Effects of DK-002, a synthesized (6aS,cis)-9,10-Dimethoxy-7,11b-dihydro- indeno[2,1-c]chromene-3,6a-diol, on platelet activity

Life Sciences

Volumn 78, Issue 10, 2006, Pages 1091-1097

  Lee, Ki Seon ^a   Khil, Lee Yong ^a   Chae, Sang Ho ^a   Kim, Deukjoon ^a   Lee, Byung Hoon ^a   Hwang, Gwi Seo ^b   Moon, Chang Hyun ^c   Chang, Tong Shin ^d   Moon, Chang Kiu ^a  

^a Seoul National University   (South Korea)

^b Gachon University   (South Korea)

^c Ajou University School of Medicine   (South Korea)

^d Ewha Womans University   (South Korea)

Author keywords

Antiplatelet agent; Brazilin derivative; Calcium mobilization; Platelet aggregation

Indexed keywords

9,10 DIMETHOXY 7, 11B DIHYDRO INDENO[2,1-C]CHROMENE 3,6A DIOL; ANTITHROMBOCYTIC AGENT; CALCIUM; COLLAGEN; DK 002; PROSTAGLANDIN E1; THROMBIN; THROMBOXANE A2; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL STIMULATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG INHIBITION; DRUG SYNTHESIS; ENZYME ACTIVITY; FATTY ACID SYNTHESIS; IC 50; NONHUMAN; RAT; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION;

ADENOSINE DIPHOSPHATE; ANIMALS; BENZOPYRANS; BLOOD PLATELETS; CALCIUM; CREATINE KINASE; CYCLIC AMP; CYCLOOXYGENASE INHIBITORS; CYTOPLASMIC GRANULES; INDENES; INDOMETHACIN; IONOPHORES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; THROMBIN; THROMBOXANE B2;

EID: 31344477940     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.06.017     Document Type: Article

References (33)

