Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis

Oncotarget

Volumn 5, Issue 5, 2014, Pages 1162-1173

  Graham, Regina M ^a   Thompson, John W ^a   Webster, Keith A ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Bafilomycin a1; Cancer; Hypoxia; Programmed cell death; Xenograft

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ADENOSINE TRIPHOSPHATASE; BAFILOMYCIN A1; PROTEIN BNIP3; SORAFENIB; 1,3 BUTADIENE DERIVATIVE; ANTINEOPLASTIC AGENT; BNIP3 PROTEIN, HUMAN; CARBANILAMIDE DERIVATIVE; ENZYME INHIBITOR; MACROLIDE; MEMBRANE PROTEIN; NICOTINAMIDE; NITRILE; ONCOPROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER CONTROL; CANCER RESISTANCE; CANCER STEM CELL; CELL DEATH; CELL HYPOXIA; CELL PROTECTION; CELL STRAIN MCF 7; CELL STRAIN MDA MB 231; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; METASTASIS INHIBITION; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; TUMOR CELL DESTRUCTION; TUMOR REGRESSION; TUMOR VOLUME; TUMOR XENOGRAFT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; DRUG EFFECTS; GENE SILENCING; GENETICS; MCF 7 CELL LINE; METABOLISM; METASTASIS; PATHOLOGY; PH; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; BUTADIENES; CELL HYPOXIA; ENZYME INHIBITORS; GENE KNOCKDOWN TECHNIQUES; HETEROGRAFTS; HUMANS; HYDROGEN-ION CONCENTRATION; MACROLIDES; MAP KINASE SIGNALING SYSTEM; MCF-7 CELLS; MEMBRANE PROTEINS; MICE; NEOPLASM METASTASIS; NIACINAMIDE; NITRILES; PHENYLUREA COMPOUNDS; PROTO-ONCOGENE PROTEINS; TUMOR BURDEN; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84898652799     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1699     Document Type: Article

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