-
1
-
-
20944436688
-
Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity
-
Beaudry P, Force J, Naumov GN, Wang A, Baker CH, Ryan A, Soker S, Johnson BE, Folkman J and Heymach JV. Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity. Clin Cancer Res. 2005; 11(9):3514-3522.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.9
, pp. 3514-3522
-
-
Beaudry, P.1
Force, J.2
Naumov, G.N.3
Wang, A.4
Baker, C.H.5
Ryan, A.6
Soker, S.7
Johnson, B.E.8
Folkman, J.9
Heymach, J.V.10
-
2
-
-
85013312416
-
Tumor angiogenesis: therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971; 285(21):1182-1186.
-
(1971)
N Engl J Med
, vol.285
, Issue.21
, pp. 1182-1186
-
-
Folkman, J.1
-
3
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin DJ and Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 2005; 23(5):1011-1027.
-
(2005)
J Clin Oncol
, vol.23
, Issue.5
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
4
-
-
0033979730
-
Anti-VEGF antibody suppresses primary tumor growth and metastasis in an experimental model of Wilms' tumor
-
discussion 32-33.
-
Rowe DH, Huang J, Kayton ML, Thompson R, Troxel A, O'Toole KM, Yamashiro D, Stolar CJ and Kandel JJ. Anti-VEGF antibody suppresses primary tumor growth and metastasis in an experimental model of Wilms' tumor. J Pediatr Surg. 2000; 35(1):30-32; discussion 32-33.
-
(2000)
J Pediatr Surg
, vol.35
, Issue.1
, pp. 30-32
-
-
Rowe, D.H.1
Huang, J.2
Kayton, M.L.3
Thompson, R.4
Troxel, A.5
O'Toole, K.M.6
Yamashiro, D.7
Stolar, C.J.8
Kandel, J.J.9
-
5
-
-
27944473690
-
VEGF as a key mediator of angiogenesis in cancer.
-
Carmeliet P. VEGF as a key mediator of angiogenesis in cancer. Oncology. 2005; 69 Suppl 3:4-10.
-
(2005)
Oncology
, vol.69
, Issue.SUPPL. 3
, pp. 4-10
-
-
Carmeliet, P.1
-
6
-
-
20544455330
-
Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy
-
Ferrara N, Hillan KJ and Novotny W. Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy. Biochem Biophys Res Commun. 2005; 333(2):328-335.
-
(2005)
Biochem Biophys Res Commun
, vol.333
, Issue.2
, pp. 328-335
-
-
Ferrara, N.1
Hillan, K.J.2
Novotny, W.3
-
7
-
-
27944490875
-
VEGF as a therapeutic target in cancer
-
Ferrara N. VEGF as a therapeutic target in cancer. Oncology. 2005; 69 Suppl 3:11-16.
-
(2005)
Oncology
, vol.69
, Issue.SUPPL. 3
, pp. 11-16
-
-
Ferrara, N.1
-
8
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
Ferrara N and Kerbel RS. Angiogenesis as a therapeutic target. Nature. 2005; 438(7070):967-974.
-
(2005)
Nature
, vol.438
, Issue.7070
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
9
-
-
23944515326
-
Intracellular signal transduction pathway proteins as targets for cancer therapy
-
Adjei AA and Hidalgo M. Intracellular signal transduction pathway proteins as targets for cancer therapy. J Clin Oncol. 2005; 23(23):5386-5403.
-
(2005)
J Clin Oncol
, vol.23
, Issue.23
, pp. 5386-5403
-
-
Adjei, A.A.1
Hidalgo, M.2
-
10
-
-
17844372539
-
Critical update and emerging trends in epidermal growth factor receptor targeting in cancer
-
Baselga J and Arteaga CL. Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J Clin Oncol. 2005; 23(11):2445-2459.
-
(2005)
J Clin Oncol
, vol.23
, Issue.11
, pp. 2445-2459
-
-
Baselga, J.1
Arteaga, C.L.2
-
11
-
-
0035432151
-
Hypoxia-inducible factor: Achilles' heel of antiangiogenic cancer therapy (review)
-
Blagosklonny MV. Hypoxia-inducible factor: Achilles' heel of antiangiogenic cancer therapy (review). Int J Oncol. 2001; 19(2):257-262.
