-
1
-
-
0034611791
-
Obesity as a medical problem
-
Kopelman PG. Obesity as a medical problem. Nature 2000;404:635-43
-
(2000)
Nature
, vol.404
, pp. 635-643
-
-
Kopelman, P.G.1
-
2
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112:1796-808
-
(2003)
J Clin Invest
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante Jr., A.W.6
-
3
-
-
38149142633
-
Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration
-
Rausch ME, Weisberg S, Vardhana P, Tortoriello DV. Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond) 2008;32:451-63
-
(2008)
Int J Obes (Lond)
, vol.32
, pp. 451-463
-
-
Rausch, M.E.1
Weisberg, S.2
Vardhana, P.3
Tortoriello, D.V.4
-
4
-
-
24944438230
-
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
-
De Souza CT, Araujo EP, Bordin S, Ashimine R, Zollner RL, Boschero AC, Saad MJ, Velloso LA. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 2005;146:4192-9
-
(2005)
Endocrinology
, vol.146
, pp. 4192-4199
-
-
de Souza, C.T.1
Araujo, E.P.2
Bordin, S.3
Ashimine, R.4
Zollner, R.L.5
Boschero, A.C.6
Saad, M.J.7
Velloso, L.A.8
-
5
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993;259:87-91
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
6
-
-
0346880505
-
Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance
-
Shoelson SE, Lee J, Yuan M. Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord 2003;27(Suppl. 3):S49-52
-
(2003)
Int J Obes Relat Metab Disord
, vol.27
, Issue.SUPPL. 3
-
-
Shoelson, S.E.1
Lee, J.2
Yuan, M.3
-
7
-
-
0037059330
-
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
-
Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 2002;277:1531-7
-
(2002)
J Biol Chem
, vol.277
, pp. 1531-1537
-
-
Aguirre, V.1
Werner, E.D.2
Giraud, J.3
Lee, Y.H.4
Shoelson, S.E.5
White, M.F.6
-
8
-
-
0034708832
-
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
-
Aguirre V, Uchida T, Yenush L, Davis R, White MF. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 2000;275:9047-54
-
(2000)
J Biol Chem
, vol.275
, pp. 9047-9054
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
10
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
-
Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001;293:1673-7
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
Hansen, L.4
Li, Z.W.5
Karin, M.6
Shoelson, S.E.7
-
11
-
-
70349852830
-
Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRbeta/IRS-1 and Akt
-
Carvalho-Filho MA, Ropelle ER, Pauli RJ, Cintra DE, Tsukumo DM, Silveira LR, Curi R, Carvalheira JB, Velloso LA, Saad MJ. Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRbeta/IRS-1 and Akt. Diabetologia 2009;52:2425-34
-
(2009)
Diabetologia
, vol.52
, pp. 2425-2434
-
-
Carvalho-Filho, M.A.1
Ropelle, E.R.2
Pauli, R.J.3
Cintra, D.E.4
Tsukumo, D.M.5
Silveira, L.R.6
Curi, R.7
Carvalheira, J.B.8
Velloso, L.A.9
Saad, M.J.10
-
12
-
-
36348981083
-
Infliximab restores glucose homeostasis in an animal model of diet-induced obesity and diabetes
-
Araujo EP, De Souza CT, Ueno M, Cintra DE, Bertolo MB, Carvalheira JB, Saad MJ, Velloso LA. Infliximab restores glucose homeostasis in an animal model of diet-induced obesity and diabetes. Endocrinology 2007;148:5991-7
-
(2007)
Endocrinology
, vol.148
, pp. 5991-5997
-
-
Araujo, E.P.1
de Souza, C.T.2
Ueno, M.3
Cintra, D.E.4
Bertolo, M.B.5
Carvalheira, J.B.6
Saad, M.J.7
Velloso, L.A.8
-
13
-
-
34748903504
-
Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet
-
Barbuio R, Milanski M, Bertolo MB, Saad MJ, Velloso LA. Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet. J Endocrinol 2007;194:539-50
-
(2007)
J Endocrinol
, vol.194
, pp. 539-550
-
-
Barbuio, R.1
Milanski, M.2
Bertolo, M.B.3
Saad, M.J.4
Velloso, L.A.5
-
14
-
-
46349088791
-
Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity
-
Weisberg SP, Leibel R, Tortoriello DV. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 2008;149:3549-58
-
(2008)
Endocrinology
, vol.149
, pp. 3549-3558
-
-
Weisberg, S.P.1
Leibel, R.2
Tortoriello, D.V.3
-
15
-
-
38049063954
-
Ginsenoside Re reduces insulin resistance through inhibition of c-Jun NH2-terminal kinase and nuclear factor-kappaB
-
Zhang Z, Li X, Lv W, Yang Y, Gao H, Yang J, Shen Y, Ning G. Ginsenoside Re reduces insulin resistance through inhibition of c-Jun NH2-terminal kinase and nuclear factor-kappaB. Mol Endocrinol 2008;22:186-95
-
(2008)
Mol Endocrinol
, vol.22
, pp. 186-195
-
-
Zhang, Z.1
Li, X.2
Lv, W.3
Yang, Y.4
Gao, H.5
Yang, J.6
Shen, Y.7
Ning, G.8
-
16
-
-
75849151693
-
Evaluation of an extract of Brazilian arnica (Solidago chilensis Meyen, Asteraceae) in treating lumbago
-
da Silva AG, de Sousa CP, Koehler J, Fontana J, Christo AG, Guedes-Bruni RR. Evaluation of an extract of Brazilian arnica (Solidago chilensis Meyen, Asteraceae) in treating lumbago. Phytother Res 2010;24:283-7
-
(2010)
Phytother Res
, vol.24
, pp. 283-287
-
-
da Silva, A.G.1
de Sousa, C.P.2
Koehler, J.3
Fontana, J.4
Christo, A.G.5
Guedes-Bruni, R.R.6
-
17
-
-
41849127119
-
The anti-inflammatory modulatory role of Solidago chilensis Meyen in the murine model of the air pouch
-
Liz R, Vigil SV, Goulart S, Moritz MI, Schenkel EP, Frode TS. The anti-inflammatory modulatory role of Solidago chilensis Meyen in the murine model of the air pouch. J Pharm Pharmacol 2008;60:515-21
-
(2008)
J Pharm Pharmacol
, vol.60
, pp. 515-521
-
-
Liz, R.1
Vigil, S.V.2
Goulart, S.3
Moritz, M.I.4
Schenkel, E.P.5
Frode, T.S.6
-
18
-
-
34547823896
-
Anti-inflammatory evaluation of Solidago chilensis Meyen in a murine model of pleurisy
-
Goulart S, Moritz MI, Lang KL, Liz R, Schenkel EP, Frode TS. Anti-inflammatory evaluation of Solidago chilensis Meyen in a murine model of pleurisy. J Ethnopharmacol 2007;113:346-53
-
(2007)
J Ethnopharmacol
, vol.113
, pp. 346-353
-
-
Goulart, S.1
Moritz, M.I.2
Lang, K.L.3
Liz, R.4
Schenkel, E.P.5
Frode, T.S.6
-
19
-
-
63749127275
-
Inhibitory effects of Solidago chilensis Meyen hydroalcoholic extract on acute inflammation
-
Tamura EK, Jimenez RS, Waismam K, Gobbo-Neto L, Lopes NP, Malpezzi-Marinho EA, Marinho EA, Farsky SH. Inhibitory effects of Solidago chilensis Meyen hydroalcoholic extract on acute inflammation. J Ethnopharmacol 2009;122:478-85
-
(2009)
J Ethnopharmacol
, vol.122
, pp. 478-485
-
-
Tamura, E.K.1
Jimenez, R.S.2
Waismam, K.3
Gobbo-Neto, L.4
Lopes, N.P.5
Malpezzi-Marinho, E.A.6
Marinho, E.A.7
Farsky, S.H.8
-
20
-
-
0347065337
-
Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene
-
Newberry EP, Xie Y, Kennedy S, Han X, Buhman KK, Luo J, Gross RW, Davidson NO. Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene. J Biol Chem 2003;278:51664-72
-
(2003)
J Biol Chem
, vol.278
, pp. 51664-51672
-
-
Newberry, E.P.1
Xie, Y.2
Kennedy, S.3
Han, X.4
Buhman, K.K.5
Luo, J.6
Gross, R.W.7
Davidson, N.O.8
-
21
-
-
