Titration-based screening for evaluation of natural product extracts: Identification of an Aspulvinone family of luciferase inhibitors

Chemistry and Biology

Volumn 18, Issue 11, 2011, Pages 1442-1452

  Cruz, Patricia G ^a,g   Auld, Douglas S ^c,h   Schultz, Pamela J ^a   Lovell, Scott ^d   Battaile, Kevin P ^e   MacArthur, Ryan ^c   Shen, Min ^c   Tamayo Castillo, Giselle ^f   Inglese, James ^c   Sherman, David H ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF KANSAS   (United States)

^e ARGONNE NATIONAL LABORATORY   (United States)

^f UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^g PHARMAMAR S A   (Spain)

^h NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; LACTONE; LUCIFERASE;

ARTICLE; ASPERGILLUS; BINDING SITE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; HIGH THROUGHPUT SCREENING; ISOLATION AND PURIFICATION; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN DATABASE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ASPERGILLUS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; ENZYME ACTIVATION; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; LACTONES; LUCIFERASES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; PROTEIN STRUCTURE, TERTIARY;

EID: 82255181177     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2011.08.011     Document Type: Article

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