Structural insights into substrate traffic and inhibition in acetylcholinesterase

EMBO Journal

Volumn 25, Issue 12, 2006, Pages 2746-2756

  Colletier, Jacques Philippe ^a   Fournier, Didier ^b   Greenblatt, Harry M ^c   Stojan, Jure ^d   Sussman, Joel L ^c   Zaccai, Giuseppe ^a,e   Silman, Israel ^c   Weik, Martin ^a  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d UNIVERSITY OF LJUBLJANA   (Slovenia)

^e INSTITUT LAUE LANGEVIN   (France)

Author keywords

Acetylcholinesterase; Enzyme catalysis; Kinetic crystallography; Substrate inhibition; Substrate traffic

Indexed keywords

ACETIC ACID; ACETYLCHOLINESTERASE; ACETYLTHIOCHOLINE; CHOLINE;

ALLOSTERISM; ARTICLE; BINDING SITE; CATALYSIS; CHOLINERGIC SYNAPSE; CONCENTRATION RESPONSE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; SYNAPSE; TORPEDO CALIFORNICA;

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ACETYLTHIOCHOLINE; ANIMALS; BINDING SITES; CHOLINESTERASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; SUBSTRATE SPECIFICITY; TORPEDO;

TORPEDO CALIFORNICA;

EID: 33745550034     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601175     Document Type: Article

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