Nitric oxide production by bone cells is fluid shear stress rate dependent

Biochemical and Biophysical Research Communications

Volumn 315, Issue 4, 2004, Pages 823-829

  Bacabac, Rommel G ^a   Smit, Theo H ^b   Mullender, Margriet G ^a   Dijcks, Saskia J ^a   Van Loon, Jack J W A ^a   Klein Nulend, Jenneke ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Bone cells; Bone formation; Fluid flow; Fluid shear stress rate; MC3T3 E1; Mechanical loading; Microgravity; Nitric oxide; Osteoblasts; Parallel plate chamber

Indexed keywords

NITRIC OXIDE;

AMPLITUDE MODULATION; ANIMAL CELL; ARTICLE; BONE CELL; CELL ACTIVATION; CONTROLLED STUDY; GENE FREQUENCY; MOUSE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; SHEAR STRESS; SIGNAL TRANSDUCTION;

HELIOTHIS ZEA VIRUS 1;

EID: 1342345247     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.01.138     Document Type: Article

References (43)

1. Wolff J. Das gesetz der tranformation der knochen. 1892;Hirschwald, Berlin.
2. Wolff J. The Law of Bone Remodelling. 1986;Springer, Berlin.
3. Piekarski K., Munro M. Transport mechanism operating between blood supply and osteocytes in long bones. Nature. 269:1977;80-82.
4. Starkebaum W., Pollack S.R., Korostoff E. Microelectrode studies of stress-generated potentials in four-point bending of bone. J. Biomed. Mater. Res. 13:1979;729-751.
5. Knothe Tate M.L., Niederer P., Knothe U. In vivo tracer transport through the lacunocanalicular system of rat bone in an environment devoid of mechanical loading. Bone. 22:1998;107-117.
6. Knothe Tate M.L., Knothe U. An ex vivo model to study transport processes and fluid flow in loaded bone. J. Biomech. 33:2000;247-254.
7. Cowin S.C., Moss-Salentijn L., Moss M.L. Candidates for the mechanosensory system in bone. J. Biomech. Eng. 113:1991;191-197.
8. Burger E.H., Klein-Nulend J., Cowin S.C. Mechanotransduction in bone, molecular and cellular biology of bone. Zaidi M., Bittar E.E., Adebanjo O.A., Huan C.L.H. Advances in Organ Biology. 1998;123-136 JAI Press, Stamford, Connecticut, USA.
9. Burger E.H., Klein-Nulend J. Mechanotransduction in bone - role of the lacuno-canalicular network. FASEB J. 13:1999;S101-S112.
10. Smit T.H., Burger E.H., Huyghe J.M. A case for strain-induced fluid flow as a regulator of BMU-coupling and osteonal alignment. J. Bone Miner. Res. 11:2002;2021-2029.
11. Frangos J.A., Johnson D. Fluid flow in bone: stimulated release at remodeling mediators. Biorheology. 32:1995;187-187.
12. Klein-Nulend J., Semeins C.M., Ajubi N.E., Nijweide P.J., Burger E.H. Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts - correlation with prostaglandin upregulation. Biochem. Biophys. Res. Commun. 217:1995;640-648.
13. Klein-Nulend J., Roelofsen J., Sterck J.G.H., Semeins C.M., Burger E.H. Mechanical loading stimulates the release of transforming growth factor-beta activity by cultured mouse calvariae and periosteal cells. J. Cell Physiol. 163:1995;115-119.
14. Klein-Nulend J., van der Plas A., Semeins C.M., Ajubi N.E., Frangos J.A., Nijweide P.J., Burger E.H. Sensitivity of osteocytes to biomechanical stress in vitro. FASEB J. 9:1995;441-445.
15. Johnson D.L., McAllister T.N., Frangos J.A. Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts. Am. J. Physiol. 271:1996;E205-E208.
16. Jacobs C.R., Yellowley C.E., Davis B.R., Zhou Z., Donahue H.J. Differential effect of steady versus oscillating flow on bone cells. J. Biomech. 31:1998;969-976.
17. 2+ regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts. Am. J. Physiol. Cell Physiol. 278:2000;C989-C997.
18. 2 by primary bone cells is shear stress dependent. J. Biomech. 34:2001;671-677.
