Analgesic, anti-pyretic and DNA cleavage studies of novel pyrimidine derivatives of coumarin moiety

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2597-2605

  Keri, Rangappa S ^a   Hosamani, Kallappa M ^a   Shingalapur, Ramya V ^a   Hugar, Mallinath H ^a  

^a KARNATAK UNIVERSITY   (India)

Author keywords

Analgesic; Anti pyretic; Coumarin; DNA cleavage; Pyrimidine

Indexed keywords

1 [4 (2 AMINO 6 PHENYL PYRIMIDIN 4 YL)PHENOXYMETHYL]BENZO[F]CHROMEN 3 ONE; 1 [4 (2 HYDROXY 6 PHENYL PYRIMIDIN 4 YL)PHENOXYMETHYL]BENZO[F]CHROMEN 3 ONE; 1 [4 (2 MERCAPTO 6 PHENYL PYRIMIDIN 4 YL)PHENOXYMETHYL] BENZO[F]CHROMEN 3 ONE; 4 [4 (2 AMINO 6 PHENYL PYRIMIDIN 4 YL)PHENOXYMETHYL] 6 CHLORO CHROMEN 2 ONE; 4 [4 (2 AMINO 6 PHENYL PYRIMIDIN 4 YL)PHENOXYMETHYL] 6 METHYL CHROMEN 2 ONE; 4 [4 (2 AMINO 6 PHENYL PYRIMIDIN 4 YL)PHENOXYMETHYL] 7 METHYL CHROMEN 2 ONE; 4 [4 (2 AMINO 6 PHENYL PYRIMIDIN 4 YL)PHENOXYMETHYL]BENZO[H]CHROMEN 2 ONE; 4 [4 (2 HYDROXY 6 PHENYL PYRIMIDIN 4 YL) PHENOXYMETHYL] 6 METHYL CHROMEN 2 ONE; 4 [4 (2 HYDROXY 6 PHENYL PYRIMIDIN 4 YL) PHENOXYMETHYL] 7 METHYL CHROMEN 2 ONE; 4 [4 (2 HYDROXY 6 PHENYL PYRIMIDIN 4 YL) PHENOXYMETHYL]BENZO[H]CHROMEN 2 ONE; 4 [4 (2 MERCAPTO 6 PHENYL PYRIMIDIN 4 YL)PHENOXYMETHYL] 6 METHYL CHROMEN 2 ONE; 4 [4 (2 MERCAPTO 6 PHENYL PYRIMIDIN 4 YL)PHENOXYMETHYL] 7 METHYL CHROMEN 2 ONE; 4 [4 (2 MERCAPTO 6 PHENYL PYRIMIDIN 4 YL)PHENOXYMETHYL]BENZO[H]CHROMEN 2 ONE; 6 CHLORO 4 [4 (2 HYDROXY 6 PHENYL PYRIMIDIN 4 YL)PHENOXYMETHYL]CHROMEN 2 ONE; 6 CHLORO 4 [4 (2 MERCAPTO 6 PHENYL PYRIMIDIN 4 YL)PHENOXYMETHYL CHROMEN 2 ONE; ACETYLSALICYLIC ACID; COUMARIN; DIPYRONE; HYDROXYL GROUP; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIPYRETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; DRUG SCREENING; DRUG SYNTHESIS; FEVER; IN VIVO STUDY; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TAIL FLICK TEST; YEAST;

ANALGESICS; ANALGESICS, NON-NARCOTIC; ANIMALS; COUMARINS; DNA; DRUG EVALUATION, PRECLINICAL; ELECTROPHORESIS; FEMALE; MALE; MICE; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77950860382     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.048     Document Type: Article

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