Nitric oxide is an early mediator of the increase in bone formation by mechanical stimulation

American Journal of Physiology - Endocrinology and Metabolism

Volumn 270, Issue 6 33-6, 1996, Pages

  Fox, S W ^a   Chambers, T J ^a   Chow, J W M ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

L arginine; nitric oxide synthase; osteogenesis

Indexed keywords

DEXTRO ARGININE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE GROWTH; CANCELLOUS BONE; CONTROLLED STUDY; FEMALE; MECHANICAL STIMULATION; NONHUMAN; PERIOSTEUM; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WEIGHT BEARING;

EID: 0029820699     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.270.6.e955     Document Type: Article

References (33)

1. Abate, C., L. Patel, F. J. Rauscher III, and T. Curran. Redox regulation of fos and jun DNA-binding activity in vitro. Science Wash. DC 249: 1157-1161, 1990.
2. Anggard, E. Nitric oxide: mediator, murderer, and medicine. Lancet 343: 1199-1206, 1994.
3. Chambers, T. J., M. Evans, T. N. Gardner, A. Turner-Smith, and J. W. M. Chow. Induction of bone formation in rat tail vertebrae by mechanical loading Bone Miner. 20: 167-178, 1993.
4. Chow, J. W. M., and T. J. Chambers. Indomethacin has distinct early and late actions on bone formation induced by mechanical stimulation. Am. J. Physiol. 267 (Endocrinol. Metab. 30): E287-E292, 1994,
5. Chow, J. W. M., C. J. Jagger, and T. J. Chambers. Characterization of osteogenic response to mechanical stimulation in cancellous bone of rat caudal vertebrae. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E340-E347, 1993.
6. Chow, J. W. M., J. M. Lean, and T. J. Chambers. 17β-Estradiol stimulates cancellous bone formation in female rats. Endocrinology 130: 3025-3032, 1992.
7. Cowin, S. C., L. Moss-Salentin, and M. L. Moss. Candidates for the mechanosensory system in bone. J. Biomech. Eng. 113: 191-197, 1991.
8. Damoulis, P. D., and P. V. Hauschka. Cytokines induce nitric oxide production in mouse osteoblasts. Biochem. Biophys. Res. Commun. 201: 924-931, 1994.
9. Dony, C., and P. Gruss. Proto-oncogene c-fos expression in growth regions of fetal bone and mesodermal web tissue. Nature Lond. 328: 711-714, 1987.
10. El Haj, A. J., S. L. Minter, S. C. F. Rawlinson, R. Suswillo, and L. E. Lanyon. Cellular responses to mechanical loading in vitro. J. Bone Miner. Res. 5: 923-932, 1990.
11. Grigoriadis, A. E., K. Schellander, Z.-Q. Wang, and E. F. Wagner. Osteoblasts are target cells for transformation in c-fos transgenic mice. J. Cell Biol. 122: 685-701, 1993.
12. Hibbs, J. B., R. R. Taintor, Z. Vavrin, and E. M. Rachlin. Nitric oxide: a cytostatic activated macrophage effector molecule. Biochem. Biophys. Res. Commun. 157: 87-94, 1989.
13. Lanyon, L. E. Functional strain as a determinant for bone remodelling. Calcif. Tissue Int. 36, Suppl.: S56-S61, 1984.
14. Lean, J. M., C. J. Jagger, T. J. Chambers, and J. W. M. Chow. Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E318-E327, 1990.
15. Lowenstein, C. J., and S. H. Snyder. Nitric oxide, a novel biologic messenger. Cell 70: 705-707, 1992.
16. Lowick, C. W. G. M., P. H. Nibbering, M. van de Ruit, and S. E. Papapoulos. Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption. J. Clin. Invest. 93: 1465-1472, 1994.
17. Moncada, S., R. M. J. Palmer, and E. A. Higgs. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43: 109-142, 1991.
18. Nathan, C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6: 1051-1064, 1992.
19. Nathan, C., and Q.-W. Xie. Regulation of biosynthesis of nitric oxide. J Biol. Chem. 269: 13725-13728, 1994.
20. Norrdin, R. W., W. S. S. Jee, and W. B. High. Review: the role of prostaglandins in bone in vivo. Prostaglandins Leukotrienes Essent. Fatty Acids 41: 139-149, 1990.
21. Palmer, R. M. J., A. G. Ferrige, and S. Moncada. Nitric oxide release accounts for the biological activity of endothelium derived relaxing factor. Nature Lond. 327: 524-526, 1987.
22. Pead, M. J., and L. E. Lanyon. Indomethacin modulation of load-related stimulation of new bone formation in vivo. Calcif. Tissue Int. 45: 34-40, 1989.
23. Pead, M. J., T. M. Skerry, and L. E. Lanyon. Direct transformation from quiescence to bone formation in the adult perios teum following a single brief period of bone loading. J. Bone Miner. Res. 3: 647-656, 1988.
24. Peunova, N., and G. Enikolopov. Amplification of calcium-induced gene transcription by nitric oxide in neuronal cells. Nature Lond. 364: 450-453, 1993.
25. Pitsillides, A. A., S. C. F. Rawlinson, R. F. L. Suswillo, and L. E. Lanyon. Nitric oxide production is stimulated by mechanical loading (Abstract). Bone 16: 682, 1995.
26. Ralston, S. H., D. Todd, M. Helfrich, N. Benjamin, and P. S. Grabowski. Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase. Endocrinology 135: 330-336, 1994.
27. Rawlinson, S. C. F., A. J. El Haj, S. L. Minter, I. A. Tavares, A. Bennett, and L. E. Lanyon. Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: a role for prostacyclin in adaptive bone remodeling? J. Bone Miner. Res. 6: 1345-1351, 1991.
28. Rees, D. D., R. M. J. Palmer, and S. Moncada. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc. Natl. Acad. Sci. USA 86: 3375-3378, 1989.
29. Riancho, J. A., E. Salas, M. T. Zarrabeitia, J. M. Olmos, J. A. Amado, J. L. Fernandez-Luna, and J. Gonzalez-Macias. Expression and functional role of nitric oxide synthase in osteoblast-like cells. J. Bone Miner. Res. 10: 439-446, 1995.
30. Rubin, C. T., and L. E. Lanyon. Dynamic strain similarity in vertebrates: an alternative to allometric limb bone scaling. J. Theor. Biol. 107: 321-327, 1984.
31. Rüther, U., C. Garber, D. Komitowski, R. Müller, and E. F. Wagner. Deregulated c-fos expression interferes with normal bone development in transgenic mice. Nature Lond. 325: 412-416, 1987.
32. Skerry, T. M., L. Bitensky, J. Chayen, and L. E. Lanyon. Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo. J. Bone Miner. Res. 4: 783-788, 1989.
33. Turner, C. H. Functional determinants of bone structure: beyond Wolff's law of bone transformation. Bone 13: 403-409, 1992.