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Volumn 8, Issue 2, 2007, Pages 139-148

Post-translational modifications regulate the ticking of the circadian clock

Author keywords

[No Author keywords available]

Indexed keywords

BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; CASEIN KINASE I; CASEIN KINASE IDELTA; CRYPTOCHROME; CRYPTOCHROME 1; CRYPTOCHROME 2; DNA; GLYCOGEN SYNTHASE KINASE 3; HISTONE ACETYLTRANSFERASE; PAR DOMAIN PROTEIN 1; PER1 PROTEIN; PER2 PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEASOME; PROTEIN; PROTEIN BMAL1; PROTEIN NPAS1; REPRESSOR PROTEIN; REPRESSOR PROTEIN FRQ; SLIMB PROTEIN; TRANSCRIPTION FACTOR CLOCK; UBIQUITIN; UNCLASSIFIED DRUG; WHITE COLLAR PROTEIN 1; WHITE COLLAR PROTEIN 2; PHOSPHATASE; PHOSPHOTRANSFERASE;

EID: 33847779219     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm2106     Document Type: Review
Times cited : (686)

References (112)
  • 1
    • 24144459585 scopus 로고    scopus 로고
    • The molecular clock mediates leptinregulated bone formation
    • Fu, L., Patel, M. S., Bradley, A., Wagner, E. F. & Karsenty, G. The molecular clock mediates leptinregulated bone formation. Cell 122, 803-815 (2005).
    • (2005) Cell , vol.122 , pp. 803-815
    • Fu, L.1    Patel, M.S.2    Bradley, A.3    Wagner, E.F.4    Karsenty, G.5
  • 2
    • 0037020198 scopus 로고    scopus 로고
    • The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo
    • Fu, L., Pelicano, H., Liu, J., Huang, P. & Lee, C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111, 41-50 (2002).
    • (2002) Cell , vol.111 , pp. 41-50
    • Fu, L.1    Pelicano, H.2    Liu, J.3    Huang, P.4    Lee, C.5
  • 3
    • 0141889955 scopus 로고    scopus 로고
    • Control mechanism of the circadian clock for timing of cell division in vivo
    • Matsuo, T. et al. Control mechanism of the circadian clock for timing of cell division in vivo. Science 302, 255-259 (2003).
    • (2003) Science , vol.302 , pp. 255-259
    • Matsuo, T.1
  • 4
    • 20844461135 scopus 로고    scopus 로고
    • Obesity and metabolic syndrome in circadian Clock mutant mice
    • Turek, F. W. et al. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308, 1043-1045 (2005).
    • (2005) Science , vol.308 , pp. 1043-1045
    • Turek, F.W.1
  • 5
    • 33746924400 scopus 로고    scopus 로고
    • The Neurospora checkpoint kinase 2: A regulatory link between the circadian and cell cycles
    • Pregueiro, A. M., Liu, Q., Baker, C. L., Dunlap, J. C. & Loros, J. J. The Neurospora checkpoint kinase 2: a regulatory link between the circadian and cell cycles. Science 313, 644-649 (2006).
    • (2006) Science , vol.313 , pp. 644-649
    • Pregueiro, A.M.1    Liu, Q.2    Baker, C.L.3    Dunlap, J.C.4    Loros, J.J.5
  • 6
    • 30544448274 scopus 로고    scopus 로고
    • Breast cancer and night work among Norwegian nurses
    • Lie, J. A., Roessink, J. & Kjaerheim, K. Breast cancer and night work among Norwegian nurses. Cancer Causes Control 17, 39-44 (2006).
    • (2006) Cancer Causes Control , vol.17 , pp. 39-44
    • Lie, J.A.1    Roessink, J.2    Kjaerheim, K.3
  • 7
    • 0032086713 scopus 로고    scopus 로고
    • Behavior of SCN-lesioned chipmunks in natural habitat: A pilot study
    • DeCoursey, P. J. & Krulas, J. R. Behavior of SCN-lesioned chipmunks in natural habitat: a pilot study. J. Biol. Rhythms 13, 229-244 (1998).
    • (1998) J. Biol. Rhythms , vol.13 , pp. 229-244
    • DeCoursey, P.J.1    Krulas, J.R.2
  • 9
    • 4544362674 scopus 로고    scopus 로고
    • Mammalian circadian biology: Elucidating genome-wide levels of temporal organization
    • Lowrey, P. L. & Takahashi, J. S. Mammalian circadian biology: elucidating genome-wide levels of temporal organization. Annu. Rev. Genomics Hum. Genet. 5, 407-441 (2004).
    • (2004) Annu. Rev. Genomics Hum. Genet , vol.5 , pp. 407-441
    • Lowrey, P.L.1    Takahashi, J.S.2
  • 10
    • 13944254430 scopus 로고    scopus 로고
    • System-level identification of transcriptional circuits underlying mammalian circadian clocks
    • Ueda, H. R. et al. System-level identification of transcriptional circuits underlying mammalian circadian clocks. Nature Genet. 37, 187-192 (2005).
    • (2005) Nature Genet , vol.37 , pp. 187-192
    • Ueda, H.R.1
  • 11
    • 0032511229 scopus 로고    scopus 로고
    • A serum shock induces circadian gene expression in mammalian tissue culture cells
    • Balsalobre, A., Damiola, F. & Schibler, U. A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell 93, 929-937 (1998).
    • (1998) Cell , vol.93 , pp. 929-937
    • Balsalobre, A.1    Damiola, F.2    Schibler, U.3
  • 12
    • 15044343742 scopus 로고    scopus 로고
    • Eide, E. J. et al. Control of mammalian circadian rhythm by CKIε-regulated proteasome-mediated PER2 degradation. Mol. Cell. Biol. 25, 2795-2807 (2005). A detailed mechanism for one function of CKI, and the first demonstration that inhibition of CKI and the proteasome actually lengthens the period.