0027405261
-
Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts
-
Carr TP, Andresen CJ, Rudel LL. Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts. Clin Biochem 1993;26:39-42
-
(1993)
Clin Biochem
, vol.26
, pp. 39-42
-
-
Carr, T.P.1
Andresen, C.J.2
Rudel, L.L.3
-
22
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444:860-7
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
23
-
-
77957078371
-
Endoplasmic reticulum stress and inflammation in obesity and diabetes
-
Hummasti S, Hotamisligil GS. Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circ Res 2010;107:579-91
-
(2010)
Circ Res
, vol.107
, pp. 579-591
-
-
Hummasti, S.1
Hotamisligil, G.S.2
-
24
-
-
55449100538
-
Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance
-
Kim F, Pham M, Maloney E, Rizzo NO, Morton GJ, Wisse BE, Kirk EA, Chait A, Schwartz MW. Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance. Arterioscler Thromb Vasc Biol 2008;28:1982-8
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 1982-1988
-
-
Kim, F.1
Pham, M.2
Maloney, E.3
Rizzo, N.O.4
Morton, G.J.5
Wisse, B.E.6
Kirk, E.A.7
Chait, A.8
Schwartz, M.W.9
-
25
-
-
58149092376
-
Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats
-
Kamisoyama H, Honda K, Tominaga Y, Yokota S, Hasegawa S. Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats. Biosci Biotechnol Biochem 2008;72:3225-31
-
(2008)
Biosci Biotechnol Biochem
, vol.72
, pp. 3225-3231
-
-
Kamisoyama, H.1
Honda, K.2
Tominaga, Y.3
Yokota, S.4
Hasegawa, S.5
-
26
-
-
34547161951
-
A green tea extract high in catechins reduces body fat and cardiovascular risks in humans
-
Nagao T, Hase T, Tokimitsu I. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity (Silver Spring) 2007;15:1473-83
-
(2007)
Obesity (Silver Spring)
, vol.15
, pp. 1473-1483
-
-
Nagao, T.1
Hase, T.2
Tokimitsu, I.3
-
27
-
-
0030063760
-
Diet fat alters expression of genes for enzymes of lipogenesis in lean and obese mice
-
Cheema SK, Clandinin MT. Diet fat alters expression of genes for enzymes of lipogenesis in lean and obese mice. Biochim Biophys Acta 1996;1299:284-8
-
(1996)
Biochim Biophys Acta
, vol.1299
, pp. 284-288
-
-
Cheema, S.K.1
Clandinin, M.T.2
-
28
-
-
0018408630
-
Lipogenesis in vivo in lean and genetically obese (ob/ob) mice fed on diets with a high fat content
-
Cawthorne MA, Cornish S. Lipogenesis in vivo in lean and genetically obese (ob/ob) mice fed on diets with a high fat content. Int J Obes 1979;3:83-90
-
(1979)
Int J Obes
, vol.3
, pp. 83-90
-
-
Cawthorne, M.A.1
Cornish, S.2
-
29
-
-
40549135297
-
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice
-
Postic C, Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 2008;118:829-38
-
(2008)
J Clin Invest
, vol.118
, pp. 829-838
-
-
Postic, C.1
Girard, J.2
-
30
-
-
65449159320
-
Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice
-
Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W, Liu Y. Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Hepatology 2009;49:1166-75
-
(2009)
Hepatology
, vol.49
, pp. 1166-1175
-
-
Wang, Q.1
Jiang, L.2
Wang, J.3
Li, S.4
Yu, Y.5
You, J.6
Zeng, R.7
Gao, X.8
Rui, L.9
Li, W.10
Liu, Y.11
-
31
-
-
61749094289
-
Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
-
McCurdy CE, Bishop JM, Williams SM, Grayson BE, Smith MS, Friedman JE, Grove KL. Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest 2009;119:323-35
