4-Aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 24, 2010, Pages 7381-7384

  Xiong, Hui ^a   Brugel, Todd A ^a   Balestra, Michael ^a   Brown, Dean G ^a   Brush, Kelly A ^a   Hightower, Caprice ^a   Hinkley, Lindsay ^a   Hoesch, Valerie ^a   Kang, James ^a   Koether, Gerard M ^a   McCauley Jr , John P ^a   McLaren, Francis M ^a   Panko, Laura M ^a   Simpson, Thomas R ^a   Smith, Reed W ^a   Woods, James M ^a   Brockel, Becky ^a   Chhajlani, Vijay ^a   Gadient, Reto A ^a   Spear, Nathan ^a   Sygowski, Linda A ^a   Zhang, Minli ^a   Arora, Jalaj ^b   Breysse, Nathalie ^b   Wilson, Julie M ^b   Isaac, Methvin ^b   Slassi, Abdelmalik ^b   King, Megan M ^a   more..

^a ASTRAZENECA   (United Kingdom)

^b NPS Pharmaceuticals   (Canada)

Author keywords

mGluR5; Positive allosteric modulator; Schizophrenia

Indexed keywords

4 ARYL PIPERAZINE; ADX 47273; AMIDE; METABOTROPIC RECEPTOR 5; MRZ 3573; PIPERAZINE; PIPERIDINE AMIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; NONHUMAN;

ALLOSTERIC REGULATION; AMIDES; HUMANS; MICROSOMES, LIVER; PIPERAZINES; PIPERIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; SCHIZOPHRENIA; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 78449302090     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.036     Document Type: Article

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