High-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity

Chemical Biology and Drug Design

Volumn 83, Issue 4, 2014, Pages 440-449

  Walter, Gladis M ^a,b   Raveh, Avi ^a,b   Mok, Sue Ann ^c   McQuade, Thomas J ^b   Arevang, Carl J ^a,b   Schultz, Pamela J ^a,b   Smith, Matthew C ^a,b   Asare, Samuel ^d   Cruz, Patricia G ^a,b   Wisen, Susanne ^a,b   Matainaho, Teatulohi ^e   Sherman, David H ^a,b   Gestwicki, Jason E ^a,b,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^e UNIVERSITY OF PAPUA NEW GUINEA   (Papua New Guinea)

Author keywords

heat shock protein 70; high throughput screening; Huntington's disease; molecular chaperones

Indexed keywords

BETA GALACTOSIDASE; CHAPERONE; CYAN FLUORESCENT PROTEIN; DACTINOMYCIN; GALACTOSE; HEAT SHOCK PROTEIN 104; HEAT SHOCK PROTEIN 26; HEAT SHOCK PROTEIN 70; HUNTINGTIN; NATURAL PRODUCT; NATURAL PRODUCT EXTRACT; POLYGLUTAMINE; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; PEPTIDE;

ARTICLE; BIOASSAY; BIOASSAY GUIDED FRACTIONATION; CELL STRESS; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; FRACTIONATION; FUNGAL STRAIN; FUNGUS GROWTH; HEAT SHOCK RESPONSE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUNTINGTON CHOREA; IMMUNOPRECIPITATION; LIQUID CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEOTOXICITY; SACCHAROMYCES CEREVISIAE; TOXICITY; WESTERN BLOTTING; YEAST CELL; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; PC12 CELL LINE; PROTEIN AGGREGATION, PATHOLOGICAL; RAT;

ANIMALS; BIOLOGICAL PRODUCTS; DACTINOMYCIN; GENE EXPRESSION REGULATION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, BIOLOGICAL; PC12 CELLS; PEPTIDES; PROTEIN AGGREGATION, PATHOLOGICAL; RATS; SACCHAROMYCES CEREVISIAE;

EID: 84899005317     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12259     Document Type: Article

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