메뉴 건너뛰기




Volumn 25, Issue 5, 2014, Pages 1427-1437

Nitric oxide signaling in mechanical adaptation of bone

Author keywords

Bone remodeling; Fluid shear stress; Mechanical loading; Nitric oxide; Osteocytes; Osteoporosis

Indexed keywords

BETA CATENIN; CYCLIC GMP DEPENDENT PROTEIN KINASE; MESSENGER RNA; NITRIC OXIDE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; SCATTER FACTOR; VASCULOTROPIN; SIGNAL PEPTIDE;

EID: 84899632394     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-013-2590-4     Document Type: Review
Times cited : (92)

References (101)
  • 2
    • 0029820699 scopus 로고    scopus 로고
    • Nitric oxide is an early mediator of the increase in bone formation by mechanical stimulation
    • 1:CAS:528:DyaK28Xktlansr8%3D 8764178
    • Fox SW, Chambers TJ, Chow JW (1996) Nitric oxide is an early mediator of the increase in bone formation by mechanical stimulation. Am J Physiol 270:E955-E960
    • (1996) Am J Physiol , vol.270
    • Fox, S.W.1    Chambers, T.J.2    Chow, J.W.3
  • 4
    • 30444439216 scopus 로고    scopus 로고
    • The discovery of nitric oxide and its role in vascular biology
    • 1:CAS:528:DC%2BD28XisVClsQ%3D%3D 1760731 16402104
    • Moncada S, Higgs EA (2006) The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol 147(Suppl 1):S193-S201
    • (2006) Br J Pharmacol , vol.147 , Issue.SUPPL. 1
    • Moncada, S.1    Higgs, E.A.2
  • 5
    • 67349230279 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase: Structure, subcellular localization, regulation, and clinical implications
    • 1:CAS:528:DC%2BD1MXltlejt7k%3D 19298861
    • Zhou L, Zhu DY (2009) Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications. Nitric Oxide 20:223-230
    • (2009) Nitric Oxide , vol.20 , pp. 223-230
    • Zhou, L.1    Zhu, D.Y.2
  • 9
    • 0036269424 scopus 로고    scopus 로고
    • Patterns of osteocytic endothelial nitric oxide synthase expression in the femoral neck cortex: Differences between cases of intracapsular hip fracture and controls
    • 1:CAS:528:DC%2BD38XktFynt74%3D 12052455
    • Loveridge N, Fletcher S, Power J, Caballero-Alias AM, Das-Gupta V, Rushton N, Parker M, Reeve J, Pitsillides AA (2002) Patterns of osteocytic endothelial nitric oxide synthase expression in the femoral neck cortex: differences between cases of intracapsular hip fracture and controls. Bone 30:866-871
    • (2002) Bone , vol.30 , pp. 866-871
    • Loveridge, N.1    Fletcher, S.2    Power, J.3    Caballero-Alias, A.M.4    Das-Gupta, V.5    Rushton, N.6    Parker, M.7    Reeve, J.8    Pitsillides, A.A.9
  • 11
    • 0029114339 scopus 로고
    • Enzyme-independent formation of nitric oxide in biological tissues
    • 1:CAS:528:DyaK2MXnt1ynu7g%3D 7585184
    • Zweier JL, Wang P, Samouilov A, Kuppusamy P (1995) Enzyme-independent formation of nitric oxide in biological tissues. Nat Med 1:804-809
    • (1995) Nat Med , vol.1 , pp. 804-809
    • Zweier, J.L.1    Wang, P.2    Samouilov, A.3    Kuppusamy, P.4
  • 13
    • 70049083635 scopus 로고    scopus 로고
    • Protein S-nitrosylation in health and disease: A current perspective
    • 1:CAS:528:DC%2BD1MXhtFKns7nN 3106339 19726230
    • Foster MW, Hess DT, Stamler JS (2009) Protein S-nitrosylation in health and disease: a current perspective. Trends Mol Med 15:391-404
    • (2009) Trends Mol Med , vol.15 , pp. 391-404
    • Foster, M.W.1    Hess, D.T.2    Stamler, J.S.3
  • 14
    • 0027752805 scopus 로고
    • The l-arginine-nitric oxide pathway
    • 1:CAS:528:DyaK2cXhsF2ntrw%3D 7504210
    • Moncada S, Higgs A (1993) The l-arginine-nitric oxide pathway. New Engl J Med 329:2002-2012
    • (1993) New Engl J Med , vol.329 , pp. 2002-2012
    • Moncada, S.1    Higgs, A.2
  • 16
