Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration

Journal of Experimental Medicine

Volumn 206, Issue 9, 2009, Pages 1957-1970

  Grundler, Rebekka ^a   Brault, Laurent ^b   Gasser, Christelle ^b   Bullock, Alex N ^c   Dechow, Tobias ^a   Woetzel, Sabine ^a   Pogacic, Vanda ^b   Villa, Antonello ^d   Ehret, Sabine ^b   Berridge, Georgina ^c   Spoo, Anke ^e   Dierks, Christine ^e   Biondi, Andrea ^d   Knapp, Stefan ^c   Duyster, Justus ^a   Schwaller, Juerg ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF MILANO BICOCCA   (Italy)

^e UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CD135 ANTIGEN; CXCL2 CHEMOKINE; MESSENGER RNA; PROTEIN BAD; PROTEIN KINASE PIM 1; PROTEIN PIM2; PROTEIN SERINE THREONINE KINASE; SERINE; SMALL INTERFERING RNA; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLAST CELL; BONE MARROW CELL; CANCER STEM CELL; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMOGENESIS; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; BONE MARROW CELLS; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; CHEMOKINE CXCL12; DNA PRIMERS; FLOW CYTOMETRY; FMS-LIKE TYROSINE KINASE 3; HUMANS; IMMUNOBLOTTING; IMMUNOPHENOTYPING; JURKAT CELLS; LEUKEMIA, MYELOID, ACUTE; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-PIM-1; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 69549086437     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20082074     Document Type: Article

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