Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 3. Structure-activity relationships of fused rings at the 7,8-positions

Journal of Medicinal Chemistry

Volumn 50, Issue 12, 2007, Pages 2858-2864

  Kemnitzer, William ^a   Drewe, John ^a   Jiang, Songchun ^a   Zhang, Hong ^a   Zhao, Jianghong ^a   Crogan Grundy, Candace ^a   Xu, Lifen ^a   Lamothe, Serge ^b   Gourdeau, Henriette ^b   Denis, Réal ^b   Tseng, Ben ^a   Kasibhatla, Shailaja ^a   Sui, Xiong Cai ^a  

^a EpiCept Corporation   (United States)

^b Shire Canada   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 CYANO 4 (3 CYANOPHENYL) 4,7 DIHYDROPYRANO[2,3 E]INDOLE; 2 AMINO 3 CYANO 4 (3 CYANOPHENYL) 4,9 DIHYDROPYRANO[3,2 G]INDOLE; 2 AMINO 3 CYANO 4 (3 IODO 4,5 DIMETHOXYPHENYL) 4H NAPHTHO[1,2 B]PYRAN; 2 AMINO 3 CYANO 4 (3 IODO 4,5 DIMETHOXYPHENYL) 4H PYRANO[2,3 F]ISOQUINOLINE; 2 AMINO 3 CYANO 4 (3,4,5 TRIMETHOXYPHENYL) 4H NAPHTHO[1,2 B]PYRAN; 2 AMINO 3 CYANO 4 (3,4,5 TRIMETHOXYPHENYL) 4H PYRANO[2,3 F]ISOQUINOLINE; 2 AMINO 3 CYANO 4 (5 METHYL 3 PYRIDYL) 4H PYRANO[2,3 F]ISOQUINOLINE; 2 AMINO 3 CYANO 4,7 DIHYDRO 4 (3 METHOXYPHENYL)PYRANO[2,3 E]INDOLE; 2 AMINO 3 CYANO 4,7 DIHYDRO 4 (3 NITROPHENYL)PYRANO[2,3 E]INDOLE; 2 AMINO 3 CYANO 4,7 DIHYDRO 4 (3 PYRIDYL)PYRANO[2,3 E]INDOLE; 2 AMINO 3 CYANO 4,7 DIHYDRO 4 (3,4,5 TRIMETHOXYPHENYL)PYRANO[2,3 E]INDOLE; 2 AMINO 3 CYANO 4,7 DIHYDRO 4 (3,5 DIMETHOXYPHENYL)PYRANO[2,3 E]INDOLE; 2 AMINO 3 CYANO 4,7 DIHYDRO 4 (5 METHOXY 3 PYRIDYL)PYRANO[2,3 E]INDOLE; 2 AMINO 3 CYANO 4,7 DIHYDRO 4 (5 METHYL 3 PYRIDYL)PYRANO[2,3 E]INDOLE; 2 AMINO 3 CYANO 4,7 DIHYDRO 4 PHENYLPYRANO[2,3 E]INDOLE; 2 AMINO 3 CYANO 4,9 DIHYDRO 4 (3 METHOXYPHENYL)PYRANO[3,2 G]INDOLE; 2 AMINO 3 CYANO 4,9 DIHYDRO 4 (3,4,5 TRIMETHOXYPHENYL)PYRANO[3,2 G]INDOLE; 2 AMINO 4 (3 BROMO 4 HYDROXY 5 METHOXYPHENYL) 3 CYANO 4,7 DIHYDROPYRANO[2,3 E]INDOLE; 2 AMINO 4 (3 BROMO 4 HYDROXY 5 METHOXYPHENYL) 3 CYANO 4,9 DIHYDROPYRANO[3,2 G]INDOLE; 2 AMINO 4 (3 BROMO 4,5 DIMETHOXYPHENYL) 3 CYANO 4,7 DIHYDROPYRANO[2,3 E]INDOLE; 2 AMINO 4 (3 BROMO 4,5 DIMETHOXYPHENYL) 3 CYANO 4,7 DIHYRO 8 METHYLPYRANO[2,3 E]INDOLE; 2 AMINO 4 (3 BROMO 4,5 DIMETHOXYPHENYL) 3 CYANO 4,9 DIHYDROPYRANO[3,2 G]INDOLE; 2 AMINO 4 (3 BROMO 4,5 DIMETHOXYPHENYL) 3 CYANO 4H NAPHTHO[1,2 B]PYRAN; 2 AMINO 4 (3 BROMO 4,5 DIMETHOXYPHENYL) 3 CYANO 4H PYRANO[2,3 F]ISOQUINOLINE; 2 AMINO 4 (3 BROMO 4,5 DIMETHOXYPHENYL) 3 CYANO 4H PYRANO[2,3 F]QUINOLINE; 2 AMINO 4 (3 BROMO 4,5 DIMETHOXYPHENYL) 3 CYANO 4H PYRANO[3,2 H]QUINOLINE; 2 AMINO 4 (3 BROMO 4,5 DIMETHOXYPHENYL) 3 CYANO 7,8,9,1O TETRAHYDRO 4H NAPHTHO[1,2 B]PYRAN; CHROMENE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOPYRANS; CASPASES; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; INDOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34250904254     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070216c     Document Type: Article

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