-
(2001)
Int J Oncol
, vol.19
, Issue.2
, pp. 257-262
-
-
Blagosklonny, M.V.1
-
12
-
-
1642472018
-
Antiangiogenic therapy and tumor progression
-
Blagosklonny MV. Antiangiogenic therapy and tumor progression. Cancer Cell. 2004; 5(1):13-17.
-
(2004)
Cancer Cell
, vol.5
, Issue.1
, pp. 13-17
-
-
Blagosklonny, M.V.1
-
13
-
-
0037530130
-
Hypoxia-induced angiogenesis during carcinogenesis
-
Choi KS, Bae MK, Jeong JW, Moon HE and Kim KW. Hypoxia-induced angiogenesis during carcinogenesis. J Biochem Mol Biol. 2003; 36(1):120-127.
-
(2003)
J Biochem Mol Biol
, vol.36
, Issue.1
, pp. 120-127
-
-
Choi, K.S.1
Bae, M.K.2
Jeong, J.W.3
Moon, H.E.4
Kim, K.W.5
-
14
-
-
1642387020
-
Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions
-
Lee JW, Bae SH, Jeong JW, Kim SH and Kim KW. Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions. Exp Mol Med. 2004; 36(1):1-12.
-
(2004)
Exp Mol Med
, vol.36
, Issue.1
, pp. 1-12
-
-
Lee, J.W.1
Bae, S.H.2
Jeong, J.W.3
Kim, S.H.4
Kim, K.W.5
-
15
-
-
0242608613
-
The genetic basis of cancer of the kidney
-
Linehan WM, Walther MM and Zbar B. The genetic basis of cancer of the kidney. J Urol. 2003; 170(6 Pt 1):2163- 2172.
-
(2003)
J Urol.
, vol.170
, Issue.6 PART 1
, pp. 2163-2172
-
-
Linehan, W.M.1
Walther, M.M.2
Zbar, B.3
-
16
-
-
4444311880
-
Hypoxia inducible factor- 1alpha as a cancer drug target
-
Powis G and Kirkpatrick L. Hypoxia inducible factor- 1alpha as a cancer drug target. Mol Cancer Ther. 2004; 3(5):647-654.
-
(2004)
Mol Cancer Ther
, vol.3
, Issue.5
, pp. 647-654
-
-
Powis, G.1
Kirkpatrick, L.2
-
17
-
-
12344262762
-
mTOR, translational control and human disease
-
Tee AR and Blenis J. mTOR, translational control and human disease. Semin Cell Dev Biol. 2005; 16(1):29-37.
-
(2005)
Semin Cell Dev Biol
, vol.16
, Issue.1
, pp. 29-37
-
-
Tee, A.R.1
Blenis, J.2
-
18
-
-
0033693293
-
Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--= hypoxia response element--= VEGF cascade differentially regulates vascular response and growth rate in tumors
-
Tsuzuki Y, Fukumura D, Oosthuyse B, Koike C, Carmeliet P and Jain RK. Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--= hypoxia response element--= VEGF cascade differentially regulates vascular response and growth rate in tumors. Cancer Res. 2000; 60(22):6248-6252.
-
(2000)
Cancer Res
, vol.60
, Issue.22
, pp. 6248-6252
-
-
Tsuzuki, Y.1
Fukumura, D.2
Oosthuyse, B.3
Koike, C.4
Carmeliet, P.5
Jain, R.K.6
-
19
-
-
0347512126
-
Hypoxia inducible factor as a cancer drug target
-
Welsh SJ and Powis G. Hypoxia inducible factor as a cancer drug target. Curr Cancer Drug Targets. 2003; 3(6):391-405.
-
(2003)
Curr Cancer Drug Targets
, vol.3
, Issue.6
, pp. 391-405
-
-
Welsh, S.J.1
Powis, G.2
-
20
-
-
0037154738
-
Effect of p53 status on tumor response to antiangiogenic therapy
-
Yu JL, Rak JW, Coomber BL, Hicklin DJ and Kerbel RS. Effect of p53 status on tumor response to antiangiogenic therapy. Science. 2002; 295(5559):1526-1528.
-
(2002)
Science
, vol.295
, Issue.5559
, pp. 1526-1528
-
-
Yu, J.L.1
Rak, J.W.2
Coomber, B.L.3
Hicklin, D.J.4
Kerbel, R.S.5
-
21
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL and Simons JW. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 1999; 59(22):5830-5835.
