Inositol polyphosphate multikinase signaling in the regulation of metabolism

Annals of the New York Academy of Sciences

Volumn 1271, Issue 1, 2012, Pages 68-74

  Lee, Joo Young ^a   Kim, Young Ran ^a,b   Park, Jina ^a   Kim, Seyun ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

AMPK; Growth; Inositol polyphosphate; IPMK; Metabolism; MTOR

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INOSITOL POLYPHOSPHATE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; RHEB PROTEIN;

AMINO ACID METABOLISM; ARTICLE; BINDING AFFINITY; CELL GROWTH; DEPHOSPHORYLATION; ENERGY METABOLISM; FOOD INTAKE; GENE DELETION; LIPID METABOLISM; METABOLIC REGULATION; METABOLIC SYNDROME X; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; YEAST;

EID: 84867348404     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06725.x     Document Type: Article

References (38)

1. Holub, B.J. 1986. Metabolism and function of myo-inositol and inositol phospholipids. Annu. Rev. Nutr. 6: 563-597.
2. Troyer, D.A., D.W. Schwertz, J.I. Kreisberg & M.A. Venkatachalam. 1986. Inositol phospholipid metabolism in the kidney. Annu. Rev. Physiol. 48: 51-71.
3. Colodny, L. & R.L. Hoffman. 1998. Inositol-clinical applications for exogenous use. Altern. Med. Rev. 3: 432-447.
4. Chakraborty, A., S. Kim & S.H. Snyder. 2011. Inositol pyrophosphates as mammalian cell signals. Sci. Signal. 4: re1.
5. Hatch, A.J. & J.D. York. 2010. SnapShot: inositol phosphates. Cell 143: 1030-1030.e1.
6. Barker, C.J., C. Illies, G.C. Gaboardi & P.O. Berggren. 2009. Inositol pyrophosphates: structure, enzymology and function. Cell Mol. Life Sci. 66: 3851-3871.
7. Streb, H., R.F. Irvine, M.J. Berridge & I. Schulz. 1983. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1, 4, 5-trisphosphate. Nature 306: 67-69.
8. Berridge, M.J., P. Lipp & M.D. Bootman. 2000. The versatility and universality of calcium signalling. Nat. Rev. Mol. Cell Biol. 1: 11-21.
9. Saiardi, A., H. Erdjument-Bromage, A.M. Snowman, et al. 1999. Synthesis of diphosphoinositolpentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr. Biol. 9: 1323-1326.
10. Odom, A.R., A. Stahlberg, S.R. Wente & J.D. York. 2000. A role for nuclear inositol 1, 4, 5-trisphosphate kinase in transcriptional control. Science 287: 2026-2029.
11. Frederick, J.P., D. Mattiske, J.A. Wofford, et al. 2000. An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production. Proc. Natl. Acad. Sci. USA 102: 8454-8459.
12. Kim, S., S.F. Kim, D. Maag, et al. 2011. Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell Metab. 13: 215-221.
13. Resnick, A.C., A.M. Snowman, B.N. Kang, et al. 2005. Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity. Proc. Natl. Acad. Sci. USA 102: 12783-12788.
14. Maag, D., M.J. Maxwell, D.A. Hardesty, et al. 2011. Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB. Proc. Natl. Acad. Sci. USA 108: 1391-1396.
15. Béchet, J., M. Grenson & J.M. Wiame. 1970. Mutations affecting the repressibility of arginine biosynthetic enzymes in Sacchromycescerevisiae. Eur. J. Biochem. 12: 31-39.
16. Dubois, E., V. Dewaste, C. Erneux & F. Messenguy. 2000. Inositol polyphosphate kinase activity of Arg82/ArgRIII is not required for the regulation of the arginine metabolism in yeast. FEBS Lett. 486: 300-304.
17. El Alami, M., F. Messenguy, B. Scherens & E. Dubois. 2003. Arg82p is a bifunctional protein whose inositol polyphosphate kinase activity is essential for nitrogen and PHO gene expression but not for Mcm1p chaperoning in yeast. Mol. Microbiol. 49: 457-468.
18. Seeds, A.M., R.J. Bastidas & J.D. York. 2005. Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1, 4, 5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae. J. Biol. Chem. 280: 27654-27661.
19. John, D. & J.D. York. 2006. Regulation of nuclear processes by inositol polyphosphates. Biochim. Biophys. Acta 1761: 552-559.
20. Zoncu, R., A. Efeyan & D.M. Sabatini. 2011. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12: 21-35.
21. Sancak, Y., T.R. Peterson, Y.D. Shaul, et al. 2008. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320: 1496-1501.
22. Kim, E., P. Goraksha-Hicks, L. Li, et al. 2008. Regulation of TORC1 by Rag GTPases in nutrient response. Nat. Cell Biol. 10: 935-945.
23. Sancak, Y., L. Bar-Peled, R. Zoncu, et al. 2010. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141: 290-303.
24. Zoncu, R., L. Bar-Peled, A. Efeyan, et al. 2011. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science 334: 678-683.
25. Han, J.M., S.J. Jeong, M.C. Park, et al. 2012. Leucyl-tRNAsynthetaseis an intracellular leucinesensor for the mTORC1-signaling pathway. Cell 149: 410-424.
26. Kim, S. & S.H. Snyder. 2011. Nutrient amino acids signal to mTOR via inositol polyphosphate multikinase. Cell Cycle 10: 1708-1710.
27. Hardie, D.G., F.A. Ross & S.A. Hawley. 2012. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 13: 251-262.
28. Alessi, D.R., K. Sakamoto & J.R. Bayascas. 2006. LKB1-dependent signaling pathways. Annu. Rev. Biochem. 75: 137-163.
29. Hawley, S.A., D.A. Pan, K.J. Mustard, et al. 2005. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2: 9-19.
30. Minokoshi, Y., T. Alquier, N. Furukawa, et al. 2004. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428: 569-574.
31. Andersson, U., K. Filipsson, C.R. Abbott, et al. 2004. AMP-activated protein kinase plays a role in the control of food intake. J. Biol. Chem. 279: 12005-12008.
32. Bang, S., S. Kim, M.J. Dailey, et al. 2012. AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase. Proc. Natl. Acad. Sci. USA 109: 616-620.
33. Dailey, M.J. & S. Kim. 2012. Inositol polyphosphate multikinase: an emerging player for the central action of AMP-activated protein kinase. Biochem. Biophys. Res. Commun. 421: 1-3.
34. Chakraborty, A., M.A. Koldobskiy, N.T. Bello, et al. 2010. Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. Cell 143: 897-910.
35. Koldobskiy, M.A., A. Chakraborty, J.K. Werner, et al. 2010. p53-mediated apoptosis requires inositol hexakisphosphate kinase-2. Proc. Natl. Acad. Sci. USA 107: 20947-20951.
36. Watson, P.J., L. Fairall, G.M. Santos & J.W. Schwabe. 2012. Structure of HDAC3 bound to co-repressor and inositol tetraphosphate. Nature 481: 335-340.
37. Meyer, R., M.M. Nalaskowski, P. Ehm, et al. 2012. Nucleocytoplasmic shuttling of human inositol phosphate multikinase is influenced by CK2 phosphorylation. Biol. Chem. 393: 149-160.
38. Blind, R.D., M. Suzawa & H.A. Ingraham. 2012. Direct modification and activation of a nuclear receptor-PIP2 complex by the inositol lipid kinase IPMK. Sci. Signal. 5: ra44.