The role of pannexin1 in the induction and resolution of inflammation

FEBS Letters

Volumn 588, Issue 8, 2014, Pages 1416-1422

  Adamson, Samantha E ^a   Leitinger, Norbert ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Extracellular ATP; Inflammation; Pannexin 1; Resolution

Indexed keywords

EXTRACELLULAR ATP; INFLAMMATION; PANNEXIN 1; RESOLUTION;

ADAPTIVE IMMUNITY; ANIMALS; CONNEXINS; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; INFLAMMATION; NERVE TISSUE PROTEINS;

EID: 84898847537     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.03.009     Document Type: Conference Paper

References (93)

1. O. Takeuchi, and S. Akira Pattern recognition receptors and inflammation Cell 140 6 2010 805 820 10.1016/j.cell.2010.01.022
2. R. Medzhitov Origin and physiological roles of inflammation Nature 454 7203 2008 428 435 10.1038/nature07201
3. A. Ortega-Gómez, M. Perretti, and O. Soehnlein Resolution of inflammation an integrated view EMBO Mol. Med. 5 5 2013 661 674 10.1002/emmm.201202382 (2013 Epub. Review)
4. J.N. Fullerton, A.J. O'Brien, and D.W. Gilroy Pathways mediating resolution of inflammation: when enough is too much J. Pathol. 231 1 2013 8 20 10.1002/path.4232
5. A.L. Alessandri, L.P. Sousa, C.D. Lucas, A.G. Rossi, V. Pinho, and M.M. Teixeira Resolution of inflammation: mechanisms and opportunity for drug development Pharmacol. Ther. 139 2 2013 189 212 10.1016/j.pharmthera.2013.04.006 (2013 Epub)
6. C. Haslett et al. Granulocyte apoptosis and the control of inflammation Philos. Trans. R. Soc. Lond. B Biol. Sci. 345 1994 327 333 10.1098/rstb.1994. 0113
7. K.S. Ravichandran "Recruitment signals" from apoptotic cells: invitation to a quiet meal Cell 113 7 2003 817 820 (Pubitemid 36792025)
8. I.K. Poon, C.D. Lucas, A.G. Rossi, and K.S. Ravichandran Apoptotic cell clearance: basic biology and therapeutic potential Nat. Rev. Immunol. 14 3 2014 166 180 10.1038/nri3607
9. A. Gombault, L. Baron, and I. Couillin ATP release and purinergic signaling in NLRP3 inflammasome activation Front. Immunol. 3 414 2013 10.3389/fimmu.2012.00414 (2012 eCollection)
10. R. Corriden, and P.A. Insel New insights regarding the regulation of chemotaxis by nucleotides, adenosine, and their receptors Purinergic Signal. 8 3 2012 587 598 10.1007/s11302-012-9311-x (2012 Epub Review)
11. L.M. Hill, M.L. Gavala, L.Y. Lenertz, and P.J. Bertics Extracellular ATP may contribute to tissue repair by rapidly stimulating purinergic receptor X7-dependent vascular endothelial growth factor release from primary human monocytes J. Immunol. 185 5 2010 3028 3034 10.4049/jimmunol.1001298 (2010 Epub)
12. W.G. Junger Immune cell regulation by autocrine purinergic signalling Nat. Rev. Immunol. 11 2011 201 212 10.1038/nri2938
13. T. Chataigneau, D. Lemoine, and T. Grutter Exploring the ATP-binding site of P2X receptors Front. Cell. Neurosci. 7 273 2013 (eCollection 2013)
14. R. Jiang, A. Taly, and T. Grutter Moving through the gate in ATP-activated P2X receptors Trends Biochem. Sci. 38 1 2013 20 29 10.1016/j.tibs.2012.10.006 (2012 Epub)
15. N. Vanlangenakker, T. Vanden Berghe, D.V. Krysko, N. Festjens, and P. Vandenabeele Molecular mechanisms and pathophysiology of necrotic cell death Curr. Mol. Med. 8 3 2008 207 220 (Review) (Pubitemid 351982539)
16. E.R. Lazarowski Vesicular and conductive mechanisms of nucleotide release Purinergic Signal. 8 3 2012 359 373 10.1007/s11302-012-9304-9 (2012 Epub Review)
