Endothelial cell injury caused by Candida albicans is dependent on iron

Infection and Immunity

Volumn 66, Issue 1, 1998, Pages 191-196

  Fratti, Rutilio A ^a   Belanger, Paul H ^b   Ghannoum, Mahmoud A ^c   Edwards Jr , John E ^d   Filler, Scott G ^a  

^a St John's Cardiovascular Research Center   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; DEFEROXAMINE; GLUTATHIONE; IRON; PHENANTHROLINE;

ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CELL ADHESION; ENDOTHELIUM INJURY; HUMAN; IRON CHELATION; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0031965215     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.1.191-196.1998     Document Type: Article

References (40)

1. Andreoli, S. P., and J. A. McAteer. 1990. Reactive oxygen molecule mediated injury in cndothclial and renal tubular epithelial cells in vitro. Kidney Int. 38:785-794.
2. Balla, J., H. S. Jacob, G. Balla, K. Nath, and J. W. Eaton. 1993. Endothelial-cell heme uptake from proteins: induction of sensitization and descnsitization to oxidant damage. Proc. Natl. Acad. Sci. USA 90:9285-9289.
3. Boelaert, J. R., M. de Locht, J. Van Cutsem, V. Kerrels, B. Cantinieaux, A. Verdonck, H. W. Van Landuyt, and J. Schneider. 1993. Mucormycosis during deferoxamine therapy is a siderophore-mediated infection. In vitro and in vivo animal studies. J. Clin. Invest. 91:1979-1986.
4. Buettner, G. R. 1993. The spin trapping of superoxide and hydroxyl free radicals with DMPO (5,5-dimethylpyrroIine-N-oxide): more about iron. Free Radical Res. Commun. 19:S79-S87.
5. Cotgreave, I. A., D. Constantin-Tcodosiu, and P. Moldeus. 1991. Nonxenobiotic manipulation and sulfur precursor specificity of human endothelial cell glutathione. J. Appl. Physiol. 70:1220-1227.
6. Cutler, J. E. 1991. Putative virulence factors of Candida albicans. Annu. Rev. Microbiol. 45:187-218.
7. Edwards, J. E., Jr., D. Rotrosen, J. W. Fontaine, C. C. Haudenschild, and R. D. Diamond. 1987. Neutrophil-mediated protection of cultured human vascular endothelial cells from damage by growing Candida albicans hyphae. Blood 69:1450-1457.
8. Filler, S. F., J. N. Swerdloff, C. Hobbs, and P. M. Luckett. 1995. Penetration and damage of endothelial cells by Candida albicans. Infect. Immun. 63:976-983.
9. Fratti, R. A., M. A. Ghannoum, J. E. Edwards, Jr., and S. G. Filler. 1996. Gamma interferon protects endothelial cells from damage by Candida albicans by inhibiting cndothelial cell phagocytosis. Infect. Immun. 64:4714-4718.
10. Cannon, D. E., J. Varani, S. H. Phan, J. H. Ward, J. Kaplan, G. O. Till, R. H. Simon, U. S. Ryan, and P. Ward. 1987. Source of iron in neutrophil-mediated killing of cndothelial cells. Lab. Invest. 57:37-44.
11. Garcia, J. G. N., R. F. Dodson, and K. S. Callahan. 1989. Effect of environmental particulates on cultured human and bovine endothelium. Cellular injury via an oxidant-depcndent pathway. Lab. Invest. 61:53-60.
12. Gerber, E., A. Uredy, and R. Kahl. 1996. Ortho-phenanthroline modulates enzymes of cellular energy metabolism. Toxicology 110:85-93.
13. Goodrum, K. J., L. L. McCormick, and B. Schneider. 1994. Group B streptococcus-induced nitric oxide production in murine macrophages is CR3 (CD11b/CD18) dependent. Infect. Immun. 62:3102-3107.
14. Gorog, P., J. D. Pearson, and V. V. Kakkar. 1988. Generation of reactive oxygen metabolites by phagocytosing cndothelial cells. Atherosclerosis 72: 19-27.
15. Hasan, S. M., M. Aziz, P. Ahmad, and M. Aggarwal. 1989. Phagocyte metabolic functions in iron deficiency anaemia of Indian children. J. Trop. Ped. 35:6-9.
16. Hiraishi, H., A. Terano, M. Razandi, A. Pedram, T. Sugimoto, T. Harada, and K. J. Ivey. 1994. Reactive oxygen metabolite-induced toxicity to cultured bovine cndothelial cells: status of cellular iron mediating injury. J. Cell Physiol. 160:132-140.
17. Ibrahim, A. S., S. G. Filler, M. A. Ghannoum, and J. E. Edwards, Jr. 1993. Interferon-gamma protects endothelial cells from damage by Candida albicans. J. Infect. Dis. 167:2239-2244.
18. Ibrahim, A. S., F. Mirbod, S. G. Filler, Y. Banno, G. T. Cole, Y. Kitajima, J. E. Edwards, Jr., Y. Nozawa, and M. A. Ghannoum. 1995. Evidence implicating phospholipase as a virulence factor of Candida albicans. Infect. Immun. 63:1993-1998.
