Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation

Retrovirology

Volumn 11, Issue 1, 2014, Pages

  Schaller, Torsten ^a   Pollpeter, Darja ^a   Apolonia, Luis ^a   Goujon, Caroline ^a   Malim, Michael H ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

HIV 1; Imp ; Imp ; Innate immunity; Karyopherin; KPNA; KPNB; Macrophages; NLS; Nuclear import; SAMHD1; Ubiquitin linkage; Vpx

Indexed keywords

ARGININE; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; KARYOPHERIN ALPHA2; KARYOPHERIN BETA1; LYSINE; PROTEIN VPX; STERILE ALPHA MOTIF DOMAIN AND HD DOMAIN 1 PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LINKAGE ANALYSIS; MACROPHAGE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEAR IMPORT; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SENSITIVITY ANALYSIS; SEQUENCE ANALYSIS; UBIQUITINATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ACTIVE TRANSPORT, CELL NUCLEUS; CELL NUCLEUS; CELLS, CULTURED; HUMANS; KARYOPHERINS; LEUKOCYTES, MONONUCLEAR; MONOMERIC GTP-BINDING PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; UBIQUITINATION; VIRAL REGULATORY AND ACCESSORY PROTEINS;

EID: 84899081413     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-11-29     Document Type: Article

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