19. Owan I., Burr D.B., Turner C.H., Qiu J., Tu Y., Onyia J.E., Duncan R.L. Mechanotransduction in bone: osteoblasts are more responsive to fluid forces than mechanical strain. Am. J. Physiol. 273:1997;C810-C815.
20. 2 in osteoblasts by wall-shear stress but not mechanical strain. Am. J. Physiol. 273:1997;E751-E758.
21. Weinbaum S., Cowin S.C., Zeng Y. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. J. Biomech. 27:1994;339-360.
22. Cowin S.C. Bone poroelasticity. J. Biomech. 32:1999;217-238.
23. Turner C.H., Owan I., Takano Y. Mechanotransduction in bone: role of strain rate. Am. J. Physiol. 269:1995;E438-E442.
24. Mosley J.R., Lanyon L.E. Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats. Bone. 23:1998;313-318.
25. Rubin C.T., Sommerfeldt D.W., Judex S., Qin Y.X. Inhibition of osteopenia by low magnitude, high-frequency mechanical stimuli. Drug Discov. Today. 6:2001;848-858.
26. Fritton S.P., McLeod J., Rubin C.T. Quantifying the strain history of bone: spatial uniformity and self-similarity of low-magnitude strains. J. Biomech. 33:2000;317-325.
27. Nordstrom P., Pettersson U., Lorentzon R. Type of physical activity, muscle strength, and pubertal stage as determinants of bone mineral density and bone area in adolescent boys. J. Bone Miner. Res. 13:1998;1141-1148.
28. Tanaka M., Ejiri S., Nakajima M., Kohno S., Ozawa H. Changes of cancellous bone mass in rat mandibular condyle following ovariectomy. Bone. 25:1999;339-347.
29. Williams J.L., Iannotti J.P., Ham A., Bleuit J., Chen J.H. Effects of fluid shear stress on bone cells. Biorheology. 31:1994;163-170.
30. Fox S.W., Chambers T.J., Chow J.W.M. Nitric oxide is an early mediator of the induction of bone formation by mechanical stimulation. Bone. 19:1996;687-687.
31. Turner C.H., Takano Y., Owan I., Murrell G.A. Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats. Am. J. Physiol. 270:1996;E634-E639.
32. G. Bergmann, F. Graichen, A. Rohlmann, Hip joint force measurements. Available from , Accessed June 3, 2003.
33. Bacabac R.G., Smit T.H., Heethaar R.M., van Loon J.J.W.A., Pourquie M.J.M.B., Nieuwstadt F.T.M., Klein-Nulend J. Characteristics of the parallel-plate flow chamber for mechanical stimulation of bone cells under microgravity. J. Gravitat. Physiol. 9:2002;P181-P182.
34. Rubin C.T., Lanyon L.E. Regulation of bone formation by applied dynamic loads. J. Bone Joint Surg. Am. 66:1984;397-402.
35. S.M. Tanaka, I. Alam, C.H. Turner, Stochastic resonance in osteogenic response to mechanical loading, FASEB J. (2002) 02-0561fje.
36. Tanaka S.M., Li J., Duncan R.L., Yokota H., Burr D.B., Turner C.H. Effects of broad frequency vibration on cultured osteoblasts. J. Biomech. 36:2003;73-80.
37. Schneider V.S., McDonald J. Skeletal calcium homeostasis and countermeasures to prevent disuse osteoporosis. Calcif. Tissue Int. 36:1984;S144-S151.
38. Van Loon J.J.W.A., Veldhuijzen J.P., Burger E.H. Bone and space flight: an overview. Moore D., Bie P., Oser H. Biological and Medical Research in Space. 1996;259-299 Springer, Berlin, Germany.
39. Zerath E., Novikov V., Leblanc A., Bakulin A., Oganov V., Grynpas M. Effects of spaceflight on bone mineralization in the rhesus monkey. J. Appl. Physiol. 81:1996;194-200.
40. Vico L., Lafage-Proust M.-H., Alexandre C. Effects of gravitational changes on the bone system in vitro and in vivo. Bone. 22:1998;95S-100S.
41. Burger E.H., Klein-Nulend J. Microgravity and bone cell mechanosensitivity. Bone. 22:1998;127S-130S.
42. Huiskes R., Ruimerman R., van Lenthe G.H., Janssen J.D. Effects of mechanical forces on maintenance and adaptation of form in trabecular bone. Nature. 405:2000;704-706.
43. Ruimerman R., Van Rietbergen B., Huiskes R. A 3-dimensional computer model to simulate trabecular bone metabolism. Biorheology. 40:2003;315-320.