Structure-Activity Relationships for Negative Allosteric mGluR5 Modulators

ChemMedChem

Volumn 7, Issue 3, 2012, Pages 440-451

  Kaae, Birgitte H ^a,b   Harpsøe, Kasper ^a   Kvist, Trine ^a   Mathiesen, Jesper M ^a   Mølck, Christina ^a   Gloriam, David ^a   Jimenez, Hermogenes N ^c   Uberti, Michelle A ^c   Nielsen, Søren M ^d   Nielsen, Birgitte ^a   Bräuner Osborne, Hans ^a   Sauerberg, Per ^e   Clausen, Rasmus P ^a   Madsen, Ulf ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Radiometer AS   (Denmark)

^c LUNDBECK RESEARCH USA   (United States)

^d H LUNDBECK A S   (Denmark)

^e NOVO NORDISK A S   (Denmark)

Author keywords

Allosteric modulators; Cross coupling; MGluR5; Molecular modeling; Structure activity relationships

Indexed keywords

1,3 BIS(PYRIDIN 2 YLETHYNYL)BENZENE; 1,3 BIS(PYRIDIN 3 YLETHYNYL)BENZENE; 1,3 BIS(PYRIDIN 4 YLETHYNYL)BENZENE; 1,3 BIS(THIAZOL 2 YLETHYNYL)BENZENE; 1,4 BIS(PYRIDIN 2 YLETHYNYL)BENZENE; 1,4 BIS(PYRIDIN 3 YLETHYNYL)BENZENE; 1,4 BIS(PYRIDIN 4 YLETHYNYL)BENZENE; 1,4 BIS(THIAZOL 2 YLETHYNYL)BENZENE; 1,4 DI(PYRIDIN 4 YL)BUTA 1,3 DIYNE; 2 (PHENYLETHYNYL)PYRIDYL; 2 (PHENYLETHYNYL)THIAZOLE; 2 (PYRIDIN 2 YLETHYNYL)THIAZOLE; 2 (PYRIDIN 3 YLETHYNYL)THIAZOLE; 2 [(3 IODOPHENYL)ETHYNYL]PYRIDINE; 2 [(5,5 DIMETHYL 1,3,2 DIOXABORINAN 2 YL)ETHYNYL]PYRIDYL; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3 (PHENYLETHYNYL)PYRIDYL; 3 [(3 IODOPHENYL)ETHYNYL]PYRIDINE; 3 [(5,5 DIMETHYL 1,3,2 DIOXABORINAN 2 YL)ETHYNYL]PYRIDYL; 3,3 BIS(PYRIDIN 4 YLETHYNYL)BIPHENYL; 3,3' BIS(PYRIDIN 2 YLETHYNYL)BIPHENYL; 3,3' BIS(PYRIDIN 3 YLETHYNYL)BIPHENYL; 4 (PHENYLETHYNYL)PYRIDYL; 4 [(5,5 DIMETHYL 1,3,2 DIOXABORINAN 2 YL)ETHYNYL]PYRIDYL; 4,4' BIS(PYRIDIN 2 YLETHYNYL)BIPHENYL; 4,4' BIS(PYRIDIN 3 YLETHYNYL)BIPHENYL; 4,4' BIS(PYRIDIN 4 YLETHYNYL)BIPHENYL; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; ATOM; BINDING SITE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MOLECULAR DOCKING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ALKYNES; ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY DISORDERS; BINDING SITES; BRAIN; CHO CELLS; CRICETINAE; DIMERIZATION; GLUTAMIC ACID; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857713749     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100578     Document Type: Article

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