메뉴 건너뛰기




Volumn 63, Issue 5, 2014, Pages 682-692

Hypothalamic endoplasmic reticulum stress and insulin resistance in offspring of mice dams fed high-fat diet during pregnancy and lactation

Author keywords

Central nervous system; Inflammatory pathway; Maternal obesity; Metabolic imprinting

Indexed keywords

GLUCOSE; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 2ALPHA; INSULIN; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; PKR LIKE ER KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

EID: 84899419103     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2014.02.002     Document Type: Article
Times cited : (55)

References (58)
  • 1
    • 0033563101 scopus 로고    scopus 로고
    • Signaling by proinflammatory cytokines: Oligomerization of traf2 and traf6 is sufficient for jnk and ikk activation and target gene induction via an amino-terminal effector domain
    • V. Baud, Z.G. Liu, and B. Bennett et al. Signaling by proinflammatory cytokines: oligomerization of traf2 and traf6 is sufficient for jnk and ikk activation and target gene induction via an amino-terminal effector domain Genes Dev 13 10 1999 1297 1308
    • (1999) Genes Dev , vol.13 , Issue.10 , pp. 1297-1308
    • Baud, V.1    Liu, Z.G.2    Bennett, B.3
  • 2
    • 0033257795 scopus 로고    scopus 로고
    • Jnk2 and ikkbeta are required for activating the innate response to viral infection
    • W.M. Chu, D. Ostertag, and Z.W. Li et al. Jnk2 and ikkbeta are required for activating the innate response to viral infection Immunity 11 6 1999 721 731
    • (1999) Immunity , vol.11 , Issue.6 , pp. 721-731
    • Chu, W.M.1    Ostertag, D.2    Li, Z.W.3
  • 3
    • 84862001089 scopus 로고    scopus 로고
    • Insulin resistance in the defense against obesity
    • A.R. Saltiel Insulin resistance in the defense against obesity Cell Metab 15 6 2012 798 804
    • (2012) Cell Metab , vol.15 , Issue.6 , pp. 798-804
    • Saltiel, A.R.1
  • 4
    • 24944438230 scopus 로고    scopus 로고
    • Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
    • C.T. De Souza, E.P. Araujo, and S. Bordin et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus Endocrinology 146 10 2005 4192 4199
    • (2005) Endocrinology , vol.146 , Issue.10 , pp. 4192-4199
    • De Souza, C.T.1    Araujo, E.P.2    Bordin, S.3
  • 5
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of ikk-beta and nf-kappab
    • D. Cai, M. Yuan, and D.F. Frantz et al. Local and systemic insulin resistance resulting from hepatic activation of ikk-beta and nf-kappab Nat Med 11 2 2005 183 190
    • (2005) Nat Med , vol.11 , Issue.2 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3
  • 6
    • 34748903504 scopus 로고    scopus 로고
    • Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet
    • R. Barbuio, M. Milanski, and M.B. Bertolo et al. Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet J Endocrinol 194 3 2007 539 550
    • (2007) J Endocrinol , vol.194 , Issue.3 , pp. 539-550
    • Barbuio, R.1    Milanski, M.2    Bertolo, M.B.3
  • 7
    • 80053450019 scopus 로고    scopus 로고
    • Solidago chilensis meyen hydroalcoholic extract reduces jnk/ikappab pathway activation and ameliorates insulin resistance in diet-induced obesity mice
    • A.M. Melo, P. Bittencourt, and F.S. Nakutis et al. Solidago chilensis meyen hydroalcoholic extract reduces jnk/ikappab pathway activation and ameliorates insulin resistance in diet-induced obesity mice Exp Biol Med (Maywood) 236 10 2011 1147 1155
    • (2011) Exp Biol Med (Maywood) , vol.236 , Issue.10 , pp. 1147-1155
    • Melo, A.M.1    Bittencourt, P.2    Nakutis, F.S.3
  • 8
    • 36849086456 scopus 로고    scopus 로고
    • Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet
    • C.A. Lalli, J.R. Pauli, and P.O. Prada et al. Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet Metabolism 57 1 2008 57 65
    • (2008) Metabolism , vol.57 , Issue.1 , pp. 57-65