    • 0035099851 scopus 로고    scopus 로고
    • Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase
    • 1:CAS:528:DC%2BD3MXhtFSrt74%3D 11159848
    • Armour KE, Armour KJ, Gallagher ME, Gödecke A, Helfrich MH, Reid DM, Ralston SH (2001) Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase. Endocrinology 142:760-766
    • (2001) Endocrinology , vol.142 , pp. 760-766
    • Armour, K.E.1    Armour, K.J.2    Gallagher, M.E.3    Gödecke, A.4    Helfrich, M.H.5    Reid, D.M.6    Ralston, S.H.7
  • 17
    • 0035139484 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase gene-deficient mice demonstrate marked retardation in postnatal bone formation, reduced bone volume, and defects in osteoblast maturation and activity
    • 1:CAS:528:DC%2BD3MXmsFKqug%3D%3D 1850250 11141498
    • Aguirre J, Buttery L, O'Shaughnessy M, Afzal F, Fernandez DM, Hukkanen M, Huang P, MacIntyre I, Polak J (2001) Endothelial nitric oxide synthase gene-deficient mice demonstrate marked retardation in postnatal bone formation, reduced bone volume, and defects in osteoblast maturation and activity. Am J Pathol 158:247-257
    • (2001) Am J Pathol , vol.158 , pp. 247-257
    • Aguirre, J.1    Buttery, L.2    O'Shaughnessy, M.3    Afzal, F.4    Fernandez, D.M.5    Hukkanen, M.6    Huang, P.7    MacIntyre, I.8    Polak, J.9
  • 22
    • 36549054084 scopus 로고    scopus 로고
    • Rationale for using nitric oxide donor therapy for prevention of bone loss and treatment of osteoporosis in humans
    • 1:CAS:528:DC%2BD1cXhtVGmu7o%3D 18056048
    • Wimalawansa SJ (2007) Rationale for using nitric oxide donor therapy for prevention of bone loss and treatment of osteoporosis in humans. Ann NY Acad Sci 1117:283-297
    • (2007) Ann NY Acad Sci , vol.1117 , pp. 283-297
    • Wimalawansa, S.J.1
  • 23
    • 42749084812 scopus 로고    scopus 로고
    • The response of bone to mechanical loading and disuse: Fundamental principles and influences on osteoblast/osteocyte homeostasis
    • 1:CAS:528:DC%2BD1cXlsFOgt7w%3D 18334226
    • Skerry TM (2008) The response of bone to mechanical loading and disuse: fundamental principles and influences on osteoblast/osteocyte homeostasis. Arch Biochem Biophys 473:117-123
    • (2008) Arch Biochem Biophys , vol.473 , pp. 117-123
    • Skerry, T.M.1
  • 25
    • 0032895922 scopus 로고    scopus 로고
    • Mechanotransduction in bone - Role of the lacuno-canalicular network
    • 1:CAS:528:DyaK1MXjtFGku7c%3D 10352151
    • Burger EH, Klein-Nulend J (1999) Mechanotransduction in bone - role of the lacuno-canalicular network. FASEB J 13:S101-S112
    • (1999) FASEB J , vol.13
    • Burger, E.H.1    Klein-Nulend, J.2
  • 27
    • 84887397000 scopus 로고    scopus 로고
    • Poromechanical stimulation of bone remodeling: A continuum micromechanics-based mathematical model and experimental validation
    • Scheiner S, Pivonka P, Hellmich C (2013) Poromechanical stimulation of bone remodeling: a continuum micromechanics-based mathematical model and experimental validation. Poromechanics V:1867-1876
    • (2013) Poromechanics , vol.5 , pp. 1867-1876
    • Scheiner, S.1    Pivonka, P.2    Hellmich, C.3
  • 28
    • 0029111672 scopus 로고
    • Mechanotransduction in bone: Role of strain rate
    • 1:CAS:528:DyaK2MXotlWrt7k%3D 7573420
    • Turner CH, Owan I, Takano Y (1995) Mechanotransduction in bone: role of strain rate. Am J Physiol 269:E438-E442
    • (1995) Am J Physiol , vol.269
    • Turner, C.H.1    Owan, I.2    Takano, Y.3
  • 29
    • 0033622817 scopus 로고    scopus 로고
    • Quantifying the strain history of bone: Spatial uniformity and self-similarity of low-magnitude strains
    • 1:STN:280:DC%2BD3c7jsFKksg%3D%3D 10673115