19. Jaffe, E. A., R. L. Nachman, C. G. Beeker, and C. R. Ninick. 1973. Culture of human endothelial cells derived from umbilical veins: identification by morphologic and immunologie criteria. J. Clin. Invest. 52:2745-2756.
20. Jones, C. W., and R. K. Poole. 1985. The analysis of cytochromes. Methods Microbiol. 18:285-328.
21. Karwatowska-Prokopczuk, E., E. Czarnowska, and A. Beresewiez. 1992. Iron availability and free radical induced injury in the isolated ischaemic/reperfused rat heart. Cardiovasc. Res. 26:58-66.
22. Kirkpatrick, C. H., I. Green, R. R. Rich, and A. L. Schade. 1971. Inhibition of growth of Candida albicans by iron-unsaturated lactoferrin: relation to host-defense mechanisms in chronic mucocutaneous candidiasis. J. Infect. Dis. 124:539-544.
23. Klotz, S. A., and R. D. Maca. 1988. Endothelial cell contraction increases Candida adherence to exposed extracellular matrix. Infect. Immun. 56:2495-2498.
24. Kvietys, P. R., W. Inauen, B. R. Bacon, and M. B. Grisham. 1989. Xanthine oxidase-injury to endothelium: role of intracellular iron and hydroxyl radical. Am. J. Physiol. 257:H1640-H1646.
25. Lane, T. E., B. A. Wu-Hsich, and D. H. Howard. 1991. Iron limitation and the gamma interferon-mediated antihistoplasma state of murine macrophages. Infect. Immun. 59:2274-2278.
26. Levitz, S. M., D. J. UiBenedetto, and R. D. Diamond. 1987. A rapid fluorescent assay to distinguish attached from phagocytized yeast particles. J. Immunol. Methods 101:37-12.
27. Moors, M. A., T. L. Slull, K. J. Blank, H. R. Buckley, and D. M. Mosser. 1992. A role for complement receptor-like molecules in iron acquisition by Candida albicans. J. Exp. Med. 175:1643-1651.
28. Omara, F. O., B. R. Blakley, and H. S. Huang. 1994. Effect of iron status on cndotoxin-induced mortality, phagocytosis and interleukin-1 alpha and tumor necrosis factor-alpha production. Vet. Human Toxicol. 36:423-128.
29. Oswald, I. P., I. Eltoum, T. A. Wynn, B. Schwanz, P. Caspar, D. Paulin, A. Sher, and S. L. James. 1994. Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma inansoni, through the production of nitric oxide. Proc. Natl. Acad. Sci. USA 91:999-1003.
30. Pakala, R., R. Pakala, and C. R. Benedict. 1995. Novel 21-aminosteroidlike compounds prevent iron-induced free radical-mediated injury to vascular endothelial cells. J. Cardiovasc. Pharmacol. 25:871-879.
31. Palmer, R. M., J. L. Bridge, N. A. Foxwcll, and S. Moncada. 1992. The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids. Br. J. Pharm. 105:11-12.
32. Parker, N. B., E. M. Berger, W. E. Curtis, M. E. Muldrow, S. L. Linas, and J. E. Repine. 1985. Hydrogen peroxide causes dimethylthiourca consumption while hydroxyl radical causes dimethyl sulfoxide consumption in vitro. J. Free Radicals Biol. Med. 1:415-419.
33. Rinaldo, J. E., and M. Gorry. 1990. Protection by deferoxamine from endothelial injury: a possible link with inhibition of intracellular xanthine oxidase. Am. J. Respir. Cell. Mol. Biol. 3:525-533.
34. Rosenkranz-Weiss, E., C. Sessa, S. Milstien, S. Kaufman, C. A. Watson, and J. S. Pober. 1994. Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthasc specific activity. J. Clin. Invest. 93:2236-2243.
35. Rotrosen, D., J. E. Edwards, Jr., T. R. Gibson, J. D. Moore, A. H. Cohen, and I. Green. 1985. Adherence of Candida to cultured vascular endothelial cells: mechanisms of attachment and endothelial cell penetration. J. Infect. Dis. 152:1264-1273.
36. Shaughnessy, S. G., M. Whaley, R. M. Lafrenie, and F. W. Orr. 1993. Walker 256 tumor cell degradation of extracellular matricies involves a latent gelatinase activated by reactive oxygen species. Arch. Biochem. Biophys. 304: 314-321.
37. Tsan, M. F., E. H. Uanis, P. J. Del Vecchio, and C. L. Rosano. 1985. Enhancement of intracellular glutathione protects endothelial cells against oxidant damage. Biochem. Biophys. Res. Commun. 127:270-276.
38. Varlivarian, S. E. 1992. Virulence properties and nonimmune pathogenetic mechanisms of fungi. Clin. Infect. Dis. 14(Suppl. 1):S30-36.
39. Weinberg, G. A. 1994. Iron chelators as therapeutic agents against Pneuinocystis carinii. Antimicrob. Agents Chemothcr. 38:997-1003.
40. Zweier, J. L., R. Broderick, P. Kuppusamy, S. Thompson-German, and G. A. Lutty. 1994. Determination of the mechanism of free radical generation in human aortic endolhclial cells exposed to anoxia and reoxygenation. J. Biol. Chem. 269:24156-24162.