Acetyl salicylic acid inhibits Th17 airway inflammation via blockade of IL-6 and IL-17 positive feedback

Experimental and Molecular Medicine

Volumn 45, Issue 1, 2013, Pages

  Moon, Hyung Geun ^a   Kang, Chil Sung ^a   Choi, Jun Pyo ^a   Choi, Dong Sic ^a   Choi, Hyun Il ^a   Choi, Yong Wook ^a   Jeon, Seong Gyu ^a   Yoo, Joo Yeon ^a   Jang, Myoung Ho ^a   Gho, Yong Song ^a   Kim, Yoon Keun ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Acetyl salicylic acid; IL 17A; IL 6; STAT3; Th17

Indexed keywords

ACETYLSALICYLIC ACID; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; GLYCOPROTEIN P 15095; INTERLEUKIN 17; INTERLEUKIN 6; RETINOID RELATED ORPHAN RECEPTOR GAMMA; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME INHIBITION; HELPER CELL; INFLAMMATORY CELL; LUNG INFILTRATE; LUNG LAVAGE; MOUSE; NONHUMAN; POLARIZATION; POSITIVE FEEDBACK; PROTEIN EXPRESSION; RESPIRATORY TRACT INFLAMMATION; TH17 CELL; TH2 CELL;

EID: 84876197796     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2013.10     Document Type: Article

References (29)

1. Busse WW, Lemanske RFJ. Asthma. N Engl J Med 2001; 344: 350-362.
2. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008; 31: 143-178.
3. Soroosh P, Doherty TA. Th9 and allergic disease. Immunology 2009; 127: 450-458.
4. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005; 6: 1133-1141.
5. Kim YS, Hong SW, Choi JP, Shin TS, Moon HG, Choi EJ et al. Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways. J Immunol 2009; 183: 5113-5120.
6. Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ et al. The orphan nuclear receptor RORgt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006; 126: 1121-11233.
7. Yang XP, Ghoreschi K, Steward-Tharp SM, Rodriguez-Canales J, Zhu J, Grainger JR et al. Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat Immunol 2011; 12: 247-254.
8. Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 cells. Annu Rev Immunol 2009; 27: 485-517.
9. Vane Jr. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature 1971; 231: 232-235.
10. Yin M-J, Yamamoto Y, Gaynor RB. The anti-inflammatory agents aspirin and salicylate inhibit the activityof IkB kinase-b. Nature 1998; 396: 77-80.
11. Clària J, Serhan CN. Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc Natl Acad Sci USA 1995; 92: 9475-9479.
12. Schwenger P, Bellosta P, Vietor I, Basilico C, Skolnik EY, Vilcek J. Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stressactivated protein kinase activation. Proc Natl Acad Sci USA 1997; 94: 2869-2873.
13. Cronstein BN, Montesinos MC, Weissmann G. Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB. Proc Natl Acad Sci USA 1999; 96: 6377-6381.
14. Moon HG, Tae YM, Kim YS, Jeon SG, Oh SY, Gho YS et al. Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. Allergy 2010; 65: 1093-1103.
15. Kim YK, Oh SY, Jeon SG, Park HW, Lee SY, Chun EY et al. Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma. J Immunol 2007; 178: 5375-5382.
16. Lutz MB, Kukutsch N, Ogilvie AL, Ro?ssner S, Koch F, Romani N et al. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 1999; 223: 77-92.
17. Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KHG. Interleukin-1 and IL-23 induce innate IL-17 production from gd T cells, amplifying Th17 responses and autoimmunity. Immunity 2009; 31: 331-341.
18. Guermonprez P, Valladeau J, Zitvogel L, Thé ry CS, Amigorena S. Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol 2002; 20: 621-667.
19. Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokiens and the expanding diversity of effector T cell leneages. Annu Rev Immunol 2007; 25: 821-852.
20. Zhao L, Tang Y, You Z, Wang Q, Liang S, Han X et al. Interleukin-17 contributes to the pathogenesis of autoimmune hepatitis through inducing hepatic interleukin-6 expression. PloS One 2011; 19: e18909.
21. Francesco F, Romagnani S. Do studies in humans better depict Th17 cells? Blood 2009; 114: 2213-2219.
22. Gao H, Ward PA. STAT3 and suppressor of cytokine signaling 3: potential targets in lung inflammatory responses. Expert Opin Ther Targets 2007; 11: 869-880.
23. Scott MJ, Godshall CJ, Cheadle WG. STATs, cytokines, and sepsis. Clin Diagn Lab Immunol 2002; 9: 1153-1159.
24. Jetten AM. Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal 2009; 7: 1-32.
25. Yuan ZL, Guan YJ, Chatterjee D, Chin YE. STAT3 dimerization regulated by reversible actylation of a single lysine residue. Science 2005; 307: 269-273.
26. Ohbayashi N, Ikeda O, Taira N, Yamamoto Y, Muromoto R, Sekine Y et al. LIF- and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation. Biol Pharm Bull-4 2007; 30: 1860.
27. Zepp J, Wu L, Li X. IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease. Trends Immunol 2011; 32: 232-239.
28. Chang SH, Dong C. Signaling of interleukin-17 family cytokines in immunity and inflammation. Cell Signal 2011; 23: 1069-1075.
29. Qian Y, Liu C, Hartupee J, Altuntas CZ, Gulen MF, Jane-Wit D et al. The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol 2007; 8: 247-256.