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Volumn 67, Issue 18, 2007, Pages 8494-8503

Activation of the signal transducers and activators of the transcription 3 pathway in alveolar epithelial cells induces inflammation and adenocarcinomas in mouse lung

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; DOXYCYCLINE; STAT3 PROTEIN; STAT3C PROTEIN; UNCLASSIFIED DRUG;

EID: 34548785120     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-0647     Document Type: Article
Times cited : (125)

References (42)
  • 1
    • 0028303977 scopus 로고
    • Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    • Akira S, Nishio Y, Inoue M, et al. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 1994;77:63-71.
    • (1994) Cell , vol.77 , pp. 63-71
    • Akira, S.1    Nishio, Y.2    Inoue, M.3
  • 2
    • 0028274299 scopus 로고
    • The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family
    • Wegenka UM, Lutticken C, Buschmann J, et al. The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family. Mol Cell Biol 1994;14:3186-96.
    • (1994) Mol Cell Biol , vol.14 , pp. 3186-3196
    • Wegenka, U.M.1    Lutticken, C.2    Buschmann, J.3
  • 3
    • 0031919849 scopus 로고    scopus 로고
    • Jaks and STATs: Biological implications
    • Leonard WJ, O'Shea JJ. Jaks and STATs: biological implications. Annu Rev Immunol 1998;16:293-322.
    • (1998) Annu Rev Immunol , vol.16 , pp. 293-322
    • Leonard, W.J.1    O'Shea, J.J.2
  • 4
    • 0030890718 scopus 로고    scopus 로고
    • Gp130 and the interleukin-6 family of cytokines
    • Taga T, Kishimoto T. Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 1997;15:797-819.
    • (1997) Annu Rev Immunol , vol.15 , pp. 797-819
    • Taga, T.1    Kishimoto, T.2
  • 5
    • 0028349735 scopus 로고
    • Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong Z, Wen Z, Darnell JE, Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994;264:95-8.
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell Jr, J.E.3
  • 6
    • 0037192781 scopus 로고    scopus 로고
    • Transcriptional stimulation of the surfactant protein B gene by STAT3 in respiratory epithelial cells
    • Yan C, Naltner A, Martin M, Naltner M, Fangman JM, Gurel O. Transcriptional stimulation of the surfactant protein B gene by STAT3 in respiratory epithelial cells. J Biol Chem 2002;277:10967-72.
    • (2002) J Biol Chem , vol.277 , pp. 10967-10972
    • Yan, C.1    Naltner, A.2    Martin, M.3    Naltner, M.4    Fangman, J.M.5    Gurel, O.6
  • 7
    • 2542430085 scopus 로고    scopus 로고
    • Synergy between signal transducer and activator of transcription 3 and retinoic acid receptor-α in regulation of the surfactant protein B gene in the lung
    • Yang L, Lian X, Cowen A, Xu H, Du H, Yan C. Synergy between signal transducer and activator of transcription 3 and retinoic acid receptor-α in regulation of the surfactant protein B gene in the lung. Mol Endocrinol 2004;18:1520-32.
    • (2004) Mol Endocrinol , vol.18 , pp. 1520-1532
    • Yang, L.1    Lian, X.2    Cowen, A.3    Xu, H.4    Du, H.5    Yan, C.6
  • 9
    • 21544473172 scopus 로고    scopus 로고
    • Targeting STAT3 affects melanoma on multiple fronts
    • Kortylewski M, Jove R, Yu H. Targeting STAT3 affects melanoma on multiple fronts. Cancer Metastasis Rev 2005;24:315-27.
    • (2005) Cancer Metastasis Rev , vol.24 , pp. 315-327
    • Kortylewski, M.1    Jove, R.2    Yu, H.3
  • 10
    • 28544438023 scopus 로고    scopus 로고
    • Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer
    • Haura EB, Zheng Z, Song L, Cantor A, Bepler G. Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer. Clin Cancer Res 2005;11:8288-94.
    • (2005) Clin Cancer Res , vol.11 , pp. 8288-8294
    • Haura, E.B.1    Zheng, Z.2    Song, L.3    Cantor, A.4    Bepler, G.5
  • 11
    • 33746238953 scopus 로고    scopus 로고
    • Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion
    • Yeh HH, Lai WW, Chen HH, Liu HS, Su WC. Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion. Oncogene 2006;25:4300-9.
    • (2006) Oncogene , vol.25 , pp. 4300-4309
    • Yeh, H.H.1    Lai, W.W.2    Chen, H.H.3    Liu, H.S.4    Su, W.C.5
  • 12
    • 19444385692 scopus 로고    scopus 로고
    • Stat3 regulates genes common to both wound healing and cancer
    • Dauer DJ, Ferraro B, Song L, et al. Stat3 regulates genes common to both wound healing and cancer. Oncogene 2005;24:3397-408.
    • (2005) Oncogene , vol.24 , pp. 3397-3408
    • Dauer, D.J.1    Ferraro, B.2    Song, L.3
  • 14
    • 0038505594 scopus 로고    scopus 로고
    • Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC)
