Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38

International Journal of Cancer

Volumn 123, Issue 11, 2008, Pages 2532-2542

  Sauvant, Christoph ^a   Nowak, Martin ^b   Wirth, Claudia ^a   Schneider, Bettina ^a   Riemann, Anne ^c   Gekle, Michael ^c   Thews, Oliver ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Acidosis; Cytotoxicity; MAP kinases; Multi drug resistance; P glycoprotein

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANGIOTENSIN 1 RECEPTOR; ANTINEOPLASTIC AGENT; CASPASE 3; DAUNORUBICIN; GLYCOPROTEIN P; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; R 3327; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ACIDIFICATION; ACIDOSIS; ANAEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER TRANSPLANTATION; CELL COMPOSITION; CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENVIRONMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; MULTIDRUG RESISTANCE; NONHUMAN; PH; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN SYNTHESIS; RAT; SINGLE DRUG DOSE; TRANSPORT KINETICS;

ACIDOSIS; ANIMALS; CASPASE 3; CELL PROLIFERATION; DAUNORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HYDROGEN-ION CONCENTRATION; MALE; NEOPLASM TRANSPLANTATION; P-GLYCOPROTEIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROSTATIC NEOPLASMS; PROTEIN KINASE C; RATS;

EID: 57349151455     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23818     Document Type: Article

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