Inhibition of HIF prolyl-4-hydroxylases by FG-4497 reduces brain tissue injury and edema formation during ischemic stroke

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Reischl, Stefan ^a   Li, Lexiao ^a   Walkinshaw, Gail ^a   Flippin, Lee A ^b   Marti, Hugo H ^a   Kunze, Reiner ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b FIBROGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; FG 4497; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE; HYPOXIA INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITOR; OCCLUDIN; PROTEIN ZO1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEUROPROTECTION; NEWBORN; NONHUMAN; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE;

ANIMALS; ASTROCYTES; BRAIN INFARCTION; BRAIN INJURIES; EDEMA; ENDOTHELIAL CELLS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASES; INTRACELLULAR SPACE; MALE; MICE; NEURONS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; STROKE; TIGHT JUNCTION PROTEINS;

EID: 84897014610     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084767     Document Type: Article

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