-
(1999)
Cancer Res
, vol.59
, Issue.22
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
-
22
-
-
76049084645
-
Inhibition of mTOR in kidney cancer. Curr Oncol
-
Kapoor A. Inhibition of mTOR in kidney cancer. Curr Oncol. 2009; 16 Suppl 1:S33-39.
-
(2009)
, vol.16
, Issue.SUPPL. 1
-
-
Kapoor, A.1
-
23
-
-
77249092487
-
Mammalian target of rapamycin: a new target in prostate cancer
-
Rai JS, Henley MJ and Ratan HL. Mammalian target of rapamycin: a new target in prostate cancer. Urol Oncol. 28(2):134-138.
-
Urol Oncol.
, vol.28
, Issue.2
, pp. 134-138
-
-
Rai, J.S.1
Henley, M.J.2
Ratan, H.L.3
-
24
-
-
28244490997
-
High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma
-
Oda K, Stokoe D, Taketani Y and McCormick F. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Cancer Res. 2005; 65(23):10669-10673.
-
(2005)
Cancer Res
, vol.65
, Issue.23
, pp. 10669-10673
-
-
Oda, K.1
Stokoe, D.2
Taketani, Y.3
McCormick, F.4
-
25
-
-
0032590011
-
PIK3CA is implicated as an oncogene in ovarian cancer
-
Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, Pinkel D, Powell B, Mills GB and Gray JW. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet. 1999; 21(1):99-102.
-
(1999)
Nat Genet
, vol.21
, Issue.1
, pp. 99-102
-
-
Shayesteh, L.1
Lu, Y.2
Kuo, W.L.3
Baldocchi, R.4
Godfrey, T.5
Collins, C.6
Pinkel, D.7
Powell, B.8
Mills, G.B.9
Gray, J.W.10
-
26
-
-
33745242315
-
Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus
-
Del Bufalo D, Ciuffreda L, Trisciuoglio D, Desideri M, Cognetti F, Zupi G and Milella M. Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus. Cancer Res. 2006; 66(11):5549-5554.
-
(2006)
Cancer Res
, vol.66
, Issue.11
, pp. 5549-5554
-
-
Del Bufalo, D.1
Ciuffreda, L.2
Trisciuoglio, D.3
Desideri, M.4
Cognetti, F.5
Zupi, G.6
Milella, M.7
-
27
-
-
36849056497
-
Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer
-
Cannistra SA, Matulonis UA, Penson RT, Hambleton J, Dupont J, Mackey H, Douglas J, Burger RA, Armstrong D, Wenham R and McGuire W. Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer. J Clin Oncol. 2007; 25(33):5180- 5186.
-
(2007)
J Clin Oncol
, vol.25
, Issue.33
, pp. 5180-5186
-
-
Cannistra, S.A.1
Matulonis, U.A.2
Penson, R.T.3
Hambleton, J.4
Dupont, J.5
Mackey, H.6
Douglas, J.7
Burger, R.A.8
Armstrong, D.9
Wenham, R.10
McGuire, W.11
-
28
-
-
85039621806
-
Phase II Study of Temsirolimus in Women With Recurrent or Metastatic Endometrial Cancer: A Trial of the NCIC Clinical Trials Group
-
Oza AM, Elit L, Tsao MS, Kamel-Reid S, Biagi J, Provencher DM, Gotlieb WH, Hoskins PJ, Ghatage P, Tonkin KS, Mackay HJ, Mazurka J, Sederias J, Ivy P, Dancey JE and Eisenhauer EA. Phase II Study of Temsirolimus in Women With Recurrent or Metastatic Endometrial Cancer: A Trial of the NCIC Clinical Trials Group. J Clin Oncol.
-
J Clin Oncol.
