Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group

Journal of Medicinal Chemistry

Volumn 47, Issue 25, 2004, Pages 6299-6310

  Kemnitzer, William ^a   Drewe, John ^a   Jiang, Songchun ^a   Zhang, Hong ^a   Wang, Yan ^a   Zhao, Jianghong ^a   Jia, Shaojuan ^a   Herich, John ^a   Labreque, Denis ^b   Storer, Richard ^b   Meerovitch, Karen ^b   Bouffard, David ^b   Rej, Rabindra ^b   Denis, Real ^b   Blais, Charles ^b   Lamothe, Serge ^b   Attardo, Giorgio ^b   Gourdeau, Henriette ^b   Tseng, Ben ^a   Kasibhatla, Shailaja ^a   Cai, Sui Xiong ^a   more..

^a Maxim Pharmaceuticals Inc   (United States)

^b Shire Canada   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 CYANO 7 (DIMETHYLAMINO) 4 (3 METHOXY 4,5 METHYLENEDIOXYPHENYL) 4H CHROMENE; 2 AMINO 3 CYANO 7 (DIMETHYLAMINO) 4 (5 METHYL 3 PYRIDYL) 4H CHROMENE; 2 AMINO 4 (3 BROMO 4,5 DIMETHOXYPHENYL) 3 CYANO 7 (DIMETHYLAMINO) 4H CHROMENE; ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; CASPASE; CHROMENE; CHROMENE DERIVATIVE; COLCHICINE; GLYCOPROTEIN P; PACLITAXEL; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE PHASE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; FRAGMENTATION REACTION; GENE OVEREXPRESSION; GROWTH INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOPYRANS; BIOPOLYMERS; CASPASES; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; DIOXOLES; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; HUMANS; POLY(ADP-RIBOSE) POLYMERASES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 9744248288     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049640t     Document Type: Article

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