    • Fritton SP, McLeod KJ, Rubin CT (2000) Quantifying the strain history of bone: spatial uniformity and self-similarity of low-magnitude strains. J Biomech 33:317-325
    • (2000) J Biomech , vol.33 , pp. 317-325
    • Fritton, S.P.1    McLeod, K.J.2    Rubin, C.T.3
  • 30
    • 78049240968 scopus 로고    scopus 로고
    • Variations in habitual bone strains in vivo: Long bone versus mandible
    • 20600955
    • De Jong WC, Korfage JA, Langenbach GE (2010) Variations in habitual bone strains in vivo: long bone versus mandible. J Struct Biol 172:311-318
    • (2010) J Struct Biol , vol.172 , pp. 311-318
    • De Jong, W.C.1    Korfage, J.A.2    Langenbach, G.E.3
  • 31
    • 0031837165 scopus 로고    scopus 로고
    • Type of physical activity, muscle strength, and pubertal stage as determinants of bone mineral density and bone area in adolescent boys
    • 1:STN:280:DyaK1czisFGiuw%3D%3D 9661078
    • Nordstrom P, Pettersson U, Lorentzon R (1998) Type of physical activity, muscle strength, and pubertal stage as determinants of bone mineral density and bone area in adolescent boys. J Bone Miner Res 13:1141-1148
    • (1998) J Bone Miner Res , vol.13 , pp. 1141-1148
    • Nordstrom, P.1    Pettersson, U.2    Lorentzon, R.3
  • 33
    • 0031444851 scopus 로고    scopus 로고
    • Effects of nitric oxide synthase inhibitors on bone formation in rats
    • 1:CAS:528:DyaK1cXjvF2qtQ%3D%3D 9430237
    • Turner CH, Owan I, Jacob DS, McClintock R, Peacock M (1997) Effects of nitric oxide synthase inhibitors on bone formation in rats. Bone 21:487-490
    • (1997) Bone , vol.21 , pp. 487-490
    • Turner, C.H.1    Owan, I.2    Jacob, D.S.3    McClintock, R.4    Peacock, M.5
  • 34
    • 0021322767 scopus 로고
    • Regulation of bone formation by applied dynamic loads
    • 1:STN:280:DyaL2c7jsF2jtw%3D%3D 6699056
    • Rubin CT, Lanyon LE (1984) Regulation of bone formation by applied dynamic loads. J Bone Joint Surg Am 66:397-402
    • (1984) J Bone Joint Surg Am , vol.66 , pp. 397-402
    • Rubin, C.T.1    Lanyon, L.E.2
  • 35
    • 17044434605 scopus 로고    scopus 로고
    • Initial stress-kick is required for fluid shear stress-induced rate dependent activation of bone cells
    • 15709711
    • Bacabac RG, Smit TH, Mullender MG, van Loon JJWA, Klein-Nulend J (2005) Initial stress-kick is required for fluid shear stress-induced rate dependent activation of bone cells. Ann Biomed Eng 33:104-110
    • (2005) Ann Biomed Eng , vol.33 , pp. 104-110
    • Bacabac, R.G.1    Smit, T.H.2    Mullender, M.G.3    Van Loon, J.4    Klein-Nulend, J.5
  • 36
    • 0034792594 scopus 로고    scopus 로고
    • A model for strain amplification in the actin cytoskeleton of osteocytes due to fluid drag on pericellular matrix
    • 1:STN:280:DC%2BD3Mrmslejsw%3D%3D 11672712
    • You L, Cowin SC, Schaffler MB, Weinbaum S (2001) A model for strain amplification in the actin cytoskeleton of osteocytes due to fluid drag on pericellular matrix. J Biomech 34:1375-1386
    • (2001) J Biomech , vol.34 , pp. 1375-1386
    • You, L.1    Cowin, S.C.2    Schaffler, M.B.3    Weinbaum, S.4
  • 37
    • 9344258590 scopus 로고    scopus 로고
    • Mechanotransduction and strain amplification in osteocyte cell processes
    • 1:CAS:528:DC%2BD2cXhtVOisbbL 534548 15539460
    • Han Y, Cowin SC, Schaffler MB, Weinbaum S (2004) Mechanotransduction and strain amplification in osteocyte cell processes. Proc Natl Acad Sci U S A 101:16689-16694
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 16689-16694
    • Han, Y.1    Cowin, S.C.2    Schaffler, M.B.3    Weinbaum, S.4
  • 38
    • 33744462626 scopus 로고    scopus 로고
    • Bone cell responses to high-frequency vibration stress: Does the nucleus oscillate within the cytoplasm?
