Novel approaches to the development of anti-sepsis drugs

Expert Opinion on Drug Discovery

Volumn 9, Issue 5, 2014, Pages 523-531

  Lehmann, Christian ^a   Sharawi, Nivin ^a   Al Banna, Nadia ^a   Corbett, Nathan ^a   Kuethe, Joshua W ^b   Caldwell, Charles C ^b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Anti inflammatory drugs; Antibiotics; Cannabinoids; Immune system; Iron chelation; Nitric oxide; Sepsis; Shock; Systemic inflammatory response syndrome; Toll like receptors

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ADRENALIN; ANANDAMIDE; ANTIBIOTIC AGENT; ANTIINFLAMMATORY AGENT; BIOLOGICAL MARKER; CANNABINOID RECEPTOR; CHELATING AGENT; CYCLIC AMP; CYTOKINE; DEFERASIROX; DEFEROXAMINE; DOPAMINE; ENDOCANNABINOID; HEPCIDIN; HYPERTENSIVE AGENT; INOTROPIC AGENT; MICRORNA; MICRORNA 146A; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NORADRENALIN; PHENYLEPHRINE; TETRAHYDROBIOPTERIN; TOBRAMYCIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; VASOPRESSIN;

CENTRAL NERVOUS SYSTEM; CYSTIC FIBROSIS; CYTOKINE PRODUCTION; DRUG RESEARCH; DRUG TARGETING; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; FLUID RESUSCITATION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HYPOTENSION; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOMODULATION; INFLAMMATION; IRON CHELATION; MICROCIRCULATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; REVIEW; SEPSIS; SEPTIC SHOCK; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; DRUG EFFECTS; IMMUNOLOGY; METABOLISM; MOLECULARLY TARGETED THERAPY;

ANTI-INFLAMMATORY AGENTS; BIOLOGICAL MARKERS; HUMANS; IMMUNOMODULATION; MOLECULAR TARGETED THERAPY; SEPSIS;

EID: 84899091013     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2014.905538     Document Type: Review

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