    • Eide, E. J. et al. Control of mammalian circadian rhythm by CKIε-regulated proteasome-mediated PER2 degradation. Mol. Cell. Biol. 25, 2795-2807 (2005). A detailed mechanism for one function of CKI, and the first demonstration that inhibition of CKI and the proteasome actually lengthens the period.
  • 13
    • 17144433663 scopus 로고    scopus 로고
    • The 5′ upstream region of mPer1 gene contains two promoters and is responsible for circadian oscillation
    • Yamaguchi, S. et al. The 5′ upstream region of mPer1 gene contains two promoters and is responsible for circadian oscillation. Curr. Biol. 10, 873-876 (2000).
    • (2000) Curr. Biol , vol.10 , pp. 873-876
    • Yamaguchi, S.1
  • 14
    • 11144353910 scopus 로고    scopus 로고
    • PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
    • Yoo, S. H. et al. PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc. Natl Acad. Sci. USA 101, 5339-5346 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 5339-5346
    • Yoo, S.H.1
  • 15
    • 0015119210 scopus 로고
    • Clock mutants of Drosophila melanogaster
    • Konopka, R. J. & Benzer, S. Clock mutants of Drosophila melanogaster. Proc. Natl Acad. Sci. USA 68, 2112-2116 (1971).
    • (1971) Proc. Natl Acad. Sci. USA , vol.68 , pp. 2112-2116
    • Konopka, R.J.1    Benzer, S.2
  • 16
    • 0023764577 scopus 로고
    • A mutation of the circadian system in golden hamsters
    • Ralph, M. R. & Menaker, M. A mutation of the circadian system in golden hamsters. Science 241, 1225-1227 (1988).
    • (1988) Science , vol.241 , pp. 1225-1227
    • Ralph, M.R.1    Menaker, M.2
  • 17
    • 4143105727 scopus 로고    scopus 로고
    • A rhythmic Ror
    • Emery, P. & Reppert, S. M. A rhythmic Ror. Neuron 43, 443-446 (2004).
    • (2004) Neuron , vol.43 , pp. 443-446
    • Emery, P.1    Reppert, S.M.2
  • 18
    • 4143142003 scopus 로고    scopus 로고
    • A functional genomics strategy reveals Rora as a component of the mammalian circadian clock
    • Sato, T. K. et al. A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron 43, 527-537 (2004).
    • (2004) Neuron , vol.43 , pp. 527-537
    • Sato, T.K.1
  • 19
    • 0035966317 scopus 로고    scopus 로고
    • Posttranslational mechanisms regulate the mammalian circadian clock
    • Lee, C., Etchegaray, J. P., Cagampang, F. R., Loudon, A. S. & Reppert, S. M. Posttranslational mechanisms regulate the mammalian circadian clock. Cell 107, 855-867 (2001).
    • (2001) Cell , vol.107 , pp. 855-867
    • Lee, C.1    Etchegaray, J.P.2    Cagampang, F.R.3    Loudon, A.S.4    Reppert, S.M.5
  • 20
    • 0037426839 scopus 로고    scopus 로고
    • Rhythmic histone acetylation underlies transcription in the mammalian circadian clock
    • Etchegaray, J. P., Lee, C., Wade, P. A. & Reppert, S. M. Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature 421, 177-182 (2003).
    • (2003) Nature , vol.421 , pp. 177-182
    • Etchegaray, J.P.1    Lee, C.2    Wade, P.A.3    Reppert, S.M.4
  • 21
    • 33746344698 scopus 로고    scopus 로고
    • The polycomb group protein EZH2 is required for mammalian circadian clock function
    • Etchegaray, J. P. et al. The polycomb group protein EZH2 is required for mammalian circadian clock function. J. Biol. Chem. 281, 21209-21215 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 21209-21215
    • Etchegaray, J.P.1
  • 22
    • 33644617485 scopus 로고    scopus 로고
    • Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions
    • Ripperger, J. A. & Schibler, U. Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nature Genet. 38, 369-374 (2006).
    • (2006) Nature Genet , vol.38 , pp. 369-374
    • Ripperger, J.A.1    Schibler, U.2
  • 23
    • 33646145721 scopus 로고    scopus 로고
    • Doi, M., Hirayama, J. & Sassone-Corsi, P. Circadian regulator CLOCK is a histone acetyltransferase. Cell 125, 497-508 (2006). Another post-translational modification that regulates transcription (see reference 24 for a complication of the story).
    • Doi, M., Hirayama, J. & Sassone-Corsi, P. Circadian regulator CLOCK is a histone acetyltransferase. Cell 125, 497-508 (2006). Another post-translational modification that regulates transcription (see reference 24 for a complication of the story).
  • 24
    • 33646130147 scopus 로고    scopus 로고
    • Debruyne, J. P. et al. A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron 50, 465-477 (2006). The title tells the story. Whether there is developmental compensation, redundancy or the model requires main alterations remains to be determined.
    • Debruyne, J. P. et al. A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron 50, 465-477 (2006). The title tells the story. Whether there is developmental compensation, redundancy or the model requires main alterations remains to be determined.
  • 25
    • 24044444531 scopus 로고    scopus 로고
    • The circadian timekeeping system of Drosophila
    • Hardin, P. E. The circadian timekeeping system of Drosophila. Curr. Biol. 15, R714-R722 (2005).
    • (2005) Curr. Biol , vol.15
    • Hardin, P.E.1
  • 26
    • 24344450660 scopus 로고    scopus 로고
    • Structural and functional features of transcription factors controlling the circadian clock
    • Hirayama, J. & Sassone-Corsi, P. Structural and functional features of transcription factors controlling the circadian clock. Curr. Opin. Genet. Dev. 15, 548-556 (2005).
    • (2005) Curr. Opin. Genet. Dev , vol.15 , pp. 548-556
    • Hirayama, J.1    Sassone-Corsi, P.2
  • 27
    • 33745145846 scopus 로고    scopus 로고
    • Brunner, M. & Schafmeier, T. Transcriptional and posttranscriptional regulation of the circadian clock of cyanobacteria and Neurospora. Genes Dev. 20, 1061-1074 (2006).
