Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression

Journal of Biological Chemistry

Volumn 280, Issue 39, 2005, Pages 33132-33140

  Gaur, Tripti ^a   Lengner, Christopher J ^a   Hovhannisyan, Hayk ^a   Bhat, Ramesh A ^b   Bodine, Peter V N ^b   Komm, Barry S ^b   Javed, Amjad ^a   Van Wijnen, Andre J ^a   Stein, Janet L ^a   Stein, Gary S ^a   Lian, Jane B ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; CELLS; GENES; MUSCULOSKELETAL SYSTEM; MUTAGENESIS; TISSUE;

BONE-FORMING CELLS; MUTATIONAL ANALYSIS; OSTEOGENESIS; SKELETAL DEVELOPMENT;

PROTEINS;

BETA CATENIN; BONE MORPHOGENETIC PROTEIN; FRIZZLED PROTEIN; MESSENGER RNA; OSTEOCALCIN; SECRETED FRIZZLED RELATED PROTEIN 1; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR 7; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; BONE MASS; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE MUTATION; GENE TARGETING; MESENCHYME CELL; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PHENOTYPE; PLURIPOTENT STEM CELL; PRECIPITATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MESENCHYMAL STEM CELLS; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; OSTEOBLASTS; OSTEOGENESIS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 25844509347     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500608200     Document Type: Article

References (69)

