Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1

Nature

Volumn 430, Issue 6999, 2004, Pages 569-573

  Sayah, David M ^a   Sokolskaja, Elena ^a   Berthoux, Lionel ^a   Luban, Jeremy ^a  

^a College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES; HUMAN ENGINEERING; PROTEINS; RNA; VIRUSES;

EXON SHUFFLING; HUMAN IMMUNODEFICIENCY VIRUS (HIV); INFECTION; OWL MONKEYS;

GENETIC ENGINEERING;

CYCLOPHILIN A; PROTEIN; RNA; TRIPARTITE MOTIF PROTEIN 5; UNCLASSIFIED DRUG; HYBRID PROTEIN; SMALL INTERFERING RNA; TRIM5(ALPHA) PROTEIN, RHESUS MONKEY;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; PRIMATE;

ANIMAL CELL; ARTICLE; CATALYSIS; CHIMERA; EMBRYO; EXON; GENE LOCUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MONKEY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIMATE; PRIORITY JOURNAL; PROTEIN BINDING; RAT; RETROPOSON; RNA INTERFERENCE; VIRUS ACTIVATION; VIRUS CAPSID; VIRUS RESISTANCE; AMINO ACID SEQUENCE; ANIMAL; AOTUS; CELL LINE; GENETIC PREDISPOSITION; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONG INTERSPERSED REPEAT; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; PHYSIOLOGY; VIROLOGY;

ANIMALIA; AOTUS TRIVIRGATUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; INSERTION SEQUENCES; PRIMATES; RNA VIRUSES; STRIGIFORMES; VERTEBRATA;

AMINO ACID SEQUENCE; ANIMALS; AOTIDAE; BASE SEQUENCE; CELL LINE; CYCLOPHILIN A; EVOLUTION, MOLECULAR; EXONS; GENETIC PREDISPOSITION TO DISEASE; HIV INFECTIONS; HIV-1; HUMANS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; MOLECULAR SEQUENCE DATA; PROTEINS; RATS; RECOMBINANT FUSION PROTEINS; RETROELEMENTS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 3242876747     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02777     Document Type: Article

References (30)

1. Hofmann, W. et al. Species-specific, postentry barriers to primate immunodeficiency virus infection. J. Virol. 73, 10020-10028 (1999).
2. Cowan, S. et al. Cellular inhibitors with Fvl-like activity restrict human and simian immunodeficiency virus tropism. Proc. Natl Acad. Sci. USA 99, 11914-11919 (2002).
3. Besnier, C., Takeuchi, Y. & Towers, G. Restriction of lentivirus in monkeys. Proc. Natl Acad. Sci. USA 99, 11920-11925 (2002).
4. Towers, G. J. et al. Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors. Nature Med. 9, 1138-1143 (2003).
5. Stremlau, M. et al. The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys. Nature 427, 848-853 (2004).
6. Luban, J., Bossolt, K. L., Franke, E. K., Kalpana, G. V. & Goff, S. P. Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell 73, 1067-1078 (1993).
7. Braaten, D. & Luban, J. Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. EMBO J. 20, 1300-1309 (2001).
8. Franke, E. K., Yuan, H. E. & Luban, J. Specific incorporation of cyclophilin A into HIV-1 virions. Nature 372, 359-362 (1994).
9. Thali, M. et al. Functional association of cyclophilin A with HIV-1 virions. Nature 372, 363-365 (1994).
10. Fehr, T., Kallen, J., Oberer, L., Sanglier, J. J. & Schilling, W. Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. II. Structure elucidation, stereochemistry and physico-chemical properties. J. Antibiot. (Tokyo) 52, 474-479 (1999).
11. Jackson, A. L. et al. Expression profiling reveals off-target gene regulation by RNAi. Nature Biotechnol. 21, 635-637 (2003).
12. Kazazian, H. H. Jr Mobile elements: drivers of genome evolution. Science 303, 1626-1632 (2004).
13. Feng, Q., Moran, J. V., Kazazian, H. H. Jr & Boeke, J. D. Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition. Cell 87, 905-916 (1996).
14. Zhang, Z., Harrison, P. M., Liu, Y. & Gerstein, M. Millions of years of evolution preserved: a comprehensive catalog of the processed pseudogenes in the human genome. Genome Res. 13, 2541-2558 (2003).
15. Xu, L. et al. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5δ. Exp. Cell Res. 288, 84-93 (2003).
16. Schwartz, O., Marechal, V., Friguet, B., Arenzana-Seisdedos, F. & Heard, J. M. Antiviral activity of the proteasome on incoming human immunodeficiency virus type 1. J. Virol. 72, 3845-3850 (1998).
17. Reymond, A. et al. The tripartite motif family identifies cell compartments. EMBO J. 20, 2140-2151 (2001).
18. Wu, J., Matunis, M. J., Kraemer, D., Blobel, G. & Coutavas, E. Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. J. Biol. Chem. 270, 14209-14213 (1995).
19. McClintock, B. The origin and behavior of mutable loci in maize. Proc. Natl Acad. Sci. USA 36, 344-355 (1950).
20. Esnault, C., Maestre, J. & Heidmann, T. Human LINE retrotransposons generate processed pseudogenes. Nature Genet. 24, 363-367 (2000).
21. Wei, W. et al. Human L1 retrotransposition: cis preference versus trans complementation. Mol. Cell. Biol. 21, 1429-1439 (2001).
22. Dewannieux, M., Esnault, C. & Heidmann, T. LINE-mediated retrotransposition of marked Alu sequences. Nature Genet. 35, 41-48 (2003).
23. Gilbert, W. Why genes in pieces? Nature 271, 501 (1978).
24. Moran, J. V., DeBerardinis, R. J. & Kazazian, H. H. Jr Exon shuffling by L1 retrotransposition. Science 283, 1530-1534 (1999).
25. Damert, A., Lower, J. & Lower, R. Leptin receptor isoform 219A: an example of protein evolution by LINE-1-mediated human-specific retrotransposition of a coding SVA element. Mol. Biol. Evol. 21, 647-651 (2004).
26. Ejima, Y. & Yang, L. Trans mobilization of genomic DNA as a mechanism for retrotransposon-mediated exon shuffling. Hum. Mol. Genet. 12, 1321-1328 (2003).
27. Long, M. & Langley, C. H. Natural selection and the origin of jingwei, a chimeric processed functional gene in Drosophila. Science 260, 91-95 (1993).
28. Roy-Engel, A. M. et al. Non-traditional Alu evolution and primate genomic diversity. J. Mol. Biol. 316, 1033-1040 (2002).
29. Brummelkamp, T. R., Bernards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550-553 (2002).
30. Asmal, M. et al. Production of ribosome components in effector CD4+ T cells is accelerated by TCR stimulation and coordinated by ERK-MAPK. Immunity 19, 535-548 (2003).