메뉴 건너뛰기




Volumn 29, Issue 3, 2014, Pages 705-715

Deletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loading

Author keywords

catenin; bone formation; mechanical loading; osteocyte

Indexed keywords

BONE FORMATION; MECHANICAL LOADING; OSTEOCYTE; Β-CATENIN;

EID: 84894467000     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2064     Document Type: Article
Times cited : (108)

References (54)
  • 1
    • 18044386744 scopus 로고    scopus 로고
    • LDL Receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Gong Y, Slee RB, Fukai N, et al. LDL Receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 2001; 107: 513-23.
    • (2001) Cell. , vol.107 , pp. 513-523
    • Gong, Y.1    Slee, R.B.2    Fukai, N.3
  • 2
    • 0036138175 scopus 로고    scopus 로고
    • A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    • Little RD, Carulli JP, Del Mastro RG, et al. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet. 2002; 70 (1): 11-9.
    • (2002) Am J Hum Genet. , vol.70 , Issue.1 , pp. 11-19
    • Little, R.D.1    Carulli, J.P.2    Del Mastro, R.G.3
  • 3
    • 0037118285 scopus 로고    scopus 로고
    • High bone density due to a mutation in LDL-receptor-related protein 5
    • Boyden LM, Mao J, Belsky J, et al. High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med. 2002; 346: 1513-21.
    • (2002) N Engl J Med. , vol.346 , pp. 1513-1521
    • Boyden, L.M.1    Mao, J.2    Belsky, J.3
  • 5
    • 2942722529 scopus 로고    scopus 로고
    • Bone biomechanical properties in LRP5 mutant mice
    • Akhter MP, Wells DJ, Short SJ, et al. Bone biomechanical properties in LRP5 mutant mice. Bone. 2004; 35 (1): 162-9.
    • (2004) Bone. , vol.35 , Issue.1 , pp. 162-169
    • Akhter, M.P.1    Wells, D.J.2    Short, S.J.3
  • 6
    • 3042732142 scopus 로고    scopus 로고
    • The high bone mass family - The role of wnt/LRP5 signaling in the regulation of bone mass
    • Johnson ML., The high bone mass family-the role of wnt/LRP5 signaling in the regulation of bone mass. J Mus Neuron Interact. 2004; 4 (2): 135-8.
    • (2004) J Mus Neuron Interact. , vol.4 , Issue.2 , pp. 135-138
    • Johnson, M.L.1
  • 7
    • 20844449569 scopus 로고    scopus 로고
    • TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro
    • Hens JR, Wilson KM, Dann P, Chen X, Horowitz MC, Wysolmerski JJ., TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. J Bone Miner Res. 2005; 20: 1103-13.
    • (2005) J Bone Miner Res. , vol.20 , pp. 1103-1113
    • Hens, J.R.1    Wilson, K.M.2    Dann, P.3    Chen, X.4    Horowitz, M.C.5    Wysolmerski, J.J.6
  • 8
    • 33747674263 scopus 로고    scopus 로고
    • The Wnt co-receptor Lrp5 is essential for skeletal mechanotransduction, but not for the anabolic bone response to parathyroid hormone treatment
    • Sawakami K, Robling AG, Ai M, et al. The Wnt co-receptor Lrp5 is essential for skeletal mechanotransduction, but not for the anabolic bone response to parathyroid hormone treatment. J Biol Chem. 2006; 281: 23698-711.
    • (2006) J Biol Chem. , vol.281 , pp. 23698-23711
    • Sawakami, K.1    Robling, A.G.2    Ai, M.3
  • 9
    • 33646902229 scopus 로고    scopus 로고
    • Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear
    • Lau K-HW, Kapur S, Kesavan C, Baylink DJ., Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear. J Biol Chem. 2006; 281: 9576-88.
    • (2006) J Biol Chem. , vol.281 , pp. 9576-9588
    • Lau, K.-H.1    Kapur, S.2    Kesavan, C.3    Baylink, D.J.4
  • 10
    • 33846026749 scopus 로고    scopus 로고
    • Wnt/b-catenin signaling is a normal physiological response to mechanical loading in bone
    • Robinson JA, Chatterjee-Kishore M, Yaworsky P, et al. Wnt/b-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem. 2006; 281: 31720-8.