    • Lalli, C.A.1    Pauli, J.R.2    Prada, P.O.3
  • 9
    • 64549104642 scopus 로고    scopus 로고
    • High-fat diet induces apoptosis of hypothalamic neurons
    • J.C. Moraes, A. Coope, and J. Morari et al. High-fat diet induces apoptosis of hypothalamic neurons PLoS One 4 4 2009 e5045
    • (2009) PLoS One , vol.4 , Issue.4 , pp. 5045
    • Moraes, J.C.1    Coope, A.2    Morari, J.3
  • 10
    • 84855426656 scopus 로고    scopus 로고
    • Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice
    • D.E. McNay, N. Briancon, and M.V. Kokoeva et al. Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice J Clin Invest 122 1 2012 142 152
    • (2012) J Clin Invest , vol.122 , Issue.1 , pp. 142-152
    • McNay, D.E.1    Briancon, N.2    Kokoeva, M.V.3
  • 11
    • 67449152696 scopus 로고    scopus 로고
    • Hypothalamic alterations in fetuses of high fat diet-fed obese female rats
    • A. Gupta, M. Srinivasan, and S. Thamadilok et al. Hypothalamic alterations in fetuses of high fat diet-fed obese female rats J Endocrinol 200 3 2009 293 300
    • (2009) J Endocrinol , vol.200 , Issue.3 , pp. 293-300
    • Gupta, A.1    Srinivasan, M.2    Thamadilok, S.3
  • 12
    • 84858289329 scopus 로고    scopus 로고
    • Maternal high-fat feeding through pregnancy and lactation predisposes mouse offspring to molecular insulin resistance and fatty liver
    • N.G. Ashino, K.N. Saito, and F.D. Souza et al. Maternal high-fat feeding through pregnancy and lactation predisposes mouse offspring to molecular insulin resistance and fatty liver J Nutr Biochem 23 4 2012 341 348
    • (2012) J Nutr Biochem , vol.23 , Issue.4 , pp. 341-348
    • Ashino, N.G.1    Saito, K.N.2    Souza, F.D.3
  • 13
    • 80054937724 scopus 로고    scopus 로고
    • Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst
    • K. Shankar, Y. Zhong, and P. Kang et al. Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst Endocrinology 152 11 2011 4158 4170
    • (2011) Endocrinology , vol.152 , Issue.11 , pp. 4158-4170
    • Shankar, K.1    Zhong, Y.2    Kang, P.3
  • 14
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • G.S. Hotamisligil Endoplasmic reticulum stress and the inflammatory basis of metabolic disease Cell 140 6 2010 900 917
    • (2010) Cell , vol.140 , Issue.6 , pp. 900-917
    • Hotamisligil, G.S.1
  • 15
    • 84856961540 scopus 로고    scopus 로고
    • Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity
    • K.K. Ryan, S.C. Woods, and R.J. Seeley Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity Cell Metab 15 2 2012 137 149
    • (2012) Cell Metab , vol.15 , Issue.2 , pp. 137-149
    • Ryan, K.K.1    Woods, S.C.2    Seeley, R.J.3
  • 16
    • 79953889813 scopus 로고    scopus 로고
    • Inflammation of the hypothalamus leads to defective pancreatic islet function
    • V.C. Calegari, A.S. Torsoni, and E.C. Vanzela et al. Inflammation of the hypothalamus leads to defective pancreatic islet function J Biol Chem 286 15 2011 12870 12880
    • (2011) J Biol Chem , vol.286 , Issue.15 , pp. 12870-12880
    • Calegari, V.C.1    Torsoni, A.S.2    Vanzela, E.C.3
  • 17
    • 79952595599 scopus 로고    scopus 로고
    • Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress
    • S. Purkayastha, H. Zhang, and G. Zhang et al. Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress Proc Natl Acad Sci U S A 108 7 2011 2939 2944
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.7 , pp. 2939-2944
    • Purkayastha, S.1    Zhang, H.2    Zhang, G.3
  • 18
    • 70349507353 scopus 로고    scopus 로고
    • Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin
    • J.C. Won, P.G. Jang, and C. Namkoong et al. Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin Obesity (Silver Spring) 17 10 2009 1861 1865
    • (2009) Obesity (Silver Spring) , vol.17 , Issue.10 , pp. 1861-1865
    • Won, J.C.1    Jang, P.G.2    Namkoong, C.3
  • 19