    • Mukohara T, Kudoh S, Yamauchi S, et al. Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC). Lung Cancer 2003;41:123-30.
    • (2003) Lung Cancer , vol.41 , pp. 123-130
    • Mukohara, T.1    Kudoh, S.2    Yamauchi, S.3
  • 15
    • 0037699512 scopus 로고    scopus 로고
    • Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells
    • Song L, Turkson J, Karras JG, Jove R, Haura EB. Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells. Oncogene 2003;22:4150-65.
    • (2003) Oncogene , vol.22 , pp. 4150-4165
    • Song, L.1    Turkson, J.2    Karras, J.G.3    Jove, R.4    Haura, E.B.5
  • 16
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • Kortylewski M, Kujawski M, Wang T, et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 2005;11:1314-21.
    • (2005) Nat Med , vol.11 , pp. 1314-1321
    • Kortylewski, M.1    Kujawski, M.2    Wang, T.3
  • 18
    • 1642379630 scopus 로고    scopus 로고
    • Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung
    • Lian X, Yan C, Yang L, Xu Y, Du H. Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung. Am J Physiol Lung Cell Mol Physiol 2004;286:L801-7.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286
    • Lian, X.1    Yan, C.2    Yang, L.3    Xu, Y.4    Du, H.5
  • 19
    • 24044508876 scopus 로고    scopus 로고
    • Neutral lipids and peroxisome proliferator-activated receptor-γ control pulmonary gene expression and inflammation-triggered pathogenesis in lysosomal acid lipase knockout mice
    • Lian X, Yan C, Qin Y, Knox L, Li T, Du H. Neutral lipids and peroxisome proliferator-activated receptor-γ control pulmonary gene expression and inflammation-triggered pathogenesis in lysosomal acid lipase knockout mice. Am J Pathol 2005;167:813-21.
    • (2005) Am J Pathol , vol.167 , pp. 813-821
    • Lian, X.1    Yan, C.2    Qin, Y.3    Knox, L.4    Li, T.5    Du, H.6
  • 20
    • 21044459500 scopus 로고    scopus 로고
    • Overexpression of Stat3C in pulmonary epithelium protects against hyperoxic lung injury
    • Lian X, Qin Y, Hossain SA, et al. Overexpression of Stat3C in pulmonary epithelium protects against hyperoxic lung injury. J Immunol 2005;174:7250-6.
    • (2005) J Immunol , vol.174 , pp. 7250-7256
    • Lian, X.1    Qin, Y.2    Hossain, S.A.3
  • 21
    • 22144492213 scopus 로고    scopus 로고
    • IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation
    • McLoughlin RM, Jenkins BJ, Grail D, et al. IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proc Natl Acad Sci U S A 2005;102:9589-94.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9589-9594
    • McLoughlin, R.M.1    Jenkins, B.J.2    Grail, D.3
  • 22
    • 0032213273 scopus 로고    scopus 로고
    • Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice
    • Takeda K, Kaisho T, Yoshida N, Takeda J, Kishimoto T, Akira S. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol 1998;161:4652-60.
    • (1998) J Immunol , vol.161 , pp. 4652-4660
    • Takeda, K.1    Kaisho, T.2    Yoshida, N.3    Takeda, J.4    Kishimoto, T.5    Akira, S.6
  • 23
    • 33748082302 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor promote malignant growth of cells from head and neck squamous cell carcinomas in vivo
    • Gutschalk CM, Herold-Mende CC, Fusenig NE, Mueller MM. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor promote malignant growth of cells from head and neck squamous cell carcinomas in vivo. Cancer Res 2006;66:8026-36.
    • (2006) Cancer Res , vol.66 , pp. 8026-8036
    • Gutschalk, C.M.1    Herold-Mende, C.C.2    Fusenig, N.E.3    Mueller, M.M.4
  • 24
    • 27744472334 scopus 로고    scopus 로고
    • Macrophage migration and gene expression in response to tumor hypoxia
    • Murdoch C, Lewis CE. Macrophage migration and gene expression in response to tumor hypoxia. Int J Cancer 2005;117:701-8.
    • (2005) Int J Cancer , vol.117 , pp. 701-708
    • Murdoch, C.1    Lewis, C.E.2
  • 25
    • 1342324748 scopus 로고    scopus 로고
    • Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer
    • Keane MP, Belperio JA, Xue YY, Burdick MD, Strieter RM. Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer. J Immunol 2004;172:2853-60.
    • (2004) J Immunol , vol.172 , pp. 2853-2860
    • Keane, M.P.1    Belperio, J.A.2    Xue, Y.Y.3    Burdick, M.D.4    Strieter, R.M.5
  • 26
    • 0025038599 scopus 로고
    • Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES
    • Schall TJ, Bacon K, Toy KJ, Goeddel DV. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 1990;347:669-71.
    • (1990) Nature , vol.347 , pp. 669-671
    • Schall, T.J.1    Bacon, K.2    Toy, K.J.3    Goeddel, D.V.4
  • 27
    • 85047695527 scopus 로고    scopus 로고
    • Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
