Identification of a nuclear localization signal in OCT4 and generation of a dominant negative mutant by its ablation

Journal of Biological Chemistry

Volumn 279, Issue 35, 2004, Pages 37013-37020

  Pan, Guangjin ^a   Qin, Baomin ^a   Liu, Nan ^a   Schöler, Hans R ^b   Pei, Duanqing ^a,c  

^a TSINGHUA UNIVERSITY   (China)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DATA REDUCTION; GENES; MUTAGENESIS;

BIOLOGICAL FUNCTIONS; NUCLEAR LOCALIZATION;

BIOCHEMISTRY;

DNA; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LYSATE; CELL TYPE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPORTER GENE; STEM CELL;

AMINO ACID MOTIFS; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; CELL NUCLEUS; DIMERIZATION; DNA PRIMERS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; GENES, DOMINANT; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; LUMINESCENT PROTEINS; MICE; MUTATION; OCTAMER TRANSCRIPTION FACTOR-3; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA;

EID: 4344707501     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M405117200     Document Type: Article

References (21)

1. Daley, G. Q. (2002) Curr. Opin. Genet. Dev. 12, 607-613
2. Fuchs, E., Tumbar, T., and Guasch, G. (2004) Cell 116, 769-778
3. Reya, T., Morrison, S. J., Clarke, M. F., and Weissman, I. L. (2001) Nature 414, 105-111
4. Goh, E. L., Ma, D., Ming, G. L., and Song, H. (2003) J. Hematother. Stem Cell Res. 12, 671-679
5. Rippon, H. J., and Bishop, A. E. (2004) Cell Proliferation 37, 23-34
6. Donovan, P. J. (2001) Nat. Genet. 29, 246-247
7. Boiani, M., Eckardt, S., Scholer, H. R., and McLaughlin, K. J. (2002) Genes Dev. 16, 1209-1219
8. Mitalipov, S. M., Kuo, H. C., Hennebold, J. D., and Wolf, D. P. (2003) Biol. Reprod. 69, 1785-1792
9. Pan, G. J., Chang, Z. Y., Scholer, H. R., and Pei, D. (2002) Cell Res. 12, 321-329
10. Niwa, H. (2001) Cell Struct. Funct. 26, 137-148
11. Scholer, H. R., Ciesiolka, T., and Gruss, P. (1991) Cell 66, 291-304
12. Scholer, H. R., Dressler, G. R., Balling, R., Rohdewohld, H., and Gruss, P. (1990) EMBO J. 9, 2185-2195
13. Pesce, M., and Scholer, H. R. (2001) Stem Cells 19, 271-278
14. Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H., Klewe-Nebenius, D., Chambers, I., Scholer, H., and Smith, A. (1998) Cell 95, 379-391
15. Pei, D. (1999) Cell Res. 9, 291-303
16. Pei, D. (1999) J. Biol. Chem. 274, 8925-8932
17. Nie, J., and Pei, D. (2003) Cancer Res. 63, 6758-6762
18. Brehm, A., Ohbo, K., and Scholer, H. (1997) Mol. Cell. Biol. 17, 154-162
19. Cui, P., Qin, B., Liu, N., Pan, G., and Pei, D. (2004) Exp. Cell Res. 293, 154-163
20. Buehr, M., Nichols, J., Stenhouse, F., Mountford, P., Greenhalgh, C. J., Kantachuvesiri, S., Brooker, G., Mullins, J., and Smith, A. G. (2003) Biol. Reprod. 68, 222-229
21. Avilion, A. A., Nicolis, S. K., Pevny, L. H., Perez, L., Vivian, N., and Lovell-Badge, R. (2003) Genes Dev. 17, 126-140