pH and drug resistance. I. Functional expression of plasmalemmal V-type H+-ATPase in drug-resistant human breast carcinoma cell lines

Biochemical Pharmacology

Volumn 57, Issue 9, 1999, Pages 1037-1046

  Martínez Zaguilán, Raul ^a   Raghunand, Natarajan ^a   Lynch, Ronald M ^a   Bellamy, William ^a   Martinez, Gloria M ^a   Rojas, Bertha ^a   Smith, Douglas ^a   Dalton, William S ^a   Gillies, Robert J ^a  

^a Departments of Biochemistry   (United States)

Author keywords

Cancer cells; H+ ATPase; Intracellular pH; MCF 7; MDR; P glycoprotein; SNARF 1; Vacuolar pH

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BAFILOMYCIN A1; DACTINOMYCIN; DOXORUBICIN; GLYCOPROTEIN P; MITOXANTRONE;

ARTICLE; BREAST CARCINOMA; CARCINOMA CELL; CELL PH; CELL VACUOLE; CONTROLLED STUDY; FLUORESCENCE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON SODIUM EXCHANGE;

ANTINEOPLASTIC AGENTS; BENZOPYRANS; BICARBONATES; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CELL COMPARTMENTATION; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENDOSOMES; FEMALE; FLUORESCENT DYES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROGEN-ION CONCENTRATION; NAPHTHOLS; PROTON-TRANSLOCATING ATPASES; RHODAMINES; SODIUM-HYDROGEN ANTIPORTER; TUMOR CELLS, CULTURED; VACUOLAR PROTON-TRANSLOCATING ATPASES; VACUOLES;

EID: 0345040164     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00022-2     Document Type: Article

References (32)

1. Juranka P.F., Zastawny R.L., Ling V. P-glycoprotein Multidrug-resistance and a superfamily of membrane-associated transport proteins . FASEB J. 3:1989;2583-2592.
2. Roninson I.B. Molecular mechanism of multidrug resistance in tumor cells. Clin Physiol Biochem. 5:1987;140-151.
3. Moscow J.A., Cowan K.H. Multidrug resistance. J Natl Cancer Inst. 80:1988;14-20.
4. Raghunand N., Martínez-Zaguilán R., Wright S.H., Gillies R.J. pH and drug resistance. II. Turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs. Biochem Pharmacol. 57:1999;1047-1058.
5. Gottesman M.M., Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem. 62:1993;385-427.
6. Lyon R.C., Cohen J.S., Faustino P.J., Megnin F., Myers C.E. Glucose metabolism in drug-sensitive and drug-resistant human breast cancer cells monitored by magnetic resonance spectroscopy. Cancer Res. 48:1988;870-877.
7. Versantvoort C.H., Broxterman H.J., Feller N., Dekker H., Kuiper C.M.L.J. Probing daunorubicin accumulation defects in non-P-glycoprotein expressing multidrug-resistant cell lines using digitonin. Int J Cancer. 50:1992;906-911.
8. Altenberg G.A., Young G., Horton J.K., Glass D., Belli J.A., Reuss L. Changes in intra- or extracellular pH do not mediate P-glycoprotein-dependent multidrug resistance. Proc Natl Acad Sci USA. 90:1993;9735-9738.
9. Boscoboinik D., Gupta R.S., Epand R.M. Investigation of the relationship between altered intracellular pH and multidrug resistance in mammalian cells. Br J Cancer. 61:1990;568-572.
10. Keizer H.G., Joenje H. Increased cytosolic pH in multidrug resistance human lung tumor cells Effect of verapamil . J Natl Cancer Inst. 81:1989;706-709.
11. Soto F., Planells-Cases R., Canaves J.M., Ferrer-Montiel A.V., Aleu J., Gamarro F., Castanys S., Gonzalez-Ros J.M., Ferragut J.A. Possible coexistence of two independent mechanisms contributing to anthracycline resistance in leukaemia P388 cells. Eur J Cancer. 29A:1993;2144-2150.
12. i homeostasis in multidrug-resistant (MDR) cells Further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein . Biochemistry. 32:1993;11042-11056.
13. Roos A., Boron W.F. Intracellular pH. Physiol Rev. 61:1981;296-434.
14. Gillies R.J., Martínez-Zaguilán R., Peterson E.P., Perona R. The role of intracellular pH in mammalian cell proliferation. Cell Physiol Biochem. 2:1992;159-179.
15. +-ATPase regulates cytoplasmic pH in murine macrophages. J Biol Chem. 265:1990;7645-7654.
16. +-ATPase types in the ruffled borders of osteoclasts. J Cell Biol. 111:1990;1305-1311.
17. +-ATPases are functionally expressed in plasma membranes of human tumor cells. Am J Physiol. 265:1993;C1015-C1029.
18. +-adenosine triphosphatase activity in multidrug resistance in HL60 cells. J Natl Cancer Inst. 83:1991;1098-1102.
19. +-ATPase subunit C is overexpressed in multidrug-resistant HL60 cells. Biochem Biophys Res Commun. 182:1992;675-681.
20. Taylor C.W., Dalton W.S., Parrish P.R., Gleason M.C., Bellany W.T., Thompson F.H., Roe D.J., Trent J.M. Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line. Br J Cancer. 63:1991;923-929.
21. + exchange by serum . J Biol Chem. 266:1991;1551-1556.
22. 2+ using the fluorescence of SNARF-1 and Fura-2. Am J Physiol. 260:1991;C297-C307.
23. 31P magnetic resonance spectroscopy. Biochem Pharmacol. 57:1999;309-312.
24. Gillies R.J., Martínez-Zaguilán R., Martinez G.M., Serrano R., Perona R. Tumorigenic 3T3 cells maintain an alkaline intracellular pH under physiological conditions. Proc Natl Acad Sci USA. 87:1990;7414-7418.
25. +-ATPase in bovine tissues. J Biol Chem. 267:1992;3696-3706.
26. Carrington W.A., Lynch R.M., Moore E.D.W., Isenberg G., Fogarty K.E., Fay F.S. Superresolution three-dimensional images of fluorescence in cells with minimal light exposure. Science. 268:1995;1483-1487.
27. Sanchez-Armass S., Martínez-Zaguilán R., Martinez G.M., Gillies R.J. Regulation of pH on rat brain synaptosomes. I. Role of sodium, bicarbonate, and potassium. J Neurophysiol. 71:1994;2236-2247.
28. -. J Neurophysiol. 71:1994;2249-2257.
29. Altan N., Chen Y., Schindler M., Simon S.M. Defective acidification in human breast tumor cells and implications for chemotherapy. J Exp Med. 187:1998;1583-1598.
30. Roepe P.D. Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug-resistant cells expressing different levels of P-glycoprotein. Biochemistry. 31:1992;12555-12564.
31. Hamilton G., Cosentini E.P., Teleky B., Koperna T., Zacheri J., Riegler M., Feil W., Schiessel R., Wenzi E. The multidrug-resistance modifiers verapamil, cyclosporine A and tamoxifen induce an intracellular acidification in colon carcinoma cell lines in vitro. Anticancer Res. 13:1993;2059-2063.
32. Simon S, Roy D and Schindler M, Intracellular pH and the control of multidrug resistance. Proc Natl Acad Sci USA 91: 1128-1132, 1994.