Overexpression of Osteopontin, αvβ3 and Pim-1 Associated with Prognostically Important Clinicopathologic Variables in Non-Small Cell Lung Cancer

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Jin, Yi ^a   Tong, Da yue ^b   Chen, Jian ning ^a   Feng, Zhi ying ^a   Yang, Jian yong ^a   Shao, Chun kui ^a   Li, Jia ping ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

OSTEOPONTIN; PROTEIN KINASE PIM 1; VITRONECTIN RECEPTOR;

ADULT; AGED; ARTICLE; CANCER STAGING; CELL CYCLE REGULATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; MALE; MOLECULAR DYNAMICS; PROGNOSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTEGRIN ALPHAVBETA3; LUNG; LUNG NEOPLASMS; MALE; MIDDLE AGED; OSTEOPONTIN; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-PIM-1;

EID: 84868283942     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048575     Document Type: Article

References (30)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, et al. (2008) Cancer statistics, 2008. CA Cancer J Clin 58: 71-96.
2. Macri A, Versaci A, Lupo G, Trimarchi G, Tomasello C, et al. (2009) Role of osteopontin in breast cancer patients. Tumori 95: 48-52.
3. Bao LH, Sakaguchi H, Fujimoto J, Tamaya T, (2007) Osteopontin in metastatic lesions as a prognostic marker in ovarian cancers. J Biomed Sci 14: 373-381.
4. Angelucci A, Festuccia C, Gravina GL, Muzi P, Bonghi L, et al. (2004) Osteopontin enhances the cell proliferation induced by the epidermal growth factor in human prostate cancer cells. Prostate 59: 157-166.
5. Coppola D, Szabo M, Boulware D, Muraca P, Alsarraj M, et al. (2004) Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies. Clin Cancer Res10: 184-190.
6. Hood JD, Cheresh DA, (2002) Role of integrins in cell invasion and migration. Nat Rev Cancer 2: 91-100.
7. Verbisck NV, Costa ET, Costa FF, Cavalher FP, Costa MD, et al. (2009) ADAM23 negatively modulates alpha(v)beta(3) integrin activation during metastasis. Cancer Res 69: 5546-5552.
8. Bachmann M, Kosan C, Xing PX, Montenarh M, Hoffmann I, et al. (2006) The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C. Int J Biochem Cell Biol 38: 430-443.
9. Trvris WD, Brambilla, Muller-Hermelink HK, Harris CC. (2004) World Health Organization Classification of Tumours. Pathology and Genetics of Tumour of the Lung, Plerua, Thymus and Heart. IARC Press:Lyon 2004.
10. Rami-Porta R, Crowley JJ, Goldstraw P, (2009) The revised TNM staging system for lung cancer. Ann Thorac Cardiovasc Surg 15: 4-9.
11. Zhao XQ, Dong JH, Zhang WZ, Liu Z, (2011) Prognosis of ampullary cancer based on immunohistochemical type and expression of osteopontin. Diagn Pathol 6: 98.
12. Chiang WF, Yen CY, Lin CN, Liaw GA, Chiu CT, et al. (2006) Up-regulation of a serine-threonine kinase proto-oncogene Pim-1 in oral squamous cell carcinoma. Int J Oral Maxillofac Surg 35: 740-745.
13. Li P, Liu F, Sun L, Zhao Z, Ding X, et al. (2011) Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin alphavbeta3. Int J Mol Med 27: 679-687.
14. Senger DR, Wirth DF, Hynes RO, (1979) Transformed mammalian cells secrete specific proteins and phosphoproteins. Cell 16: 885-893.
15. Zhang J, Takahashi K, Takahashi F, Shimizu K, Ohshita F, et al. (2001) Differential osteopontin expression in lung cancer. Cancer Lett 171: 215-222.
16. Hu Z, Lin D, Yuan J, Xiao T, Zhang H, et al. (2005) Overexpression of osteopontin is associated with more aggressive phenotypes in human non-small cell lung cancer. Clin Cancer Res 11: 4646-4652.
17. Rodrigues LR, Teixeira JA, Schmitt FL, Paulsson M, Lindmark-Mansson H, (2007) The role of osteopontin in tumor progression and metastasis in breast cancer. Cancer Epidemiol Biomarkers Prev 16: 1087-1097.
18. Chetty C, Lakka SS, Bhoopathi P, Rao JS, (2010) MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells. Int J Cancer 127: 1081-1095.
19. Krishnan N, Pan H, Buckley DJ, Buckley A, (2003) Prolactin-regulated pim-1 transcription: identification of critical promoter elements and Akt signaling. Endocrine 20: 123-130.
20. Beer AJ, Niemeyer M, Carlsen J, Sarbia M, Nahrig J, et al. (2008) Patterns of alphavbeta3 expression in primary and metastatic human breast cancer as shown by 18F-Galacto-RGD PET. J Nucl Med 49: 255-259.
21. Lossner D, Abou-Ajram C, Benge A, Aumercier M, Schmitt M, et al. (2009) Integrin alphavbeta3 upregulates integrin-linked kinase expression in human ovarian cancer cells via enhancement of ILK gene transcription. J Cell Physiol 220: 367-375.
22. Hsu AR, Hou LC, Veeravagu A, Greve JM, Vogel H, et al. (2006) In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in an orthotopic glioblastoma model. Mol Imaging Biol 8: 315-323.
23. Wang Z, Bhattacharya N, Weaver M, Petersen K, Meyer M, et al. (2001) Pim-1: a serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis. J Vet Sci 2: 167-179.
24. Guo S, Mao X, Chen J, Huang B, Jin C, et al. (2010) Overexpression of Pim-1 in bladder cancer. J Exp Clin Cancer Res 29: 161.
25. Warnecke-Eberz U, Bollschweiler E, Drebber U, Metzger R, Baldus SE, et al. (2009) Prognostic impact of protein overexpression of the proto-oncogene PIM-1 in gastric cancer. Anticancer Res 29: 4451-4455.
26. Kim DS, Sung JS, Shin ES, Ryu JS, Choi IK, et al. (2008) Association of single nucleotide polymorphisms in PIM-1 gene with the risk of Korean lung cancer. Cancer Res Treat 40: 190-196.
27. Zhang Y, Wang Z, Magnuson NS, (2007) Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells. Mol Cancer Res 5: 909-922.
28. He HC, Bi XC, Zheng ZW, Dai QS, Han ZD, et al. (2009) Real-time quantitative RT-PCR assessment of PIM-1 and hK2 mRNA expression in benign prostate hyperplasia and prostate cancer. Med Oncol 26: 303-308.
29. Fong YC, Liu SC, Huang CY, Li TM, Hsu SF, et al. (2009) Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway. Lung Cancer 64: 263-270.
30. Cui R, Takahashi F, Ohashi R, Gu T, Yoshioka M, et al. (2007) Abrogation of the interaction between osteopontin and alphavbeta3 integrin reduces tumor growth of human lung cancer cells in mice. Lung Cancer 57: 302-310.