    • 1:CAS:528:DC%2BD28XksVemsbY%3D 16675843
    • Bacabac RG, Smit TH, van Loon JJWA, Zandieh-Doulabi B, Helder MN, Klein-Nulend J (2006) Bone cell responses to high-frequency vibration stress: does the nucleus oscillate within the cytoplasm? FASEB J 20:858-864
    • (2006) FASEB J , vol.20 , pp. 858-864
    • Bacabac, R.G.1    Smit, T.H.2    Van Loon, J.3    Zandieh-Doulabi, B.4    Helder, M.N.5    Klein-Nulend, J.6
  • 39
    • 14644436314 scopus 로고    scopus 로고
    • A comparison of strain and fluid shear stress in stimulating bone cell responses - A computational and experimental study
    • 1:CAS:528:DC%2BD2MXit1Kkt7Y%3D 15625080
    • McGarry JG, Klein-Nulend J, Mullender MG, Prendergast PJ (2005) A comparison of strain and fluid shear stress in stimulating bone cell responses - a computational and experimental study. FASEB J 19:482-484
    • (2005) FASEB J , vol.19 , pp. 482-484
    • McGarry, J.G.1    Klein-Nulend, J.2    Mullender, M.G.3    Prendergast, P.J.4
  • 41
    • 77952584430 scopus 로고    scopus 로고
    • Correlation of cell strain in single osteocytes with intracellular calcium, but not intracellular nitric oxide, in response to fluid flow
    • 2866825 20189178
    • Rath AL, Bonewald LF, Ling J, Jiang JX, Van Dyke ME, Nicolella DP (2010) Correlation of cell strain in single osteocytes with intracellular calcium, but not intracellular nitric oxide, in response to fluid flow. J Biomech 43:1560-1564
    • (2010) J Biomech , vol.43 , pp. 1560-1564
    • Rath, A.L.1    Bonewald, L.F.2    Ling, J.3    Jiang, J.X.4    Van Dyke, M.E.5    Nicolella, D.P.6
  • 44
    • 15444368753 scopus 로고    scopus 로고
    • The effect of cytoskeletal disruption on pulsatile fluid flow-induced nitric oxide and prostaglandin E2 release in osteocytes and osteoblasts
    • 1:CAS:528:DC%2BD2MXisVCmsbc%3D 15781270
    • McGarry JG, Klein-Nulend J, Prendergast PJ (2005) The effect of cytoskeletal disruption on pulsatile fluid flow-induced nitric oxide and prostaglandin E2 release in osteocytes and osteoblasts. Biochem Biophys Res Commun 330:341-348
    • (2005) Biochem Biophys Res Commun , vol.330 , pp. 341-348
    • McGarry, J.G.1    Klein-Nulend, J.2    Prendergast, P.J.3
  • 45
    • 33846459086 scopus 로고    scopus 로고
    • Bio imaging of intracellular NO production in single bone cells after mechanical stimulation
    • 1:CAS:528:DC%2BD28Xht1ert7vO 17002570
    • Vatsa A, Mizuno D, Smit TH, Schmidt CF, MacKintosh FC, Klein-Nulend J (2006) Bio imaging of intracellular NO production in single bone cells after mechanical stimulation. J Bone Miner Res 21:1722-1728
    • (2006) J Bone Miner Res , vol.21 , pp. 1722-1728
    • Vatsa, A.1    Mizuno, D.2    Smit, T.H.3    Schmidt, C.F.4    MacKintosh, F.C.5    Klein-Nulend, J.6
  • 47
    • 0031779953 scopus 로고    scopus 로고
    • Role of nitric oxide and prostaglandins in mechanically induced bone formation
    • 1:CAS:528:DyaK1cXjvFSmurw%3D 9626636
    • Chow JW, Fox SW, Lean JM, Chambers TJ (1998) Role of nitric oxide and prostaglandins in mechanically induced bone formation. J Bone Miner Res 13:1039-1044
    • (1998) J Bone Miner Res , vol.13 , pp. 1039-1044
    • Chow, J.W.1    Fox, S.W.2    Lean, J.M.3    Chambers, T.J.4
  • 48
    • 0029617377 scopus 로고
    • Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts - Correlation with prostaglandin upregulation
    • 1:CAS:528:DyaK2MXpvFemt7s%3D 7503746
    • Klein-Nulend J, Semeins CM, Ajubi NE, Nijweide PJ, Burger EH (1995) Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts - correlation with prostaglandin upregulation. Biochem Biophys Res Commun 217:640-648
    • (1995) Biochem Biophys Res Commun , vol.217 , pp. 640-648
    • Klein-Nulend, J.1    Semeins, C.M.2    Ajubi, N.E.3    Nijweide, P.J.4    Burger, E.H.5
  • 49
    • 33745393001 scopus 로고    scopus 로고
    • Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts
    • 1:CAS:528:DyaK28Xkslygurg%3D
    • Johnson DL, McAllister TN, Frangos JA (1996) Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts. Am J Physiol Endocrinol Metab 271:E205-E208
