메뉴 건너뛰기




Volumn 13, Issue 5, 2009, Pages 985-994

Reduced ligand affinity leads to an impaired function of the adenosine A2A receptor of human granulocytes in sepsis

Author keywords

A2A receptor; Human PMN; Ligand affinity; Sepsis

Indexed keywords

ADENOSINE; ADENOSINE A2A RECEPTOR; ADENYLATE CYCLASE; CYTOKINE; ISOPROTEIN; LIPOPOLYSACCHARIDE; REACTIVE OXYGEN METABOLITE;

EID: 67249089932     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00530.x     Document Type: Article
Times cited : (24)

References (47)
  • 1
    • 1642290140 scopus 로고    scopus 로고
    • Molecular basis of endothelial dysfunction in sepsis
    • DOI 10.1016/S0008-6363(03)00397-3, PII S0008636303003973
    • Peters K, Unger RE, Brunner J, Kirkpatrick CJ. Molecular basis of endothelial dysfunction in sepsis. Cardiovasc Res. 2003 60 : 49 57. (Pubitemid 38373475)
    • (2003) Cardiovascular Research , vol.60 , Issue.1 , pp. 49-57
    • Peters, K.1    Unger, R.E.2    Brunner, J.3    Kirkpatrick, C.J.4
  • 2
    • 0037180768 scopus 로고    scopus 로고
    • The immunopathogenesis of sepsis
    • Cohen J. The immunopathogenesis of sepsis. Nature. 2002 420 : 885 91.
    • (2002) Nature. , vol.420 , pp. 885-91
    • Cohen, J.1
  • 4
    • 2342437653 scopus 로고    scopus 로고
    • Upregulation of reactive oxygen species generation and phagocytosis, and increased apoptosis in human neutrophils during severe sepsis and septic shock
    • Martins PS, Kallas EG, Neto MC, Dalboni MA, Blecher S, Salomao R. Upregulation of reactive oxygen species generation and phagocytosis, and increased apoptosis in human neutrophils during severe sepsis and septic shock. Shock. 2003 20 : 208 12.
    • (2003) Shock. , vol.20 , pp. 208-12
    • Martins, P.S.1    Kallas, E.G.2    Neto, M.C.3    Dalboni, M.A.4    Blecher, S.5    Salomao, R.6
  • 5
    • 33747330314 scopus 로고    scopus 로고
    • Polymorphonuclear leukocyte dysfunction syndrome in patients with increasing sepsis severity
    • Kaufmann I, Hoelzl A, Schliephake F, Hummel T, Chouker A, Peter K, Thiel M. Polymorphonuclear leukocyte dysfunction syndrome in patients with increasing sepsis severity. Shock. 2006 26 : 254 61.
    • (2006) Shock. , vol.26 , pp. 254-61
    • Kaufmann, I.1    Hoelzl, A.2    Schliephake, F.3    Hummel, T.4    Chouker, A.5    Peter, K.6    Thiel, M.7
  • 6
  • 7
    • 0033065893 scopus 로고    scopus 로고
    • Extracellular adenosine concentrations during in vitro ischaemia in rat hippocampal slices
    • Latini S, Bordoni F, Pedata F, Corradetti R. Extracellular adenosine concentrations during in vitro ischaemia in rat hippocampal slices. Br J Pharmacol. 1999 127 : 729 39.
    • (1999) Br J Pharmacol. , vol.127 , pp. 729-39
    • Latini, S.1    Bordoni, F.2    Pedata, F.3    Corradetti, R.4
  • 8
    • 33845720371 scopus 로고    scopus 로고
    • Effects of adenosine on functions of polymorphonuclear leukocytes from patients with septic shock
    • DOI 10.1097/01.shk.0000238066.00074.90, PII 0002438220070100000005
    • Kaufmann I, Hoelzl A, Schliephake F, Hummel T, Chouker A, Lysenko L, Thiel M. Effects of adenosine on functions of polymorphonuclear leukocytes from patients with septic shock. Shock. 2007 27 : 25 31. (Pubitemid 44968006)
    • (2007) Shock , vol.27 , Issue.1 , pp. 25-31
    • Kaufmann, I.1    Hoelzl, A.2    Schliephake, F.3    Hummel, T.4    Chouker, A.5    Lysenko, L.6    Peter, K.7    Thiel, M.8
  • 9
    • 0035209620 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
    • Fredholm BB, IJzerman AP, Jacobson KA, Klotz KN, Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev. 2001 53 : 527 52.
    • (2001) Pharmacol Rev. , vol.53 , pp. 527-52
