Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- Aldoxime and -Amidoxime hybrids as efficient uncharged reactivators of nerve agent-Inhibited human acetylcholinesterase

European Journal of Medicinal Chemistry

Volumn 78, Issue , 2014, Pages 455-467

  Kliachyna, Maria ^a   Santoni, Gianluca ^b   Nussbaum, Valentin ^a   Renou, Julien ^c   Sanson, Benoit ^b   Colletier, Jacques Philippe ^b   Arboléas, Mélanie ^d   Loiodice, Mélanie ^d   Weik, Martin ^b   Jean, Ludovic ^c   Renard, Pierre Yves ^c   Nachon, Florian ^b,d   Baati, Rachid ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^c UNIVERSITÉ DE ROUEN   (France)

^d INSTITUT DE RECHERCHE BIOMÉDICALE DES ARMÉES   (France)

Author keywords

Hybrids; Organophosphorus nerve agents; Oximes; Pyridinaldoximes; Reactivation of acetylcholinesterase; Tacrine

Indexed keywords

1,2,3,4 TETRAHYDRO 9 AMINOACRIDINE A HYDROXYPYRIDINE ALDOXIME; 1,2,3,4 TETRAHYDRO 9 AMINOACRIDINE ALPHA HYDROXYPYRIDINE AMIDOXIME; 1,2,3,4 TETRAHYDRO 9 THIOACRIDINE HYDROXYPYRIDINE ALDOXIME; 2 [(1E)(HYDROXYIMINO)METHYL] 6 [5 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PENTY]PYRIDIN 3 OL; 2 [1 (HYDROXYIMINO)METHYL] 6 [4 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]BUTYL]PYRIDIN 3 OL; 3 HYDROXY 6 [4 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]BUTYL]PYRIDINE 2 CARBALDEHYDE; 3 HYDROXY 6 [5 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PENTYL]PYRIDINE 2 CARBALDEHYDE; ACETYLCHOLINESTERASE; ALDOXIME; AMIDOXIME; HETERODIMER; METHYL 3 (BENZYLOXY) 6 [4 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]BUT 1 YN 1 YL]PYRIDINE 2 CARBOXYLATE; METHYL 3 (BENZYLOXY) 6 [5 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PENT 1 YN 1 YL]PYRIDINE 2 CARBOXYLATE; METHYL 3 (BENZYLOXY) 6 [5 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PENTYL]PYRIDINE 2 CARBOXYLATE; METHYL 3 HYDROXY 6 [4 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]BUTYL]PYRIDINE 2 CARBOXYLATE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; PARAOXON; PYRIDINE DERIVATIVE; TABUN; TACRINE DERIVATIVE; UNCLASSIFIED DRUG; ACETALDOXIME; AMIDE; CHEMICAL WARFARE AGENT; CHOLINESTERASE INHIBITOR; OXIME; PYRIDINE; TACRINE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CLINICAL EVALUATION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REACTIVATION; HUMAN; HYBRID; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NERVE; ORGANOPHOSPHATE POISONING; PROTON NUCLEAR MAGNETIC RESONANCE; SONOGASHIRA REACTION; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; SYNTHESIS;

ACETYLCHOLINESTERASE; AMIDES; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXIMES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 84898755282     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.044     Document Type: Article

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