    • (1996) Am J Physiol Endocrinol Metab , vol.271
    • Johnson, D.L.1    McAllister, T.N.2    Frangos, J.A.3
  • 50
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • 1:CAS:528:DyaK1MXjvFegu7s%3D 10376603
    • Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399:601-605
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 51
    • 84868208113 scopus 로고    scopus 로고
    • Expression of endothelial nitric oxide synthase protein is not necessary for mechanical strain-induced nitric oxide production by cultured osteoblasts
    • 1:CAS:528:DC%2BC38XhsF2nt7bM 22402674
    • Das-Gupta V, Williamson RA, Pitsillides AA (2012) Expression of endothelial nitric oxide synthase protein is not necessary for mechanical strain-induced nitric oxide production by cultured osteoblasts. Osteoporos Int 23:2635-2647
    • (2012) Osteoporos Int , vol.23 , pp. 2635-2647
    • Das-Gupta, V.1    Williamson, R.A.2    Pitsillides, A.A.3
  • 52
    • 84873719784 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase is not essential for nitric oxide production by osteoblasts subjected to fluid shear stress in vitro
    • 1:CAS:528:DC%2BC3sXit1KjtLc%3D 23203546
    • Bakker AD, Huesa C, Hughes A, Aspden RM, van't Hof RJ, Klein-Nulend J, Helfrich MH (2013) Endothelial nitric oxide synthase is not essential for nitric oxide production by osteoblasts subjected to fluid shear stress in vitro. Calcif Tissue Int 92:228-239
    • (2013) Calcif Tissue Int , vol.92 , pp. 228-239
    • Bakker, A.D.1    Huesa, C.2    Hughes, A.3    Aspden, R.M.4    Van'T Hof, R.J.5    Klein-Nulend, J.6    Helfrich, M.H.7
  • 53
    • 67651102789 scopus 로고    scopus 로고
    • Shear flow increases S-nitrosylation of proteins in endothelial cells
    • 1:CAS:528:DC%2BD1MXovVeru70%3D 19447776
    • Huang B, Chen SC, Wang DL (2009) Shear flow increases S-nitrosylation of proteins in endothelial cells. Cardiovasc Res 83:536-546
    • (2009) Cardiovasc Res , vol.83 , pp. 536-546
    • Huang, B.1    Chen, S.C.2    Wang, D.L.3
  • 54
    • 0017869566 scopus 로고
    • Guanylate cyclase: Activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin
    • 1:CAS:528:DyaE1cXkvVKhsL0%3D 27076
    • Murad F, Mittal CK, Arnold WP, Katsuki S, Kimura H (1978) Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin. Adv Cyclic Nucleotide Res 9:145-158
    • (1978) Adv Cyclic Nucleotide Res , vol.9 , pp. 145-158
    • Murad, F.1    Mittal, C.K.2    Arnold, W.P.3    Katsuki, S.4    Kimura, H.5
  • 56
    • 0028294282 scopus 로고
    • Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption
    • 294160 8163651
    • Löwik CW, Nibbering PH, van de Ruit M, Papapoulos SE (1994) Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption. J Clin Invest 93:1465-1472
    • (1994) J Clin Invest , vol.93 , pp. 1465-1472
    • Löwik, C.W.1    Nibbering, P.H.2    Van De Ruit, M.3    Papapoulos, S.E.4
  • 57
    • 0033392377 scopus 로고    scopus 로고
    • Evidence for a pathogenic role of nitric oxide in inflammation-induced osteoporosis
    • 1:CAS:528:DC%2BD3cXkslaisQ%3D%3D 10620073
    • Armour KE, Van 't Hoff RJ, Grabowski PS, Reid DM, Ralston SH (1999) Evidence for a pathogenic role of nitric oxide in inflammation-induced osteoporosis. J Bone Miner Res 14:2137-2142
    • (1999) J Bone Miner Res , vol.14 , pp. 2137-2142
    • Armour, K.E.1    Van 'T Hoff, R.J.2    Grabowski, P.S.3    Reid, D.M.4    Ralston, S.H.5
  • 60
    • 84856602560 scopus 로고    scopus 로고
    • Expression of muscle anabolic and metabolic factors in mechanically loaded MLO-Y4 osteocytes
    • 1:CAS:528:DC%2BC38XjsFKgs78%3D 22114022
    • Juffer P, Jaspers RT, Lips P, Bakker AD, Klein-Nulend J (2012) Expression of muscle anabolic and metabolic factors in mechanically loaded MLO-Y4 osteocytes. Am J Physiol Endocrinol Metab 302:E389-E395
    • (2012) Am J Physiol Endocrinol Metab , vol.302
    • Juffer, P.1    Jaspers, R.T.2    Lips, P.3    Bakker, A.D.4    Klein-Nulend, J.5