    • Brunner, M. & Schafmeier, T. Transcriptional and posttranscriptional regulation of the circadian clock of cyanobacteria and Neurospora. Genes Dev. 20, 1061-1074 (2006).
  • 28
    • 33645010948 scopus 로고    scopus 로고
    • Yu, W., Zheng, H., Houl, J. H., Dauwalder, B. & Hardin, P. E. PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription. Genes Dev. 20, 723-733 (2006). Illustrates the many roles of DBT kinase: it regulates nuclear entry, protein stability and, as shown in this article, transcriptional activity of CLK.
    • Yu, W., Zheng, H., Houl, J. H., Dauwalder, B. & Hardin, P. E. PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription. Genes Dev. 20, 723-733 (2006). Illustrates the many roles of DBT kinase: it regulates nuclear entry, protein stability and, as shown in this article, transcriptional activity of CLK.
  • 29
    • 0037423224 scopus 로고    scopus 로고
    • vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock
    • Cyran, S. A. et al. vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell 112, 329-341 (2003).
    • (2003) Cell , vol.112 , pp. 329-341
    • Cyran, S.A.1
  • 30
    • 0028258994 scopus 로고
    • Negative feedback defining a circadian clock: Autoregulation of the clock gene frequency
    • Aronson, B. D., Johnson, K. A., Loros, J. J. & Dunlap, J. C. Negative feedback defining a circadian clock: autoregulation of the clock gene frequency. Science 263, 1578-1584 (1994).
    • (1994) Science , vol.263 , pp. 1578-1584
    • Aronson, B.D.1    Johnson, K.A.2    Loros, J.J.3    Dunlap, J.C.4
  • 31
    • 33749402900 scopus 로고    scopus 로고
    • Proteins in the Neurospora circadian clockworks
    • Dunlap, J. C. Proteins in the Neurospora circadian clockworks. J. Biol. Chem. 281, 28489-28493 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 28489-28493
    • Dunlap, J.C.1
  • 32
    • 12144266896 scopus 로고    scopus 로고
    • Regulation of the Neurospora circadian clock by an RNA helicase
    • Cheng, P., He, Q., He, Q., Wang, L. & Liu, Y. Regulation of the Neurospora circadian clock by an RNA helicase. Genes Dev. 19, 234-241 (2005).
    • (2005) Genes Dev , vol.19 , pp. 234-241
    • Cheng, P.1    He, Q.2    He, Q.3    Wang, L.4    Liu, Y.5
  • 33
    • 22744455874 scopus 로고    scopus 로고
    • Schafmeier, T. et al. Transcriptional feedback of Neurospora circadian clock gene by phosphorylationdependent inactivation of its transcription factor. Cell 122, 235-246 (2005). Both kinases and phosphatases regulate the activity of the circadian transcription factor WCC.
    • Schafmeier, T. et al. Transcriptional feedback of Neurospora circadian clock gene by phosphorylationdependent inactivation of its transcription factor. Cell 122, 235-246 (2005). Both kinases and phosphatases regulate the activity of the circadian transcription factor WCC.
  • 34
    • 33748687611 scopus 로고    scopus 로고
    • CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop
    • He, Q. et al. CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop. Genes Dev. 20, 2552-2565 (2006).
    • (2006) Genes Dev , vol.20 , pp. 2552-2565
    • He, Q.1
  • 35
    • 32044466225 scopus 로고    scopus 로고
    • Phosphorylation-dependent maturation of Neurospora circadian clock protein from a nuclear repressor toward a cytoplasmic activator
    • Schafmeier, T., Kaldi, K., Diernfellner, A., Mohr, C. & Brunner, M. Phosphorylation-dependent maturation of Neurospora circadian clock protein from a nuclear repressor toward a cytoplasmic activator. Genes Dev. 20, 297-306 (2006).
    • (2006) Genes Dev , vol.20 , pp. 297-306
    • Schafmeier, T.1    Kaldi, K.2    Diernfellner, A.3    Mohr, C.4    Brunner, M.5
  • 36
    • 28444464476 scopus 로고    scopus 로고
    • Molecular mechanism of light responses in Neurospora: From light-induced transcription to photoadaptation
    • He, Q. & Liu, Y. Molecular mechanism of light responses in Neurospora: from light-induced transcription to photoadaptation. Genes Dev. 19, 2888-2899 (2005).
    • (2005) Genes Dev , vol.19 , pp. 2888-2899
    • He, Q.1    Liu, Y.2
  • 37
    • 0034602768 scopus 로고    scopus 로고
    • Phosphorylation of the Neurospora clock protein FREQUENCY determines its degradation rate and strongly influences the period length of the circadian clock
    • Liu, Y., Loros, J. & Dunlap, J. C. Phosphorylation of the Neurospora clock protein FREQUENCY determines its degradation rate and strongly influences the period length of the circadian clock. Proc. Natl Acad. Sci. USA 97, 234-239 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 234-239
    • Liu, Y.1    Loros, J.2    Dunlap, J.C.3
  • 38
    • 0042237024 scopus 로고    scopus 로고
    • FWD1-mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation
    • He, Q. et al. FWD1-mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation. EMBO J. 22, 4421-4430 (2003).
    • (2003) EMBO J , vol.22 , pp. 4421-4430
    • He, Q.1
  • 39
    • 0037187636 scopus 로고    scopus 로고
    • Drosophila CLOCK protein is under posttranscriptional control and influences lightinduced activity
    • Kim, E. Y. et al. Drosophila CLOCK protein is under posttranscriptional control and influences lightinduced activity. Neuron 34, 69-81 (2002).
