Preparation and characterization of spray-dried powders intended for pulmonary delivery of Insulin with regard to the selection of excipients

International Journal of Pharmaceutics

Volumn 465, Issue 1-2, 2014, Pages 464-478

  Razavi Rohani, Seyed Salman ^a   Abnous, Khalil ^b   Tafaghodi, Mohsen ^a,c  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Chitosan; Dry powder inhaler; Insulin; Mannitol; Sodium alginate; Spray drying

Indexed keywords

ALANINE; ALGINIC ACID; CHITOSAN; DIPALMITOYLPHOSPHATIDYLCHOLINE; MANNITOL; RECOMBINANT HUMAN INSULIN; AEROSOL; ANTIDIABETIC AGENT; CITRATE SODIUM; CITRIC ACID; EXCIPIENT; GLUCURONIC ACID; HEXURONIC ACID; HUMAN INSULIN; POWDER; RECOMBINANT PROTEIN; WATER; SILVER NITRATE;

AEROSOL; ARTICLE; COMPARATIVE STUDY; CRYSTALLIZATION; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG STABILITY; DRY POWDER; IN VITRO STUDY; MOISTURE; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN STABILITY; SCANNING ELECTRON MICROSCOPY; SPECTROFLUOROMETRY; SPRAY DRYING; SUSTAINED DRUG RELEASE; CHEMICAL STRUCTURE; CHEMISTRY; DESICCATION; DIFFERENTIAL SCANNING CALORIMETRY; HUMAN; INHALATIONAL DRUG ADMINISTRATION; KINETICS; MEDICINAL CHEMISTRY; PHARMACEUTICS; POWDER; PROCEDURES; SOLUBILITY; CONTROLLED STUDY; DENSITY; DRUG RELEASE; ELECTROPHORESIS; FLUORESCENCE SPECTROSCOPY; MELTING POINT; MOLECULAR WEIGHT; NATIVE POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN SECRETION;

ADMINISTRATION, INHALATION; AEROSOLS; ALGINATES; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CITRATES; DESICCATION; EXCIPIENTS; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN, REGULAR, HUMAN; KINETICS; MANNITOL; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR STRUCTURE; PARTICLE SIZE; POWDERS; RECOMBINANT PROTEINS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 84898599360     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.02.030     Document Type: Article

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