-
-
Oza, A.M.1
Elit, L.2
Tsao, M.S.3
Kamel-Reid, S.4
Biagi, J.5
Provencher, D.M.6
Gotlieb, W.H.7
Hoskins, P.J.8
Ghatage, P.9
Tonkin, K.S.10
Mackay, H.J.11
Mazurka, J.12
Sederias, J.13
Ivy, P.14
Dancey, J.E.15
Eisenhauer, E.A.16
-
29
-
-
84899024525
-
An Innovative Phase I Trial Design Allowing for the Identification of Multiple Potential Maximum Tolerated Doses with Combination Therapy of Targeted Agents
-
Paper 72
-
Piha-Paul S. "An Innovative Phase I Trial Design Allowing for the Identification of Multiple Potential Maximum Tolerated Doses with Combination Therapy of Targeted Agents" (2010). UT GSBS Dissertations and Theses. Paper 72. http://digitalcommons.library.tmc.edu/utgsbs_ dissertations/72.
-
(2010)
UT GSBS Dissertations and Theses
-
-
Piha-Paul, S.1
-
30
-
-
84899534704
-
Cancer Therapy Evaluation Program CTCfAE
-
Version 3.0, DCTD, NCI, NIH, DHHS March 31.Publish Date: August 9, 2006.
-
Cancer Therapy Evaluation Program CTCfAE, Version 3.0, DCTD, NCI, NIH, DHHS March 31, 2003 (http://ctep.cancer.gov), Publish Date: August 9, 2006.
-
(2003)
-
-
-
31
-
-
57849117384
-
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)
-
Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, Rubinstein L, Shankar L, Dodd L, Kaplan R, Lacombe D and Verweij J. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009; 45(2):228-247.
-
(2009)
Eur J Cancer
, vol.45
, Issue.2
, pp. 228-247
-
-
Eisenhauer, E.A.1
Therasse, P.2
Bogaerts, J.3
Schwartz, L.H.4
Sargent, D.5
Ford, R.6
Dancey, J.7
Arbuck, S.8
Gwyther, S.9
Mooney, M.10
Rubinstein, L.11
Shankar, L.12
Dodd, L.13
Kaplan, R.14
Lacombe, D.15
Verweij, J.16
-
32
-
-
34249030871
-
We should desist using RECIST, at least in GIST
-
Benjamin RS, Choi H, Macapinlac HA, Burgess MA, Patel SR, Chen LL, Podoloff DA and Charnsangavej C. We should desist using RECIST, at least in GIST. J Clin Oncol. 2007; 25(13):1760-1764.
-
(2007)
J Clin Oncol
, vol.25
, Issue.13
, pp. 1760-1764
-
-
Benjamin, R.S.1
Choi, H.2
Macapinlac, H.A.3
Burgess, M.A.4
Patel, S.R.5
Chen, L.L.6
Podoloff, D.A.7
Charnsangavej, C.8
-
33
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B and Velculescu VE. High frequency of mutations of the PIK3CA gene in human cancers. Science. 2004; 304(5670):554.
-
(2004)
Science
, vol.304
, Issue.5670
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Yan, H.7
Gazdar, A.8
Powell, S.M.9
Riggins, G.J.10
Willson, J.K.11
Markowitz, S.12
Kinzler, K.W.13
Vogelstein, B.14
Velculescu, V.E.15
-
34
-
-
68249089660
-
Application of COLD-PCR for improved detection of KRAS mutations in clinical samples
-
Zuo Z, Chen SS, Chandra PK, Galbincea JM, Soape M, Doan S, Barkoh BA, Koeppen H, Medeiros LJ and Luthra R. Application of COLD-PCR for improved detection of KRAS mutations in clinical samples. Mod Pathol. 2009; 22(8):1023-1031.
-
(2009)
Mod Pathol
, vol.22
, Issue.8
, pp. 1023-1031
-
-
Zuo, Z.1
Chen, S.S.2
Chandra, P.K.3
Galbincea, J.M.4
Soape, M.5
Doan, S.6
Barkoh, B.A.7
Koeppen, H.8
Medeiros, L.J.9
Luthra, R.10
-
35
-
-
33745888913
-
PTEN function in normal and neoplastic growth
-
Chow LM and Baker SJ. PTEN function in normal and neoplastic growth. Cancer Lett. 2006; 241(2):184-196.
-
(2006)
Cancer Lett
, vol.241
, Issue.2
, pp. 184-196
-
-
Chow, L.M.1
Baker, S.J.2
-
36
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman JA, Luo J and Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 2006; 7(8):606-619.