    • (2002) Neuron , vol.34 , pp. 69-81
    • Kim, E.Y.1
  • 40
    • 0035102288 scopus 로고    scopus 로고
    • Role of molecular oscillations in generating behavioral rhythms in Drosophila
    • Yang, Z. & Sehgal, A. Role of molecular oscillations in generating behavioral rhythms in Drosophila. Neuron 29, 453-467 (2001).
    • (2001) Neuron , vol.29 , pp. 453-467
    • Yang, Z.1    Sehgal, A.2
  • 41
    • 14044272804 scopus 로고    scopus 로고
    • Role of cyclic mPer2 expression in the mammalian cellular clock
    • Yamamoto, Y., Yagita, K. & Okamura, H. Role of cyclic mPer2 expression in the mammalian cellular clock. Mol. Cell. Biol. 25, 1912-1921 (2005).
    • (2005) Mol. Cell. Biol , vol.25 , pp. 1912-1921
    • Yamamoto, Y.1    Yagita, K.2    Okamura, H.3
  • 42
    • 33644863308 scopus 로고    scopus 로고
    • Constitutive expression of the Period1 gene impairs behavioral and molecular circadian rhythms
    • Numano, R. et al. Constitutive expression of the Period1 gene impairs behavioral and molecular circadian rhythms. Proc. Natl Acad. Sci. USA 103, 3716-3721 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 3716-3721
    • Numano, R.1
  • 43
    • 33645808673 scopus 로고    scopus 로고
    • Does mPER2 protein oscillate without its coding mRNA cycling? post-transcriptional regulation by cell clock
    • Fujimoto, Y., Yagita, K. & Okamura, H. Does mPER2 protein oscillate without its coding mRNA cycling? post-transcriptional regulation by cell clock. Genes Cells 11, 525-530 (2006).
    • (2006) Genes Cells , vol.11 , pp. 525-530
    • Fujimoto, Y.1    Yagita, K.2    Okamura, H.3
  • 44
    • 0037053314 scopus 로고    scopus 로고
    • The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase lepsilon
    • Eide, E. J., Vielhaber, E. L., Hinz, W. A. & Virshup, D. M. The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase lepsilon. J. Biol. Chem. 277, 17248-17254 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 17248-17254
    • Eide, E.J.1    Vielhaber, E.L.2    Hinz, W.A.3    Virshup, D.M.4
  • 45
    • 33746041826 scopus 로고    scopus 로고
    • Gallego, M., Eide, E. J., Woolf, M. F., Virshup, D. M. & Forger, D. B. An opposite role for tau in circadian rhythms revealed by mathematical modeling. Proc. Natl Acad. Sci. USA 103, 10618-10623 (2006). Untangling a confused story; a model prediction leads to an important clarification of how a key mutant in circadian rhythms really works.
    • Gallego, M., Eide, E. J., Woolf, M. F., Virshup, D. M. & Forger, D. B. An opposite role for tau in circadian rhythms revealed by mathematical modeling. Proc. Natl Acad. Sci. USA 103, 10618-10623 (2006). Untangling a confused story; a model prediction leads to an important clarification of how a key mutant in circadian rhythms really works.
  • 46
    • 0037016665 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1
    • Sanada, K., Okano, T. & Fukada, Y. Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1. J. Biol. Chem. 277, 267-271 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 267-271
    • Sanada, K.1    Okano, T.2    Fukada, Y.3
  • 47
    • 33646591926 scopus 로고    scopus 로고
    • Balance between DBT/CKIε kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein
    • Kim, E. Y. & Edery, I. Balance between DBT/CKIε kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein. Proc. Natl Acad. Sci. USA 103, 6178-6183 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 6178-6183
    • Kim, E.Y.1    Edery, I.2
  • 48
    • 0032504041 scopus 로고    scopus 로고
    • The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iε
    • Kloss, B. et al. The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iε. Cell 94, 97-107 (1998).
    • (1998) Cell , vol.94 , pp. 97-107
    • Kloss, B.1
  • 49
    • 0032503969 scopus 로고    scopus 로고
    • double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation
    • Price, J. L. et al. double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell 94, 83-95 (1998).
    • (1998) Cell , vol.94 , pp. 83-95
    • Price, J.L.1
  • 50
    • 0029036113 scopus 로고
    • Isolation and characterization of human casein kinase Iε (CKI), a novel member of the CKI gene family
    • Fish, K. J., Cegielska, A., Getman, M. E., Landes, G. M. & Virshup, D. M. Isolation and characterization of human casein kinase Iε (CKI), a novel member of the CKI gene family. J. Biol. Chem. 270, 14875-14883 (1995).
    • (1995) J. Biol. Chem , vol.270 , pp. 14875-14883
    • Fish, K.J.1    Cegielska, A.2    Getman, M.E.3    Landes, G.M.4    Virshup, D.M.5
  • 51
    • 0034933482 scopus 로고    scopus 로고
    • Casein kinase I: From obscurity to center stage
    • Vielhaber, E. & Virshup, D. M. Casein kinase I: from obscurity to center stage. IUBMB Life 51, 73-78 (2001).
    • (2001) IUBMB Life , vol.51 , pp. 73-78
    • Vielhaber, E.1    Virshup, D.M.2
  • 52
    • 0034697099 scopus 로고    scopus 로고
    • Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau
    • Lowrey, P. L. et al. Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau. Science 288, 483-492 (2000).
    • (2000) Science , vol.288 , pp. 483-492
    • Lowrey, P.L.1
  • 53
    • 0032872087 scopus 로고    scopus 로고
    • Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans
    • Jones, C. R. et al. Familial advanced sleep-phase syndrome: a short-period circadian rhythm variant in humans. Nature Med. 5, 1062-1065 (1999).
    • (1999) Nature Med , vol.5 , pp. 1062-1065
    • Jones, C.R.1
  • 54
    • 0035136677 scopus 로고    scopus 로고
    • An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome
    • Toh, K. L. et al. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science 291, 1040-1043 (2001).