  • 61
    • 33947605189 scopus 로고    scopus 로고
    • HGF inhibits BMP-induced osteoblastogenesis: Possible implications for the bone disease of multiple myeloma
    • 1:CAS:528:DC%2BD2sXjvVyntr8%3D 17138824
    • Standal T, Abildgaard N, Fagerli U-M, Stordal B, Hjertner O, Borset M, Sundan A (2007) HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma. Blood 109:3024-3030
    • (2007) Blood , vol.109 , pp. 3024-3030
    • Standal, T.1    Abildgaard, N.2    Fagerli, U.-M.3    Stordal, B.4    Hjertner, O.5    Borset, M.6    Sundan, A.7
  • 62
    • 33749370406 scopus 로고    scopus 로고
    • Hepatocyte growth factor can substitute for M-CSF to support osteoclastogenesis
    • 1:CAS:528:DC%2BD28XhtVCrtrzO 17022947
    • Adamopoulos IE, Xia Z, Lau YS, Athanasou NA (2006) Hepatocyte growth factor can substitute for M-CSF to support osteoclastogenesis. Biochem Biophys Res Commun 350:478-483
    • (2006) Biochem Biophys Res Commun , vol.350 , pp. 478-483
    • Adamopoulos, I.E.1    Xia, Z.2    Lau, Y.S.3    Athanasou, N.A.4
  • 63
    • 79951878190 scopus 로고    scopus 로고
    • Osteocyte apoptosis is mechanically regulated and induces angiogenesis in vitro
    • 21337392
    • Cheung WY, Liu C, Tonelli-Zasarsky RM, Simmons CA, You L (2011) Osteocyte apoptosis is mechanically regulated and induces angiogenesis in vitro. J Orthop Res 29:523-530
    • (2011) J Orthop Res , vol.29 , pp. 523-530
    • Cheung, W.Y.1    Liu, C.2    Tonelli-Zasarsky, R.M.3    Simmons, C.A.4    You, L.5
  • 64
    • 77649181032 scopus 로고    scopus 로고
    • Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse
    • 1:CAS:528:DC%2BC3cXitV2hurY%3D 2887492 19857613
    • Zaman G, Saxon LK, Sunters A, Hilton H, Underhill P, Williams D, Price JS, Lanyon LE (2010) Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse. Bone 46:628-642
    • (2010) Bone , vol.46 , pp. 628-642
    • Zaman, G.1    Saxon, L.K.2    Sunters, A.3    Hilton, H.4    Underhill, P.5    Williams, D.6    Price, J.S.7    Lanyon, L.E.8
  • 65
    • 0038308502 scopus 로고    scopus 로고
    • Vascular endothelial growth factor principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis
    • 1:CAS:528:DC%2BD3sXlsFanur4%3D 12801915
    • Furumatsu T, Shen ZN, Kawai A, Nishida K, Manabe H, Oohashi T, Inoue H, Ninomiya Y (2003) Vascular endothelial growth factor principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis. J Biochem 133:633-639
    • (2003) J Biochem , vol.133 , pp. 633-639
    • Furumatsu, T.1    Shen, Z.N.2    Kawai, A.3    Nishida, K.4    Manabe, H.5    Oohashi, T.6    Inoue, H.7    Ninomiya, Y.8
  • 66
    • 70349216501 scopus 로고    scopus 로고
    • Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes
    • 1:CAS:528:DC%2BD1MXht12hu7nJ 19353691
    • Santos A, Bakker AD, Zandieh-Doulabi B, Semeins CM, Klein-Nulend J (2009) Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes. J Orthop Res 27:1280-1287
    • (2009) J Orthop Res , vol.27 , pp. 1280-1287
    • Santos, A.1    Bakker, A.D.2    Zandieh-Doulabi, B.3    Semeins, C.M.4    Klein-Nulend, J.5
  • 68
    • 84894467000 scopus 로고    scopus 로고
    • Deletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loading
    • 10.1002/jbmr.2064 Epub ahead of print
    • Javaheri B, Stern A, Lara N, Dallas M, Zhao H, Liu Y, Bonewald LF, Johnon ML (2013) Deletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loading. J Bone Miner Res. doi: 10.1002/jbmr.2064, Epub ahead of print
    • (2013) J Bone Miner Res
    • Javaheri, B.1    Stern, A.2    Lara, N.3    Dallas, M.4    Zhao, H.5    Liu, Y.6    Bonewald, L.F.7    Johnon, M.L.8
  • 74
    • 0031719754 scopus 로고    scopus 로고
    • Intracortical remodeling in adult rat long bones after fatigue loading
    • 1:STN:280:DyaK1cvgslelug%3D%3D 9737350
    • Bentolila V, Boyce TM, Fyhrie DP, Drumb R, Skerry TM, Schaffler MB (1998) Intracortical remodeling in adult rat long bones after fatigue loading. Bone 23:275-281
    • (1998) Bone , vol.23 , pp. 275-281
