고    scopus 로고
    • Inhibition of Pim-1 attenuates the proliferation and migration in nasopharyngeal carcinoma cells
    • Jie W, He QY, Luo BT, et al: Inhibition of Pim-1 attenuates the proliferation and migration in nasopharyngeal carcinoma cells. Asian Pac J Trop Med 5: 645-650, 2012.
    • (2012) Asian Pac J Trop Med , vol.5 , pp. 645-650
    • Jie, W.1    He, Q.Y.2    Luo, B.T.3
  • 94
    • 70350052791 scopus 로고    scopus 로고
    • Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors
    • Akué-Gédu R, Rossignol E, Azzaro S, et al: Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors. J Med Chem 52: 6369-6381, 2009.
    • (2009) J Med Chem , vol.52 , pp. 6369-6381
    • Akué-Gédu, R.1    Rossignol, E.2    Azzaro, S.3
  • 95
    • 77957905244 scopus 로고    scopus 로고
    • Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion
    • Santio NM, Vahakoski RL, Rainio EM, et al: Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion. Mol Cancer 9: 279, 2010.
    • (2010) Mol Cancer , vol.9 , pp. 279
    • Santio, N.M.1    Vahakoski, R.L.2    Rainio, E.M.3
  • 96
    • 84874339477 scopus 로고    scopus 로고
    • A combination strategy to inhibit Pim-1: Synergism between noncompetitive and ATP-competitive inhibitors
    • Mori M, Tintori C, Christopher RS, et al: A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. ChemMedChem 8: 484-496, 2013.
    • (2013) ChemMedChem , vol.8 , pp. 484-496
    • Mori, M.1    Tintori, C.2    Christopher, R.S.3
  • 97
    • 69549086437 scopus 로고    scopus 로고
    • Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration
    • Grundler R, Brault L, Gasser C, et al: Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. J Exp Med 206: 1957-1970, 2009.
    • (2009) J Exp Med , vol.206 , pp. 1957-1970
    • Grundler, R.1    Brault, L.2    Gasser, C.3


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