    • Fredholm, B.B.1    Ijzerman, A.P.2    Jacobson, K.A.3    Klotz, K.N.4    Linden, J.5
  • 10
    • 19544391973 scopus 로고    scopus 로고
    • The 'danger' sensors that STOP the immune response: The A2 adenosine receptors?
    • DOI 10.1016/j.it.2005.04.004, PII S1471490605001031
    • Sitkovsky MV, Ohta A. The 'danger' sensors that STOP the immune response: the A2 adenosine receptors? Trends Immunol. 2005 26 : 299 304. (Pubitemid 40732662)
    • (2005) Trends in Immunology , vol.26 , Issue.6 , pp. 299-304
    • Sitkovsky, M.V.1    Ohta, A.2
  • 11
    • 33745839262 scopus 로고    scopus 로고
    • New insights into the regulation of inflammation by adenosine
    • Linden J. New insights into the regulation of inflammation by adenosine. J Clin Invest. 2006 116 : 1835 7.
    • (2006) J Clin Invest. , vol.116 , pp. 1835-7
    • Linden, J.1
  • 13
    • 51349100782 scopus 로고    scopus 로고
    • Differential expression of 5′-UTR splice variants of the adenosine A2A receptor gene in human granulocytes: Identification, characterization, and functional impact on activation
    • Kreth S, Ledderose C, Kaufmann I, Groeger G, Thiel M. Differential expression of 5′-UTR splice variants of the adenosine A2A receptor gene in human granulocytes: identification, characterization, and functional impact on activation. FASEB J. 2008 22 : 3276 86.
    • (2008) FASEB J. , vol.22 , pp. 3276-86
    • Kreth, S.1    Ledderose, C.2    Kaufmann, I.3    Groeger, G.4    Thiel, M.5
  • 14
    • 33646096475 scopus 로고    scopus 로고
    • Differential expression of adenosine receptors in human neu-trophils: Up-regulation by specific Th1 cytokines and lipopolysaccharide
    • Fortin A, Harbour D, Fernandes M, Borgeat P, Bourgoin S. Differential expression of adenosine receptors in human neu-trophils: up-regulation by specific Th1 cytokines and lipopolysaccharide. J Leukoc Biol. 2006 79 : 574 85.
    • (2006) J Leukoc Biol. , vol.79 , pp. 574-85
    • Fortin, A.1    Harbour, D.2    Fernandes, M.3    Borgeat, P.4    Bourgoin, S.5
  • 17
    • 0035924320 scopus 로고    scopus 로고
    • Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage
    • Ohta A, Sitkovsky M. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature. 2001 414 : 916 20.
    • (2001) Nature. , vol.414 , pp. 916-20
    • Ohta, A.1    Sitkovsky, M.2
  • 18
    • 0026710191 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. the ACCP-SCCM Consensus Conference Committee. American College of Chest Physicians-Society of Critical Care Medicine
    • Bone RC, Balk A, Cerra FB, Dellinger R P, Fein AM, Knaus WA Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP-SCCM Consensus Conference Committee. American College of Chest Physicians-Society of Critical Care Medicine. Chest. 1992 101 : 1644 55.
    • (1992) Chest. , vol.101 , pp. 1644-55
    • Bone, R.C.1    Balk, A.2    Cerra, F.B.3    Dellinger, R.P.4    Fein, A.M.5    Knaus, W.A.6    Schein, R.M.7    Sibbald, W.J.8
  • 20
    • 0348222661 scopus 로고    scopus 로고
    • Adenosine: An endogenous regulator of innate immunity
    • Haskó G, Cronstein BN. Adenosine: an endogenous regulator of innate immunity. Trends Immunol. 2004 25 : 33 9.
    • (2004) Trends Immunol. , vol.25 , pp. 33-9
    • Haskó, G.1    Cronstein, B.N.2
  • 21
    • 2542432162 scopus 로고    scopus 로고
    • Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A(2A) receptors
    • Sitkovsky MV, Lukashev D, Apasov S, Kojima H, Koshiba M, Caldwell C, Ohta A, Thiel M. Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A(2A) receptors. Annu Rev Immun. 2004 22 : 657 82.
    • (2004) Annu Rev Immun. , vol.22 , pp. 657-82