    • (2001) Science , vol.291 , pp. 1040-1043
    • Toh, K.L.1
  • 55
    • 15844420887 scopus 로고    scopus 로고
    • Xu, Y. et al. Functional consequences of a CKI? mutation causing familial advanced sleep phase syndrome. Nature 434, 640-644 (2005). The first genetic evidence that CKIδ is a circadian rhythms gene, and the identification of the first kinase mutation that alters rhythms in humans.
    • Xu, Y. et al. Functional consequences of a CKI? mutation causing familial advanced sleep phase syndrome. Nature 434, 640-644 (2005). The first genetic evidence that CKIδ is a circadian rhythms gene, and the identification of the first kinase mutation that alters rhythms in humans.
  • 56
    • 0037126627 scopus 로고    scopus 로고
    • A PEST-like element in FREQUENCY determines the length of the circadian period in Neurospora crassa
    • Gorl, M. et al. A PEST-like element in FREQUENCY determines the length of the circadian period in Neurospora crassa. EMBO J. 20, 7074-7084 (2001).
    • (2001) EMBO J , vol.20 , pp. 7074-7084
    • Gorl, M.1
  • 57
    • 0037334895 scopus 로고    scopus 로고
    • One-thousand-and-one substrates of protein kinase CK2?
    • Meggio, F. & Pinna, L. A. One-thousand-and-one substrates of protein kinase CK2? FASEB J. 17, 349-368 (2003).
    • (2003) FASEB J , vol.17 , pp. 349-368
    • Meggio, F.1    Pinna, L.A.2
  • 58
    • 22344447747 scopus 로고    scopus 로고
    • Casein kinase 2, circadian clocks, and the flight from mutagenic light
    • Allada, R. & Meissner, R. A. Casein kinase 2, circadian clocks, and the flight from mutagenic light. Mol. Cell Biochem. 274, 141-149 (2005).
    • (2005) Mol. Cell Biochem , vol.274 , pp. 141-149
    • Allada, R.1    Meissner, R.A.2
  • 59
    • 0037180767 scopus 로고    scopus 로고
    • A role for casein kinase 2α in the Drosophila circadian clock
    • Lin, J. M. et al. A role for casein kinase 2α in the Drosophila circadian clock. Nature 420, 816-820 (2002).
    • (2002) Nature , vol.420 , pp. 816-820
    • Lin, J.M.1
  • 60
    • 30644471172 scopus 로고    scopus 로고
    • In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD
    • Lin, J. M., Schroeder, A. & Allada, R. In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD. J. Neurosci. 25, 11175-11183 (2005).
    • (2005) J. Neurosci , vol.25 , pp. 11175-11183
    • Lin, J.M.1    Schroeder, A.2    Allada, R.3
  • 61
    • 0344091557 scopus 로고    scopus 로고
    • A role for CK2 in the Drosophila circadian oscillator
    • Akten, B. et al. A role for CK2 in the Drosophila circadian oscillator. Nature Neurosci. 6, 251-257 (2003).
    • (2003) Nature Neurosci , vol.6 , pp. 251-257
    • Akten, B.1
  • 62
    • 0037089657 scopus 로고    scopus 로고
    • Regulation of the Neurospora circadian clock by casein kinase II
    • Yang, Y., Cheng, P. & Liu, Y. Regulation of the Neurospora circadian clock by casein kinase II. Genes Dev. 16, 994-1006 (2002).
    • (2002) Genes Dev , vol.16 , pp. 994-1006
    • Yang, Y.1    Cheng, P.2    Liu, Y.3
  • 63
    • 0041387632 scopus 로고    scopus 로고
    • Phosphorylation of FREQUENCY protein by casein kinase II is necessary for the function of the Neurospora circadian clock
    • Yang, Y., Cheng, P., He, Q., Wang, L. & Liu, Y. Phosphorylation of FREQUENCY protein by casein kinase II is necessary for the function of the Neurospora circadian clock. Mol. Cell. Biol. 23, 6221-6228 (2003).
    • (2003) Mol. Cell. Biol , vol.23 , pp. 6221-6228
    • Yang, Y.1    Cheng, P.2    He, Q.3    Wang, L.4    Liu, Y.5
  • 64
    • 0035875069 scopus 로고    scopus 로고
    • A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock
    • Martinek, S., Inonog, S., Manoukian, A. S. & Young, M. W. A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock. Cell 105, 769-779 (2001).
    • (2001) Cell , vol.105 , pp. 769-779
    • Martinek, S.1    Inonog, S.2    Manoukian, A.S.3    Young, M.W.4
  • 65
    • 23844460834 scopus 로고    scopus 로고
    • A role for glycogen synthase kinase-3β in the mammalian circadian clock
    • Iitaka, C., Miyazaki, K., Akaike, T. & Ishida, N. A role for glycogen synthase kinase-3β in the mammalian circadian clock. J. Biol. Chem. 280, 29397-29402 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 29397-29402
    • Iitaka, C.1    Miyazaki, K.2    Akaike, T.3    Ishida, N.4
  • 66
    • 33144465537 scopus 로고    scopus 로고
    • Nuclear receptor Rev-erb? is a critical lithium-sensitive component of the circadian clock
    • Yin, L., Wang, J., Klein, P. S. & Lazar, M. A. Nuclear receptor Rev-erb? is a critical lithium-sensitive component of the circadian clock. Science 311, 1002-1005 (2006).
    • (2006) Science , vol.311 , pp. 1002-1005
    • Yin, L.1    Wang, J.2    Klein, P.S.3    Lazar, M.A.4
  • 67
    • 24744436847 scopus 로고    scopus 로고
    • Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3β
    • Harada, Y., Sakai, M., Kurabayashi, N., Hirota, T. & Fukada, Y. Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3β. J. Biol. Chem. 280, 31714-31721 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 31714-31721
    • Harada, Y.1    Sakai, M.2    Kurabayashi, N.3    Hirota, T.4    Fukada, Y.5
  • 68
    • 33745101711 scopus 로고    scopus 로고
    • Second messenger and Ras/MAPK signalling pathways regulate CLOCK/CYCLE-dependent transcription
    • Weber, F., Hung, H. C., Maurer, C. & Kay, S. A. Second messenger and Ras/MAPK signalling pathways regulate CLOCK/CYCLE-dependent transcription. J. Neurochem. 98, 248-257 (2006).