17. S. Penuela, R. Gehi, and D.W. Laird The biochemistry and function of pannexin channels Biochim. Biophys. Acta 1828 1 2013 15 22 10.1016/j.bbamem. 2012.01.017 (2012 Epub)
18. F.B. Chekeni et al. Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis Nature 467 2010 863 867 10.1038/nature09413
19. M. Billaud et al. Pannexin1 regulates alpha1-adrenergic receptor- mediated vasoconstriction Circ. Res. 109 2011 80 85 10.1161/CIRCRESAHA.110. 237594
20. J.K. Sandilos et al. Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region J. Biol. Chem. 287 2012 11303 11311 10.1074/jbc.M111.323378
21. K.E. Scheckenbach, S. Crespin, B.R. Kwak, and M. Chanson Connexin channel-dependent signaling pathways in inflammation J. Vasc. Res. 48 2 2011 91 103 10.1159/000316942 (2010 Epub)
22. G.E. Sosinsky et al. Pannexin channels are not gap junction hemichannels Channels 5 2011 193 197
23. C. D'Hondt et al. Pannexin channels in ATP release and beyond: an unexpected rendezvous at the endoplasmic reticulum Cell. Signal. 23 2011 305 316 10.1016/j.cellsig.2010.07.018
24. S. Penuela, A.W. Lohman, W. Lai, L. Gyenis, D.W. Litchfield, B.E. Isakson, and D.W. Laird Diverse post-translational modifications of the pannexin family of channel-forming proteins Channels (Austin) 8 2 2014 1 10 (Epub ahead of print)
25. A.W. Lohman et al. S-nitrosylation inhibits pannexin 1 channel function J. Biol. Chem. 287 2012 39602 39612 10.1074/jbc.M112.397976
26. H. Negoro, S.E. Lutz, L.S. Liou, A. Kanematsu, O. Ogawa, E. Scemes, and S.O. Suadicani Pannexin 1 involvement in bladder dysfunction in a multiple sclerosis model Sci. Rep. 3 2013 2152 10.1038/srep02152
27. G. Dahl, F. Qiu, and J. Wang The bizarre pharmacology of the ATP release channel pannexin1 Neuropharmacology 75 2013 583 593 10.1016/j.neuropharm.2013. 02.019 (2013 Epub)
28. J. Wang, D.G. Jackson, and G. Dahl The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1 J. Gen. Physiol. 141 5 2013 649 656 10.1085/jgp.201310966 (2013 Epub)
29. M.C. Kienitz, K. Bender, R. Dermietzel, L. Pott, and G. Zoidl Pannexin 1 constitutes the large conductance cation channel of cardiac myocytes J. Biol. Chem. 286 1 2011 290 298
30. A.R. Pinheiro, D. Paramos-de-Carvalho, M. Certal, M.A. Costa, C. Costa, M.T. Magalhães-Cardoso, F. Ferreirinha, J. Sévigny, and P. Correia-de-Sá Histamine induces ATP release from human subcutaneous fibroblasts, via pannexin-1 hemichannels, leading to Ca2+ mobilization and cell proliferation J. Biol. Chem. 288 38 2013 27571 27583 10.1074/jbc.M113.460865 (2013 Epub)
31. M.A. Timóteo, I. Carneiro, I. Silva, J.B. Noronha-Matos, F. Ferreirinha, M. Silva-Ramos, and P. Correia-de-Sá ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6 receptors Biochem. Pharmacol. 87 2 2014 371 379 10.1016/j.bcp.2013.11.007 (2013 Epub)
32. A. Babelova, K. Moreth, W. Tsalastra-Greul, J. Zeng-Brouwers, O. Eickelberg, and M.F. Young et al. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors J. Biol. Chem. 284 2009 24035 24048
33. K. Niemi, L. Teirila, J. Lappalainen, K. Rajamaki, M.H. Baumann, and K. Oorni et al. Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway J. Immunol. 186 2011 6119 6128
34. G. Ayna, D.V. Krysko, A. Kaczmarek, G. Petrovski, P. Vandenabeele, and L. Fésüs ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages PLoS ONE 7 6 2012 e40069 10.1371/journal.pone.0040069 (2012 Epub)
35. N. Riteau, L. Baron, B. Villeret, N. Guillou, F. Savigny, B. Ryffel, F. Rassendren, M. Le Bert, A. Gombault, and I. Couillin ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation Cell Death Dis. 11 3 2012 e403 10.1038/cddis.2012.144
