Synthesis and receptor assay of aromatic-ethynyl-aromatic derivatives with potent mGluR5 antagonist activity

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 1, 2005, Pages 197-209

  Alagille, David ^a   Baldwin, Ronald M ^a   Roth, Bryan L ^b   Wroblewski, Jarda T ^c   Grajkowska, Ewa ^c   Tamagnan, Gilles D ^a,d  

^a YALE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^d Inst for Neurodeg Disorders   (United States)

Author keywords

Antagonist; Gluatamate; Metabotropic; mGluR5; Synthesis

Indexed keywords

1 METHYL 3 PHENYLETHYNYLBENZENE; 1 METHYL 5 (6 METHYLPYRIDIN 2 YLETHYNYL) 1H INDOLE; 1 METHYL 6 (6 METHYLPYRIDIN 2 YLETHYNYL) 1H INDOLE; 2 (2 METHOXYPHENYLETHYNYL) 6 METHYLPYRIDINE; 2 (2,4 DIMETHOXYPHENYLETHYNYL) 6 METHYLPYRIDINE; 2 (2,5 DIMETHOXYPHENYLETHYNYL) 6 METHYLPYRIDINE; 2 (3 ALLYLOXYPHENYLETHYNYL) 6 METHYLPYRIDINE; 2 (3 FLUOROPHENYLETHYNYL) 6 METHYLPYRIDINE; 2 (3 METHOXYPHENYLETHYNYL) 6 METHYLPYRIDINE; 2 (3,4 DIMETHOXY PHENYLETHYNYL) 6 METHYLPYRIDINE; 2 (4 METHOXYPHENYLETHYNYL) 6 METHYLPYRIDINE; 2 BENZO[1,3]DIOXOL 5 YLETHYNYL 6 METHYLPYRIDINE; 2 BROMO 6 PHENYLETHYNYLPYRIDINE; 2 METHOXY 6 PHENYLETHYNYLPYRYLPYRIDINE; 2 METHYL 6 (3 METHYLTHIOPHENYLETHYNYL)PYRIDINE; 2 METHYL 6 (3 TRIFLUOROMETHYLPHENYLETHYNYL)PYRIDINE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 2 METHYL 6 PYRIDIN 4 YLETHYNYLPYRIDINE; 2,4 DIMETHYL 6 PHENYLETHYNYLPYRIDINE; 3 (6 METHYLPYRIDIN 2 YLETHYNYL) 5 METHOXYPYRIDINE; 3 (6 METHYLPYRIDIN 2 YLETHYNYL)QUINOLINE; 3 METHYL 2 PHENYLETHYNYLPYRIDINE; 4 (6 METHYLPYRIDIN 2 YLETHYNYL)ISOQUINOLINE; 4 METHYL 2 PHENYLETHYNYLPYRIDINE; 5 (6 METHYLPYRIDIN 2 YLETHYNYL)PYRIMIDINE; 5 METHYL 2 PHENYLETHYNYLPYRIDINE; AROMATIC COMPOUND; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; ASSAY; DRUG SYNTHESIS; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; RECEPTORS, METABOTROPIC GLUTAMATE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 9644281056     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.09.042     Document Type: Article

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