Inhibition of endosomal sequestration of basic anticancer drugs: Influence on cytotoxicity and tissue penetration

British Journal of Cancer

Volumn 94, Issue 6, 2006, Pages 863-869

  Lee, C M ^a   Tannock, I F ^a,b  

^a Princess Margaret Hospital University of Toronto   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Basic anticancer drugs; Chloroquine; Endosomal pH; Omeprazole; Tissue penetration

Indexed keywords

BAFILOMYCIN A1; CHLOROQUINE; DOXORUBICIN; MITOXANTRONE; OMEPRAZOLE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CULTURE; CLONOGENIC ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG POTENTIATION; DRUG UPTAKE; ENDOSOME; HUMAN; HUMAN CELL; HYPOTHESIS; MOUSE; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIMALARIALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CHLOROQUINE; DOXORUBICIN; DRUG INTERACTIONS; ENDOSOMES; ENZYME INHIBITORS; HYDROGEN-ION CONCENTRATION; MACROLIDES; MAMMARY NEOPLASMS, ANIMAL; MICE; MITOXANTRONE; OMEPRAZOLE; SARCOMA; TUMOR CELLS, CULTURED;

EID: 33645307960     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6603010     Document Type: Article

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