    • Bentolila, V.1    Boyce, T.M.2    Fyhrie, D.P.3    Drumb, R.4    Skerry, T.M.5    Schaffler, M.B.6
  • 75
    • 0029829117 scopus 로고    scopus 로고
    • DNA fragmentation during bone formation in neonatal rodents assessed by transferase-mediated end labeling
    • 1:CAS:528:DyaK28Xls1ChtLY%3D 8864903
    • Bronckers ALJJ, Goei SW, Luo G, Karsenty G, D'souza RN, Lyaruu DM, Burger EH (1996) DNA fragmentation during bone formation in neonatal rodents assessed by transferase-mediated end labeling. J Bone Miner Res 11:1281-1291
    • (1996) J Bone Miner Res , vol.11 , pp. 1281-1291
    • Bronckers, A.1    Goei, S.W.2    Luo, G.3    Karsenty, G.4    D'Souza, R.N.5    Lyaruu, D.M.6    Burger, E.H.7
  • 76
    • 0033981552 scopus 로고    scopus 로고
    • Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo
    • 1:STN:280:DC%2BD3c7htFGrtg%3D%3D 10646115
    • Verborgt O, Gibson GJ, Schaffler MB (2000) Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. J Bone Miner Res 15:60-67
    • (2000) J Bone Miner Res , vol.15 , pp. 60-67
    • Verborgt, O.1    Gibson, G.J.2    Schaffler, M.B.3
  • 77
    • 84859360993 scopus 로고    scopus 로고
    • Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations
    • 3366436 22342796
    • Kennedy OD, Herman BC, Laudier DM, Majeska RJ, Sun HB, Schaffler MB (2012) Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations. Bone 50:1115-1122
    • (2012) Bone , vol.50 , pp. 1115-1122
    • Kennedy, O.D.1    Herman, B.C.2    Laudier, D.M.3    Majeska, R.J.4    Sun, H.B.5    Schaffler, M.B.6
  • 78
    • 0028362416 scopus 로고
    • Osteonal and hemi-osteonal remodeling: The spatial and temporal framework for signal traffic in adult human bone
    • 1:STN:280:DyaK2M%2FltFSksg%3D%3D 7962158
    • Parfitt AM (1994) Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem 55:273-286
    • (1994) J Cell Biochem , vol.55 , pp. 273-286
    • Parfitt, A.M.1
  • 79
    • 0035130601 scopus 로고    scopus 로고
    • A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy
    • 1:STN:280:DC%2BD3M7mslegug%3D%3D 11182371
    • Kamioka H, Honjo T, Takano-Yamamoto T (2001) A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy. Bone 28:145-149
    • (2001) Bone , vol.28 , pp. 145-149
    • Kamioka, H.1    Honjo, T.2    Takano-Yamamoto, T.3
  • 80
    • 0033963131 scopus 로고    scopus 로고
    • Is BMU-coupling a strain-regulated phenomenon? A finite element analysis
    • 1:STN:280:DC%2BD3c7ms1Kqug%3D%3D 10703932
    • Smit TH, Burger EH (2000) Is BMU-coupling a strain-regulated phenomenon? A finite element analysis. J Bone Miner Res 15:301-307
    • (2000) J Bone Miner Res , vol.15 , pp. 301-307
    • Smit, T.H.1    Burger, E.H.2
  • 81
    • 0141565397 scopus 로고    scopus 로고
    • Strain-derived canalicular fluid flow regulates osteoclast activity in a remodeling osteon - A proposal
    • 14499294
    • Burger EH, Klein-Nulend J, Smit TH (2003) Strain-derived canalicular fluid flow regulates osteoclast activity in a remodeling osteon - a proposal. J Biomech 36:1453-1459
    • (2003) J Biomech , vol.36 , pp. 1453-1459
    • Burger, E.H.1    Klein-Nulend, J.2    Smit, T.H.3
  • 82
    • 0036829261 scopus 로고    scopus 로고
    • A case for strain-induced fluid flow as a regulator of BMU-coupling and osteonal alignment
    • Smit TH, Burger EH, Huyghe JM (2002) A case for strain-induced fluid flow as a regulator of BMU-coupling and osteonal alignment. J Bone Miner Res 18:2021-2029
    • (2002) J Bone Miner Res , vol.18 , pp. 2021-2029
    • Smit, T.H.1    Burger, E.H.2    Huyghe, J.M.3
  • 84
    • 3142762332 scopus 로고    scopus 로고
    • Shear stress inhibits while disuse promotes osteocyte apoptosis
    • 1:CAS:528:DC%2BD2cXls1eis7w%3D 15249211
    • Bakker AD, Klein-Nulend J, Burger EH (2004) Shear stress inhibits while disuse promotes osteocyte apoptosis. Biochem Biophys Res Commun 320:1163-1168
    • (2004) Biochem Biophys Res Commun , vol.320 , pp. 1163-1168
    • Bakker, A.D.1    Klein-Nulend, J.2    Burger, E.H.3
  • 86
    • 84855514294 scopus 로고    scopus 로고
