Structure-activity relationships comparing N-(6-methylpyridin-yl)- substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists

Journal of Medicinal Chemistry

Volumn 52, Issue 11, 2009, Pages 3563-3575

  Kulkarni, Santosh S ^a   Zou, Mu Fa ^a   Cao, Jianjing ^a   Deschamps, Jeffrey R ^b   Rodriguez, Alice L ^c   Conn, P Jeffrey ^c   Newman, Amy Hauck ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (PYRIDIN 3 YL) 2 FLUORO 4 (2 METHYLTHIAZOL 4 YLETHYNYL)BENZENE; 1 FLUORO 3 (PYRIDIN 3 YL) 5 (2 METHYLTHIAZOL 4 YLETHYNYL)BENZENE; 2 (3 FLUOROPHENYL) 5 (6 METHYLPYRIDIN 2 YLETHYNYL)BENZONITRILE; 2 (4 FLUOROPHENYL) 5 (6 METHYLPYRIDIN 2 YLETHYNYL)BENZONITRILE; 2 (PYRIDIN 3 YL) 5 (2 METHYLTHIAZOL 4 YLETHYNYL)PYRIDINE; 2 METHYL 4 (PYRIDIN 3 YLETHYNYL)THIAZOLE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 2 PHENYL 5 (2 METHYLTHIAZOL 4 YLETHYNYL)PYRIDINE; 2 PHENYL 5 (6 METHYLPYRIDIN 2 YLETHYNYL)BENZONITRILE; 3 [(6 METHYLPYRIDIN 2 YL)ETHYNYL]BENZONITRILE; 3 CYANO 5 FLUORO N (6 METHYLPYRIDIN 2 YL)BENZAMIDE HYDROCHLORIDE; 3 FLUORO 5 CYANO 1 (2 METHYLTHIAZOL 4 YLETHYNYL)BENZENE; 3 FLUORO N (6 METHYLPYRIDIN 2 YL) 5 (PYRIDIN 3 YL)BENZAMIDE; 3 PHENYL 1 (2 METHYLTHIAZOL 4 YLETHYNYL)BENZENE; 3,4 DIFLUORO N (6 METHYLPYRIDIN 2 YL)BENZAMIDE; 3,5 DIFLUORO N (6 METHYLPYRIDIN 2 YL)BENZAMIDE; 4 (3' CHLOROPHENYL) N (6 METHYLPYRIDIN 2 YL)BENZAMIDE HYDROBROMIDE; 4 (3' CYANOPHENYL) N (6 METHYLPYRIDIN 2 YL)BENZAMIDE HYDROBROMIDE; 4 (BENZYLOXY) N (6 METHYLPYRIDIN 2 YL)BENZAMIDE; 4 BROMO N (6 METHYLPYRIDIN 2 YL)BENZAMIDE HYDROBROMIDE; 4 CYANO N (6 METHYLPYRIDIN 2 YL)BENZAMIDE; 4 PHENOXY N (6 METHYLPYRIDIN 2 YL)BENZAMIDE HYDROBROMIDE; 4 PHENYL N (6 METHYLPYRIDIN 2 YL)BENZAMIDE HYDROBROMIDE; ALKYNE DERIVATIVE; AMIDE; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; PYRIDINE DERIVATIVE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CHEMICAL BOND; CONFORMATIONAL TRANSITION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALKYNES; ANIMALS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; PYRIDINES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 66749109859     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900172f     Document Type: Article

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