-
(2006)
Nat Rev Genet
, vol.7
, Issue.8
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
37
-
-
80054111295
-
PTEN protein loss by immunostaining: analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients
-
Lotan TL, Gurel B, Sutcliffe S, Esopi D, Liu W, Xu J, Hicks JL, Park BH, Humphreys E, Partin AW, Han M, Netto GJ, Isaacs WB and De Marzo AM. PTEN protein loss by immunostaining: analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients. Clin Cancer Res. 17(20):6563-6573.
-
Clin Cancer Res
, vol.17
, Issue.20
, pp. 6563-6573
-
-
Lotan, T.L.1
Gurel, B.2
Sutcliffe, S.3
Esopi, D.4
Liu, W.5
Xu, J.6
Hicks, J.L.7
Park, B.H.8
Humphreys, E.9
Partin, A.W.10
Han, M.11
Netto, G.J.12
Isaacs, W.B.13
De Marzo, A.M.14
-
38
-
-
0032577699
-
The tumor suppressor, PTEN/ MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T and Dixon JE. The tumor suppressor, PTEN/ MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem. 1998; 273(22):13375-13378.
-
(1998)
J Biol Chem
, vol.273
, Issue.22
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
39
-
-
80455173410
-
A phase I trial of liposomal Doxorubicin, bevacizumab, and temsirolimus in patients with advanced gynecologic and breast malignancies
-
Moroney JW, Schlumbrecht MP, Helgason T, Coleman RL, Moulder S, Naing A, Bodurka DC, Janku F, Hong DS and Kurzrock R. A phase I trial of liposomal Doxorubicin, bevacizumab, and temsirolimus in patients with advanced gynecologic and breast malignancies. Clin Cancer Res. 17(21):6840-6846.
-
Clin Cancer Res.
, vol.17
, Issue.21
, pp. 6840-6846
-
-
Moroney, J.W.1
Schlumbrecht, M.P.2
Helgason, T.3
Coleman, R.L.4
Moulder, S.5
Naing, A.6
Bodurka, D.C.7
Janku, F.8
Hong, D.S.9
Kurzrock, R.10
-
40
-
-
67749122122
-
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
-
Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer. 2009; 9(8):550-562.
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.8
, pp. 550-562
-
-
Engelman, J.A.1
-
41
-
-
0142227019
-
Targeting the PI3KAkt pathway in human cancer: rationale and promise
-
Luo J, Manning BD and Cantley LC. Targeting the PI3KAkt pathway in human cancer: rationale and promise. Cancer Cell. 2003; 4(4):257-262.
-
(2003)
Cancer Cell
, vol.4
, Issue.4
, pp. 257-262
-
-
Luo, J.1
Manning, B.D.2
Cantley, L.C.3
-
42
-
-
85039627326
-
Catalogue of Somatic Mutations in Cancer
-
Catalogue of Somatic Mutations in Cancer. Wellcome Trust Sanger Institute. http://cancer.sanger.ac.uk/cancergenome/ projects/cosmic/
-
Wellcome Trust Sanger Institute
-
-
-
43
-
-
0032431032
-
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
-
Wu X, Senechal K, Neshat MS, Whang YE and Sawyers CL. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci U S A. 1998; 95(26):15587-15591.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, Issue.26
, pp. 15587-15591
-
-
Wu, X.1
Senechal, K.2
Neshat, M.S.3
Whang, Y.E.4
Sawyers, C.L.5
-
44
-
-
79952690921
-
PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors
-
Janku F, Tsimberidou AM, Garrido-Laguna I, Wang X, Luthra R, Hong DS, Naing A, Falchook GS, Moroney JW, Piha-Paul SA, Wheler JJ, Moulder SL, Fu S and Kurzrock R. PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors. Mol Cancer Ther. 10(3):558-565.
-
Mol Cancer Ther.
, vol.10
, Issue.3
, pp. 558-565
-
-
Janku, F.1
Tsimberidou, A.M.2
Garrido-Laguna, I.3
Wang, X.4
Luthra, R.5
Hong, D.S.6
Naing, A.7
Falchook, G.S.8
Moroney, J.W.9
Piha-Paul, S.A.10
Wheler, J.J.11
Moulder, S.L.12
Fu, S.13
Kurzrock, R.14
-
45
-
-
85039609250
-
PI3K/AKT/mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies Harboring PIK3CA Mutations
-
Janku F, Wheler JJ, Westin SN, Moulder SL, Naing A, Tsimberidou AM, Fu S, Falchook GS, Hong DS, Garrido- Laguna I, Luthra R, Lee JJ, Lu KH and Kurzrock R. PI3K/AKT/mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies Harboring PIK3CA Mutations. J Clin Oncol.