    • (2006) J. Neurochem , vol.98 , pp. 248-257
    • Weber, F.1    Hung, H.C.2    Maurer, C.3    Kay, S.A.4
  • 69
    • 0037119440 scopus 로고    scopus 로고
    • The p42/44 mitogen-activated protein kinase pathway couples photic input to circadian clock entrainment
    • Butcher, G. Q., Dziema, H., Collamore, M., Burgoon, P. W. & Obrietan, K. The p42/44 mitogen-activated protein kinase pathway couples photic input to circadian clock entrainment. J. Biol. Chem. 277, 29519-29525 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 29519-29525
    • Butcher, G.Q.1    Dziema, H.2    Collamore, M.3    Burgoon, P.W.4    Obrietan, K.5
  • 70
    • 0038371139 scopus 로고    scopus 로고
    • cGMP-dependent protein kinase II modulates mPer1 and mPer2 gene induction and influences phase shifts of the circadian clock
    • Oster, H. et al. cGMP-dependent protein kinase II modulates mPer1 and mPer2 gene induction and influences phase shifts of the circadian clock. Curr. Biol. 13, 725-733 (2003).
    • (2003) Curr. Biol , vol.13 , pp. 725-733
    • Oster, H.1
  • 71
    • 4143147421 scopus 로고    scopus 로고
    • Protein kinase G type II is required for night-to-day progression of the mammalian circadian clock
    • Tischkau, S. A. et al. Protein kinase G type II is required for night-to-day progression of the mammalian circadian clock. Neuron 43, 539-549 (2004).
    • (2004) Neuron , vol.43 , pp. 539-549
    • Tischkau, S.A.1
  • 72
    • 15044348175 scopus 로고    scopus 로고
    • Protein serine/threonine phosphatases: Life, death, and sleeping
    • Gallego, M. & Virshup, D. M. Protein serine/threonine phosphatases: life, death, and sleeping. Curr. Opin. Cell Biol. 17, 197-202 (2005).
    • (2005) Curr. Opin. Cell Biol , vol.17 , pp. 197-202
    • Gallego, M.1    Virshup, D.M.2
  • 74
    • 0346728803 scopus 로고    scopus 로고
    • Functional diversity of protein phosphatase-1, a cellular economizer and reset button
    • Ceulemans, H. & Bollen, M. Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol. Rev. 84, 1-39 (2004).
    • (2004) Physiol. Rev , vol.84 , pp. 1-39
    • Ceulemans, H.1    Bollen, M.2
  • 75
    • 1042266554 scopus 로고    scopus 로고
    • Distinct roles for PP1 and PP2A in the Neurospora circadian clock
    • Yang, Y. et al. Distinct roles for PP1 and PP2A in the Neurospora circadian clock. Genes Dev. 18, 255-260 (2004).
    • (2004) Genes Dev , vol.18 , pp. 255-260
    • Yang, Y.1
  • 76
    • 1342285689 scopus 로고    scopus 로고
    • Sathyanarayanan, S., Zheng, X., Xiao, R. & Sehgal, A. Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell 116, 603-615 (2004). The first genetic and biochemical demonstration of a phosphatase in the clock; oscillating PP2A regulatory subunits control PER stability.
    • Sathyanarayanan, S., Zheng, X., Xiao, R. & Sehgal, A. Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell 116, 603-615 (2004). The first genetic and biochemical demonstration of a phosphatase in the clock; oscillating PP2A regulatory subunits control PER stability.
  • 77
    • 33745918016 scopus 로고    scopus 로고
    • Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5
    • Partch, C. L., Shields, K. F., Thompson, C. L., Selby, C. P. & Sancar, A. Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5. Proc. Natl Acad. Sci. USA 103, 10467-10472 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 10467-10472
    • Partch, C.L.1    Shields, K.F.2    Thompson, C.L.3    Selby, C.P.4    Sancar, A.5
  • 78
    • 0032568812 scopus 로고    scopus 로고
    • Regulation of casein kinase Iε and casein kinase Iδ by an in vivo futile phosphorylation cycle
    • Rivers, A., Gietzen, K. F., Vielhaber, E. & Virshup, D. M. Regulation of casein kinase Iε and casein kinase Iδ by an in vivo futile phosphorylation cycle. J. Biol. Chem. 273, 15980-15984 (1998).
    • (1998) J. Biol. Chem , vol.273 , pp. 15980-15984
    • Rivers, A.1    Gietzen, K.F.2    Vielhaber, E.3    Virshup, D.M.4
  • 79
    • 0031914640 scopus 로고    scopus 로고
    • Autoinhibition of casein kinase Iε (CKIε) is relieved by protein phosphatases and limited proteolysis
    • Cegielska, A., Gietzen, K. F., Rivers, A. & Virshup, D. M. Autoinhibition of casein kinase Iε (CKIε) is relieved by protein phosphatases and limited proteolysis. J. Biol. Chem. 273, 1357-1364 (1998).
    • (1998) J. Biol. Chem , vol.273 , pp. 1357-1364
    • Cegielska, A.1    Gietzen, K.F.2    Rivers, A.3    Virshup, D.M.4
  • 80
    • 33745503975 scopus 로고    scopus 로고
    • JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS
    • Koh, K., Zheng, X. & Sehgal, A. JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. Science 312, 1809-1812 (2006).
    • (2006) Science , vol.312 , pp. 1809-1812
    • Koh, K.1    Zheng, X.2    Sehgal, A.3
  • 81
    • 0033543596 scopus 로고    scopus 로고
    • A role for the proteasome in the light response of the timeless clock protein
    • Naidoo, N., Song, W., Hunter-Ensor, M. & Sehgal, A. A role for the proteasome in the light response of the timeless clock protein. Science 285, 1737-1741 (1999).