    • 84863869595 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and lipid metabolism
    • H. Zhou, K. Zhang, and S. Janciauskiene et al. Endoplasmic reticulum stress and lipid metabolism Biochem Res Int 2012 2012 257528
    • (2012) Biochem Res Int , vol.2012 , pp. 257528
    • Zhou, H.1    Zhang, K.2    Janciauskiene, S.3
  • 20
    • 84861918690 scopus 로고    scopus 로고
    • Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver
    • M. Milanski, A.P. Arruda, and A. Coope et al. Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver Diabetes 61 6 2012 1455 1462
    • (2012) Diabetes , vol.61 , Issue.6 , pp. 1455-1462
    • Milanski, M.1    Arruda, A.P.2    Coope, A.3
  • 21
    • 0347065337 scopus 로고    scopus 로고
    • Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene
    • E.P. Newberry, Y. Xie, and S. Kennedy et al. Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene J Biol Chem 278 51 2003 51664 51672
    • (2003) J Biol Chem , vol.278 , Issue.51 , pp. 51664-51672
    • Newberry, E.P.1    Xie, Y.2    Kennedy, S.3
  • 22
    • 0027405261 scopus 로고
    • Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts
    • T.P. Carr, C.J. Andresen, and L.L. Rudel Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts Clin Biochem 26 1 1993 39 42
    • (1993) Clin Biochem , vol.26 , Issue.1 , pp. 39-42
    • Carr, T.P.1    Andresen, C.J.2    Rudel, L.L.3
  • 23
    • 84876588037 scopus 로고    scopus 로고
    • Hypothalamic inhibition of acetyl-coa carboxylase stimulates hepatic counter-regulatory response independent of ampk activation in rats
    • G.A. Santos, V.D. Pereira, and E.A. Roman et al. Hypothalamic inhibition of acetyl-coa carboxylase stimulates hepatic counter-regulatory response independent of ampk activation in rats PLoS One 8 4 2013 e62669
    • (2013) PLoS One , vol.8 , Issue.4 , pp. 62669
    • Santos, G.A.1    Pereira, V.D.2    Roman, E.A.3
  • 24
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of ikkbeta
    • M. Yuan, N. Konstantopoulos, and J. Lee et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of ikkbeta Science 293 5535 2001 1673 1677
    • (2001) Science , vol.293 , Issue.5535 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3
  • 25
    • 0036009115 scopus 로고    scopus 로고
    • Nf-kappab at the crossroads of life and death
    • M. Karin, and A. Lin Nf-kappab at the crossroads of life and death Nat Immunol 3 3 2002 221 227
    • (2002) Nat Immunol , vol.3 , Issue.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 26
    • 33750475618 scopus 로고    scopus 로고
    • Current insights into the regulation of programmed cell death by nf-kappab
    • J. Dutta, Y. Fan, and N. Gupta et al. Current insights into the regulation of programmed cell death by nf-kappab Oncogene 25 51 2006 6800 6816
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6800-6816
    • Dutta, J.1    Fan, Y.2    Gupta, N.3
  • 27
    • 84867051812 scopus 로고    scopus 로고
    • Ikkbeta/nf-kappab disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes
    • J. Li, Y. Tang, and D. Cai Ikkbeta/nf-kappab disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes Nat Cell Biol 14 10 2012 999 1012
    • (2012) Nat Cell Biol , vol.14 , Issue.10 , pp. 999-1012
    • Li, J.1    Tang, Y.2    Cai, D.3
  • 28
    • 79952003715 scopus 로고    scopus 로고
    • Ffa-induced adipocyte inflammation and insulin resistance: Involvement of ER stress and ikkbeta pathways
    • P. Jiao, J. Ma, and B. Feng et al. Ffa-induced adipocyte inflammation and insulin resistance: involvement of ER stress and ikkbeta pathways Obesity (Silver Spring) 19 3 2011 483 491
    • (2011) Obesity (Silver Spring) , vol.19 , Issue.3 , pp. 483-491
    • Jiao, P.1    Ma, J.2    Feng, B.3
  • 29
    • 84871285143 scopus 로고    scopus 로고
    • Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats
    • S. Nurnberger, I. Miller, and J.C. Duvigneau et al. Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats Am J Physiol Gastrointest Liver Physiol 303 12 2012 G1373 G1383
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.303 , Issue.12
    • Nurnberger, S.1    Miller, I.2    Duvigneau, J.C.3
  • 30
    • 57849115277 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress plays a central role in development of leptin resistance
    • L. Ozcan, A.S. Ergin, and A. Lu et al. Endoplasmic reticulum stress plays a central role in development of leptin resistance Cell Metab 9 1 2009 35 51
    • (2009) Cell Metab , vol.9 , Issue.1 , pp. 35-51
    • Ozcan, L.1    Ergin, A.S.2    Lu, A.3
  • 31
    • 77950216899 scopus 로고    scopus 로고
    • Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet
    • B.E. Grayson, P.R. Levasseur, and S.M. Williams et al. Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet Endocrinology 151 4 2010 1622 1632
    • (2010) Endocrinology , vol.151 , Issue.4 , pp. 1622-1632
    • Grayson, B.E.1    Levasseur, P.R.2    Williams, S.M.3
  • 32
    • 0037153158 scopus 로고    scopus 로고
    • A central role for jnk in obesity and insulin resistance
    • J. Hirosumi, G. Tuncman, and L. Chang et al. A central role for jnk in obesity and insulin resistance Nature 420 6913 2002 333 336
    • (2002) Nature , vol.420 , Issue.6913 , pp. 333-336
    • Hirosumi, J.1    Tuncman, G.2    Chang, L.3
  • 33
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • U. Ozcan, Q. Cao, and E. Yilmaz et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes Science 306 5695 2004 457 461
    • (2004) Science , vol.306 , Issue.5695 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3
  • 34
    • 0025800652 scopus 로고
    • Studies in human lactation: Milk volume and nutrient composition during weaning and lactogenesis
    • M.C. Neville, J.C. Allen, and P.C. Archer et al. Studies in human lactation: milk volume and nutrient composition during weaning and lactogenesis Am J Clin Nutr 54 1 1991 81 92
    • (1991) Am J Clin Nutr , vol.54 , Issue.1 , pp. 81-92
    • Neville, M.C.1    Allen, J.C.2    Archer, P.C.3
  • 35
    • 84884532580 scopus 로고    scopus 로고
    • Nutritional mismatch in postnatal life of low birth weight rat offspring leads to increased phosphorylation of hepatic eukaryotic initiation factor 2 alpha in adulthood
    • G. Sohi, A. Revesz, and D.B. Hardy Nutritional mismatch in postnatal life of low birth weight rat offspring leads to increased phosphorylation of hepatic eukaryotic initiation factor 2 alpha in adulthood Metabolism 62 10 2013 1367 1374
    • (2013) Metabolism , vol.62 , Issue.10 , pp. 1367-1374
    • Sohi, G.1    Revesz, A.2    Hardy, D.B.3
  • 36
    • 77957078371 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and inflammation in obesity and diabetes
    • S. Hummasti, and G.S. Hotamisligil Endoplasmic reticulum stress and inflammation in obesity and diabetes Circ Res 107 5 2010 579 591
    • (2010) Circ Res , vol.107 , Issue.5 , pp. 579-591
    • Hummasti, S.1    Hotamisligil, G.S.2
  • 37
    • 58149484392 scopus 로고    scopus 로고
    • Inflammation and endoplasmic reticulum stress in obesity and diabetes
    • G.S. Hotamisligil Inflammation and endoplasmic reticulum stress in obesity and diabetes Int J Obes (Lond) 32 Suppl 7 2008 S52 S54
    • (2008) Int J Obes (Lond) , vol.32 , Issue.SUPPL. 7
    • Hotamisligil, G.S.1
  • 38
    • 84855605795 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress, obesity and diabetes
    • M. Cnop, F. Foufelle, and L.A. Velloso Endoplasmic reticulum stress, obesity and diabetes Trends Mol Med 18 1 2012 59 68
    • (2012) Trends Mol Med , vol.18 , Issue.1 , pp. 59-68
    • Cnop, M.1    Foufelle, F.2    Velloso, L.A.3
  • 39
    • 33748450150 scopus 로고    scopus 로고
    • Postnatal environment overrides genetic and prenatal factors influencing offspring obesity and insulin resistance
