Intracortical remodeling in adult rat long bones after fatigue loading

Bone

Volumn 23, Issue 3, 1998, Pages 275-281

  Bentolila, V ^a   Boyce, T M ^a   Fyhrie, D P ^a   Drumb, R ^a   Skerry, T M ^b   Schaffler, Mitchell B ^a,c  

^a HENRY FORD HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF YORK   (United Kingdom)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Bone microdamage; Bone remodeling; Fatigue; Osteocytes; Rat

Indexed keywords

FUCHSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE BOWING; BONE INJURY; BONE REMODELING; BONE TURNOVER; CELL DEATH; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORTICAL BONE; LONG BONE; MORPHOMETRICS; NONHUMAN; OSTEOCYTE; OSTEOLYSIS; OSTEOTOMY; RAT; ULNA;

NON-PROGRAMMATIC;

ANIMALS; BONE REMODELING; BONE RESORPTION; FRACTURES, STRESS; MICROSCOPY, CONFOCAL; RATS; RATS, SPRAGUE-DAWLEY; ULNA; WEIGHT-BEARING;

EID: 0031719754     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(98)00104-5     Document Type: Article

References (45)

1. Agarwal, B. D. and Broutman, L. J. Analysis and Performance of Fiber Composites. New York: Wiley; 1980.
2. Baron, R., Tross, R., and Vignery, A. Evidence of sequential remodeling in rat trabecular bone: Morphology, dynamic histomorphometry and changes during skeletal maturation. Anat Rec 208:137-145; 1984.
3. Bentolila, V., Hillam, R. A., Skerry, T., Boyce, T. M., Fyhrie, D. P., and Schaffler, M. B. Activation of intracortical remodeling in adult rat long bones by fatigue loading. Trans Orthop Res Soc 22:578; 1997.
4. Boyce, T. M., Fyhrie, D. P., Brodie, F. R., and Schaffler, M. B. Residual mechanical properties of human cortical bone following fatigue loading. Am Soc Biomech 20:23-24; 1996.
5. Boyce, T. M., Fyhrie, D. P., Radin, E. L., and Schaffler, M. B. Damage and strain mode associations in human compact bone bending fatigue. J Orthop Res. In press.
6. Bronckers, A. L. J. J., Goei, W., Luo, G., Karsenty, G., D-Souza, R. N., Lyaruu, D. M., and Burger, E. H. DNA fragmentation during bone formation in neonatal rodent assessed by transferase mediated end labeling. J Bone Miner Res 11:1281-1291; 1996.
7. Burr, D. B., Forwood, M. R., Schaffler, M. B., Fyhrie, D. P., Martin, R. B., and Turner, C. H. Bone microdamage and skeletal fragility in osteoporotic and stress fractures. J Bone Miner Res 12:6-15; 1997.
8. Burr, D. B., Martin, R. B., Schaffler, M. B., and Radin, E. L. Bone remodeling in response to in vivo fatigue microdamage. J Biomech 18:189-200; 1985.
9. Burr, D. B. and Stafford, T. Validation of the bulk-staining technique to separate artifactual from in vivo bone microdamage. Clin Orthop 260:305-309; 1991.
10. Carter, D. R., Caler, W. E., Spengler, D. M., and Frankel, V. H. Fatigue behavior of adult cortical bone: The influence of mean strain and strain range. Acta Orthop Scand 52:481-490; 1981.
11. Carter, D. R., Caler, W. E., Spengler, D. M., and Frankel, V. H. Uniaxial fatigue of human cortical bone: The influence of tissue physical characteristics. J Biomech 14:461-470; 1981.
12. Carter, D. R. and Hayes, W. C. Compact bone fatigue damage: A microscopic examination. Clin Orthop 127:265-274; 1977.
13. Doty, S. B., Robinson, R. A., and Schofield, B. Morphological and histochemical staining characteristics of bone cells. In: Aurbach, G. D., Ed., Handbook of Physiology. Washington, DC: American Society of Physiology; 1976; 3-23.
14. Dunstan, C. R., Somers, N. M., and Evans, R. A. Osteocyte death and hip fracture. Calcif Tissue Int 53(Suppl.):113-119; 1993.
15. Fermor, B. and Skerry, T. M. PTH/PTHrP receptor expression on osteoblasts and osteocytes but not resorbing bone surfaces in growing rats. J Bone Miner Res 10:1935-1943; 1995.
16. Forwood, M. R. and Parker, A. W. Microdamage in response to repetitive torsional loading in the rat tibia. Calcif Tissue Int 45:47-53; 1989.
17. Frost, H. M. Presence of microscopic cracks in vivo in bone. Henry Ford Med Bull 8:27-35; 1960.
18. Frost, H. M. Bone microdamage: Factors that impair its repair. In: Uhthoff, H. K., Ed. Current Concepts in Bone Fragility. Berlin: Springer; 1985.
19. Hillam, R. A. and Skerry, T. M. Inhibition of bone resorption and stimulation of formation by mechanical loading of the modeling rats ulna in vivo. J Bone Miner Res 10:683-689; 1995.
20. 2 enhances cortical bone mass and activates intracortical bone remodeling in intact and ovariectomized female rats. Bone 11:253-266; 1990.