    • Pro-survival effects of 17β-estradiol on osteocytes are mediated by nitric oxide/cGMP via differential actions of cGMP-dependent protein kinases i and II
    • 1:CAS:528:DC%2BC38Xjsl2jtQ%3D%3D 3256896 22117068
    • Marathe N, Rangaswami H, Zhuang S, Boss GR, Pilz RB (2012) Pro-survival effects of 17β-estradiol on osteocytes are mediated by nitric oxide/cGMP via differential actions of cGMP-dependent protein kinases I and II. J Biol Chem 287:978-988
    • (2012) J Biol Chem , vol.287 , pp. 978-988
    • Marathe, N.1    Rangaswami, H.2    Zhuang, S.3    Boss, G.R.4    Pilz, R.B.5
  • 87
    • 44449087410 scopus 로고    scopus 로고
    • Apoptotic bodies convey activity capable of initiating osteoclastogenesis and localized bone destruction
    • 18435576
    • Kogianni G, Mann V, Noble BS (2008) Apoptotic bodies convey activity capable of initiating osteoclastogenesis and localized bone destruction. J Bone Miner Res 23:915-927
    • (2008) J Bone Miner Res , vol.23 , pp. 915-927
    • Kogianni, G.1    Mann, V.2    Noble, B.S.3
  • 92
    • 78650180083 scopus 로고    scopus 로고
    • Inhibition of osteoclastogenesis by mechanically loaded osteocytes: Involvement of MEPE
    • 1:CAS:528:DC%2BC3cXhtlentr7K 2964475 20725825
    • Kulkarni RN, Bakker AD, Everts V, Klein-Nulend J (2010) Inhibition of osteoclastogenesis by mechanically loaded osteocytes: involvement of MEPE. Calcif Tissue Int 87:461-468
    • (2010) Calcif Tissue Int , vol.87 , pp. 461-468
    • Kulkarni, R.N.1    Bakker, A.D.2    Everts, V.3    Klein-Nulend, J.4
  • 93
    • 35348853189 scopus 로고    scopus 로고
    • Osteocytes subjected to fluid flow inhibit osteoclast formation and bone resorption
    • 1:CAS:528:DC%2BD2sXhtF2htb%2FE 17855178
    • Tan SD, de Vries TJ, Kuijpers-Jagtman AM, Semeins CM, Everts V, Klein-Nulend J (2007) Osteocytes subjected to fluid flow inhibit osteoclast formation and bone resorption. Bone 41:745-751
    • (2007) Bone , vol.41 , pp. 745-751
    • Tan, S.D.1    De Vries, T.J.2    Kuijpers-Jagtman, A.M.3    Semeins, C.M.4    Everts, V.5    Klein-Nulend, J.6
  • 94
  • 95
    • 0034621881 scopus 로고    scopus 로고
    • Effects of mechanical forces on maintenance and adaptation of form in trabecular bone
    • 1:CAS:528:DC%2BD3cXktlGnsbo%3D 10864330
    • Huiskes R, Ruimerman R, van Lenthe GH, Janssen JD (2000) Effects of mechanical forces on maintenance and adaptation of form in trabecular bone. Nature 405:704-706
    • (2000) Nature , vol.405 , pp. 704-706
    • Huiskes, R.1    Ruimerman, R.2    Van Lenthe, G.H.3    Janssen, J.D.4
  • 97
    • 0029134676 scopus 로고
    • Proposal for the regulatory mechanism of Wolff's law
    • 1:STN:280:DyaK2MvgsVeltQ%3D%3D 7674066
    • Mullender MG, Huiskes R (1995) Proposal for the regulatory mechanism of Wolff's law. J Orthop Res 13:503-512
    • (1995) J Orthop Res , vol.13 , pp. 503-512
    • Mullender, M.G.1    Huiskes, R.2
  • 98
    • 0031425115 scopus 로고    scopus 로고
    • A tutorial on the diffusibility and reactivity of free nitric oxide
    • 1:CAS:528:DyaK2sXislaht7o%3D 9701041
    • Lancaster JR Jr (1997) A tutorial on the diffusibility and reactivity of free nitric oxide. Nitric Oxide 1:18-30
    • (1997) Nitric Oxide , vol.1 , pp. 18-30
    • Lancaster Jr., J.R.1
  • 99
    • 0029819899 scopus 로고    scopus 로고
    • Diffusion of free nitric oxide
    • 1:CAS:528:DyaK28XlvFejurk%3D 8782571
    • Lancaster JR Jr (1996) Diffusion of free nitric oxide. Methods Enzymol 268:31-50
    • (1996) Methods Enzymol , vol.268 , pp. 31-50
    • Lancaster Jr., J.R.1
  • 101
    • 34249885105 scopus 로고    scopus 로고
    • Extracellular NO signalling from a mechanically stimulated osteocyte
    • 17512530
    • Vatsa A, Smit TH, Klein-Nulend J (2007) Extracellular NO signalling from a mechanically stimulated osteocyte. J Biomech 40(Suppl 1):S89-95
    • (2007) J Biomech , vol.40 , Issue.SUPPL. 1 , pp. 89-95
    • Vatsa, A.1    Smit, T.H.2    Klein-Nulend, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.