-
(2009)
J Clin Invest
, vol.119
, pp. 323-335
-
-
McCurdy, C.E.1
Bishop, J.M.2
Williams, S.M.3
Grayson, B.E.4
Smith, M.S.5
Friedman, J.E.6
Grove, K.L.7
-
32
-
-
59249098656
-
Oxidative stress in rats fed a high-fat high-sucrose diet and preventive effect of polyphenols: Involvement of mitochondrial and NAD(P)H oxidase systems
-
Feillet-Coudray C, Sutra T, Fouret G, Ramos J, Wrutniak-Cabello C, Cabello G, Cristol JP, Coudray C. Oxidative stress in rats fed a high-fat high-sucrose diet and preventive effect of polyphenols: involvement of mitochondrial and NAD(P)H oxidase systems. Free Radic Biol Med 2009;46:624-32
-
(2009)
Free Radic Biol Med
, vol.46
, pp. 624-632
-
-
Feillet-Coudray, C.1
Sutra, T.2
Fouret, G.3
Ramos, J.4
Wrutniak-Cabello, C.5
Cabello, G.6
Cristol, J.P.7
Coudray, C.8
-
33
-
-
69249228674
-
Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha
-
Ramirez-Tortosa MC, Ramirez-Tortosa CL, Mesa MD, Granados S, Gil A, Quiles JL. Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha. Free Radic Biol Med 2009;47:924-31
-
(2009)
Free Radic Biol Med
, vol.47
, pp. 924-931
-
-
Ramirez-Tortosa, M.C.1
Ramirez-Tortosa, C.L.2
Mesa, M.D.3
Granados, S.4
Gil, A.5
Quiles, J.L.6
-
34
-
-
75449094816
-
Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications
-
Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 2010;51:679-89
-
(2010)
Hepatology
, vol.51
, pp. 679-689
-
-
Fabbrini, E.1
Sullivan, S.2
Klein, S.3
-
35
-
-
0035855858
-
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
-
Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 2001;413:131-8
-
(2001)
Nature
, vol.413
, pp. 131-138
-
-
Yoon, J.C.1
Puigserver, P.2
Chen, G.3
Donovan, J.4
Wu, Z.5
Rhee, J.6
Adelmant, G.7
Stafford, J.8
Kahn, C.R.9
Granner, D.K.10
Newgard, C.B.11
Spiegelman, B.M.12
-
36
-
-
34250740323
-
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator
-
Li X, Monks B, Ge Q, Birnbaum MJ. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature 2007;447:1012-6
-
(2007)
Nature
, vol.447
, pp. 1012-1016
-
-
Li, X.1
Monks, B.2
Ge, Q.3
Birnbaum, M.J.4
-
37
-
-
2342428466
-
Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner
-
de Alvaro C, Teruel T, Hernandez R, Lorenzo M. Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. J Biol Chem 2004;279:17070-8
-
(2004)
J Biol Chem
, vol.279
, pp. 17070-17078
-
-
de Alvaro, C.1
Teruel, T.2
Hernandez, R.3
Lorenzo, M.4
-
38
-
-
69949099328
-
C-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-alpha induces insulin resistance in human visceral but not subcutaneous adipocytes: Reversal by liver X receptor agonists
-
Fernandez-Veledo S, Vila-Bedmar R, Nieto-Vazquez I, Lorenzo M. C-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-alpha induces insulin resistance in human visceral but not subcutaneous adipocytes: reversal by liver X receptor agonists. J Clin Endocrinol Metab 2009;94:3583-93
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 3583-3593
-
-
Fernandez-Veledo, S.1
Vila-Bedmar, R.2
Nieto-Vazquez, I.3
Lorenzo, M.4
-
39
-
-
33845873659
-
Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression
-
Jager J, Gremeaux T, Cormont M, Le Marchand-Brustel Y, Tanti JF. Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology 2007;148:241-51
-
(2007)
Endocrinology
, vol.148
, pp. 241-251
-
-
Jager, J.1
Gremeaux, T.2
Cormont, M.3
Le Marchand-Brustel, Y.4
Tanti, J.F.5
|