Small molecule inhibitors of DNA repair nuclease activities of APE1

Cellular and Molecular Life Sciences

Volumn 67, Issue 21, 2010, Pages 3621-3631

  Wilson III, David M ^b   Simeonov, Anton ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

Abasic endonuclease; APE1 APEX1 REF 1; Base excision DNA repair; Cancer treatment; DNA damage; Inhibitor

Indexed keywords

2,4,9 TRIMETHYLBENZO[B][1,8]NAPHTHYRIDIN 5 AMINE; 7 NITROINDOLE 2 CARBOXYLIC ACID; ANTINEOPLASTIC AGENT; AURINTRICARBOXYLIC ACID; CIBACRON BLUE F3GA; CRT 0044876; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; LUCANTHONE; METHOXYAMINE; MYRICETIN; NSC 13755; NSC 13793; OXIDOPAMINE; TEMOZOLOMIDE; TRC 102; TROXACITABINE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ADVANCED CANCER; BLOOD TOXICITY; BRAIN TUMOR; CELLULAR DISTRIBUTION; CLINICAL TRIAL; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME INHIBITION; EXCISION REPAIR; GASTROINTESTINAL TOXICITY; HIGH THROUGHPUT SCREENING; HUMAN; IC 50; LIGAND BINDING; LUNG CANCER; MELANOMA; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; PROTEIN DNA BINDING; REVIEW; SINGLE STRANDED DNA BREAK; SOLID TUMOR; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION; VIRTUAL REALITY;

ANIMALS; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, MOLECULAR;

EID: 78149466586     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0488-2     Document Type: Review

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