    • Sitkovsky, M.V.1    Lukashev, D.2    Apasov, S.3    Kojima, H.4    Koshiba, M.5    Caldwell, C.6    Ohta, A.7    Thiel, M.8
  • 22
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol. 2001 1 : 135 45.
    • (2001) Nat Rev Immunol. , vol.1 , pp. 135-45
    • Medzhitov, R.1
  • 23
    • 0142031430 scopus 로고    scopus 로고
    • Role of toll-like receptors in pathogen recognition
    • Janssens S, Beyaert R. Role of toll-like receptors in pathogen recognition. Clin Microbiol Rev. 2003 16 : 637 46.
    • (2003) Clin Microbiol Rev. , vol.16 , pp. 637-46
    • Janssens, S.1    Beyaert, R.2
  • 24
    • 0035104119 scopus 로고    scopus 로고
    • LPS induction of gene expression in human monocytes
    • DOI 10.1016/S0898-6568(00)00149-2, PII S0898656800001492
    • Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cell Signal. 2001 13 : 85 94. (Pubitemid 32222977)
    • (2001) Cellular Signalling , vol.13 , Issue.2 , pp. 85-94
    • Guha, M.1    Mackman, N.2
  • 25
    • 0031572429 scopus 로고    scopus 로고
    • In vivo inhibition of nuclear factor-kappa B activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock
    • Liu SF, Ye X, Malik AB. In vivo inhibition of nuclear factor-kappa B activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock. J Immunol. 1997 159 : 3976 83.
    • (1997) J Immunol. , vol.159 , pp. 3976-83
    • Liu, S.F.1    Ye, X.2    Malik, A.B.3
  • 26
    • 0033592288 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate in vivo prevents expression of proinflammatory genes
    • Liu SF, Ye X, Malik AB. Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate in vivo prevents expression of proinflammatory genes. Circulation. 1999 100 : 1330 7.
    • (1999) Circulation. , vol.100 , pp. 1330-7
    • Liu, S.F.1    Ye, X.2    Malik, A.B.3
  • 27
    • 0029360536 scopus 로고
    • Acting via A2 receptors, adenosine inhibits the production of tumor necrosis factor-alpha of endotoxin-stimulated human polymorphonuclear leukocytes
    • Thiel M, Chouker A. Acting via A2 receptors, adenosine inhibits the production of tumor necrosis factor-alpha of endotoxin-stimulated human polymorphonuclear leukocytes. J Lab Clin Med. 1995 126 : 275 82.
    • (1995) J Lab Clin Med. , vol.126 , pp. 275-82
    • Thiel, M.1    Chouker, A.2
  • 28
    • 0036349887 scopus 로고    scopus 로고
    • Interaction of bacterial endotoxine (lipopolysaccharide) with latex particles: Application to latex agglutination immunoassays
    • Peula-GarcÌa JM, Molina-Bolivar JA, Velasco J, Rojas A, Galisteo-González F. Interaction of bacterial endotoxine (lipopolysaccharide) with latex particles: application to latex agglutination immunoassays. J Colloid Interface Sci. 2002 245 : 230 6.
    • (2002) J Colloid Interface Sci. , vol.245 , pp. 230-6
    • Peula-Garcìa, J.M.1    Molina-Bolivar, J.A.2    Velasco, J.3    Rojas, A.4    Galisteo-González, F.5
  • 29
    • 0028950759 scopus 로고
    • Endotoxemia: Methods of detection and clinical correlates
    • Hurley JC. Endotoxemia: methods of detection and clinical correlates. Clin Microbiol Rev. 1995 8 : 268 92.
    • (1995) Clin Microbiol Rev. , vol.8 , pp. 268-92
    • Hurley, J.C.1
  • 30
    • 0026706317 scopus 로고
    • Compartmentalization of lipopolysaccharide production correlates with clinical presentation in meningococcal disease
    • Brandtzaeg P, Ovstebøo R, Kierulf P. Compartmentalization of lipopolysaccharide production correlates with clinical presentation in meningococcal disease. J Infect Dis. 1992 166 : 650 2.
    • (1992) J Infect Dis. , vol.166 , pp. 650-2
    • Brandtzaeg, P.1    Ovstebøo, R.2    Kierulf, P.3
  • 31
    • 0035477981 scopus 로고    scopus 로고
    • Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells
    • Khoa ND, Montesinos MC, Reiss AB, Delano D, Awadallah N, Cronstein BN. Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells. J Immunol. 2001 167 : 4026 32.
    • (2001) J Immunol. , vol.167 , pp. 4026-32
    • Khoa, N.D.1    Montesinos, M.C.2    Reiss, A.B.3    Delano, D.4    Awadallah, N.5    Cronstein, B.N.6
  • 32
    • 0141923779 scopus 로고    scopus 로고
    • Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells
    • Khoa ND, Montesinos MC, Williams AJ, Kelly M, Cronstein BN. Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells. J Immunol. 2003 171 : 3991 8.
    • (2003) J Immunol. , vol.171 , pp. 3991-8
    • Khoa, N.D.1    Montesinos, M.C.2    Williams, A.J.3    Kelly, M.4    Cronstein, B.N.5
  • 33
    • 33645100368 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha prevents desensitization of Galphas-coupled receptors by regulating GRK2 association with the plasma membrane
    • Khoa ND, Postow M, Danielsson J, Cronstein BN. Tumor necrosis factor-alpha prevents desensitization of Galphas-coupled receptors by regulating GRK2 association with the plasma membrane. Mol Pharmacol. 2006 69 : 1311 9.
    • (2006) Mol Pharmacol. , vol.69 , pp. 1311-9
    • Khoa, N.D.1    Postow, M.2    Danielsson, J.3    Cronstein, B.N.4
  • 34
  • 35
    • 0013355591 scopus 로고    scopus 로고
    • G-protein coupled receptors: Putting the brake on inflammation
    • Kirkpatrick P. G-protein coupled receptors: putting the brake on inflammation. Nat Rev Drug Discov. 2002 1 : 99.
    • (2002) Nat Rev Drug Discov. , vol.1 , pp. 99
    • Kirkpatrick, P.1
  • 37
    • 40349114499 scopus 로고    scopus 로고
    • Agonist-selective mechanisms of GPCR desensitization
    • Kelly E, Bailey C P, Henderson G. Agonist-selective mechanisms of GPCR desensitization. Br J Pharmacol. 2008 153 : 379 88.
    • (2008) Br J Pharmacol. , vol.153 , pp. 379-88
    • Kelly, E.1    Bailey, C.P.2    Henderson, G.3
  • 40
    • 0344972943 scopus 로고    scopus 로고
    • Ligand-binding studies: Old beliefs and new strategies
    • Rovati GE. Ligand-binding studies: old beliefs and new strategies. Trends Pharmacol Sci. 1998 19 : 365 9.
    • (1998) Trends Pharmacol Sci. , vol.19 , pp. 365-9
    • Rovati, G.E.1
  • 42
    • 34447620659 scopus 로고    scopus 로고
    • Modulating G-protein-coupled receptors: From traditional pharmacology to allosterics
    • Gilchrist A. Modulating G-protein-coupled receptors: from traditional pharmacology to allosterics. Trends Pharmacol Sci. 2007 28 : 431 7.
    • (2007) Trends Pharmacol Sci. , vol.28 , pp. 431-7
    • Gilchrist, A.1
  • 43
    • 40349110968 scopus 로고    scopus 로고
    • The A2A-adenosine receptor: A GPCR with unique features?
    • Zezula J, Freissmuth M. The A2A-adenosine receptor: a GPCR with unique features? Br J Pharmacol. 2008 153 : 184 90.
    • (2008) Br J Pharmacol. , vol.153 , pp. 184-90
    • Zezula, J.1    Freissmuth, M.2
  • 45
    • 0034284626 scopus 로고    scopus 로고
    • Allosteric modulation of A(2A) adenosine receptors by amiloride analogues and sodium ions
    • Gao ZG, Ijzerman AP. Allosteric modulation of A(2A) adenosine receptors by amiloride analogues and sodium ions. Biochem Pharmacol. 2000 60 : 669 76.
    • (2000) Biochem Pharmacol. , vol.60 , pp. 669-76
    • Gao, Z.G.1    Ijzerman, A.P.2
  • 47
    • 0036258990 scopus 로고    scopus 로고
    • G protein-coupled receptor allosterism and complexing
    • Christopoulos A, Kenakin T. G protein-coupled receptor allosterism and complexing. Pharmacol Rev. 2002 54 : 323 74.
    • (2002) Pharmacol Rev. , vol.54 , pp. 323-74
    • Christopoulos, A.1    Kenakin, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.