Discovery and synthesis of novel substituted benzocoumarins as orally active lipid modulating agents

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 22, 2011, Pages 6709-6713

  Sashidhara, Koneni V ^a   Kumar, Manoj ^a   Modukuri, Ram K ^a   Srivastava, Anuj ^a   Puri, Anju ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Antidyslipidemic; Benzocoumarin; Statins; Synthesis

Indexed keywords

ANTILIPEMIC AGENT; ATORVASTATIN; BENZOCOUMARIN DERIVATIVE; COUMARIN DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERLIPIDEMIC ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; DYSLIPIDEMIA; HAMSTER; HYPERLIPIDEMIA; LIPID DIET; NONHUMAN; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; BENZENE; CHOLESTEROL; CHOLESTEROL, HDL; COUMARINS; CRICETINAE; HYPERLIPIDEMIAS; HYPOLIPIDEMIC AGENTS; SCHIFF BASES; TRIGLYCERIDES;

CRICETINAE;

EID: 80054755763     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.053     Document Type: Article

References (17)

1. T. Inoue, M. Hayashi, K. Takayanagi, and S. Morooka Artherosclerosis 160 2002 369
2. R. Ross Nature 362 1993 801
3. J.L. Witzum, and D.J. Steinberg Clin. Invest. 88 1991 1785
4. D.J. Graham, J.A. Staffa, D. Shatin, S.E. Andrade, S.D. Schech, L. Grenade, J.H. Gurwitz, K.A. Chan, M.J. Goodman, and R. Platt JAMA 292 2004 2585
5. M. Evans, and A. Rees Curr. Opin. Lipidol. 13 2002 415
6. K.V. Sashidhara, A. Kumar, M. Kumar, R. Sonkar, G. Bhatia, and A.K. Khanna Bioorg. Med. Chem. Lett. 20 2010 4248
7. K.V. Sashidhara, J.N. Rosaiah, A. Kumar, G. Bhatia, and A.K. Khanna Bioorg. Med. Chem. Lett. 20 2010 3065
8. K.V. Sashidhara, A. Kumar, M. Kumar, A. Srivastava, and A. Puri Bioorg. Med. Chem. Lett. 20 2010 6504
9. K.V. Sashidhara, J.N. Rosaiah, G. Bhatia, and J.K. Saxena Eur. J. Med. Chem. 43 2008 2592
10. +.
11. R. Rizvi, A. Puri, G. Bhatia, A.K. Khanna, E.M. Wulf, A.K. Rastogi, and R. Chandra Biochem. Biophys. Res. Commun. 305 2003 215
12. G. Bhatia, F. Rizvi, R. Saxena, A. Puri, A.K. Khanna, R. Chander, E.M. Wulf, R. Chandra, and A.K. Rastogi Indian J. Exp. Biol. 41 2003 1456
13. T.S. Griffin, E.L. Docks, R.J. Brotherton, and I.H. Hall Eur. J. Med. Chem. 26 1991 517
14. D. Chaturvedi, S. Ray, A.K. Srivastava, and R. Chander Bioorg. Med. Chem. 16 2008 2489
15. K.V. Sashidhara, A. Kumar, G. Bhatia, M.M. Khan, A.K. Khanna, and J.K. Saxena Eur. J. Med. Chem. 44 2009 1813
16. R.N. Russel Engl. J. Med. 314 1986 488
17. K.V. Sashidhara, S.P. Singh, A. Srivastava, and A. Puri Nat. Prod. Res. 25 2011 918