1. Karaplis, A. (2002) in Principles of Bone Biology (Bilezikian, J. P., Raisz, L. G., and Rodan, G. A., eds) pp. 33-58, Academic Press, Inc., San Diego, CA
2. Lian, J. B., Stein, G. S., and Aubin, J. E. (2003) in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (Favus, M. J., ed) pp. 13-28, American Society for Bone and Mineral Research, Washington, D. C.
3. Church, V. L., and Francis-West, P. (2002) Int. J. Dev. Biol. 46, 927-936
4. Westendorf, J. J., Kahler, R. A., and Schroeder, T. M. (2004) Gene (Amst.) 341, 19-39
5. Komori, T. (2005) J. Cell. Biochem. 95, 445-453
6. Kobayashi, T., and Kronenberg, H. (2005) Endocrinology 146, 1012-1017
7. Pandur, P., Maurus, D., and Kuhl, M. (2002) BioEssays 24, 881-884
8. Logan, C. Y., and Nusse, R. (2004) Annu. Rev. Cell Dev. Biol. 20, 781-810
9. Ikeya, M., and Takada, S. (2001) Mech. Dev. 103, 27-33
10. Hartmann, C., and Tabin, C. J. (2001) Cell 104, 341-351
11. Hartmann, C., and Tabin, C. J. (2000) Development (Camb.) 127, 3141-3159
12. Yamaguchi, T. P., Bradley, A., McMahon, A. P., and Jones, S. (1999) Development (Camb.) 126, 1211-1223
13. Adamska, M., MacDonald, B. T., Sarmast, Z. H., Oliver, E. R., and Meisler, M. H. (2004) Dev. Biol. 272, 134-144
14. Niemann, S., Zhao, C., Pascu, F., Stahl, U., Aulepp, U., Niswander, L., Weber, J. L., and Muller, U. (2004) Am. J. Hum. Genet. 74, 558-563
15. Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., and Lifton, R. P. (2002) N. Engl. J. Med. 346, 1513-1521
16. Little, R. D., Recker, R. R., and Johnson, M. L. (2002) N. Engl. J. Med. 347, 943-944
17. Akhter, M. P., Wells, D. J., Short, S. J., Cullen, D. M., Johnson, M. L., Haynatzki, G. R., Babij, P., Allen, K. M., Yaworsky, P. J., Bex, F., and Recker, R. R. (2004) Bone (N. Y.) 35, 162-169
18. Babij, P., Zhao, W., Small, C., Kharode, Y., Yaworsky, P. J., Bouxsein, M. L., Reddy, P. S., Bodine, P. V., Robinson, J. A., Bhat, B., Marzolf, J., Moran, R. A., and Bex, F. (2003) J. Bone Miner. Res. 18, 960-974
19. Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., Zacharin, M., Oexle, K., Marcelino, J., Suwairi, W., Heeger, S., Sabatakos, G., Apte, S., Adkins, W. N., Allgrove, J., Arslan-Kirchner, M., Batch, J. A., Beighton, P., Black, G. C., Boles, R. G., Boon, L. M., Borrone, C., Brunner, H. G., Carle, G. F., Dallapiccola, B., De Paepe, A., Floege, B., Halfhide, M. L., Hall, B., Hennekam, R. C., Hirose, T., Jans, A., Juppner, H., Kim, C. A., Keppler-Noreuil, K., Kohlschuetter, A., LaCombe, D., Lambert, M., Lemyre, E., Letteboer, T., Peltonen, L., Ramesar, R. S., Romanengo, M., Somer, H., Steichen-Gersdorf, E., Steinmann, B., Sullivan, B., Superti-Furga, A., Swoboda, W., van den Boogaard, M. J., van Hul, W., Vikkula, M., Votruba, M., Zabel, B., Garcia, T., Baron, R., Olsen, B. R., and Warman, M. L. (2001) Cell 107, 513-523
20. Kato, M., Patel, M. S., Levasseur, R., Lobov, I., Chang, B. H., Glass, D. A., Hartmann, C., Li, L., Hwang, T. H., Brayton, C. F., Lang, R. A., Karsenty, G., and Chan, L. (2002) J. Cell Biol. 157, 303-314
21. Yu, H. M., Jerchow, B., Sheu, T. J., Liu, B., Costantini, F., Puzas, J. E., Birchmeier, W., and Hsu, W. (2005) Development (Camb.) 132, 1995-2005
22. Haegel, H., Larue, L., Ohsugi, M., Fedorov, L., Herrenknecht, K., and Kemler, R. (1995) Development (Camb.) 121, 3529-3537
