Hwanggeumchal sorghum induces cell cycle arrest, and suppresses tumor growth and metastasis through jak2/stat pathways in breast cancer xenografts

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Park, Jin Hee ^a   Darvin, Pramod ^a   Lim, Eun Joung ^a   Joung, Youn Hee ^a   Hong, Dae Young ^b   Park, Eui U ^a   Park, Seung Hwa ^a   Choi, Soo Keun ^c   Moon, Eon Soo ^a   Cho, Byung Wook ^d   Park, Kyung Do ^e   Lee, Hak Kyo ^e   Kim, Myong Jo ^f   Park, Dong Sik ^g   Chung, Ill Min ^h   Yang, Young Mok ^a  

^a Konkuk University School of Medicine   (South Korea)

^b Konkuk University Hospital   (South Korea)

^c Kyung Hee University   (South Korea)

^d Pusan National University   (South Korea)

^e Hankyong National University   (South Korea)

^f Kangwon National University   (South Korea)

^g National Institute of Animal Science   (South Korea)

^h Konkuk University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN D; CYCLIN E; HWANGGEUMCHAL SORGHUM EXTRACT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; JANUS KINASE 2; PLANT EXTRACT; PROTEIN P53; SOMATOMEDIN C RECEPTOR; STAT PROTEIN; STAT3 PROTEIN; STAT5B PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL CYCLE ARREST; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; DRUG SCREENING; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HWANGGEUMCHAL SORGHUM; IN VITRO STUDY; IN VIVO STUDY; MEDICINAL PLANT; METASTASIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST NEOPLASMS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; JANUS KINASE 2; LUNG NEOPLASMS; MCF-7 CELLS; MICE; MICE, NUDE; NEOPLASM METASTASIS; ONCOGENE PROTEINS; PLANT EXTRACTS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; SORGHUM; STAT TRANSCRIPTION FACTORS; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA;

EID: 84863658769     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040531     Document Type: Article

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