Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Choi, Yong Jun ^a,h   Li, Han ^a,i   Son, Mi Young ^a   Wang, Xiao Hong ^b   Fornsaglio, Jamie L ^b,j   Sobol, Robert W ^b,c,d   Lee, Moonsook ^e   Vijg, Jan ^e   Imholz, Sandra ^f   Dollé, Martijn E T ^f   Van Steeg, Harry ^f   Reiling, Erwin ^f,g   Hasty, Paul ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^d UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^f NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^g ERASMUS MEDICAL CENTER   (Netherlands)

^h NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

ⁱ Centro Nacional de Investigaciones Oncológicas   (Spain)

^j SETON HILL UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HOLOENZYME; KU ANTIGEN; NUCLEIC ACID BINDING PROTEIN; PROTEIN KU80; PROTEIN P53; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; APURINIC SITE; APYRIMIDINIC SITE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA END JOINING REPAIR; EXCISION REPAIR; FEMALE; GENE DELETION; GENE MUTATION; IN VITRO STUDY; LIFESPAN; MALE; MOUSE; NONHUMAN; PHENOTYPE; SENSITIVITY ANALYSIS; SURVIVAL;

ANIMALS; ANTIGENS, NUCLEAR; APURINIC ACID; DNA END-JOINING REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; EPISTASIS, GENETIC; FEMALE; GENE DELETION; INDOLES; LONGEVITY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEAR PROTEINS; PHENOTYPE; POINT MUTATION; PROTEIN SUBUNITS; RADIATION TOLERANCE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84899688897     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086358     Document Type: Article

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