36. V. Poornima, M. Madhupriya, S. Kootar, G. Sujatha, A. Kumar, and A.K. Bera P2X7 receptor-pannexin 1 hemichannel association effect of extracellular calcium on membrane permeabilization J. Mol. Neurosci. 46 3 2012 585 594 10.1007/s12031-011-9646-8 (2011 Epub)
37. X.J. Xu, M. Boumechache, L.E. Robinson, V. Marschall, D.C. Gorecki, M. Masin, and R.D. Murrell-Lagnado Splice variants of the P2X7 receptor reveal differential agonist dependence and functional coupling with pannexin-1 J. Cell Sci. 125 Pt 16 2012 3776 3789 10.1242/jcs.099374 (2012 Epub)
38. S.C. Hung, C.H. Choi, N. Said-Sadier, L. Johnson, K.R. Atanasova, H. Sellami, Ö Yilmaz, and D.M. Ojcius P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation PLoS ONE 8 7 2013 e70210 10.1371/journal.pone.0070210 (2013 Print)
39. A.V. Alberto, R.X. Faria, C.G. Couto, L.G. Ferreira, C.A. Souza, P.C. Teixeira, M.M. Fróes, and L.A. Alves Is pannexin the pore associated with the P2X7 receptor? Naunyn Schmiedebergs Arch. Pharmacol. 386 9 2013 775 787 10.1007/s00210-013-0868-x (2013 Epub)
40. Y. Qu, S. Misaghi, K. Newton, L.L. Gilmour, S. Louie, J.E. Cupp, G.R. Dubyak, D. Hackos, and V.M. Dixit Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation J. Immunol. 186 11 2011 6553 6561
41. Y. He, L. Franchi, and G. Núñez TLR agonists stimulate Nlrp3-dependent IL-1β production independently of the purinergic P2X7 receptor in dendritic cells and in vivo J. Immunol. 190 1 2013 334 339 10.4049/jimmunol.1202737 (2012 Epub)
42. P.J. Hanley, M. Kronlage, C. Kirschning, A. del Rey, F. Di Virgilio, J. Leipziger, I.P. Chessell, S. Sargin, M.A. Filippov, O. Lindemann, S. Mohr, V. Königs, H. Schillers, M. Bähler, and A. Schwab Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins J. Biol. Chem. 287 13 2012 10650 10663 10.1074/jbc.M111.332676 (2012 Epub)
43. N. Riteau, P. Gasse, L. Fauconnier, A. Gombault, M. Couegnat, L. Fick, J. Kanellopoulos, V.F. Quesniaux, S. Marchand-Adam, B. Crestani, B. Ryffel, and I. Couillin Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis Am. J. Respir. Crit. Care Med. 182 6 2010 774 783
44. W. Li, J. Li, A.E. Sama, and H. Wang Carbenoxolone blocks endotoxin-induced protein kinase R (PKR) activation and high mobility group box 1 (HMGB1) release Mol. Med. 24 19 2013 203 211 10.2119/molmed.2013.00064
45. Y. Chen, R. Corriden, Y. Inoue, L. Yip, N. Hashiguchi, A. Zinkernagel, V. Nizet, P.A. Insel, and W.G. Junger ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors Science 314 5806 2006 1792 1795 (Pubitemid 44969094)
46. M. Kronlage, J. Song, L. Sorokin, K. Isfort, T. Schwerdtle, J. Leipziger, B. Robaye, P.B. Conley, H.C. Kim, S. Sargin, P. Schön, A. Schwab, and P.J. Hanley Autocrine purinergic receptor signaling is essential for macrophage chemotaxis Sci. Signal. 3 132 2010 ra55 10.1126/scisignal.2000588
47. H. Kawamura, T. Kawamura, Y. Kanda, T. Kobayashi, and T. Abo Extracellular ATP-stimulated macrophages produce macrophage inflammatory protein-2 which is important for neutrophil migration Immunology 136 4 2012 448 458
48. F. Kukulski, F. Ben Yebdri, J. Lecka, G. Kauffenstein, S.A. Lévesque, M. Martín-Satué, and J. Sévigny Extracellular ATP and P2 receptors are required for IL-8 to induce neutrophil migration Cytokine 46 2 2009 166 170
49. Y. Bao, Y. Chen, C. Ledderose, L. Li, and W.G. Junger Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils J. Biol. Chem. 288 31 2013 22650 22657