    • J.N. Gorski, A.A. Dunn-Meynell, and T.G. Hartman et al. Postnatal environment overrides genetic and prenatal factors influencing offspring obesity and insulin resistance Am J Physiol Regul Integr Comp Physiol 291 3 2006 R768 R778
    • (2006) Am J Physiol Regul Integr Comp Physiol , vol.291 , Issue.3
    • Gorski, J.N.1    Dunn-Meynell, A.A.2    Hartman, T.G.3
  • 40
    • 74949110443 scopus 로고    scopus 로고
    • Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: Rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation
    • C.M. Mayer, and D.D. Belsham Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation Endocrinology 151 2 2010 576 585
    • (2010) Endocrinology , vol.151 , Issue.2 , pp. 576-585
    • Mayer, C.M.1    Belsham, D.D.2
  • 41
    • 0346880505 scopus 로고    scopus 로고
    • Inflammation and the ikk beta/i kappa b/nf-kappa b axis in obesity- and diet-induced insulin resistance
    • S.E. Shoelson, J. Lee, and M. Yuan Inflammation and the ikk beta/i kappa b/nf-kappa b axis in obesity- and diet-induced insulin resistance Int J Obes Relat Metab Disord 27 Suppl 3 2003 S49 S52
    • (2003) Int J Obes Relat Metab Disord , vol.27 , Issue.SUPPL. 3
    • Shoelson, S.E.1    Lee, J.2    Yuan, M.3
  • 42
    • 84869412459 scopus 로고    scopus 로고
    • Hypothalamic akt/pkb signaling in regulation of food intake
    • D.H. Kim, S.C. Woods, and R.J. Seeley Hypothalamic akt/pkb signaling in regulation of food intake Front Biosci (Schol Ed) 4 2012 953 966
    • (2012) Front Biosci (Schol Ed) , vol.4 , pp. 953-966
    • Kim, D.H.1    Woods, S.C.2    Seeley, R.J.3
  • 43
    • 84867348404 scopus 로고    scopus 로고
    • Inositol polyphosphate multikinase signaling in the regulation of metabolism
    • J.Y. Lee, Y.R. Kim, and J. Park et al. Inositol polyphosphate multikinase signaling in the regulation of metabolism Ann N Y Acad Sci 1271 2012 68 74
    • (2012) Ann N y Acad Sci , vol.1271 , pp. 68-74
    • Lee, J.Y.1    Kim, Y.R.2    Park, J.3
  • 44
    • 1842484296 scopus 로고    scopus 로고
    • Amp-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
    • Y. Minokoshi, T. Alquier, and N. Furukawa et al. Amp-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus Nature 428 6982 2004 569 574
    • (2004) Nature , vol.428 , Issue.6982 , pp. 569-574
    • Minokoshi, Y.1    Alquier, T.2    Furukawa, N.3
  • 45
    • 19944426367 scopus 로고    scopus 로고
    • Enhanced hypothalamic amp-activated protein kinase activity contributes to hyperphagia in diabetic rats
    • C. Namkoong, M.S. Kim, and P.G. Jang et al. Enhanced hypothalamic amp-activated protein kinase activity contributes to hyperphagia in diabetic rats Diabetes 54 1 2005 63 68
    • (2005) Diabetes , vol.54 , Issue.1 , pp. 63-68
    • Namkoong, C.1    Kim, M.S.2    Jang, P.G.3
  • 46
    • 47849091265 scopus 로고    scopus 로고
    • Intracerebroventricular injection of citrate inhibits hypothalamic ampk and modulates feeding behavior and peripheral insulin signaling
    • G.R. Stoppa, M. Cesquini, and E.A. Roman et al. Intracerebroventricular injection of citrate inhibits hypothalamic ampk and modulates feeding behavior and peripheral insulin signaling J Endocrinol 198 1 2008 157 168
    • (2008) J Endocrinol , vol.198 , Issue.1 , pp. 157-168
    • Stoppa, G.R.1    Cesquini, M.2    Roman, E.A.3
  • 47
    • 1842582870 scopus 로고    scopus 로고
    • Amp-activated protein kinase plays a role in the control of food intake
    • U. Andersson, K. Filipsson, and C.R. Abbott et al. Amp-activated protein kinase plays a role in the control of food intake J Biol Chem 279 13 2004 12005 12008
    • (2004) J Biol Chem , vol.279 , Issue.13 , pp. 12005-12008
    • Andersson, U.1    Filipsson, K.2    Abbott, C.R.3
  • 48
    • 84877877476 scopus 로고    scopus 로고
    • Cellular insulin resistance disrupts leptin-mediated control of neuronal signaling and transcription