    • (2006) J Biol Chem. , vol.281 , pp. 31720-31728
    • Robinson, J.A.1    Chatterjee-Kishore, M.2    Yaworsky, P.3
  • 11
    • 34547111836 scopus 로고    scopus 로고
    • Wnt/b-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor a
    • Armstrong VJ, Muzylak M, Sunters A, et al. Wnt/b-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor a. J Biol Chem. 2007; 282: 20715-27.
    • (2007) J Biol Chem. , vol.282 , pp. 20715-20727
    • Armstrong, V.J.1    Muzylak, M.2    Sunters, A.3
  • 12
    • 40849111953 scopus 로고    scopus 로고
    • Estrogen receptor a is required for strain-related b-catenin signaling in osteoblasts
    • (suppl 1):S95 (abstr S064)
    • Armstrong VJ, Muzylak M, Sunters A, et al. Estrogen receptor a is required for strain-related b-catenin signaling in osteoblasts. J Bone Miner Res. 2007; 22 (suppl 1):S95 (abstr S064).
    • (2007) J Bone Miner Res. , vol.22
    • Armstrong, V.J.1    Muzylak, M.2    Sunters, A.3
  • 13
    • 77957755212 scopus 로고    scopus 로고
    • Activation of beta-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE(2): Implications for the study of mechanosensation in bone
    • Kamel MA, Picconi JL, Lara-Castillo N, Johnson ML., Activation of beta-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE(2): implications for the study of mechanosensation in bone. Bone. 2010; 47 (5): 872-81.
    • (2010) Bone. , vol.47 , Issue.5 , pp. 872-881
    • Kamel, M.A.1    Picconi, J.L.2    Lara-Castillo, N.3    Johnson, M.L.4
  • 14
    • 73149114381 scopus 로고    scopus 로고
    • Early activation of the beta-catenin pathway in osteocytes is mediated by nitric oxide, phosphatidyl inositol-3 kinase/Akt, and focal adhesion kinase
    • Santos A, Bakker AD, Zandieh-Doulabi B, de Blieck-Hogervorst JM, Klein-Nulend J., Early activation of the beta-catenin pathway in osteocytes is mediated by nitric oxide, phosphatidyl inositol-3 kinase/Akt, and focal adhesion kinase. Biochem Biophys Res Commun. 2010; 391 (1): 364-9.
    • (2010) Biochem Biophys Res Commun. , vol.391 , Issue.1 , pp. 364-369
    • Santos, A.1    Bakker, A.D.2    Zandieh-Doulabi, B.3    De Blieck-Hogervorst, J.M.4    Klein-Nulend, J.5
  • 15
    • 79958772955 scopus 로고    scopus 로고
    • Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V high bone mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it
    • Saxon LK, Jackson BF, Sugiyama T, Lanyon LE, Price JS., Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V high bone mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it. Bone. 2011; 49 (2): 184-93.
    • (2011) Bone. , vol.49 , Issue.2 , pp. 184-193
    • Saxon, L.K.1    Jackson, B.F.2    Sugiyama, T.3    Lanyon, L.E.4    Price, J.S.5
  • 16
    • 40849106249 scopus 로고    scopus 로고
    • Osteocytes, mechanosensing and Wnt signaling
    • Bonewald LF, Johnson ML., Osteocytes, mechanosensing and Wnt signaling. Bone. 2008; 42: 606-15.
    • (2008) Bone. , vol.42 , pp. 606-615
    • Bonewald, L.F.1    Johnson, M.L.2
  • 17
    • 77950567146 scopus 로고    scopus 로고
    • Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor a-mediated control of insulin-like growth factor (IGF) i receptor sensitivity to ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling
    • Sunters A, Armstrong VJ, Zaman G, et al. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor a-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling. J Biol Chem. 2010; 285 (12): 8743-58.
    • (2010) J Biol Chem. , vol.285 , Issue.12 , pp. 8743-8758
    • Sunters, A.1    Armstrong, V.J.2    Zaman, G.3
  • 18
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T, Clevers H., Wnt signalling in stem cells and cancer. Nature. 2005; 434: 843-50.
    • (2005) Nature. , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 19
    • 0037092049 scopus 로고    scopus 로고
    • Cbfa 1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
    • Kato M, Patel MS, Levasseur R, et al. Cbfa 1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol. 2002; 157: 303-14.