    • (1999) Science , vol.285 , pp. 1737-1741
    • Naidoo, N.1    Song, W.2    Hunter-Ensor, M.3    Sehgal, A.4
  • 82
    • 0034647656 scopus 로고    scopus 로고
    • Cloning and characterization of rat casein kinase 1ε
    • Takano, A. et al. Cloning and characterization of rat casein kinase 1ε. FEBS Lett. 477, 106-112 (2000).
    • (2000) FEBS Lett , vol.477 , pp. 106-112
    • Takano, A.1
  • 83
    • 0001619410 scopus 로고    scopus 로고
    • Phosphorylation and destabilization of human period I clock protein by human casein kinase Iε
    • Keesler, G. A. et al. Phosphorylation and destabilization of human period I clock protein by human casein kinase Iε. Neuroreport 11, 951-955 (2000).
    • (2000) Neuroreport , vol.11 , pp. 951-955
    • Keesler, G.A.1
  • 84
    • 0034045931 scopus 로고    scopus 로고
    • Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase Iε
    • Vielhaber, E., Eide, E., Rivers, A., Gao, Z. H. & Virshup, D. M. Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase Iε. Mol. Cell. Biol. 20, 4888-4899 (2000).
    • (2000) Mol. Cell. Biol , vol.20 , pp. 4888-4899
    • Vielhaber, E.1    Eide, E.2    Rivers, A.3    Gao, Z.H.4    Virshup, D.M.5
  • 85
    • 0035793451 scopus 로고    scopus 로고
    • Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2
    • Camacho, F. et al. Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2. FEBS Lett. 489, 159-165 (2001).
    • (2001) FEBS Lett , vol.489 , pp. 159-165
    • Camacho, F.1
  • 86
    • 0036178045 scopus 로고    scopus 로고
    • Control of intracellular dynamics of mammalian period proteins by casein kinase Iε (CKIε) and CKIδ in cultured cells
    • Akashi, M., Tsuchiya, Y., Yoshino, T. & Nishida, E. Control of intracellular dynamics of mammalian period proteins by casein kinase Iε (CKIε) and CKIδ in cultured cells. Mol. Cell. Biol. 22, 1693-1703 (2002).
    • (2002) Mol. Cell. Biol , vol.22 , pp. 1693-1703
    • Akashi, M.1    Tsuchiya, Y.2    Yoshino, T.3    Nishida, E.4
  • 87
    • 2642574991 scopus 로고    scopus 로고
    • Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts
    • Miyazaki, K. et al. Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts. Biochem. J. 380, 95-103 (2004).
    • (2004) Biochem. J , vol.380 , pp. 95-103
    • Miyazaki, K.1
  • 88
    • 22844432019 scopus 로고    scopus 로고
    • SCFβ-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein
    • Shirogane, T., Jin, J., Ang, X. L. & Harper, J. W. SCFβ-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J. Biol. Chem. 280, 26863-26872 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 26863-26872
    • Shirogane, T.1    Jin, J.2    Ang, X.L.3    Harper, J.W.4
  • 89
    • 33749360459 scopus 로고    scopus 로고
    • Protein phosphatase 1 regulates the stability of the circadian protein PER2
    • Gallego, M., Kang, H. & Virshup, D. M. Protein phosphatase 1 regulates the stability of the circadian protein PER2. Biochem. J. 399, 169-175 (2006).
    • (2006) Biochem. J , vol.399 , pp. 169-175
    • Gallego, M.1    Kang, H.2    Virshup, D.M.3
  • 90
    • 1942502180 scopus 로고    scopus 로고
    • The many faces of β-TrCP E3 ubiquitin ligases: Reflections in the magic mirror of cancer
    • Fuchs, S. Y., Spiegelman, V. S. & Kumar, K. G. The many faces of β-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer. Oncogene 23, 2028-2036 (2004).
    • (2004) Oncogene , vol.23 , pp. 2028-2036
    • Fuchs, S.Y.1    Spiegelman, V.S.2    Kumar, K.G.3
  • 91
    • 18344386695 scopus 로고    scopus 로고
    • SCF-mediated protein degradation and cell cycle control
    • Ang, X. L. & Wade Harper, J. SCF-mediated protein degradation and cell cycle control. Oncogene 24, 2860-2870 (2005).
    • (2005) Oncogene , vol.24 , pp. 2860-2870
    • Ang, X.L.1    Wade Harper, J.2
  • 92
    • 0037079034 scopus 로고    scopus 로고
    • The F-box protein slimb controls the levels of clock proteins period and timeless
    • Grima, B. et al. The F-box protein slimb controls the levels of clock proteins period and timeless. Nature 420, 178-182 (2002).
    • (2002) Nature , vol.420 , pp. 178-182
    • Grima, B.1
  • 93
    • 0037069671 scopus 로고    scopus 로고
    • Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime
    • Ko, H. W., Jiang, J. & Edery, I. Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Nature 420, 673-678 (2002).
    • (2002) Nature , vol.420 , pp. 673-678
    • Ko, H.W.1    Jiang, J.2    Edery, I.3
  • 94
    • 0034800310 scopus 로고    scopus 로고
    • Photic signaling by cryptochrome in the Drosophila circadian system
    • Lin, F. J., Song, W., Meyer-Bernstein, E., Naidoo, N. & Sehgal, A. Photic signaling by cryptochrome in the Drosophila circadian system. Mol. Cell. Biol. 21, 7287-7294 (2001).
