Studies on the synthesis, in vitro antitumor activity of 4H-benzo[h]chromene, 7H-benzo[h]chromene[2,3-d]pyrimidine derivatives and structure-Activity relationships of the 2-,3- and 2,3-positions

Medicinal Chemistry Research

Volumn 23, Issue 6, 2014, Pages 3187-3199

  El Agrody, Ahmed M ^a,b   Fouda, Ahmed M ^b   Al Dies, Al Anood M ^b  

^a Al Azhar University   (Egypt)

^b KING KHALID UNIVERSITY   (Saudi Arabia)

Author keywords

4 Methoxy 1 naphthol; 4H Benzo h chromenes; 7H Benzo h chromeno 2 3 d pyrimidines; Antitumor; SAR; Cyanocinnamonitriles

Indexed keywords

2 AMINO 4 (4 CHLOROPHENYL) 6 METHOXY 4H BENZO[H]CHROMENE 3 CARBONITRILE; 2 AMINOMETHYLENEAMINO 4 (4 CHLOROPHENYL) 6 METHOXY 4H BENZO[H]CHROMENE 3 CARBONITRILE; 2 BENZYLIDENEAMINO 4 (4 CHLOROPHENYL) 6 METHOXY 4H BENZO[H]CHROMENE 3 CARBONITRILE; 2 DIACETYLAMINO 4 (4 CHLOROPHENYL) 6 METHOXY 4H BENZO[H]CHROMENE 3 CARBONITRILE; 2 METHYLAMINOMETHYLENEAMINO 4 (4 CHLOROPHENYL) 6 METHOXY 4H BENZO[H]CHROMENE 3 CARBONITRILE; 4 (4 CHLOROPHENYL) 2 DIMETHYLAMINOMETHYLENEAMINO 6 METHOXY 4H BENZO[H]CHROMENE 3 CARBONITRILE; 4 (4 CHLOROPHENYL) 2 ETHOXYMETHYLENEAMINO 6 METHOXY 4H BENZO[H]CHROMENE 3 CARBONITRILE; 4H BENZO[H]CHROMENE; 7 (4 CHLOROPHENYL) 5 METHOXY 7H,9H BENZO[H]CHROMENO[2,3 D]PYRIMIDIN 8 ONE; 7H BENZO[H]CHROMENE[2,3 D ]PYRIMIDINE DERIVATIVE; 8 AMINO 7 (4 CHLOROPHENYL) 5 METHOXY 7H BENZO[H]CHROMENO[2,3 D]PYRIMIDINE; 9 AMINE 7 (4 CHLOROPHENYL) 5 METHOXY 8 IMINO 7H BENZO[H]CHROMENO[2,3 D]PYRIMIDINE; 9 BENZYLIDENEAMINO 7 (4 CHLOROPHENYL) 5 METHOXY 8 IMINO 7H BENZO[H]CHROMENO[2,3-D]PYRIMIDINE; CHROMENE DERIVATIVE; COLCHICINE; CYTOTOXIC AGENT; DOXORUBICIN; ETHYL 2 AMINO 4 (4 CHLOROPHENYL) 6 METHOXY 4H BENZO[H]CHROMENE 3 CARBOXYALTE; ETHYL 4 (4 CHLOROPHENYL) 2 DIMETHYLAMINOMETHYLENEAMINO 6 METHOXY 4H BENZO[H]CHROMENE 3 CARBOXYLATE; ETHYL 4 (4 CHLOROPHENYL) 2 FORMAMIDO 6 METHOXY 4H BENZO[H]CHROMENE 3 CARBOXYLATE; FUNCTIONAL GROUP; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; VINBLASTINE;

ANALYTIC METHOD; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN HCT; CELL STRAIN HEPG2; CELL STRAIN MCF 7; CHEMICAL MODIFICATION; COLORIMETRY; CONTROLLED STUDY; DISTORTIONLESS ENHANCEMENT BY POLARIZATION TRANSFER; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; LIPOPHILICITY; MTT ASSAY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

EID: 84898877282     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-013-0904-x     Document Type: Article

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