-
J Clin Oncol.
-
-
Janku, F.1
Wheler, J.J.2
Westin, S.N.3
Moulder, S.L.4
Naing, A.5
Tsimberidou, A.M.6
Fu, S.7
Falchook, G.S.8
Hong, D.S.9
Garrido-Laguna, I.10
Luthra, R.11
Lee, J.J.12
Lu, K.H.13
Kurzrock, R.14
-
46
-
-
53849132331
-
A novel AKT3 mutation in melanoma tumours and cell lines
-
Davies MA, Stemke-Hale K, Tellez C, Calderone TL, Deng W, Prieto VG, Lazar AJ, Gershenwald JE and Mills GB. A novel AKT3 mutation in melanoma tumours and cell lines. Br J Cancer. 2008; 99(8):1265-1268.
-
(2008)
Br J Cancer
, vol.99
, Issue.8
, pp. 1265-1268
-
-
Davies, M.A.1
Stemke-Hale, K.2
Tellez, C.3
Calderone, T.L.4
Deng, W.5
Prieto, V.G.6
Lazar, A.J.7
Gershenwald, J.E.8
Mills, G.B.9
-
47
-
-
77952243626
-
Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer
-
Sato T, Nakashima A, Guo L, Coffman K and Tamanoi F. Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer. Oncogene. 29(18):2746-2752.
-
Oncogene
, vol.29
, Issue.18
, pp. 2746-2752
-
-
Sato, T.1
Nakashima, A.2
Guo, L.3
Coffman, K.4
Tamanoi, F.5
-
48
-
-
33847651745
-
Point mutations in TOR confer Rhebindependent growth in fission yeast and nutrientindependent mammalian TOR signaling in mammalian cells
-
Urano J, Sato T, Matsuo T, Otsubo Y, Yamamoto M and Tamanoi F. Point mutations in TOR confer Rhebindependent growth in fission yeast and nutrientindependent mammalian TOR signaling in mammalian cells. Proc Natl Acad Sci U S A. 2007; 104(9):3514-3519.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.9
, pp. 3514-3519
-
-
Urano, J.1
Sato, T.2
Matsuo, T.3
Otsubo, Y.4
Yamamoto, M.5
Tamanoi, F.6
-
49
-
-
0030761409
-
Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
-
Tashiro H, Blazes MS, Wu R, Cho KR, Bose S, Wang SI, Li J, Parsons R and Ellenson LH. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res. 1997; 57(18):3935-3940.
-
(1997)
Cancer Res
, vol.57
, Issue.18
, pp. 3935-3940
-
-
Tashiro, H.1
Blazes, M.S.2
Wu, R.3
Cho, K.R.4
Bose, S.5
Wang, S.I.6
Li, J.7
Parsons, R.8
Ellenson, L.H.9
-
50
-
-
80053047138
-
Salivary duct carcinoma: targeting the phosphatidylinositol 3-kinase pathway by blocking mammalian target of rapamycin with temsirolimus
-
Piha-Paul SA, Cohen PR and Kurzrock R. Salivary duct carcinoma: targeting the phosphatidylinositol 3-kinase pathway by blocking mammalian target of rapamycin with temsirolimus. J Clin Oncol. 29(26):e727-730.
-
J Clin Oncol
, vol.29
, Issue.26
-
-
Piha-Paul, S.A.1
Cohen, P.R.2
Kurzrock, R.3
-
51
-
-
79955045309
-
Response of lymphangioleiomyomatosis to a mammalian target of rapamycin inhibitor (temsirolimus) -based treatment
-
Piha-Paul SA, Hong DS and Kurzrock R. Response of lymphangioleiomyomatosis to a mammalian target of rapamycin inhibitor (temsirolimus) -based treatment. J Clin Oncol. 29(12):e333-335.
-
J Clin Oncol.
, vol.29
, Issue.12
-
-
Piha-Paul, S.A.1
Hong, D.S.2
Kurzrock, R.3
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