    • (2002) J Cell Biol. , vol.157 , pp. 303-314
    • Kato, M.1    Patel, M.S.2    Levasseur, R.3
  • 20
    • 2342529836 scopus 로고    scopus 로고
    • The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice
    • Bodine PVN, Zhao W, Kharode YP, et al. The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol Endocrinol. 2004; 18: 1222-37.
    • (2004) Mol Endocrinol. , vol.18 , pp. 1222-1237
    • Bodine, P.V.N.1    Zhao, W.2    Kharode, Y.P.3
  • 21
    • 10744224854 scopus 로고    scopus 로고
    • High bone mass in mice expressing a mutant LRP5 gene
    • Babij P, Zhao W, Small C, et al. High bone mass in mice expressing a mutant LRP5 gene. J Bone Miner Res. 2003; 18: 960-74.
    • (2003) J Bone Miner Res. , vol.18 , pp. 960-974
    • Babij, P.1    Zhao, W.2    Small, C.3
  • 22
    • 20244373613 scopus 로고    scopus 로고
    • Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    • Glass DA, Bialek P, Ahn JD, et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 2005; 8: 751-64.
    • (2005) Dev Cell. , vol.8 , pp. 751-764
    • Glass, D.A.1    Bialek, P.2    Ahn, J.D.3
  • 23
    • 20444376156 scopus 로고    scopus 로고
    • Essential role of b-catenin in postnatal bone acquisition
    • Holmen SL, Zylstra CR, Mukherjee A, et al. Essential role of b-catenin in postnatal bone acquisition. J Biol Chem. 2005; 280: 21162-8.
    • (2005) J Biol Chem. , vol.280 , pp. 21162-21168
    • Holmen, S.L.1    Zylstra, C.R.2    Mukherjee, A.3
  • 24
    • 77953407742 scopus 로고    scopus 로고
    • Osteocyte Wnt/b-catenin signaling is required for normal bone homeostasis
    • Kramer I, Halleux C, Keller H, et al. Osteocyte Wnt/b-catenin signaling is required for normal bone homeostasis. Mol Cell Biol. 2010; 30: 3071-85.
    • (2010) Mol Cell Biol. , vol.30 , pp. 3071-3085
    • Kramer, I.1    Halleux, C.2    Keller, H.3
  • 25
    • 80053938104 scopus 로고    scopus 로고
    • Evidence for osteocyte regulation of bone homeostasis through RANKL expression
    • Nakashima T, Hayashi M, Fukunaga T, et al. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med. 2011; 17 (10): 1231-4.
    • (2011) Nat Med. , vol.17 , Issue.10 , pp. 1231-1234
    • Nakashima, T.1    Hayashi, M.2    Fukunaga, T.3
  • 26
  • 29
    • 84872866350 scopus 로고    scopus 로고
    • Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee
    • Dempster DW, Compston JE, Drezner MK, et al. Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res. 2013; 28 (1): 2-17.
    • (2013) J Bone Miner Res. , vol.28 , Issue.1 , pp. 2-17
    • Dempster, D.W.1    Compston, J.E.2    Drezner, M.K.3
  • 31
    • 70449536506 scopus 로고    scopus 로고
    • Effect of the Vitamin D receptor on bone geometry and strength during gestation and lactation in mice
    • Korecki C, Zinser G, Liu X, Siedler J, Welsh J, Niebur G., Effect of the Vitamin D receptor on bone geometry and strength during gestation and lactation in mice. Calcif Tissue Int. 2009; 85 (5): 405-11.
    • (2009) Calcif Tissue Int. , vol.85 , Issue.5 , pp. 405-411
    • Korecki, C.1    Zinser, G.2    Liu, X.3    Siedler, J.4    Welsh, J.5    Niebur, G.6
  • 34
    • 77951998251 scopus 로고    scopus 로고
    • Overexpression of secreted frizzled-related protein 1 inhibits bone formation and attenuates parathyroid hormone bone anabolic effects
    • Yao W, Cheng Z, Shahnazari M, Dai W, Johnson ML, Lane NE., Overexpression of secreted frizzled-related protein 1 inhibits bone formation and attenuates parathyroid hormone bone anabolic effects. J Bone Miner Res. 2010; 25 (2): 190-9.