1. D.L. Bhatt, and E.J. Topol Scientific and therapeutic advances in antiplatelet therapy Nature Reviews Drug Discovery 2 2003 15 28
2. R.A. Blake, G.L. Schieven, and S.P. Watson Collagen stimulates tyrosine phosphorylation of phospholipase C-γ2 but not phospholipase C-γ1 in human platelets FEBS Letters 353 1994 212 216
3. H. Bult, and I.L. Bonta Rat platelets aggregate in the absence of endogenous precursors of prostaglandin endoperoxides Nature 264 1976 449 451
4. 2 receptor blockade by 2-[(4-cyanophenyl)amino]-3-chloro-1,4-naphthalenedione (NQ-Y15) in rat platelets Biochemical Pharmacology 54 1997 259 268
5. K.J. Clemetson, and J.M. Clemetson Platelet collagen receptors Thrombosis and Haemostasis 86 2001 189 197
6. S.R. Coughlin, G.R. Sambrano, E.J. Weiss, Y.W. Zheng, and W. Huang Thrombin signalling and protease-activated receptors - Role of thrombin signalling in platelets in haemostasis and thrombosis Nature 407 2000 258 264
7. M.J. Davies The pathophysiology of acute coronary syndromes Heart 83 2000 361 366
8. G. Defreyn, C. Gachet, P. Savi, F. Driot, J.P. Cazenave, and J.P. Maffrand Ticlopidine and clopidogrel (SR 25990C) selectively neutralize ADP inhibition of PGE1-activated platelet adenylate cyclase in rats and rabbits Thrombosis and Haemostasis 65 1991 186 190
9. W.G. Eisert How to get from antiplatelet to antithrombotic treatment American Journal of Therapeutics 8 2001 443 449
10. J.E. Fabre, M. Nguyen, A. Latour, J.A. Keifer, L.P. Audoly, T.M. Coffman, and B.H. Koller Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice Nature Medicine 5 1999 1199 1202
11. E. Falk, P.K. Shah, and V. Fuster Coronary plaque disruption Circulation 92 1995 657 671
12. 2 as an amplifying signal for other agonists American Journal of Cardiology 68 1991 11B 15B
13. V. Fuster, L. Badimon, J.J. Badimon, J.H. Chesebro, E. Falk, and P.K. Shah The pathogenesis of coronary artery disease and the acute coronary syndromes (1) Coronary plaque disruption New England Journal of Medicine 326 1992 242 250
14. B.S. Gross, S.K. Melford, and S.P. Watson Evidence that phospholipase C-γ2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor γ-chain after stimulation of the collagen receptor glycoprotein VI in human platelets European Journal of Biochemistry 263 1999 612 623
15. 2+ indicators with greatly improved fluorescence properties Journal of Biological Chemistry 260 1985 3440 3450
16. 2+ channels in human platelets Journal of Biological Chemistry 267 1992 17078 17081
17. B. Hechler, C. Leon, C. Vial, P. Vigne, C. Frelin, J.P. Cazenave, and C. Gachet The P2Y1 receptor is necessary for adenosine 5′-diphosphate-induced platelet aggregation Blood 92 1998 152 159
18. H. Hikino, T. Taguchi, H. Fujimura, and Y. Hiramatsu Antiinflammatory principles of Caesalpinia sappan wood and of Haematoxylon campechianum wood Planta Medica 31 1977 214 220
19. G. Hollopeter, H.M. Jantzen, D. Vincent, G. Li, L. England, V. Ramakrishnan, R.B. Yang, P. Nurden, A. Nurden, D. Julius, and P.B. Conley Identification of the platelet ADP receptor targeted by antithrombotic drugs Nature 409 2001 202 207
20. H. Holmsen, C.A. Dangelmaier, and H.K. Holmsen Thrombin-induced platelet responses differ in requirement for receptor occupancy. Evidence for tight coupling of occupancy and compartmentalized phosphatidic acid formation Journal of Biological Chemistry 256 1981 9393 9396
21. 2 activity and changes of intracellular free calcium concentration in rat platelets Archives of Pharmacal Research 21 1998 774 778
22. J. Jin, J.L. Daniel, and S.P. Kunapuli Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets Journal of Biological Chemistry 273 1998 2030 2034
23. C. Leon, B. Hechler, M. Freund, A. Eckly, C. Vial, P. Ohlmann, A. Dierich, M. LeMeur, J.P. Cazenave, and C. Gachet Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice. Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice Journal of Clinical Investigation 104 1999 1731 1737
24. M. Magocsi, B. Sarkadi, T. Kovacs, and G. Gardos Thrombin-induced activation of calcium transport pathways and their role in platelet functions Biochimica et biophysica acta 984 1989 88 96
25. D.M. Monroe, M. Hoffman, and H.R. Roberts Platelets and thrombin generation Arteriosclerosis, Thrombosis, and Vascular Biology 22 2002 1381 1389
26. J.F. Mustard, D.W. Perry, N.G. Ardlie, and M.A. Packham Preparation of suspensions of washed platelets from humans British Journal of Haematology 22 1972 193 204
27. S. Offermanns, C.F. Toombs, Y.-H. Hu, and M.I. Simon Defective platelet activation in G[alpha](q)-deficient mice Nature 389 1997 183 186
28. S.G. Rhee Regulation of phosphoinositide-specific phospholipase C Annual Review of Biochemistry 70 2001 281 312
29. T.J. Rink, and S.O. Sage Calcium signaling in human platelets Annual Review of Physiology 52 1990 431 449
30. R. Ross Atherosclerosis-an inflammatory disease New England Journal of Medicine 340 1999 115 126
31. Z.M. Ruggeri Platelets in atherothrombosis Nature Medicine 8 2002 1227 1234
32. G.R. Sambrano, E.J. Weiss, Y.W. Zheng, W. Huang, and S.R. Coughlin Role of thrombin signalling in platelets in haemostasis and thrombosis Nature 413 2001 74 78
33. Y.-W. Xie, D.-S. Ming, H.-X. Xu, H. Dong, and P.P.-H. But Vasorelaxing effects of Caesalpinia sappan: involvement of endogenous nitric oxide Life Sciences 67 2000 1913 1918