50. M.R. Elliott et al. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance Nature 461 2009 282 286 10.1038/nature08296
51. K. Isfort et al. Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent J. Biol. Chem. 286 2011 44776 44787 10.1074/jbc.M111.289793
52. S. Oishi, T. Sasano, Y. Tateishi, N. Tamura, M. Isobe, and T. Furukawa Stretch of atrial myocytes stimulates recruitment of macrophages via ATP released through gap-junction channels J. Pharmacol. Sci. 120 4 2012 296 304 (Epub 2012)
53. I. Lemaire, S. Falzoni, B. Zhang, P. Pellegatti, and F. Di Virgilio The P2X7 receptor and Pannexin-1 are both required for the promotion of multinucleated macrophages by the inflammatory cytokine GM-CSF J. Immunol. 187 7 2011 3878 3887 10.4049/jimmunol.1002780 (2011 Epub)
54. U. Schenk, A.M. Westendorf, E. Radaelli, A. Casati, M. Ferro, M. Fumagalli, C. Verderio, J. Buer, E. Scanziani, and F. Grassi Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels Sci. Signal. 1 39 2008 ra6
55. T. Woehrle, L. Yip, A. Elkhal, Y. Sumi, Y. Chen, Y. Yao, P.A. Insel, and W.G. Junger Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse Blood 116 18 2010 3475 3484 10.1182/blood-2010-04-277707 (2010 Epub)
56. T. Woehrle, L. Yip, M. Manohar, Y. Sumi, Y. Yao, Y. Chen, and W.G. Junger Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors J. Leukoc. Biol. 88 6 2010 1181 1189 10.1189/jlb.0410211 (2010 Epub)
57. G. Borsellino, M. Kleinewietfeld, D. Di Mitri, A. Sternjak, A. Diamantini, R. Giometto, S. Höpner, D. Centonze, G. Bernardi, M.L. Dell'Acqua, P.M. Rossini, L. Battistini, O. Rötzschke, and K. Falk Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression Blood 110 4 2007 1225 1232 (Epub 2007) (Pubitemid 47281420)
58. C. Séror, M.T. Melki, F. Subra, S.Q. Raza, M. Bras, H. Saïdi, R. Nardacci, L. Voisin, A. Paoletti, F. Law, I. Martins, A. Amendola, A.A. Abdul-Sater, F. Ciccosanti, O. Delelis, F. Niedergang, S. Thierry, N. Said-Sadier, C. Lamaze, D. Métivier, J. Estaquier, G.M. Fimia, L. Falasca, R. Casetti, N. Modjtahedi, J. Kanellopoulos, J.F. Mouscadet, D.M. Ojcius, M. Piacentini, M.L. Gougeon, G. Kroemer, and J.L. Perfettini Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection J. Exp. Med. 208 9 2011 1823 1834 10.1084/jem.20101805 (2011 Epub)
59. J.E. Hazleton, J.W. Berman, and E.A. Eugenin Purinergic receptors are required for HIV-1 infection of primary human macrophages J. Immunol. 188 9 2012 4488 4495 10.4049/jimmunol.1102482 (2012 Epub)
60. C. Barat, C. Gilbert, M. Imbeault, and M.J. Tremblay Extracellular ATP reduces HIV-1 transfer from immature dendritic cells to CD4+ T lymphocytes Retrovirology 28 5 2008 30 10.1186/1742-4690-5-30 (Pubitemid 351597624)
61. M. Horckmans, B. Marcet, F. Marteau, F. Bulté, A. Maho, M. Parmentier, J.M. Boeynaems, and D. Communi Extracellular adenine nucleotides inhibit the release of major monocyte recruiters by human monocyte-derived dendritic cells FEBS Lett. 580 3 2006 747 754 (Epub 2006) (Pubitemid 43152292)
62. F. Wilkin, P. Stordeur, M. Goldman, J.M. Boeynaems, and B. Robaye Extracellular adenine nucleotides modulate cytokine production by human monocyte-derived dendritic cells: dual effect on IL-12 and stimulation of IL-10 Eur. J. Immunol. 32 9 2002 2409 2417
63. M. Schnurr, T. Toy, A. Shin, M. Wagner, J. Cebon, and E. Maraskovsky Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway Blood 105 4 2005 1582 1589 (Epub 2004) (Pubitemid 40223678)