    • (2010) J Bone Miner Res. , vol.25 , Issue.2 , pp. 190-199
    • Yao, W.1    Cheng, Z.2    Shahnazari, M.3    Dai, W.4    Johnson, M.L.5    Lane, N.E.6
  • 35
    • 33846949349 scopus 로고    scopus 로고
    • Dickkopf-1 is a master regulator of joint remodeling
    • Diarra D, Stolina M, Polzer K, et al. Dickkopf-1 is a master regulator of joint remodeling. Nat Med. 2007; 13: 156-63.
    • (2007) Nat Med. , vol.13 , pp. 156-163
    • Diarra, D.1    Stolina, M.2    Polzer, K.3
  • 36
    • 44449099165 scopus 로고    scopus 로고
    • Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
    • Li X, Ominsky MS, Niu Q-T, et al. Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res. 2008; 23 (6): 860-9.
    • (2008) J Bone Miner Res. , vol.23 , Issue.6 , pp. 860-869
    • Li, X.1    Ominsky, M.S.2    Niu, Q.-T.3
  • 37
    • 84860430529 scopus 로고    scopus 로고
    • Lrp5 is not required for the proliferative response of osteoblasts to strain but regulates proliferation,apoptosis in a cell autonomous manner
    • Javaheri B, Sunters A, Zaman G, et al. Lrp5 is not required for the proliferative response of osteoblasts to strain but regulates proliferation,apoptosis in a cell autonomous manner. PLOS ONE. 2012; 7 (5): e35726.
    • (2012) PLOS ONE. , vol.7 , Issue.5
    • Javaheri, B.1    Sunters, A.2    Zaman, G.3
  • 38
    • 84876001884 scopus 로고    scopus 로고
    • Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist sost is mediated by estrogen receptor β
    • Galea GL, Meakin LB, Sugiyama T, et al. Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist sost is mediated by estrogen receptor β. J Biol Chem. 2013; 288 (13): 9035-48.
    • (2013) J Biol Chem. , vol.288 , Issue.13 , pp. 9035-9048
    • Galea, G.L.1    Meakin, L.B.2    Sugiyama, T.3
  • 39
    • 28044434415 scopus 로고    scopus 로고
    • Global gene expression analysis in the bones reveals involvement of several novel genes and pathways in mediating an anabolic response of mechanical loading in mice
    • Xing W, Baylink D, Kesavan C, et al. Global gene expression analysis in the bones reveals involvement of several novel genes and pathways in mediating an anabolic response of mechanical loading in mice. J Cell Biochem. 2005; 96 (5): 1049-60.
    • (2005) J Cell Biochem. , vol.96 , Issue.5 , pp. 1049-1060
    • Xing, W.1    Baylink, D.2    Kesavan, C.3
  • 40
    • 84890935259 scopus 로고    scopus 로고
    • LRP5 and bone mass regulation: Where are we now
    • Johnson ML., LRP5 and bone mass regulation: where are we now ? BoneKEy Rep. 2012; 1: 1-6.
    • (2012) BoneKEy Rep. , vol.1 , pp. 1-6
    • Johnson, M.L.1
  • 42
    • 13444295117 scopus 로고    scopus 로고
    • Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6
    • Holmen SL, Giambernardi TA, Zylstra CR, et al. Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res. 2004; 19: 2033-40.
    • (2004) J Bone Miner Res. , vol.19 , pp. 2033-2040
    • Holmen, S.L.1    Giambernardi, T.A.2    Zylstra, C.R.3
  • 43
    • 70949101564 scopus 로고    scopus 로고
    • Lrp4, a novel receptor for dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo
    • Choi HY, Dieckmann M, Herz J, Niemeier A., Lrp4, a novel receptor for dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo. PLOS ONE. 2009; 4 (11): e7930.
    • (2009) PLOS ONE. , vol.4 , Issue.11
    • Choi, H.Y.1    Dieckmann, M.2    Herz, J.3    Niemeier, A.4
  • 44
    • 84886305502 scopus 로고    scopus 로고
    • The osteocyte: An endocrine cell and more
    • Apr 26. [Epub ahead of print]
    • Dallas SL, Prideaux M, Bonewald LF., The osteocyte: an endocrine cell and more. Endocrine Rev. 2013 Apr 26. [Epub ahead of print].
