Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site

ACS Chemical Neuroscience

Volumn 5, Issue 4, 2014, Pages 282-295

  Gregory, Karen J ^a,b   Nguyen, Elizabeth D ^a   Malosh, Chrysa ^a,b   Mendenhall, Jeffrey L ^a   Zic, Jessica Z ^a,b   Bates, Brittney S ^a,b   Noetzel, Meredith J ^a,b   Squire, Emma F ^a,b   Turner, Eric M ^a,b   Rook, Jerri M ^a,b   Emmitte, Kyle A ^a,b   Stauffer, Shaun R ^a,b   Lindsley, Craig W ^a,b   Meiler, Jens ^a   Conn, P Jeffrey ^a,b,c  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MONASH UNIVERSITY   (Australia)

Author keywords

affinity; cooperativity; metabotropic glutamate receptor 5; Mutagenesis; operational model; structure activity relationships

Indexed keywords

A809 PROTEIN; BENZAMIDE DERIVATIVE; LIGAND; METABOTROPIC RECEPTOR 5; P654 PROTEIN; PROTEIN; S808 PROTEIN; SCAFFOLD PROTEIN; T780 PROTEIN; UNCLASSIFIED DRUG; W784 PROTEIN; Y658 PROTEIN; PROTEIN BINDING;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; CHEMISTRY; COMPUTER SIMULATION; MOLECULAR DOCKING; PROCEDURES; ULTRASTRUCTURE;

BINDING SITES; COMPUTER SIMULATION; MOLECULAR DOCKING SIMULATION; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; RECEPTOR, METABOTROPIC GLUTAMATE 5; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899020574     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn400225x     Document Type: Article

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