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Angewandte Chemie - International Edition

Volumn 41, Issue 6, 2002, Pages 1053-1057

Click chemistry in situ: Acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks

(8) Lewis, Warren G a Green, Luke G a Grynszpan, Flavio a Radić, Zoran b Carlier, Paul R c Taylor, Palmer b Finn, M G a Sharpless, K Barry a

a SCRIPPS RESEARCH INSTITUTE (United States)

b San Diego (United States)

c VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY (United States)

Author keywords

Combinatorial chemistry; Cycloaddition; Heterocycles; Hydrolases; Inhibitors

Indexed keywords

ADDITION REACTIONS; ENZYMES; PROTEINS;

REACTION VESSELS;

CHEMISTRY;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR;

ARTICLE; BINDING AFFINITY; CATALYSIS; CATALYST; CHEMICAL BINDING; CHEMICAL REACTION; CHEMICAL STRUCTURE; HYDROLYSIS; LIGAND BINDING; SYNTHESIS; ANIMAL; BINDING SITE; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG DESIGN; KINETICS; METHODOLOGY; MOUSE; TORPEDO;

ACETYLCHOLINESTERASE; ANIMALS; BINDING SITES; CHOLINESTERASE INHIBITORS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; KINETICS; MICE; TORPEDO;

EID: 0037087516 PISSN: 14337851 EISSN: None Source Type: Journal
DOI: 10.1002/1521-3773(20020315)41:6<1053::AID-ANIE1053>3.0.CO;2-4 Document Type: Article

Times cited : (777)

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