64. C. Paustian, P. Taylor, T. Johnson, M. Xu, N. Ramirez, K.S. Rosenthal, S. Shu, P.A. Cohen, B.J. Czerniecki, and G.K. Koski Extracellular ATP and Toll-like receptor 2 agonists trigger in human monocytes an activation program that favors T helper 17 PLoS ONE 8 1 2013 e54804 10.1371/journal.pone.0054804 (2013 Epub)
65. M. Idzko, H. Hammad, M. van Nimwegen, M. Kool, M.A. Willart, F. Muskens, H.C. Hoogsteden, W. Luttmann, D. Ferrari, F. Di Virgilio, J.C. Virchow Jr., and B.N. Lambrecht Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells Nat. Med. 13 8 2007 913 919 (Epub 2007) (Pubitemid 47222044)
66. T. Müller, B. Robaye, R.P. Vieira, D. Ferrari, M. Grimm, T. Jakob, S.F. Martin, F. Di Virgilio, J.M. Boeynaems, J.C. Virchow, and M. Idzko The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation Allergy 65 12 2010 1545 1553 10.1111/j.1398-9995.2010.02426.x (2010 Epub)
67. O. Yoshida, S. Kimura, E.K. Jackson, S.C. Robson, D.A. Geller, N. Murase, and A.W. Thomson CD39 expression by hepatic myeloid dendritic cells attenuates inflammation in liver transplant ischemia-reperfusion injury in mice Hepatology 58 6 2013 2163 2175 10.1002/hep.26593 (2013 Epub)
68. Y. Ma, S. Adjemian, H. Yang, J.P. Catani, D. Hannani, I. Martins, M. Michaud, O. Kepp, A.Q. Sukkurwala, E. Vacchelli, L. Galluzzi, L. Zitvogel, and G. Kroemer ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy Oncoimmunology 2 6 2013 e24568 (Epub 2013)
69. F. Jacob, C. Pérez Novo, C. Bachert, and K. Van Crombruggen Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses Purinergic Signal. 9 3 2013 285 306 10.1007/s11302-013-9357-4 (2013 Epub)
70. L. Vitiello, S. Gorini, G. Rosano, and A. la Sala Immunoregulation through extracellular nucleotides Blood 120 3 2012 511 518 10.1182/blood-2012- 01-406496 (2012 Epub)
71. W.R. Silverman, J.P. de Rivero Vaccari, S. Locovei, F. Qiu, S.K. Carlsson, E. Scemes, R.W. Keane, and G. Dahl The pannexin 1 channel activates the inflammasome in neurons and astrocytes J. Biol. Chem. 284 27 2009 18143 18151 10.1074/jbc.M109.004804 (2009 Epub)
72. M.V. Bennett, J.M. Garré, J.A. Orellana, F.F. Bukauskas, M. Nedergaard, and J.C. Sáez Connexin and pannexin hemichannels in inflammatory responses of glia and neurons Brain Res. 1487 2012 3 15 10.1016/j.brainres.2012.08.042 (2010 Epub Review)
73. J.A. Orellana, N. Froger, P. Ezan, J.X. Jiang, M.V. Bennett, C.C. Naus, C. Giaume, and J.C. Sáez ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels J. Neurochem. 118 5 2011 826 840 10.1111/j.1471-4159.2011.07210.x (2011 Epub)
74. J.M. Garré, M.A. Retamal, P. Cassina, L. Barbeito, F.F. Bukauskas, J.C. Sáez, M.V. Bennett, and V. Abudara FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels Proc. Natl. Acad. Sci. USA 107 52 2010 22659 22664 10.1073/pnas.1013793107 (2010 Epub)
75. D. Križaj, D.A. Ryskamp, N. Tian, G. Tezel, C.H. Mitchell, V.Z. Slepak, and V.I. Shestopalov From mechanosensitivity to inflammatory responses new players in the pathology of glaucoma Curr. Eye Res. 39 2 2014 105 119 10.3109/02713683.2013.836541 (2013 Epub)
76. G. Dvoriantchikova, D. Ivanov, D. Barakat, A. Grinberg, R. Wen, V.Z. Slepak, and V.I. Shestopalov Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury PLoS ONE 7 2 2012 e31991 10.1371/journal.pone. 0031991 (2012 Epub)
77. B.D. Gulbransen, M. Bashashati, S.A. Hirota, X. Gui, J.A. Roberts, J.A. MacDonald, D.A. Muruve, D.M. McKay, P.L. Beck, G.M. Mawe, R.J. Thompson, and K.A. Sharkey Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis Nat. Med. 18 4 2012 600 604 10.1038/nm.2679