23. Brault, V., Moore, R., Kutsch, S., Ishibashi, M., Rowitch, D. H., McMahon, A. P., Sommer, L., Boussadia, O., and Kemler, R. (2001) Development (Camb.) 128, 1253-1264
24. Day, T. F., Guo, X., Garrett-Beal, L., and Yang, Y. (2005) Developmental Cell 8, 739-750
25. Hill, T. P., Spater, D., Taketo, M. M., Birchmeier, W., and Hartmann, C. (2005) Developmental Cell 8, 727-738
26. Holmen, S. L., Zylstra, C. R., Mukherjee, A., Sigler, R. E., Faugere, M. C., Bouxsein, M. L., Deng, L., Clemens, T. L., and Williams, B. O. (2005) J. Biol. Chem. 280, 21162-21168
27. Tamamura, Y., Otani, T., Kanatani, N., Koyama, E., Kitagaki, J., Komori, T., Yamada, Y., Costantini, F., Wakisaka, S., Pacifici, M., Iwamoto, M., and Enomoto-Iwamoto, M. (2005) J. Biol. Chem. 280, 19185-19195
28. Kawano, Y., and Kypta, R. (2003) J. Cell Sci. 116, 2627-2634
29. Bodine, P. V., Zhao, W., Kharode, Y. P., Bex, F. J., Lambert, A. J., Goad, M. B., Gaur, T., Stein, G. S., Lian, J. B., and Komm, B. S. (2004) Mol. Endocrinol. 18, 1222-1237
30. Banerjee, C., McCabe, L. R., Choi, J.-Y., Hiebert, S. W., Stein, J. L., Stein, G. S., and Lian, J. B. (1997) J. Cell. Biochem. 66, 1-8
31. Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., and Karsenty, G. (1997) Cell 89, 747-754
32. Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., Sato, M., Okamoto, R., Kitamura, Y., Yoshiki, S., and Kishimoto, T. (1997) Cell 89, 755-764
33. Otto, F., Thornell, A. P., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G. W. H., Beddington, R. S. P., Mundlos, S., Olsen, B. R., Selby, P. B., and Owen, M. J. (1997) Cell 89, 765-771G. W. H.R. S. P.
34. Choi, J.-Y., Pratap, J., Javed, A., Zaidi, S. K., Xing, L., Balint, E., Dalamangas, S., Boyce, B., van Wijnen, A. J., Lian, J. B., Stein, J. L., Jones, S. N., and Stein, G. S. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 8650-8655
35. Otto, F., Kanegane, H., and Mundlos, S. (2002) Hum. Mutat. 19, 209-216
36. Yoshida, T., Kanegane, H., Osato, M., Yanagida, M., Miyawaki, T., Ito, Y., and Shigesada, K. (2003) Blood Cells Mol. Dis. 30, 184-193
37. Lian, J. B., Javed, A., Zaidi, S. K., Lengner, C., Montecino, M., van Wijnen, A. J., Stein, J. L., and Stein, G. S. (2004) Crit. Rev. Eukaryot. Gene Expr. 14, 1-41
38. Paredes, R., Arriagada, G., Cruzat, F., Villagra, A., Olate, J., Zaidi, K., van Wijnen, A. J., Lian, J. B., Stein, G. S., Stein, J. L., and Montecino, M. (2004) Mol. Cell. Biol. 24, 8847-8861
39. Afzal, F., Pratap, J., Ito, K., Ito, Y., Stein, J. L., van Wijnen, A. J., Stein, G. S., Lian, J. B., and Javed, A. (2005) J. Cell. Physiol. 204, 63-72
40. Zaidi, S. K., Sullivan, A. J., van Wijnen, A. J., Stein, J. L., Stein, G. S., and Lian, J. B. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 8048-8053
41. Zaidi, S. K., Sullivan, A. J., Medina, R., Ito, Y., van Wijnen, A. J., Stein, J. L., Lian, J. B., and Stein, G. S. (2004) EMBO J. 23, 790-799
42. Lengner, C. J., Drissi, H., Choi, J.-Y., van Wijnen, A. J., Stein, J. L., Stein, G. S., and Lian, J. B. (2002) Mech. Dev. 114, 167-170
43. Lengner, C. J., Lepper, C., van Wijnen, A. J., Stein, J. L., Stein, G. S., and Lian, J. B. (2004) J. Cell. Physiol. 200, 327-333
44. Drissi, H., Luc, Q., Shakoori, R., Chuva de Sousa Lopes, S., Choi, J.-Y., Terry, A., Hu, M., Jones, S., Neil, J. C., Lian, J. B., Stein, J. L., van Wijnen, A. J., and Stein, G. S. (2000) J. Cell Physiol. 184, 341-350
