Antileishmanial activity of indole alkaloids from Aspidosperma ramiflorum

Phytomedicine

Volumn 14, Issue 6, 2007, Pages 377-380

  Tanaka, J C A ^a   da Silva, C C ^a   Ferreira, I C P ^a   Machado, G M C ^b   Leon, L L ^b   de Oliveira, A J B ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Antileishmanial activity; Aspidosperma ramiflorum; Leishmania amazonensis; Monoterpenoid indole alkaloids; Ramiflorines A and B

Indexed keywords

10 METHOXYGEISSOSCHIZOLINE; ACID; ALCOHOL; ANTILEISHMANIAL AGENT; ASPIDOSPERMA RAMIFLORUM EXTRACT; BASE; CAMPTOTHECIN; INDOLE ALKALOID; MONOTERPENOID INDOLE ALKALOID; PLANT EXTRACT; RAMIFLORINE A; RAMIFLORINE B; SILICA GEL; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; ASPIDOSPERMA; ASPIDOSPERMA RAMIFLORUM; BIOASSAY; COLUMN CHROMATOGRAPHY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; FRACTIONATION; GRAM POSITIVE BACTERIUM; LD 50; LEISHMANIA; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL; PROMASTIGOTE;

ANIMALS; ANTIPROTOZOAL AGENTS; ASPIDOSPERMA; INDOLE ALKALOIDS; LEISHMANIA; MOLECULAR CONFORMATION; PHYTOTHERAPY; PLANT BARK; PLANT STEMS;

ASPIDOSPERMA RAMIFLORUM; LEISHMANIA AMAZONENSIS; POSIBACTERIA;

EID: 34249284800     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2006.09.002     Document Type: Article

References (15)

1. Angenot L., Quentin-Leclercq J., Phillipson D.J., Warhurst D.C., O'Neill M.J., Bray D.H., and Wright C.W. Antiamoebic and antiplasmodial activities of alkaloids isolated from Strychnos usambarensis. Planta Med. 57 (1991) 337-340
2. Barata L.E.S., Santos L.S., Ferri P.H., Phillipson J.D., Paine A., and Croft S.L. Anti-leishmanial activity of neolignans from Virola species and synthetic analogues. Phytochemistry 55 (2000) 589-595
3. Bonjean K., De Pauw-Gellet M.C., Defresne M.P., Colson P., Houssier C., Dassonneville L., Bailly C., Greimers R., Wright C., Quentin-Leclercq J., Tits M., and Angenot L. The DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells. Biochemistry 37 (1998) 5136-5146
4. Camacho M.D., Mata R., Castaneda P., Kirby G.C., Warhurst D.C., Croft S.L., and Phillipson J.D. Bioactive compounds from Celaenodendron mexicanum. Planta Med. 66 (2000) 463-468
5. Delorenzi J.C., Attias M., Gattass C.R., Andrade M., Rezende C., Pinto A.D., Henriques A.T., Bou-Habib D.C., and Saraiva E.M.B. Antileishmanial activity of an indole alkaloid from Peschiera australis. Antimicrob. Agents Chemother. 45 (2001) 1349-1354
6. Ferreira I.C.P., Leon L.L., Gobbi Filho L., Lonardoni M.V.C., Silveira T.G.V., Machado G.M.C., and Oliveira A.J.B. Antileishmanial activity of alkaloidal extract from Aspidosperma ramiflorum. Mem. Inst. Oswaldo Cruz. 99 (2004) 325-327
7. Frezard F., Michalick M.S.M., Soares C.F., and Demicheli C. Novel methods for encapsulation of meglumine antimoniate into liposomes. Braz. J. Med. Biol. Res. 33 (2000) 841-846
8. Handman E. Leishmaniasis - current status of vaccine development. Clin. Microb. Rev. 14 (2001) 229-241
9. Kayser O., Kiderlen A.F., Laatsch H., and Croft S.L. In vitro leishmanicidal activity of monomeric and dimeric naphtoquinones. Acta Tropica 76 (2000) 131-138
10. Lorenzi H. Árvores Brasileiras, Plantarum, Nova Odessa (1992), São Paulo, Brasil pp. 21-26
11. Murray H.W. Clinical and experimental advances in treatment of visceral leishmaniases. Antimicrob. Agents Chemother. 45 (2001) 2185-2197
12. Reis F.A.M., Marques M.F.S., Filho H.L.F., and Kato L. Indole alkaloids from Aspidosperma ramiflorum. Phytochemistry 41 (1996) 963-967
13. Sauvain M., Kunesch N., Poisson J., Gantier J.C., Gayral P., and Dedet J.P. Isolation of leishmanicidal triterpenes and lignans from Amazonian liana Doliocorpus dentatus (Dilleniaceae). Phytother. Res. 10 (1996) 1-4
14. Torres-Santos E.C., Moreira D.L., Kaplan M.A.C., Meirelles M.N., and Rossi-Bergmann B. Selective effect of 2′,6′-di-hydroxy-4′-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis. Antimicrob. Agents Chemother. 43 (1999) 1234-1241
15. WHO/TDR, 1997. Tropical Diseases Research - Leishmaniasis Fourteen Programme Report, pp. 101-111.