    • (2001) Mol. Cell. Biol , vol.21 , pp. 7287-7294
    • Lin, F.J.1    Song, W.2    Meyer-Bernstein, E.3    Naidoo, N.4    Sehgal, A.5
  • 95
    • 0344736694 scopus 로고    scopus 로고
    • A detailed predictive model of the mammalian circadian clock
    • Forger, D. B. & Peskin, C. S. A detailed predictive model of the mammalian circadian clock. Proc. Natl Acad. Sci. USA 100, 14806-14811 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 14806-14811
    • Forger, D.B.1    Peskin, C.S.2
  • 96
    • 4444289719 scopus 로고    scopus 로고
    • Model based conjectures on mammalian clock controversies
    • Forger, D. B. & Peskin, C. S. Model based conjectures on mammalian clock controversies. J. Theor. Biol. 230, 533-539 (2004).
    • (2004) J. Theor. Biol , vol.230 , pp. 533-539
    • Forger, D.B.1    Peskin, C.S.2
  • 97
    • 23944470712 scopus 로고    scopus 로고
    • Cardone, L. et al. Circadian clock control by SUMOylation of BMAL1. Science 309, 1390-1394 (2005). Phosphorylation and dephosphorylation are not the only post-translational modifications that regulate the clock.
    • Cardone, L. et al. Circadian clock control by SUMOylation of BMAL1. Science 309, 1390-1394 (2005). Phosphorylation and dephosphorylation are not the only post-translational modifications that regulate the clock.
  • 98
    • 20044390202 scopus 로고    scopus 로고
    • The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period
    • Cyran, S. A. et al. The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period. J. Neurosci. 25, 5430-5437 (2005).
    • (2005) J. Neurosci , vol.25 , pp. 5430-5437
    • Cyran, S.A.1
  • 99
    • 0442319504 scopus 로고    scopus 로고
    • The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity
    • Nawathean, P. & Rosbash, M. The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity. Mol. Cell 13, 213-223 (2004).
    • (2004) Mol. Cell , vol.13 , pp. 213-223
    • Nawathean, P.1    Rosbash, M.2
  • 100
    • 0033597904 scopus 로고    scopus 로고
    • mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop
    • Kume, K. et al. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98, 193-205 (1999).
    • (1999) Cell , vol.98 , pp. 193-205
    • Kume, K.1
  • 101
    • 3543005291 scopus 로고    scopus 로고
    • Identification of mPer1 phosphorylation sites responsible for the nuclear entry
    • Takano, A., Isojima, Y. & Nagai, K. Identification of mPer1 phosphorylation sites responsible for the nuclear entry. J. Biol. Chem. 279, 32578-32585 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 32578-32585
    • Takano, A.1    Isojima, Y.2    Nagai, K.3
  • 102
    • 0030293638 scopus 로고    scopus 로고
    • Regulation of nuclear entry of the Drosophila clock proteins period and timeless
    • Saez, L. & Young, M. W. Regulation of nuclear entry of the Drosophila clock proteins period and timeless. Neuron 17, 911-920 (1996).
    • (1996) Neuron , vol.17 , pp. 911-920
    • Saez, L.1    Young, M.W.2
  • 103
    • 0037101628 scopus 로고    scopus 로고
    • Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster
    • Shafer, O. T., Rosbash, M. & Truman, J. W. Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster. J. Neurosci. 22, 5946-5954 (2002).
    • (2002) J. Neurosci , vol.22 , pp. 5946-5954
    • Shafer, O.T.1    Rosbash, M.2    Truman, J.W.3
  • 104
    • 30844466208 scopus 로고    scopus 로고
    • Meyer, P., Saez, L. & Young, M. W. PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock. Science 311, 226-229 (2006). A previously unrecognized timing mechanism when moving PER and TIM from the cytoplasm to the nucleus.
    • Meyer, P., Saez, L. & Young, M. W. PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock. Science 311, 226-229 (2006). A previously unrecognized timing mechanism when moving PER and TIM from the cytoplasm to the nucleus.
  • 105
    • 30844472463 scopus 로고    scopus 로고
    • Dunlap, J. C. Physiology. Running a clock requires quality time together. Science 311, 184-186 (2006).
    • Dunlap, J. C. Physiology. Running a clock requires quality time together. Science 311, 184-186 (2006).
  • 106
    • 17244373578 scopus 로고    scopus 로고
    • Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro
    • Nakajima, M. et al. Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro. Science 308, 414-415 (2005).
    • (2005) Science , vol.308 , pp. 414-415
    • Nakajima, M.1
  • 107
    • 0346668358 scopus 로고    scopus 로고
    • Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors
    • Liu, F., Virshup, D. M., Nairn, A. C. & Greengard, P. Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. J. Biol. Chem. 277, 45393-45399 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 45393-45399
    • Liu, F.1    Virshup, D.M.2    Nairn, A.C.3    Greengard, P.4
  • 108
    • 1842424730 scopus 로고    scopus 로고
    • Regulation of casein kinase I ε activity by Wnt signaling
    • Swiatek, W. et al. Regulation of casein kinase I ε activity by Wnt signaling. J. Biol. Chem. 279, 13011-13017 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 13011-13017
    • Swiatek, W.1
  • 109
    • 0036435674 scopus 로고    scopus 로고
    • Molecular genetics of timing in intrinsic circadian rhythm sleep disorders
    • Wijnen, H., Boothroyd, C., Young, M. W. & Claridge-Chang, A. Molecular genetics of timing in intrinsic circadian rhythm sleep disorders. Ann. Med. 34, 386-393 (2002).
    • (2002) Ann. Med , vol.34 , pp. 386-393
    • Wijnen, H.1    Boothroyd, C.2    Young, M.W.3    Claridge-Chang, A.4
  • 111
    • 0035035554 scopus 로고    scopus 로고
    • Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome
    • 342-346
    • Ebisawa, T. et al. Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome. EMBO Rep. 2, 342-346 (2001).
    • (2001) EMBO Rep , vol.2
    • Ebisawa, T.1
  • 112
    • 5044224429 scopus 로고    scopus 로고
    • A missense variation in human casein kinase I ε gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders
    • Takano, A. et al. A missense variation in human casein kinase I ε gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders. Neuropsychopharmacology 29, 1901-1909 (2004).
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1901-1909
    • Takano, A.1


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