21. Kerr, J. F. R. and Harmon, B. V. Definition and incidence of apoptosis. In: Tomei, L. D. and Cope, F. O., Eds. Apoptosis: The Molecular Basis of Cell Death. Cold Spring Harbor, NY: Cold Spring Harbor; 1991; 5-30.
22. Lanyon, L. E. Osteocytes, strain detection and bone modeling and remodeling. Calcif Tissue Int 53(Suppl.):102-107; 1993.
23. Li, X. J., Jee, W. S. S., Ke, H. Z., Mori, S., and Akamine, T. Age-related changes of cancellous and cortical bone histomorphometry in female Sprague-Dawley rats. Scann Microsc Int (Cells Mater) (Suppl. 1):25-36; 1991.
24. Martin, R. B. and Burr, D. B. A hypothetical mechanism for the stimulation of osteonal remodeling by fatigue damage. J Biomech 15:137-139; 1982.
25. Miller, S. C., Shupe, J. G., Redd, E. H., Miller, M. A., and Omura, T. H. Changes in bone mineral and bone formation rates during pregnancy and lactation in rats. Bone 7:283-287; 1986.
26. Mori, S. and Burr, D. B. Increased intracortical remodeling following fatigue damage. Bone 14:103-109; 1993.
27. Mori, S., Harruff, R., Ambrosius, W., and Burr, D. B. Trabecular bone volume and microdamage accumulation in femoral heads of women with and without femoral neck fractures. Bone 21:521-526; 1997.
28. Noble, B. S., Stevens, H., Loveridge, N., and Reeve, J. Identification of apoptotic changes in osteocytes in normal and pathological human bone. Bone 20:273-282; 1997.
29. Noble, B. S., Stevens, H., Mosley, J. R., Pitsillades, A. A., Reeve, J., and Lanyon, L. Bone loading changes the number and distribution of apoptotic osteocytes in cortical bone. J Bone Miner Res 12(Suppl. 1):36; 1997.
30. Nunamaker, D. M., Butterweck, D. M., and Provost, T. M. Fatigue fractures in thoroughbred racehorses: Relationship with age, peak bone strain and training. J Orthop Res 8:604-611; 1990.
31. Parfitt, A. M., Mundy, G. R., Roodman, G. D., Hughes, D. E., and Boyce, B. F. A new model for the regulation of bone resorption with particular reference to the effect of bisphosphonates. J Bone Miner Res 11:150-159; 1996.
32. Pattin, C. A., Caler, W. E., and Carter, D. R. Cyclic mechanical property degradation during fatigue loading of cortical bone. J Biomech 29:69-79; 1996.
33. Qiu, S.-J., Hoshaw, S. J., Gibson, G. J., Lundin-Cannon, K. D., and Schaffler, M. B. Osteocyte apoptosis in reaction to matrix damage in compact bone. Trans Orthop Res Soc 22:89; 1997.
34. Rubin, C. T. Skeletal strain and the functional significance of bone architecture. Calcif Tissue Int 36(Suppl.):11-18; 1984.
35. Rubin, C. T. and Lanyon, L. E. Limb mechanics as a function of speed and gait: A study of functional strains in the radius and tibia of horse and dog. J Exp Biol 101:187-211; 1982.
36. Ruth, E. B. Bone studies II. An experimental study of the haversian type vascular channels. Am J Anat 93:429-455; 1953.
37. Schaffler, M. B., Boyce, T. M., and Fyhrie, D. P. Tissue and matrix failure modes in human compact bone during tensile fatigue. Trans Orthop Res Soc 21:57; 1996.
38. Schaffler, M. B., Burr, D. B., and Radin, E. L. Mechanical and morphological effects of strain rate on fatigue in compact bone. Bone 10:207-214; 1989.
39. Schaffler, M. B., Choi, K., and Milgrom, C. Aging and matrix microdamage accumulation in human compact bone. Bone 17:521-525; 1995.
40. Schaffler, M. B., Pitchford, W. C., Choi, K., and Riddle, J. M. Examination of compact bone microdamage using back-scattered electron microscopy. Bone 15:483-488; 1994.
41. Schaffler, M. B., Radin, E. L., and Burr, D. B. Long-term fatigue behavior of compact bone at low strain magnitude and rate. Bone 11:321-326; 1990.
42. Tomkinson, A., Reeve, J., Shaw, R. W., and Noble, B. S. The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone. J Clin Endocrinol Metab 82:3128-3135; 1997.
43. Torrance, A. G., Mosley, J. M., Suswillo, R. F. L., and Lanyon, L. E. Noninvasive loading of the rat ulna in vivo induces modeling response uncomplicated by periosteal trauma. Calcif Tissue Int 54:241-247; 1994.
44. Wong, S. Y. P., Dunstan, C. R., Evans, R. A., and Hills, E. The determination of bone viability: A histochemical methods for identification of lactate dehydrogenase activity in osteocytes in fresh and decalcified sections of human bone. Pathology 14:439-442; 1982.
45. Zioupos, P., Wang, X. T., and Currey, J. D. Experimental and theoretical quantification of the development of damage in fatigue tests of bone and antler. J Biomech 29:989-1002; 1996.