    • A. Nazarians-Armavil, J.A. Menchella, and D.D. Belsham Cellular insulin resistance disrupts leptin-mediated control of neuronal signaling and transcription Mol Endocrinol 27 6 2013 990 1003
    • (2013) Mol Endocrinol , vol.27 , Issue.6 , pp. 990-1003
    • Nazarians-Armavil, A.1    Menchella, J.A.2    Belsham, D.D.3
  • 49
    • 84872663273 scopus 로고    scopus 로고
    • Ampk and the neuroendocrine regulation of appetite and energy expenditure
    • R. Stark, S.E. Ashley, and Z.B. Andrews Ampk and the neuroendocrine regulation of appetite and energy expenditure Mol Cell Endocrinol 366 2 2013 215 223
    • (2013) Mol Cell Endocrinol , vol.366 , Issue.2 , pp. 215-223
    • Stark, R.1    Ashley, S.E.2    Andrews, Z.B.3
  • 50
    • 23744515608 scopus 로고    scopus 로고
    • Role of hypothalamic 5'-amp-activated protein kinase in the regulation of food intake and energy homeostasis
    • M.S. Kim, and K.U. Lee Role of hypothalamic 5'-amp-activated protein kinase in the regulation of food intake and energy homeostasis J Mol Med (Berl) 83 7 2005 514 520
    • (2005) J Mol Med (Berl) , vol.83 , Issue.7 , pp. 514-520
    • Kim, M.S.1    Lee, K.U.2
  • 51
    • 84874776349 scopus 로고    scopus 로고
    • The hypothalamus-adipose axis is a key target of developmental programming by maternal nutritional manipulation
    • C. Breton The hypothalamus-adipose axis is a key target of developmental programming by maternal nutritional manipulation J Endocrinol 216 2 2013 R19 R31
    • (2013) J Endocrinol , vol.216 , Issue.2
    • Breton, C.1
  • 52
    • 84855597740 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and lipid metabolism: Mechanisms and therapeutic potential
    • S. Basseri, and R.C. Austin Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential Biochem Res Int 2012 2012 841362
    • (2012) Biochem Res Int , vol.2012 , pp. 841362
    • Basseri, S.1    Austin, R.C.2
  • 53
    • 79957605136 scopus 로고    scopus 로고
    • Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
    • S. Fu, L. Yang, and P. Li et al. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity Nature 473 7348 2011 528 531
    • (2011) Nature , vol.473 , Issue.7348 , pp. 528-531
    • Fu, S.1    Yang, L.2    Li, P.3
  • 54
    • 29044447292 scopus 로고    scopus 로고
    • Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappab pathway in rat liver
    • G. Boden, P. She, and M. Mozzoli et al. Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappab pathway in rat liver Diabetes 54 12 2005 3458 3465
    • (2005) Diabetes , vol.54 , Issue.12 , pp. 3458-3465
    • Boden, G.1    She, P.2    Mozzoli, M.3
  • 55
    • 34249911241 scopus 로고    scopus 로고
    • Hypothalamic resistin induces hepatic insulin resistance
    • E.D. Muse, T.K. Lam, and P.E. Scherer et al. Hypothalamic resistin induces hepatic insulin resistance J Clin Invest 117 6 2007 1670 1678
    • (2007) J Clin Invest , vol.117 , Issue.6 , pp. 1670-1678
    • Muse, E.D.1    Lam, T.K.2    Scherer, P.E.3
  • 56
    • 20044364733 scopus 로고    scopus 로고
    • Western diet modulates insulin signaling, c-jun n-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion
    • P.O. Prada, H.G. Zecchin, and A.L. Gasparetti et al. Western diet modulates insulin signaling, c-jun n-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion Endocrinology 146 3 2005 1576 1587
    • (2005) Endocrinology , vol.146 , Issue.3 , pp. 1576-1587
    • Prada, P.O.1    Zecchin, H.G.2    Gasparetti, A.L.3
  • 58
    • 84893463340 scopus 로고    scopus 로고
    • Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding
    • M.C. Vogt, L. Paeger, and S. Hess et al. Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding Cell 156 3 2014 495 509
    • (2014) Cell , vol.156 , Issue.3 , pp. 495-509
    • Vogt, M.C.1    Paeger, L.2    Hess, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.