45. Zhang, Y. W., Yasui, N., Ito, K., Huang, G., Fujii, M., Hanai, J., Nogami, H., Ochi, T., Miyazono, K., and Ito, Y. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 10549-10554
46. Javed, A., Barnes, G. L., Jassanya, B. O., Stein, J. L., Gerstenfeld, L., Lian, J. B., and Stein, G. S. (2001) Mol. Cell. Biol. 21, 2891-2905
47. Hovhannisyan, H., Cho, B., Mitra, P., Montecino, M., Stein, G. S., van Wijnen, A. J., and Stein, J. L. (2003) Mol. Cell. Biol. 23, 1460-1469
48. Kockx, M., McCabe, L., Stein, J. L., Lian, J. B., and Stein, G. S. (1994) J. Cell. Biochem. 54, 47-55
49. Holmen, S. L., Giambernardi, T. A., Zylstra, C. R., Buckner-Berghuis, B. D., Resau, J. H., Hess, J. F., Glatt, V., Bouxsein, M. L., Ai, M., Warman, M. L., and Williams, B. O. (2004) J. Bone Miner. Res. 19, 2033-2040
50. Kokubu, C., Heinzmann, U., Kokubu, T., Sakai, N., Kubota, T., Kawai, M., Wahl, M. B., Galceran, J., Grosschedl, R., Ozono, K., and Imai, K. (2004) Development (Camb.) 131, 5469-5480
51. Zambotti, A., Makhluf, H., Shen, J., and Ducy, P. (2002) J. Biol. Chem. 277, 41497-41506
52. Clevers, H., and van de Wetering, M. (1997) Trends Genet. 13, 485-489
53. Vaes, B. L., Dechering, K. J., van Someren, E. P., Hendriks, J. M., van de Ven, C. J., Feijen, A., Mummery, C. L., Reinders, M. J., Olijve, W., Van Zoelen, E. J., and Steegenga, W. T. (2005) Bone (N. Y.) 36, 803-811
54. Bennett, C. N., Longo, K. A., Wright, W. S., Suva, L. J., Lane, T. F., Hankenson, K. D., and MacDougald, O. A. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 3324-3329
55. Hovanes, K., Li, T. W., Munguia, J. E., Truong, T., Milovanovic, T., Lawrence, M. J., Holcombe, R. F., and Waterman, M. L. (2001) Nat. Genet. 28, 53-57
56. Filali, M., Cheng, N., Abbott, D., Leontiev, V., and Engelhardt, J. F. (2002) J. Biol. Chem. 277, 33398-33410
57. Roose, J., Huls, G., van Beest, M., Moerer, P., van der Horn, K., Goldschmeding, R., Logtenberg, T., and Clevers, H. (1999) Science 285, 1923-1926
58. Glass, D. A., Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A., and Karsenty, G. (2005) Dev. Cell 8, 751-764
59. Augustine, K., Liu, E. T., and Sadler, T. W. (1993) Developmental Genet. 14, 500-520
60. Zakany, J., and Duboule, D. (1993) Nature 362, 546-549
61. Hoang, B. H., Thomas, J. T., Abdul-Karim, F. W., Correia, K. M., Conlon, R. A., Luyten, F. P., and Ballock, R. T. (1998) Dev. Dyn. 212, 364-372
62. Aulehla, A., Wehrle, C., Brand-Saberi, B., Kemler, R., Gossler, A., Kanzler, B., and Herrmann, B. G. (2003) Developmental Cell 4, 395-406
63. Hu, H., Hilton, M. J., Tu, X., Yu, K., Ornitz, D. M., and Long, F. (2005) Development (Camb.) 132, 49-60
64. Lee, M. H., Kim, Y. J., Kim, H. J., Park, H. D., Kang, A. R., Kyung, H. M., Sung, J. H., Wozney, J. M., Kim, H. J., and Ryoo, H. M. (2003) J. Biol. Chem. 278, 34387-34394
65. Soshnikova, N., Zechner, D., Huelsken, J., Mishina, Y., Behringer, R. R., Taketo, M. M., Crenshaw, E. B., III, and Birchmeier, W. (2003) Genes Dev. 17, 1963-1968
66. Gazzerro, E., Pereira, R. C., Jorgetti, V., Olson, S., Economides, A. N., and Canalis, E. (2005) Endocrinology 146, 655-665
67. Derfoul, A., Carlberg, A. L., Tuan, R. S., and Hall, D. J. (2004) Differentiation 72, 209-223
68. Zhou, S., Eid, K., and Glowacki, J. (2004) J. Bone Miner. Res. 19, 463-470
69. Lengner, C. J., Hassan, M. Q., Serra, R. W., Lepper, C., van Wijnen, A. J., Stein, J. L., Lian, J. B., and Stein, G. S. (2005) J. Biol. Chem. 280, 15872-15879