    • (2013) Endocrine Rev.
    • Dallas, S.L.1    Prideaux, M.2    Bonewald, L.F.3
  • 45
    • 78649542978 scopus 로고    scopus 로고
    • Mechanical induction of PGE(2) in osteocytes blocks glucocorticoid induced apoptosis through both the beta-catenin and PKA pathways
    • Kitase Y, Barragan L, Jiang JX, Johnson ML, Bonewald LF., Mechanical induction of PGE(2) in osteocytes blocks glucocorticoid induced apoptosis through both the beta-catenin and PKA pathways. J Bone Miner Res. 2010; 25 (12): 2657-68.
    • (2010) J Bone Miner Res. , vol.25 , Issue.12 , pp. 2657-2668
    • Kitase, Y.1    Barragan, L.2    Jiang, J.X.3    Johnson, M.L.4    Bonewald, L.F.5
  • 46
    • 71749108831 scopus 로고    scopus 로고
    • Mechanical loading regulates NFATc1 and beta-catenin signaling through a GSK3beta control node
    • Sen B, Styner M, Xie Z, Case N, Rubin CT, Rubin J., Mechanical loading regulates NFATc1 and beta-catenin signaling through a GSK3beta control node. J Biol Chem. 2009; 284 (50): 34607-17.
    • (2009) J Biol Chem. , vol.284 , Issue.50 , pp. 34607-34617
    • Sen, B.1    Styner, M.2    Xie, Z.3    Case, N.4    Rubin, C.T.5    Rubin, J.6
  • 47
    • 57649237947 scopus 로고    scopus 로고
    • Beta-catenin levels influence rapid mechanical responses in osteoblasts
    • Case N, Ma M, Sen B, Xie Z, Gross TS, Rubin J., Beta-catenin levels influence rapid mechanical responses in osteoblasts. J Biol Chem. 2008; 283 (43): 29196-205.
    • (2008) J Biol Chem. , vol.283 , Issue.43 , pp. 29196-29205
    • Case, N.1    Ma, M.2    Sen, B.3    Xie, Z.4    Gross, T.S.5    Rubin, J.6
  • 48
    • 77954688948 scopus 로고    scopus 로고
    • Prostaglandin E2 is crucial in the response of podocytes to fluid flow shear stress
    • Srivastava T, McCarthy ET, Sharma R, et al. Prostaglandin E2 is crucial in the response of podocytes to fluid flow shear stress. J Cell Commun Signal. 2010; 4 (2): 79-90.
    • (2010) J Cell Commun Signal. , vol.4 , Issue.2 , pp. 79-90
    • Srivastava, T.1    McCarthy, E.T.2    Sharma, R.3
  • 49
    • 79958146175 scopus 로고    scopus 로고
    • Role of Wnt/β-catenin signaling in liver metabolism and cancer
    • Monga SPS., Role of Wnt/β-catenin signaling in liver metabolism and cancer. Int J Biochem Cell Biol. 2011; 43 (7): 1021-9.
    • (2011) Int J Biochem Cell Biol. , vol.43 , Issue.7 , pp. 1021-1029
    • Monga, S.P.S.1
  • 50
    • 33845234807 scopus 로고    scopus 로고
    • Cytoskeleton out of the cupboard: Colon cancer and cytoskeletal changes induced by loss of APC
    • Nathke I., Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC. Nat Rev Cancer. 2006; 6 (12): 967-74.
    • (2006) Nat Rev Cancer. , vol.6 , Issue.12 , pp. 967-974
    • Nathke, I.1
  • 51
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis P., Wnt signaling and cancer. Gene Dev. 2000; 14: 1837-51.
    • (2000) Gene Dev. , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 52
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt Signaling pathway in development and disease
    • Logan CY, Nusse R., The Wnt Signaling pathway in development and disease. Annu Rev Cell Dev Biol. 2004; 20: 781-810.
    • (2004) Annu Rev Cell Dev Biol. , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 53
    • 19644373254 scopus 로고    scopus 로고
    • Wnt signaling in disease and development
    • Nusse R., Wnt signaling in disease and development. Cell Res. 2005; 15: 28-32.
    • (2005) Cell Res. , vol.15 , pp. 28-32
    • Nusse, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.