78. E.F. Diezmos, S.L. Sandow, I. Markus, D. Shevy Perera, D.Z. Lubowski, D.W. King, P.P. Bertrand, and L. Liu Expression and localization of pannexin-1 hemichannels in human colon in health and disease Neurogastroenterol. Motil. 25 6 2013 e395 e405 10.1111/nmo.12130 (2013 Epub)
79. Y. Li, X.F. Du, C.S. Liu, Z.L. Wen, and J.L. Du Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo Dev. Cell 23 2012 1189 1202 (http://dx.doi.org/10.1016/j.devcel.2012.10.027, PMID:23201120)
80. Y. Li, X.F. Du, and J.L. Du Resting microglia respond to and regulate neuronal activity in vivo Commun. Integr. Biol. 6 4 2013 e24493 10.4161/cib.24493 (2013 Epub)
81. S. Li et al. Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet Circ. Res. 105 2009 1072 1082 10.1161/CIRCRESAHA.109.199570
82. G. Lopez-Castejón, A. Baroja-Mazo, and P. Pelegrín Novel macrophage polarization model from gene expression to identification of new anti-inflammatory molecules Cell. Mol. Life Sci. 68 18 2011 3095 3107 10.1007/s00018-010-0609-y (2010 Epub)
83. M.S. Bynoe, A.T. Waickman, D.A. Mahamed, C. Mueller, J.H. Mills, and A. Czopik CD73 is critical for the resolution of murine colonic inflammation J. Biomed. Biotechnol. 2012 2012 260983 10.1155/2012/260983 (2012 Epub)
84. J.S. Frick, C.F. MacManus, M. Scully, L.E. Glover, H.K. Eltzschig, and S.P. Colgan Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis J. Immunol. 182 8 2009 4957 4964 10.4049/jimmunol. 0801324
85. H.G. Folkesson, S.R. Kuzenko, D.A. Lipson, M.A. Matthay, and M.A. Simmons The adenosine 2A receptor agonist GW328267C improves lung function after acute lung injury in rats Am. J. Physiol. Lung Cell. Mol. Physiol. 303 3 2012 L259 L271 10.1152/ajplung.00395.2011 (2012 Epub)
86. K. Köröskényi, E. Duró, A. Pallai, Z. Sarang, D. Kloor, D.S. Ucker, S. Beceiro, A. Castrillo, A. Chawla, C.A. Ledent, L. Fésüs, and Z. Szondy Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation J. Immunol. 186 12 2011 7144 7155 10.4049/jimmunol.1002284 (2011 Epub)
87. P.B. Ernst, J.C. Garrison, and L.F. Thompson Much ado about adenosine: adenosine synthesis and function in regulatory T cell biology J. Immunol. 185 4 2010 1993 1998 10.4049/jimmunol.1000108
88. R.J. Soares-Bezerra, A.S. Calheiros, N.C. da Silva Ferreira, V. da Silva Frutuoso, and L.A. Alves Natural products as a source for new anti-inflammatory and analgesic compounds through the inhibition of purinergic P2X receptors Pharmaceuticals (Basel) 6 5 2013 650 658 10.3390/ph6050650
89. N. Mehta, M. Kaur, M. Singh, S. Chand, B. Vyas, P. Silakari, M.S. Bahia, and O. Silakari Purinergic receptor P2X7 A novel target for anti-inflammatory therapy Bioorg. Med. Chem. 22 1 2014 54 88 10.1016/j.bmc.2013.10.054 (2013 Epub)
90. L.A. Alves, R.J. Bezerra, R.X. Faria, L.G. Ferreira, and V. da Silva Frutuoso Physiological roles and potential therapeutic applications of the P2X7 receptor in inflammation and pain Molecules 18 9 2013 10953 10972 10.3390/molecules180910953
91. P. Pelegrin Targeting interleukin-1 signaling in chronic inflammation: focus on P2X(7) receptor and Pannexin-1 Drug News Perspect. 21 8 2008 424 433 10.1358/dnp.2008.21.8.1265800. Review
92. S. Madec et al. Adipocyte P2X7 receptors expression: a role in modulating inflammatory response in subjects with metabolic syndrome? Atherosclerosis 219 2011 552 558 10.1016/j.atherosclerosis.2011.09.012
93. D.C. Henshall, M. Diaz-Hernandez, M.T. Miras-Portugal, and T. Engel P2X receptors as targets for the treatment of status epilepticus Front. Cell. Neurosci. 7 237 2013 (eCollection 2013 Review)