Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase - Structure-activity relationships

Biochemical Pharmacology

Volumn 83, Issue 12, 2012, Pages 1700-1706

  Worek, Franz ^a   Wille, Timo ^a   Koller, Marianne ^a   Thiermann, Horst ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

Author keywords

Acetylcholinesterase; Kinetics; Organophosphorus compounds; Oximes; Structure activity relationship

Indexed keywords

ACETYLCHOLINESTERASE; BIS(PYRIDINIUM OXIME) DERIVATIVE; CYCLOSARIN; ORGANOPHOSPHATE; PARAOXON; TABUN;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG BINDING; DRUG EFFICACY; ENZYME INHIBITION; ENZYME REACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; HUMANS; KINETICS; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; PARAOXON; PHOSPHORIC ACID ESTERS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84860139134     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.03.002     Document Type: Article

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