    • Niu G, Wright KL, Huang M, et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 2002;21:2000-8.
    • (2002) Oncogene , vol.21 , pp. 2000-2008
    • Niu, G.1    Wright, K.L.2    Huang, M.3
  • 28
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFκB
    • Yang J, Liao X, Agarwal MK, Barnes L, Auron PE, Stark GR. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFκB. Genes Dev 2007;21:1396-408.
    • (2007) Genes Dev , vol.21 , pp. 1396-1408
    • Yang, J.1    Liao, X.2    Agarwal, M.K.3    Barnes, L.4    Auron, P.E.5    Stark, G.R.6
  • 29
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • Lewis CE, Pollard JW. Distinct role of macrophages in different tumor microenvironments. Cancer Res 2006;66:605-12.
    • (2006) Cancer Res , vol.66 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 30
  • 31
    • 0032563948 scopus 로고    scopus 로고
    • Sonic hedgehog regulates branching morphogenesis in the mammalian lung
    • Pepicelli CV, Lewis PM, McMahon AP. Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol 1998;8:1083-6.
    • (1998) Curr Biol , vol.8 , pp. 1083-1086
    • Pepicelli, C.V.1    Lewis, P.M.2    McMahon, A.P.3
  • 32
    • 0031711075 scopus 로고    scopus 로고
    • Sonic hedgehog is essential to foregut development
    • Litingtung Y, Lei L, Westphal H, Chiang C. Sonic hedgehog is essential to foregut development. Nat Genet 1998;20:58-61.
    • (1998) Nat Genet , vol.20 , pp. 58-61
    • Litingtung, Y.1    Lei, L.2    Westphal, H.3    Chiang, C.4
  • 33
  • 34
    • 2342481730 scopus 로고    scopus 로고
    • Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis
    • Li Y, Zhang H, Choi SC, Litingtung Y, Chiang C. Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis. Dev Biol 2004;270:214-31.
    • (2004) Dev Biol , vol.270 , pp. 214-231
    • Li, Y.1    Zhang, H.2    Choi, S.C.3    Litingtung, Y.4    Chiang, C.5
  • 35
    • 0033754122 scopus 로고    scopus 로고
    • The sonic hedgehog-patched-gli pathway in human development and disease
    • Villavicencio EH, Walterhouse DO, Iannaccone PM. The sonic hedgehog-patched-gli pathway in human development and disease. Am J Hum Genet 2000;67:1047-54.
    • (2000) Am J Hum Genet , vol.67 , pp. 1047-1054
    • Villavicencio, E.H.1    Walterhouse, D.O.2    Iannaccone, P.M.3
  • 36
    • 0034695567 scopus 로고    scopus 로고
    • More surprises in the Hedgehog signaling pathway
    • McMahon AP. More surprises in the Hedgehog signaling pathway. Cell 2000;100:185-8.
    • (2000) Cell , vol.100 , pp. 185-188
    • McMahon, A.P.1
  • 37
    • 4143129753 scopus 로고    scopus 로고
    • Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung
    • Miller LA, Wert SE, Clark JC, Xu Y, Perl AK, Whitsett JA. Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn 2004;231:57-71.
    • (2004) Dev Dyn , vol.231 , pp. 57-71
    • Miller, L.A.1    Wert, S.E.2    Clark, J.C.3    Xu, Y.4    Perl, A.K.5    Whitsett, J.A.6
  • 38
    • 0030057596 scopus 로고    scopus 로고
    • The T/ebp null mouse: Thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary
    • Kimura S, Hara Y, Pineau T, et al. The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev 1996;10:60-9.
    • (1996) Genes Dev , vol.10 , pp. 60-69
    • Kimura, S.1    Hara, Y.2    Pineau, T.3
  • 39
    • 0026340586 scopus 로고
    • The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain
    • Lazzaro D, Price M, de Felice M, Di Lauro R. The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development 1991;113:1093-104.
    • (1991) Development , vol.113 , pp. 1093-1104
    • Lazzaro, D.1    Price, M.2    de Felice, M.3    Di Lauro, R.4
  • 40
    • 0026696107 scopus 로고
    • Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3α, HNF-3β, HNF-3γ, and HNF-4
    • Avraham KB, Prezioso VR, Chen WS, et al. Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3α, HNF-3β, HNF-3γ, and HNF-4. Genomics 1992;13:264-8.
    • (1992) Genomics , vol.13 , pp. 264-268
    • Avraham, K.B.1    Prezioso, V.R.2    Chen, W.S.3
  • 41
    • 0027322128 scopus 로고
    • Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
    • Clevidence DE, Overdier DG, Tao W, et al. Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A 1993;90:3948-52.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 3948-3952
    • Clevidence, D.E.1    Overdier, D.G.2    Tao, W.3
  • 42
    • 0030935260 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
    • Takeda K, Noguchi K, Shi W, et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A 1997;94:3801-4.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 3801-3804
    • Takeda, K.1    Noguchi, K.2    Shi, W.3


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